| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S C Woods, M Chavez, C R Park, C Riedy, K Kaiyala, R D Richardson, D P Figlewicz, M W Schwartz, D Porte, R J Seele. The evaluation of insulin as a metabolic signal influencing behavior via the brain. Neuroscience and biobehavioral reviews. vol 20. issue 1. 1996-06-14. PMID:8622820. |
finally, experimentally-induced changes of insulin in the brain cause predictable changes of food intake and body weight. |
1996-06-14 |
2023-08-12 |
Not clear |
| S C Woods, M Chavez, C R Park, C Riedy, K Kaiyala, R D Richardson, D P Figlewicz, M W Schwartz, D Porte, R J Seele. The evaluation of insulin as a metabolic signal influencing behavior via the brain. Neuroscience and biobehavioral reviews. vol 20. issue 1. 1996-06-14. PMID:8622820. |
given these observations, the question is then asked: since endogenous insulin, acting within the brain, appears to decrease food intake, can a decrease of food intake caused by exogenous insulin administered into the same area of the brain be ascribed to the same, naturally-occurring response system, or should it be attributed to malaise or a non-specific depression of behavior? |
1996-06-14 |
2023-08-12 |
Not clear |
| S C Woods, M Chavez, C R Park, C Riedy, K Kaiyala, R D Richardson, D P Figlewicz, M W Schwartz, D Porte, R J Seele. The evaluation of insulin as a metabolic signal influencing behavior via the brain. Neuroscience and biobehavioral reviews. vol 20. issue 1. 1996-06-14. PMID:8622820. |
arguments are presented supporting the former position that exogenous insulin, when administered in small quantities directly into the brain, taps into the natural caloric/metabolic system and hence influences food intake and body weight. |
1996-06-14 |
2023-08-12 |
Not clear |
| I Bergerot, N Fabien, A Mayer, C Thivole. Active suppression of diabetes after oral administration of insulin is determined by antigen dosage. Annals of the New York Academy of Sciences. vol 778. 1996-05-24. PMID:8610991. |
we have previously demonstrated that feeding six-week-old female mice with 20 units of human insulin every 2 - 3 days for 15 or 30 days induced an active mechanism of suppression through the generation of regulatory t cells that reduced the number of successful diabetic transfers in irradiated nod recipients. |
1996-05-24 |
2023-08-12 |
mouse |
| I Bergerot, N Fabien, A Mayer, C Thivole. Active suppression of diabetes after oral administration of insulin is determined by antigen dosage. Annals of the New York Academy of Sciences. vol 778. 1996-05-24. PMID:8610991. |
the effects of the dose of insulin feeding were therefore compared during cotransfer experiments of 5 x 10(6) t cells from diabetic mice and 5 x 10(6) t cells from the spleen of mice receiving 10 units, 20 units, or 40 units of insulin or saline every 2 - 3 days for 15 days. |
1996-05-24 |
2023-08-12 |
mouse |
| J A Higgins, J C Brand Miller, G S Denye. Development of insulin resistance in the rat is dependent on the rate of glucose absorption from the diet. The Journal of nutrition. vol 126. issue 3. 1996-04-25. PMID:8598543. |
amylopectin-fed animals became progressively insulin resistant from 12 to 26 wk of feeding. |
1996-04-25 |
2023-08-12 |
rat |
| J A Higgins, J C Brand Miller, G S Denye. Development of insulin resistance in the rat is dependent on the rate of glucose absorption from the diet. The Journal of nutrition. vol 126. issue 3. 1996-04-25. PMID:8598543. |
the area under the plasma insulin curves in response to a glucose load (ivgtt) for these animals rose progressively from 15.1 +/- 2.5 nmol/l.30 min at 8 wk to 45.8 +/- 3.5 nmol/l.30 min (p < 0.001) at 26 wk of feeding. |
1996-04-25 |
2023-08-12 |
rat |
| J A Higgins, J C Brand Miller, G S Denye. Development of insulin resistance in the rat is dependent on the rate of glucose absorption from the diet. The Journal of nutrition. vol 126. issue 3. 1996-04-25. PMID:8598543. |
amylose-fed animals did not exhibit insulin resistance until 26 wk of feeding when insulin secretion in response to a glucose load was 28.3 +/- 0.9 vs. 14.6 +/- 3.2 nmol/l.30 min at 16 wk of feeding (p < 0.005). |
1996-04-25 |
2023-08-12 |
rat |
| J A Higgins, J C Brand Miller, G S Denye. Development of insulin resistance in the rat is dependent on the rate of glucose absorption from the diet. The Journal of nutrition. vol 126. issue 3. 1996-04-25. PMID:8598543. |
glucose-fed animals displayed insulin resistance after only 8 wk of feeding. |
1996-04-25 |
2023-08-12 |
rat |
| M F Dallman, S F Akana, A M Strack, E S Hanson, R J Sebastia. The neural network that regulates energy balance is responsive to glucocorticoids and insulin and also regulates HPA axis responsivity at a site proximal to CRF neurons. Annals of the New York Academy of Sciences. vol 771. 1996-04-17. PMID:8597446. |
