| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohamed K Hankir, Christelle Le Fol. Central nervous system pathways targeted by amylin in the regulation of food intake. Biochimie. 2024-10-19. PMID:39426704. |
while the caudal hindbrain was originally implicated as a major site of action in this regard, it is becoming increasingly clear that amylin recruits numerous central nervous system pathways to exert multifaceted effects on food intake. |
2024-10-19 |
2024-10-22 |
Not clear |
| Tomas P Bachor, Eunsang Hwang, Ernie Yulyaningsih, Kush Attal, Francois Mifsud, Viana Pham, Eirini Vagena, Renzo Huarcaya, Martin Valdearcos, Christian Vaisse, Kevin W Williams, Paul J Emmerson, Allison W X. Identification of AgRP cells in the murine hindbrain that drive feeding. Molecular metabolism. 2024-01-21. PMID:38246589. |
identification of agrp cells in the murine hindbrain that drive feeding. |
2024-01-21 |
2024-01-24 |
mouse |
| Javier Jurado-Aguilar, Emma Barroso, Maribel Bernard, Meijian Zhang, Mona Peyman, Patricia Rada, Ángela M Valverde, Walter Wahli, Xavier Palomer, Manuel Vázquez-Carrer. GDF15 activates AMPK and inhibits gluconeogenesis and fibrosis in the liver by attenuating the TGF-β1/SMAD3 pathway. Metabolism: clinical and experimental. 2024-01-04. PMID:38176644. |
this stress response cytokine regulates energy metabolism mainly by reducing food intake through its hindbrain receptor gfral. |
2024-01-04 |
2024-01-07 |
mouse |
| Drew Mackenzie Neyens, Lynne Anne Brenner, Rowan J Calkins, Eric Thomas Winzenried, Robert C Ritter, Suzanne M Appleyar. CCK-sensitive C fibers activate NTS leptin receptor-expressing neurons via NMDA receptors. American journal of physiology. Regulatory, integrative and comparative physiology. 2023-12-18. PMID:38105761. |
the hormone leptin reduces food intake through actions in the peripheral and central nervous system, including in the hindbrain nucleus of the solitary tract (nts). |
2023-12-18 |
2023-12-21 |
mouse |
| Ruth B S Harri. Low dose peripheral leptin infusion produces selective activation of ventromedial hypothalamic and hindbrain STAT3. American journal of physiology. Endocrinology and metabolism. 2023-06-07. PMID:37285599. |
these results suggest that activation of leptin vmh receptors contributes to the suppression of food intake, but that hindbrain receptors contribute to a sustained change in metabolism that maintains a reduced weight and fat mass. |
2023-06-07 |
2023-08-14 |
rat |
| Song-Yang Zhang, Kyla Bruce, Zahra Danaei, Rosa J W Li, Daniel R Barros, Rachel Kuah, Yu-Mi Lim, Laura H Mariani, David Z Cherney, Jennifer F M Chiu, Heather N Reich, Tony K T La. Metformin triggers a kidney GDF15-dependent area postrema axis to regulate food intake and body weight. Cell metabolism. 2023-04-15. PMID:37060902. |
metformin increases plasma growth/differentiation factor 15 (gdf15) levels to regulate energy balance, while gdf15 administration activates gdnf family receptor α-like (gfral) that is highly expressed in the area postrema (ap) and the nucleus of the solitary tract (nts) of the hindbrain to lower food intake and body weight. |
2023-04-15 |
2023-08-14 |
rat |
| Hallie S Wald, Misgana Y Ghidewon, Matthew R Hayes, Harvey J Gril. Hindbrain ghrelin and LEAP2, ligands for GHSR, bidirectionally control food intake. American journal of physiology. Regulatory, integrative and comparative physiology. 2023-02-27. PMID:36847494. |
hindbrain ghrelin and leap2, ligands for ghsr, bidirectionally control food intake. |
2023-02-27 |
2023-08-14 |
Not clear |
| Hallie S Wald, Misgana Y Ghidewon, Matthew R Hayes, Harvey J Gril. Hindbrain ghrelin and LEAP2, ligands for GHSR, bidirectionally control food intake. American journal of physiology. Regulatory, integrative and comparative physiology. 2023-02-27. PMID:36847494. |
hindbrain growth hormone secretagogue receptor (ghsr) agonism increases food intake, yet the underlying neural mechanisms remain unclear. |
2023-02-27 |
2023-08-14 |
Not clear |
| Hallie S Wald, Misgana Y Ghidewon, Matthew R Hayes, Harvey J Gril. Hindbrain ghrelin and LEAP2, ligands for GHSR, bidirectionally control food intake. American journal of physiology. Regulatory, integrative and comparative physiology. 2023-02-27. PMID:36847494. |
to test the hypothesis that hindbrain ghsr agonism attenuates the food intake inhibitory effect of gastrointestinal (gi) satiation signals, ghrelin (at a feeding subthreshold dose) was administered to the fourth ventricle (4v) or directly to the nucleus tractus solitarius (nts) prior to systemic delivery of the gi satiation signal cholecystokinin (cck). |
2023-02-27 |
2023-08-14 |
Not clear |
| Hallie S Wald, Misgana Y Ghidewon, Matthew R Hayes, Harvey J Gril. Hindbrain ghrelin and LEAP2, ligands for GHSR, bidirectionally control food intake. American journal of physiology. Regulatory, integrative and comparative physiology. 2023-02-27. PMID:36847494. |
to investigate an alternate hypothesis, that hindbrain ghsr agonism enhances feeding motivation and food-seeking, intake stimulatory ghrelin doses were administered to the 4v and fixed ratio 5 (fr-5), progressive ratio (pr), and operant reinstatement paradigms for palatable food responding were evaluated. |
