| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Íñigo M Pérez Castillo, Josep M Argilés, Ricardo Rueda, María Ramírez, José M López Pedros. Skeletal muscle atrophy and dysfunction in obesity and type-2 diabetes mellitus: Myocellular mechanisms involved. Reviews in endocrine & metabolic disorders. 2025-03-11. PMID:40064750. |
insulin signaling not only facilitates skeletal muscle glucose uptake but also plays a central role in skeletal muscle anabolism mainly due to suppression of catabolic pathways and facilitating an anabolic response to nutrient feeding. |
2025-03-11 |
2025-03-13 |
Not clear |
| Sydney Banton, Shari Raheb, Pawanpreet Singh, John P Cant, Anna K Shovelle. Dogs fed a high protein, low carbohydrate diet have elevated postprandial plasma glucagon and amino acid concentrations and tend to have lower glucose concentrations compared to two different moderate protein, moderate carbohydrate diets. Translational animal science. vol 9. 2025-03-07. PMID:40051530. |
an echocardiogram and a 12-h glucose, insulin and glucagon response and 6-h aa meal response were performed on day 42 of feeding. |
2025-03-07 |
2025-03-09 |
dog |
| Maedeh Movahednasab, Hassan Dianat-Moghadam, Sana Khodadad, Reza Nedaeinia, Saeid Safabakhsh, Gordon Ferns, Rasoul Saleh. GLP-1-based therapies for type 2 diabetes: from single, dual and triple agonists to endogenous GLP-1 production and L-cell differentiation. Diabetology & metabolic syndrome. vol 17. issue 1. 2025-02-19. PMID:39962520. |
glp-1 secretion is stimulated by nutrient intake and exerts its effects on glucose homeostasis by stimulating insulin secretion, gastric emptying confiding the food intake, and β-cell proliferation. |
2025-02-19 |
2025-02-23 |
human |
| Shuntaro Izawa, Debora Fusca, Hong Jiang, Christian Heilinger, A Christine Hausen, F Thomas Wunderlich, Lukas Steuernagel, Peter Kloppenburg, Jens C Brünin. Orexin/hypocretin receptor 2 signaling in MCH neurons regulates REM sleep and insulin sensitivity. Cell reports. vol 44. issue 2. 2025-02-13. PMID:39946231. |
ox2r inactivation in mch neurons reduced transitions from non-rapid eye movement (nrem) to rem sleep and impaired insulin sensitivity with excessive feeding after a fasting period in female mice. |
2025-02-13 |
2025-02-16 |
mouse |
| Yuzuru Ohshir. Continuous Feeding Insulin Injection (CFII): A New Simple Method to Stabilize Severe Glucose Variability and Nutrition Delivery in Critically Ill Patients. Cureus. vol 17. issue 2. 2025-02-11. PMID:39931500. |
continuous feeding insulin injection (cfii): a new simple method to stabilize severe glucose variability and nutrition delivery in critically ill patients. |
2025-02-11 |
2025-02-13 |
Not clear |
| Yuzuru Ohshir. Continuous Feeding Insulin Injection (CFII): A New Simple Method to Stabilize Severe Glucose Variability and Nutrition Delivery in Critically Ill Patients. Cureus. vol 17. issue 2. 2025-02-11. PMID:39931500. |
this report describes a new, simple, and systematic approach, continuous feeding insulin injection (cfii), designed to stabilize severe glucose variability and optimize nutritional delivery in critically ill patients when intensive insulin therapy (iit) alone proves insufficient. |
2025-02-11 |
2025-02-13 |
Not clear |
| Yuzuru Ohshir. Continuous Feeding Insulin Injection (CFII): A New Simple Method to Stabilize Severe Glucose Variability and Nutrition Delivery in Critically Ill Patients. Cureus. vol 17. issue 2. 2025-02-11. PMID:39931500. |
cfii was initiated with enteral feeding starting at 1000 kcal/day and gradually increased to 1400 kcal/day, while insulin infusion was dynamically adjusted every three hours. |
2025-02-11 |
2025-02-13 |
Not clear |
| Hideki Nakamura, Tsuyoshi Endo, Makoto Tsud. Pharmacological Profile of NCP-322, a Novel G Protein-Coupled Receptor 119 Agonist, as an Orally Active Therapeutic Agent for Type 2 Diabetes Mellitus. Biological & pharmaceutical bulletin. vol 48. issue 1. 2025-02-02. PMID:39894557. |
