| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Claes Fryklund, Madelene Borg, Tobias Svensson, Sara Schumacher, Florentina Negoita, Björn Morén, Karin G Stenkul. Impaired glucose transport in inguinal adipocytes after short-term high-sucrose feeding in mice. The Journal of nutritional biochemistry. vol 78. 2021-02-23. PMID:32004930. |
altogether, we demonstrate that short-term hsd feeding has deleterious impact on insulin response and glucose transport in the inguinal adipose tissue depot, specifically. |
2021-02-23 |
2023-08-13 |
mouse |
| Daniela Regazzo, Mattia Barbot, Carla Scaroni, Nora Albiger, Gianluca Occh. The pathogenic role of the GIP/GIPR axis in human endocrine tumors: emerging clinical mechanisms beyond diabetes. Reviews in endocrine & metabolic disorders. vol 21. issue 1. 2021-02-16. PMID:31933128. |
gip has a variety of effects on different systems, including the potentiation of insulin secretion from pancreatic β-cells after food intake (i.e. |
2021-02-16 |
2023-08-13 |
human |
| Renan Fudoli Lins Vieira, Vitor Rosetto Muñoz, Rafael Lima Junqueira, Fellipe de Oliveira, Rafael Calais Gaspar, Susana Castelo Branco Ramos Nakandakari, Suleyma de Oliveira Costa, Marcio Alberto Torsoni, Adelino S R da Silva, Dennys Esper Cintra, Leandro Pereira de Moura, Eduardo Rochete Ropelle, Iman Zaghloul, Rania A Mekary, José Rodrigo Paul. Time-restricted feeding combined with aerobic exercise training can prevent weight gain and improve metabolic disorders in mice fed a high-fat diet. The Journal of physiology. 2021-02-16. PMID:33450053. |
trf combined with ae training attenuated the detrimental effects of high-fat diet feeding on the insulin signalling pathway in the liver. |
2021-02-16 |
2023-08-13 |
mouse |
| Jian Qiu, Martha A Bosch, Chungang Zhang, Oline K Rønnekleiv, Martin J Kell. Estradiol Protects Neuropeptide Y/Agouti-Related Peptide Neurons against Insulin Resistance in Females. Neuroendocrinology. vol 110. issue 1-2. 2021-02-15. PMID:31212279. |
since the anorexigenic hormone 17β-estradiol (e2) regulates food intake in part by inhibiting the excitability of the hypothalamic neuropeptide y/agouti-related peptide (npy/agrp) neurons, we hypothesized that e2 would protect against insulin resistance in npy/agrp neurons with diet-induced obesity (dio). |
2021-02-15 |
2023-08-13 |
mouse |
| Akira Kitagawa, Yoshiji Ohta, Koji Ohashi, Koji Yashiro, Kenji Fukuzaw. Effect of High Fructose-Induced Metabolic Syndrome on Tissue Vitamin E and Lipid Peroxide Levels in Rats. Journal of nutritional science and vitaminology. vol 66. issue 2. 2021-02-10. PMID:32350182. |
feeding of a diet containing 60% fructose (hfd) to wistar rats for 2, 4, and 6 wk caused week-dependent increases in homa-ir score and serum insulin, triglyceride, total cholesterol, and free fatty acid concentrations. |
2021-02-10 |
2023-08-13 |
rat |
| Alejandro A Floh, Brian W McCrindle, Cedric Manlhiot, Masayuki Nakada, Gustavo La Rotta, Glen Van Arsdell, Steven M Schwart. Feeding May Modulate the Relationship Between Systemic Inflammation, Insulin Resistance, and Poor Outcome Following Cardiopulmonary Bypass for Pediatric Cardiac Surgery. JPEN. Journal of parenteral and enteral nutrition. vol 44. issue 2. 2021-02-08. PMID:30887547. |
feeding may modulate the relationship between systemic inflammation, insulin resistance, and poor outcome following cardiopulmonary bypass for pediatric cardiac surgery. |
2021-02-08 |
2023-08-13 |
Not clear |
| Nigel Irwin, Victor A Gault, Finbarr P M O'Harte, Peter R Flat. Blockade of gastric inhibitory polypeptide (GIP) action as a novel means of countering insulin resistance in the treatment of obesity-diabetes. Peptides. vol 125. 2021-02-08. PMID:31733230. |