2023-02-27 |
2023-08-14 |
Not clear |
| Hallie S Wald, Misgana Y Ghidewon, Matthew R Hayes, Harvey J Gril. Hindbrain ghrelin and LEAP2, ligands for GHSR, bidirectionally control food intake. American journal of physiology. Regulatory, integrative and comparative physiology. 2023-02-27. PMID:36847494. |
4v leap2 reduced chow intake and bw and blocked hindbrain ghrelin-stimulated feeding. |
2023-02-27 |
2023-08-14 |
Not clear |
| Hallie S Wald, Misgana Y Ghidewon, Matthew R Hayes, Harvey J Gril. Hindbrain ghrelin and LEAP2, ligands for GHSR, bidirectionally control food intake. American journal of physiology. Regulatory, integrative and comparative physiology. 2023-02-27. PMID:36847494. |
data support a role for hindbrain ghsr in bidirectional control of food intake through mechanisms that include interacting with the nts neural processing of gi satiation signals but not food motivation and food-seeking. |
2023-02-27 |
2023-08-14 |
Not clear |
| Kim Eerola, Francesco Longo, Thomas Reinbothe, Jennifer Richard, Olesya T Shevchouk, Lorena López-Ferreras, Devesh Mishra, Mohammed Asker, Johan Tolö, Caroline Miranda, Saliha Musovic, Charlotta S Olofsson, Patrik Rorsman, Karolina P Skibick. Hindbrain insulin controls feeding behavior. Molecular metabolism. 2022-10-16. PMID:36244663. |
hindbrain insulin controls feeding behavior. |
2022-10-16 |
2023-08-14 |
mouse |
| Sissel Norland, Mariann Eilertsen, Ivar Rønnestad, Jon Vidar Helvik, Ana S Gome. Mapping key neuropeptides involved in the melanocortin system in Atlantic salmon (Salmo salar) brain. The Journal of comparative neurology. 2022-10-11. PMID:36217593. |
extrahypothalamic brain regions might also be involved in regulating food intake, including the olfactory bulb, telencephalon, midbrain, and hindbrain. |
2022-10-11 |
2023-08-14 |
Not clear |
| Stephanie Murphy, Metika Collis Glynn, Tiarani N Dixon, Harvey J Grill, Gavan P McNally, Zhi Yi On. Nucleus of the solitary tract A2 neurons control feeding behaviors via projections to the paraventricular hypothalamus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-09-16. PMID:36114285. |
hindbrain nts neurons are highly attuned to internal physiological and external environmental factors that contribute to the control of food intake but the relevant neural phenotypes and pathways remain elusive. |
2022-09-16 |
2023-08-14 |
rat |
| Anders B Klein, Trine S Nicolaisen, Kornelia Johann, Andreas M Fritzen, Cecilie V Mathiesen, Cláudia Gil, Nanna S Pilmark, Kristian Karstoft, Martin B Blond, Jonas S Quist, Randy J Seeley, Kristine Færch, Jens Lund, Maximilian Kleinert, Christoffer Clemmense. The GDF15-GFRAL pathway is dispensable for the effects of metformin on energy balance. Cell reports. vol 40. issue 8. 2022-08-24. PMID:36001956. |
recently, it was reported that metformin lowers body weight via induction of growth differentiation factor 15 (gdf15), which suppresses food intake by binding to the gdnf family receptor α-like (gfral) in the hindbrain. |
2022-08-24 |
2023-08-14 |
mouse |
| Wenwen Cheng, Desiree Gordian, Mette Q Ludwig, Tune H Pers, Randy J Seeley, Martin G Myer. Hindbrain circuits in the control of eating behaviour and energy balance. Nature metabolism. vol 4. issue 7. 2022-07-25. PMID:35879458. |
although the hypothalamus plays a crucial role in matching caloric intake with energy expenditure to achieve a stable body weight, it is now recognized that neuronal circuits in the hindbrain not only serve to produce nausea and to terminate feeding in response to food consumption or during pathological states, but also contribute to the long-term control of body weight. |
2022-07-25 |
2023-08-14 |
Not clear |
| Wenwen Cheng, Desiree Gordian, Mette Q Ludwig, Tune H Pers, Randy J Seeley, Martin G Myer. Hindbrain circuits in the control of eating behaviour and energy balance. Nature metabolism. vol 4. issue 7. 2022-07-25. PMID:35879458. |
additionally, recent work has identified hindbrain neurons that are capable of suppressing food intake without producing aversive responses like those associated with nausea. |
2022-07-25 |
2023-08-14 |
Not clear |
| Wenwen Cheng, Desiree Gordian, Mette Q Ludwig, Tune H Pers, Randy J Seeley, Martin G Myer. Hindbrain circuits in the control of eating behaviour and energy balance. Nature metabolism. vol 4. issue 7. 2022-07-25. PMID:35879458. |
here we review recent advances in our understanding of the hindbrain neurons that control feeding, particularly those located in the area postrema and the nucleus tractus solitarius. |
2022-07-25 |
2023-08-14 |
Not clear |
| Wenwen Cheng, Desiree Gordian, Mette Q Ludwig, Tune H Pers, Randy J Seeley, Martin G Myer. Hindbrain circuits in the control of eating behaviour and energy balance. Nature metabolism. vol 4. issue 7. 2022-07-25. PMID:35879458. |
we frame this information in the context of new atlases of hindbrain neuronal populations and develop a model of the hindbrain circuits that control food intake and energy balance, suggesting important areas for additional research. |
2022-07-25 |
2023-08-14 |
Not clear |