pharmacological activation of g protein-coupled receptor 119 (gpr119) produces pleiotropic beneficial effects, including the promotion of insulin secretion from pancreatic β-cells, enhancement of glucagon-like peptide (glp)-1 secretion from intestinal l cells, glucose-dependent insulin secretion, and food intake and body weight gain suppression. |
2025-02-02 |
2025-02-05 |
Not clear |
| Kevin Lee, Keszya Kurniawa. Are Seed Oils the Culprit in Cardiometabolic and Chronic Diseases? A Narrative Review. Nutrition reviews. 2025-01-17. PMID:39820582. |
furthermore, high saturated fat intake may potentially induce insulin resistance and non-alcoholic fatty liver disease, based on human isocaloric feeding studies. |
2025-01-17 |
2025-01-20 |
human |
| Sara E L Tolouei, Rodrigo Marcon, Fabiana Cardoso Vilela, Cristina Setim Freitas, Melina Heller, Edineia Lemos de Andrade, Sergio José Macedo Júnior, Adara Áurea Dos Santos, Ruth Fernandes Rocha, Guilherme Pasetto Fadanni, Naiani Ferreira Marques, Jarbas Mota Siqueira Júnior, João B Calixt. Preclinical development of a standardized extract of Ilex paraguariensis A.St.-Hil for the treatment of obesity and metabolic syndrome. Pharmacological research. 2025-01-17. PMID:39824371. |
the five in vivo proofs of concept studies revealed that ti-076 reduced obesity, hyperglycaemia, blood pressure, liver fat accumulation, levels of serum insulin, leptin and cholesterol, food intake, inflammation and increased glp-1 levels. |
2025-01-17 |
2025-01-21 |
mouse |
| Xuejing Lu, Norio Harada, Takuma Yasuda, Eri Ikeguchi, Daishiro Kobayashi, Masaya Denda, Yohei Seno, Shunsuke Yamane, Daisuke Yabe, Akira Otaka, Nobuya Inagak. Effects of tryptophan-selective lipidated GLP-1 peptides on the GLP-1 receptor. The Journal of endocrinology. 2025-01-14. PMID:39807656. |
under high-fat diet feeding, both long-term administration of peptide a and peptide b improved glucose tolerance and insulin sensitivity similarly to liraglutide. |
2025-01-14 |
2025-01-16 |
Not clear |
| Paulo Cezar de Freitas Mathias, Aline Milena Dantas Rodrigues, Patrícia Cristina Lisboa, Rosiane Aparecida Miranda, Ananda Malta, Tatiane Aparecida Ribeiro, Luiz Felipe Barella, Ginislene Dias, Thalyne Aparecida Leite Lima, Rodrigo Mello Gomes, Egberto Gaspar de Moura, Júlio Cezar de Oliveir. Maternal Low-Protein Diet During Nursing Leads to Glucose-Insulin Dyshomeostasis and Pancreatic-Islet Dysfunction by Disrupting Glucocorticoid Responsiveness in Male Rats. Biology. vol 13. issue 12. 2025-01-08. PMID:39765703. |
body weight, food intake, intravenous glucose tolerance test (ivgtt) results, insulin secretion and biochemical parameters were assessed. |
2025-01-08 |
2025-01-13 |
rat |
| Letícia Baciuk-Souza, Laura Ferrer Del Pra, Luca Schiliró Tristão, Mayco José Reinaldi Serra, Vera Esteves Vagnozzi Rull. Effects of enteral insulin on enteral diet tolerance in premature infants: systematic review. Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo. vol 43. 2025-01-08. PMID:39775611. |
the primary objective of this systematic review was to evaluate the effect of enteral insulin supplementation provided to premature newborns on the time to achieve full enteral feeding. |
2025-01-08 |
2025-01-13 |
Not clear |
| Ryosuke Sato, Guilherme Wesley Peixoto da Fonseca, Willian das Neves, Stephan von Haehlin. Mechanisms and pharmacotherapy of cancer cachexia-associated anorexia. Pharmacology research & perspectives. vol 13. issue 1. 2025-01-08. PMID:39776294. |
inflammation, insulin resistance, increased muscle protein degradation, decreased food intake, and anorexia are the primary pathophysiological drivers of cachexia. |
2025-01-08 |
2025-01-31 |
Not clear |
| Cheukyau Luk, Katherine I Bridge, Nele Warmke, Katie J Simmons, Michael Drozd, Amy Moran, Amanda D V MacCannell, Chew W Cheng, Sam Straw, Jason L Scragg, Jessica Smith, Claire H Ozber, Chloe G Wilkinson, Anna Skromna, Natallia Makava, Hiran A Prag, T Simon Futers, Oliver I Brown, Alexander-Francisco Bruns, Andrew Mn Walker, Nicole T Watt, Romana Mughal, Kathryn J Griffin, Nadira Y Yuldasheva, Sunti Limumpornpetch, Hema Viswambharan, Piruthivi Sukumar, David J Beech, Antonio Vidal-Puig, Klaus K Witte, Michael P Murphy, Richard C Hartley, Stephen B Wheatcroft, Richard M Cubbon, Lee D Roberts, Mark T Kearney, Natalie J Haywoo. Paracrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice. Nature communications. vol 16. issue 1. 2025-01-03. PMID:39747815. |