by contrast, the action of insulin in the periphery is anabolic, causing energy storage; its action in the central nervous system is inhibitory to energy acquisition (food intake). |
1996-04-17 |
2023-08-12 |
rat |
| M F Dallman, S F Akana, A M Strack, E S Hanson, R J Sebastia. The neural network that regulates energy balance is responsive to glucocorticoids and insulin and also regulates HPA axis responsivity at a site proximal to CRF neurons. Annals of the New York Academy of Sciences. vol 771. 1996-04-17. PMID:8597446. |
thus over the long term, stimulation of insulin secretion by corticosteroids tends to supply an automatic brake on the effects of corticosteroids on feeding. |
1996-04-17 |
2023-08-12 |
rat |
| L M Karabatas, Y Lombardo, J C Basab. Effect of high-protein feeding on insulin secretion in mice injected with splenocytes from diabetic mice. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 211. issue 1. 1996-04-11. PMID:8594623. |
effect of high-protein feeding on insulin secretion in mice injected with splenocytes from diabetic mice. |
1996-04-11 |
2023-08-12 |
mouse |
| L M Karabatas, Y Lombardo, J C Basab. Effect of high-protein feeding on insulin secretion in mice injected with splenocytes from diabetic mice. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 211. issue 1. 1996-04-11. PMID:8594623. |
we also evaluated the effect of high-protein feeding on the capacity of "diabetic" splenocytes to transfer an impaired insulin secretion in recipient mice. |
1996-04-11 |
2023-08-12 |
mouse |
| T Boswell, R D Richardson, R J Seeley, M Ramenofsky, J C Wingfield, M I Friedman, S C Wood. Regulation of food intake by metabolic fuels in white-crowned sparrows. The American journal of physiology. vol 269. issue 6 Pt 2. 1996-04-08. PMID:8594950. |
importantly, these drugs, as well as insulin and glucagon, were demonstrated to increase plasma fatty acids as well as to decrease feeding. |
1996-04-08 |
2023-08-12 |
Not clear |
| M Binou. The IGF system in metabolism regulation. Diabete & metabolisme. vol 21. issue 5. 1996-03-27. PMID:8586149. |
in the case of igfbp-1, whose hepatic synthesis is negatively regulated by insulin, plasma concentrations are subject to extensive nycthemeral variation, rising with fasting and dropping after feeding, which may be involved in controlling the access of free igf-i to its cellular receptors and hence igf-i-regulated glucose and amino acid uptake. |
1996-03-27 |
2023-08-12 |
human |
| C E Mondon, K J Rodnick, C B Dolkas, S Azhar, G M Reave. Alterations in glucose and protein metabolism in animals subjected to simulated microgravity. Advances in space research : the official journal of the Committee on Space Research (COSPAR). vol 12. issue 2-3. 1996-03-25. PMID:11537005. |
reduction of physical activity due to disease or environmental restraints, such as total bed rest or exposure to spaceflight, leads to atrophy of skeletal muscle and is frequently accompanied by alterations in food intake and the concentration of metabolic regulatory hormones such as insulin. |
1996-03-25 |
2023-08-12 |
rat |
| R R Grumme. Impact of changes in organic nutrient metabolism on feeding the transition dairy cow. Journal of animal science. vol 73. issue 9. 1996-03-21. PMID:8582873. |
feeding more fermentable carbohydrate during the prepartum transition period may acclimate the microbial population to lactation diets, promote development of ruminal papillae, increase absorptive capacity of the rumen epithelium, and reduce lipolysis by delivering more glucogenic precursor to the liver and enhancing blood insulin. |
1996-03-21 |
2023-08-12 |
Not clear |
| T Sato, Y Nara, Y Kato, Y Yamor. Effects of high-calorie diet on blood pressure and sodium retention in spontaneously hypertensive rats and normotensive Wistar-Kyoto rats. Journal of diabetes and its complications. vol 9. issue 4. 1996-03-13. PMID:8573731. |
previous reports from our laboratory have documented that spontaneously hypertensive rats (shr) have insulin resistance and that insulin resistance is enhanced by high-caloric diet (hcd) feeding. |
1996-03-13 |
2023-08-12 |
rat |
| T Sato, Y Nara, Y Kato, Y Yamor. Effects of high-calorie diet on blood pressure and sodium retention in spontaneously hypertensive rats and normotensive Wistar-Kyoto rats. Journal of diabetes and its complications. vol 9. issue 4. 1996-03-13. PMID:8573731. |
after the 8-week feeding period, insulin suppression tests were performed. |
1996-03-13 |
2023-08-12 |
rat |
| E Guillot, R Morand, C Bouloy, M T Eon, I Ange. Involvement of alpha 2-adrenoceptors in metabolic and hormonal responses to a mixed meal in beagle dogs. The American journal of physiology. vol 269. issue 6 Pt 1. 1996-03-07. PMID:8572207. |
the alpha 2-adrenoceptor antagonist deriglidole (1 mg/kg po), administered 45 min before feeding, significantly reduced glycemia and increased insulin, ffa, and glycerol levels. |
1996-03-07 |
2023-08-12 |
dog |