| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yong Han, Yang He, Lauren Harris, Yong Xu, Qi W. Identification of a GABAergic neural circuit governing leptin signaling deficiency-induced obesity. eLife. vol 12. 2023-04-12. PMID:37043384. |
the hormone leptin is known to robustly suppress food intake by acting upon the leptin receptor (lepr) signaling system residing within the agouti-related protein (agrp) neurons of the hypothalamus. |
2023-04-12 |
2023-08-14 |
Not clear |
| Jubiao Zhang, Yang Chen, Lihong Yan, Xin Zhang, Xiaoyan Zheng, Junxia Qi, Fen Yang, Juxue L. EphA3 deficiency in the hypothalamus promotes high-fat diet-induced obesity in mice. Journal of biomedical research. 2023-04-04. PMID:37013864. |
in the current study, we demonstrated that the deletion of epha3 in the hypothalamus by crispr/cas9-mediated gene editing promotes obesity in male mice with high-fat diet feeding rather than those with normal chow diet feeding. |
2023-04-04 |
2023-08-14 |
mouse |
| Songhee Jeon, Jeong-Eun Park, Young Ho Do, Renata Santos, Seong Mi Lee, Bung-Nyun Kim, Jae Hoon Cheong, Yeni Ki. Atomoxetine and Fluoxetine Activate AMPK-ACC-CPT1 Pathway in Human SH-SY5Y and U-87 MG Cells. Psychiatry investigation. vol 20. issue 3. 2023-03-29. PMID:36990664. |
adenosine monophosphate-activated protein kinase (ampk) is the cellular energy sensor that regulate metabolism and energy, being activated by fasting and inhibited by feeding in the hypothalamus. |
2023-03-29 |
2023-08-14 |
human |
| Sebastián Zagmutt, Paula Mera, Ismael González-García, Kevin Ibeas, María Del Mar Romero, Arnaud Obri, Beatriz Martin, Anna Esteve-Codina, M Carmen Soler-Vázquez, Marianela Bastias-Pérez, Laia Cañes, Elisabeth Augé, Carme Pelegri, Jordi Vilaplana, Xavier Ariza, Jordi García, José Martinez-González, Núria Casals, Miguel López, Richard Palmiter, Elisenda Sanz, Albert Quintana, Laura Herrero, Dolors Serr. CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst. Biology of sex differences. vol 14. issue 1. 2023-03-25. PMID:36966335. |
fatty acid metabolism in the hypothalamus has an important role in food intake, but its specific role in agrp neurons is poorly understood. |
2023-03-25 |
2023-08-14 |
Not clear |
| Nicholas J Queen, Wei Huang, Suraj Komatineni, Anthony G Mansour, Run Xiao, Logan A Chrislip, Lei Ca. Social isolation exacerbates diet-induced obesity and peripheral inflammation in young male mice under thermoneutrality. iScience. vol 26. issue 3. 2023-03-14. PMID:36915694. |
we report si promotes weight gain, increases food intake, increases adiposity, worsens glycemic control, reduces insulin signaling, exacerbates systemic and adipose inflammatory responses, and induces a molecular signature within the hypothalamus. |
2023-03-14 |
2023-08-14 |
mouse |
| Razieh Amini Zadeh, Hossein Jonaidi, Saeed Esmaeili Mahani, Mahsa Salehi, Mojtaba Emam Bakhs. Effects of intracerebroventricular injection of apelin-13 on food intake in broiler chicks. Veterinary research forum : an international quarterly journal. vol 14. issue 2. 2023-03-13. PMID:36909688. |
apelin is expressed in most tissues of the body including hypothalamus that is responsible for regulating water and food intake, the gastrointestinal tract, the circulatory system, adipose and muscle tissues, and the immune system. |
2023-03-13 |
2023-08-14 |
Not clear |
| Katlyn J An, Ashley N Hanato, Katherine W Hui, Matthew W Pitts, Lucia A Seale, Jessica L Nicholson, Pamela Toh, Jun Kyoung Kim, Marla J Berry, Daniel J Torre. Selenium Protects Mouse Hypothalamic Cells from Glucocorticoid-Induced Endoplasmic Reticulum Stress Vulnerability and Insulin Signaling Impairment. Antioxidants (Basel, Switzerland). vol 12. issue 2. 2023-02-25. PMID:36830084. |
the hypothalamus, a central regulator of feeding behavior and energy expenditure, is highly responsive to glucocorticoids, and it has been proposed that it plays a role in glucocorticoid-induced metabolic defects. |
2023-02-25 |
2023-08-14 |
mouse |
| Bing Feng, Hesong Liu, Ila Mishra, Clemens Duerrschmid, Peiyu Gao, Pingwen Xu, Chunmei Wang, Yanlin H. Asprosin promotes feeding through SK channel-dependent activation of AgRP neurons. Science advances. vol 9. issue 8. 2023-02-22. PMID:36812308. |
asprosin, a recently identified adipokine, activates agouti-related peptide (agrp) neurons in the arcuate nucleus of the hypothalamus (arh) via binding to protein tyrosine phosphatase receptor δ (ptprd) to increase food intake. |