sustained administration of peptide-based gipr inhibitors, low molecular weight gipr antagonists, gipr neutralising antibodies as well as genetic knockout of gipr's or vaccination against gip all demonstrate amelioration of insulin resistance and reduced body weight gain in response to high fat feeding. |
2021-02-08 |
2023-08-13 |
Not clear |
| Koji Ohashi, Yoshiji Ohta, Hiroaki Ishikawa, Akira Kitagaw. Orally administered octacosanol improves some features of high fructose-induced metabolic syndrome in rats. Journal of clinical biochemistry and nutrition. vol 68. issue 1. 2021-02-06. PMID:33536713. |
three- or four-week high fructose feeding increased insulin resistance, serum insulin, triglyceride, total cholesterol, free fatty acids, uric acid, and lipid peroxide concentrations, and hepatic triglyceride and cholesterol contents significantly and decreased serum high-density lipoprotein cholesterol and adiponectin concentrations significantly but did not affect blood pressure and hepatic lipid peroxide and reduced glutathione contents. |
2021-02-06 |
2023-08-13 |
rat |
| Koji Ohashi, Yoshiji Ohta, Hiroaki Ishikawa, Akira Kitagaw. Orally administered octacosanol improves some features of high fructose-induced metabolic syndrome in rats. Journal of clinical biochemistry and nutrition. vol 68. issue 1. 2021-02-06. PMID:33536713. |
oral administration of octacosanol (10 or 50 mg/kg body weight) to high fructose-fed rats for the last 1-week fructose diet feeding attenuated these changes except serum insulin level and insulin resistance significantly and increased hepatic reduced glutathione content significantly. |
2021-02-06 |
2023-08-13 |
rat |
| Chak Kwong Cheng, Chenguang Wang, Wenbin Shang, Chi Wai Lau, Jiang-Yun Luo, Li Wang, Yu Huan. A high methionine and low folate diet alters glucose homeostasis and gut microbiome. Biochemistry and biophysics reports. vol 25. 2021-02-06. PMID:33537464. |
the hmlf diet feeding resulted in a progressive body weight loss, and development of slight glucose intolerance and insulin resistance in hhcy mice. |
2021-02-06 |
2023-08-13 |
mouse |
| Xiao Wang, Shuchang Lai, Yanshi Ye, Yuanyuan Hu, Daoyan Pan, Xiaochun Bai, Jie She. Conditional knockout of pyruvate dehydrogenase in mouse pancreatic β‑cells causes morphological and functional changes. Molecular medicine reports. vol 21. issue 4. 2021-02-03. PMID:32319629. |
though no changes were found in food intake, development status, fasting blood glucose or weight between the groups, the level of insulin secretion at 30 min after glucose injection in the βko group was significantly lower compared with the control group. |
2021-02-03 |
2023-08-13 |
mouse |
| Yan Liu, Haiyan Lin, Lin Jiang, Qingsen Shang, Lei Yin, Jiandie D Lin, Wen-Shu Wu, Liangyou Ru. Hepatic Slug epigenetically promotes liver lipogenesis, fatty liver disease, and type 2 diabetes. The Journal of clinical investigation. vol 130. issue 6. 2021-02-02. PMID:32365055. |
hepatic slug levels were markedly upregulated in mice by either feeding or insulin treatment. |
2021-02-02 |
2023-08-13 |
mouse |
| John L Sievenpipe. Low-carbohydrate diets and cardiometabolic health: the importance of carbohydrate quality over quantity. Nutrition reviews. vol 78. issue Suppl 1. 2021-02-02. PMID:32728757. |
although the clinical investigations of the "carbohydrate-insulin model" have shown the requisite decreases in insulin secretion and increases in fat oxidation, there has been a failure to achieve the expected fat loss under low-carbohydrate feeding. |
2021-02-02 |
2023-08-13 |
Not clear |