we show that a reduction in endothelial igf-1r expression in the presence of high-fat feeding in male mice leads to depot-specific beneficial white adipose tissue remodelling, increases whole-body energy expenditure and enhances insulin sensitivity via a non-cell-autonomous paracrine mechanism. |
2025-01-03 |
2025-01-05 |
mouse |
| Bobrowicz Małgorzata, Nagórska Anna, Karpiłowska Anna, Rosłon Marek, Hubska Joanna, Gładka Adrianna, Toutounchi Sadegh, Koperski Łukasz, Ambroziak Urszul. Case report: Pheochromocytoma-induced pseudo-Cushing's syndrome. Frontiers in endocrinology. vol 15. 2025-01-01. PMID:39741882. |
the patient underwent adrenalectomy following pre-treatment with doxazosin and metyrapone, enteral feeding, protein supplementation, and insulin administration. |
2025-01-01 |
2025-01-04 |
Not clear |
| Amélie Paquet, Nadia Bahlouli, Xavier Coutel, Damien Leterme, Jérôme Delattre, Véronique Gauthier, Flore Miellot, Séverine Delplace, Hélène Rouge-Labriet, Nicolas Bertheaume, Christophe Chauveau, Hamanou Benachou. Obesity and insulinopenic type 2 diabetes differentially impact, bone phenotype, bone marrow adipose tissue, and serum levels of the cathelicidin-related antimicrobial peptide in mice. Bone. 2025-01-01. PMID:39742907. |
as compared to low-fat diet (lfd) control group after 16 weeks of feeding, the hfd mice exhibit a significant weight gain, moderate hyperglycaemia, impaired glucose tolerance and insulin sensitivity, and significant increase in serum insulin levels. |
2025-01-01 |
2025-01-04 |
mouse |
| Krittika Dotania, Mamta Tripathy, Umesh Ra. Nesfatin-1 as a crucial mediator of glucose homeostasis in the reptile, Hemidactylus flaviviridis. Scientific reports. vol 14. issue 1. 2024-12-31. PMID:39738077. |
therefore, present study elucidates role of nesfatin-1 in glucose homeostasis in wall lizard wherein fasting stimulated hepatic nucb2/nesfatin-1, glycogen phosphorylase (glyp), phosphoenolpyruvate carboxykinase (pepck), and fructose 1,6-bisphosphatase (fbp), while feeding upregulated pancreatic nucb2/nesfatin-1 and insulin, suggesting towards tissue-specific dual role of nesfatin-1 in glucoregulation. |
2024-12-31 |
2025-01-02 |
Not clear |
| S'thandiwe Nozibusiso Magwaza, Vunene Nkateko Chabalala, Nothando Philile Hlongwane, Huda Ismail, Md Shahidul Isla. Anti-Obesity Effects of Sulphated Polysaccharides Derived from Marine Macro Algae or Seaweeds: A Systematic Review and Meta-Analysis. Marine drugs. vol 22. issue 12. 2024-12-27. PMID:39728103. |
a comprehensive summary of the included articles was conducted, focusing on the following obesity-related parameters: food intake, body weight gain, epididymal fat size, adipocyte size, liver weight, serum alanine transaminase (alt) and aspartate transaminase (ast), insulin and tumour necrosis factor-α (tnf-α), and the lipid profile (total cholesterol, triglyceride, high-density lipoprotein cholesterol (hdl-c), and low-density lipoprotein cholesterol (ldl-c)). |
2024-12-27 |
2024-12-29 |
human |
| S'thandiwe Nozibusiso Magwaza, Vunene Nkateko Chabalala, Nothando Philile Hlongwane, Huda Ismail, Md Shahidul Isla. Anti-Obesity Effects of Sulphated Polysaccharides Derived from Marine Macro Algae or Seaweeds: A Systematic Review and Meta-Analysis. Marine drugs. vol 22. issue 12. 2024-12-27. PMID:39728103. |
the systematic review demonstrated that seaweed-derived sps exhibit ameliorative effects against obesity, as evidenced by reductions in food intake, body weight gain, epididymal fat and adipocyte size, liver weight, alt and ast levels, serum insulin and tnf-α, ldl-c, total cholesterol, and triglycerides and an increase in hdl-c in obese rats administered with seaweed-derived sps. |
2024-12-27 |
2024-12-29 |
human |