| Xu Si, Jinlong Tian, Chi Shu, Yuehua Wang, Ersheng Gong, Ye Zhang, Weijia Zhang, Huijun Cui, Bin L. Serum Ceramide Reduction by Blueberry Anthocyanin-Rich Extract Alleviates Insulin Resistance in Hyperlipidemia Mice. Journal of agricultural and food chemistry. vol 68. issue 31. 2021-01-27. PMID:32692177. |
a bae-containing diet effectively controlled food intake and liver weight and significantly attenuated insulin resistance triggered by a hfd. |
2021-01-27 |
2023-08-13 |
mouse |
| Hui Deng, Weimin L. Therapeutic potential of targeting α/β-Hydrolase domain-containing 6 (ABHD6). European journal of medicinal chemistry. vol 198. 2021-01-26. PMID:32371333. |
abhd6 and its substrates have been shown to be involved in the modulation of various (patho)physiological processes, including neurotransmission, inflammation, insulin secretion, adipose browning, food intake, autoimmune disorders, as well as neurological and metabolic diseases, making this enzyme a promising therapeutic target to treat several diseases. |
2021-01-26 |
2023-08-13 |
Not clear |
| Ya Liu, Xiaoqing Zhou, Ye Xiao, Changjun Li, Yan Huang, Qi Guo, Tian Su, Lei Fu, Liping Lu. miR-188 promotes liver steatosis and insulin resistance via the autophagy pathway. The Journal of endocrinology. vol 245. issue 3. 2021-01-25. PMID:32252024. |
in contrast, liver-specific overexpression of mir-188 aggravated hepatic steatosis and insulin resistance during high-fat diet feeding. |
2021-01-25 |
2023-08-13 |
mouse |
| Hongshan Yin, Weini Li, Somik Chatterjee, Xuekai Xiong, Pradip Saha, Vijay Yechoor, Ke M. Metabolic-sensing of the skeletal muscle clock coordinates fuel oxidation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 5. 2021-01-22. PMID:32212194. |
bmal1 in skeletal muscle responds robustly to feeding in vivo and insulin induces its expression. |
2021-01-22 |
2023-08-13 |
mouse |
| June Guo, Troy J Pereira, Yusaku Mori, Marel Gonzalez Medina, Danna M Breen, Prasad S Dalvi, Hangjun Zhang, Declan F McCole, Michael W McBurney, Scott P Heximer, Evangelia L Tsiani, Vernon W Dolinsky, Adria Giacc. Resveratrol Inhibits Neointimal Growth after Arterial Injury in High-Fat-Fed Rodents: The Roles of SIRT1 and AMPK. Journal of vascular research. vol 57. issue 6. 2021-01-18. PMID:32777783. |
we found that high-fat feeding decreased insulin sensitivity and increased neointimal area and that rsv improved insulin sensitivity (p < 0.05) and decreased neointimal area in high-fat-fed rats (p < 0.05). |
2021-01-18 |
2023-08-13 |
mouse |
| Guang Ren, Teayoun Kim, Hae-Suk Kim, Martin E Young, Donald D Muccio, Venkatram R Atigadda, Samuel I Blum, Hubert M Tse, Kirk M Habegger, Sushant Bhatnagar, Tatjana Coric, Mary-Ann Bjornsti, Anath Shalev, Stuart J Frank, Jeong-A Ki. A Small Molecule, UAB126, Reverses Diet-Induced Obesity and its Associated Metabolic Disorders. Diabetes. vol 69. issue 9. 2021-01-15. PMID:32611548. |
oral administration of uab126 ameliorated obesity, insulin resistance, hepatic steatosis, and hyperlipidemia without changes in food intake, physical activity, and thyroid hormone levels. |
2021-01-15 |
2023-08-13 |
Not clear |
| Satoshi Yoshino, Yusaku Iwasaki, Shunichi Matsumoto, Tetsurou Satoh, Atsushi Ozawa, Eijiro Yamada, Satoru Kakizaki, Juan Alejandro Oliva Trejo, Yasuo Uchiyama, Masanobu Yamada, Masatomo Mor. Administration of small-molecule guanabenz acetate attenuates fatty liver and hyperglycemia associated with obesity. Scientific reports. vol 10. issue 1. 2021-01-11. PMID:32792584. |
this activity significantly improves insulin resistance to decrease hyperglycemia and hepatocyte and adipocyte weights, resulting in bw reduction without reducing food intake. |
2021-01-11 |
2023-08-13 |
mouse |