2023-02-22 |
2023-08-14 |
Not clear |
| Ana Luiza Machado Wunderlich, Andressa Busetti Martins, Camila Franciele de Souza, Larissa Rugila S Stopa, Érica Cristina A M Monteiro, Danielly D Aguiar, Rhauany P Guergolette, Cássia Thaïs B V Zaia, Ernane Torres Uchô. Neonatal overnutrition, but not neonatal undernutrition, disrupts CCK-induced hypophagia and neuron activation of the Nucleus of the Solitary Tract and Paraventricular Nucleus of hypothalamus of male Wistar rats. Brain research bulletin. 2023-02-22. PMID:36813046. |
in order to investigate the effects of nutritional programming on the anorexigenic function of cck in adulthood, pups were raised in small (sl, 3 pups per dam), normal (nl, 10 pups per dam), or large litters (ll, 16 pups per dam), and on postnatal day 60, male rats were treated with vehicle or cck (10µg/kg) for the evaluation of food intake and c-fos expression in the area postrema (ap), nucleus of solitary tract (nts), and paraventricular (pvn), arcuate (arc), ventromedial (vmh), and dorsomedial (dmh) nuclei of the hypothalamus. |
2023-02-22 |
2023-08-14 |
rat |
| Yajie Guo, Zhongxin Jiang, Tingting Jin, Jinfang Huang, Xiangrong Su. Activation of calcium-sensing receptors in the basolateral nucleus of the amygdala inhibits food intake and induces anxiety-depressive-like emotions via dopamine system. Behavioural brain research. 2023-02-22. PMID:36813182. |
studies have demonstrated that the casr is also expressed in feeding-related brain areas, such as the hypothalamus and limbic system, but the effect of the central casr on feeding has not been reported. |
2023-02-22 |
2023-08-14 |
mouse |
| Yajie Guo, Zhongxin Jiang, Tingting Jin, Jinfang Huang, Xiangrong Su. Activation of calcium-sensing receptors in the basolateral nucleus of the amygdala inhibits food intake and induces anxiety-depressive-like emotions via dopamine system. Behavioural brain research. 2023-02-22. PMID:36813182. |
our results showed that microinjection of r568 into the bla could inhibit both standard and palatable food intake in mice for 0-2h, induce anxiety-depression-like behaviours, increase glutamate levels in the bla, and activate dynorphin and gamma-aminobutyric acid neurons through the n-methyl-d-aspartate receptor and thus reduce the content of dopamine in the arcuate nucleus of the hypothalamus (arc) and ventral tegmental area (vta), respectively. |
2023-02-22 |
2023-08-14 |
mouse |
| Rizaldy C Zapata, Dinghong Zhang, Avraham Libster, Alessandra Porcu, Patricia Montilla-Perez, Aisha Nur, Baijie Xu, Zhi Zhang, Stephanie M Correa, Chen Liu, Francesca Telese, Olivia Osbor. Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia. Molecular psychiatry. 2023-02-10. PMID:36765131. |
while agrp is expressed specifically in the arcuate nucleus of the hypothalamus and plays a critical role in appetite stimulation, nr5a2 is expressed in both the cns and periphery, but its role in food intake behaviors remains unknown. |
2023-02-10 |
2023-08-14 |
mouse |
| Rafik Dali, Judith Estrada-Meza, Fanny Langle. Tanycyte, the neuron whisperer. Physiology & behavior. 2023-02-05. PMID:36740135. |
in vertebrates, the homeostatic process that adjusts food intake and energy expenditure in line with physiological requirements is tightly controlled by numerous neural cell types located within the hypothalamus and the brainstem and organized in complex networks. |
2023-02-05 |
2023-08-14 |
Not clear |
| Rosalía Rodríguez-Rodríguez, Anna Fosch, Jesús Garcia-Chica, Sebastián Zagmutt, Nuria Casal. Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: A promising strategy to regulate energy balance. Journal of neuroendocrinology. 2023-02-03. PMID:36735894. |
the brain, and in particular the hypothalamus, is a major integrator of metabolic signals from peripheral tissues that regulate functions such as feeding behavior and energy expenditure. |
2023-02-03 |
2023-08-14 |
Not clear |
| Katarzyna Romejko, Aleksandra Rymarz, Katarzyna Szamotulska, Zbigniew Bartoszewicz, Stanisław Niemczy. Relationships between Sclerostin, Leptin and Metabolic Parameters in Non-Dialysis Chronic Kidney Disease Males. Journal of personalized medicine. vol 13. issue 1. 2023-01-21. PMID:36675692. |
leptin is an adipocytokine which inhibits food intake by stimulating the satiety center in the hypothalamus. |
2023-01-21 |
2023-08-14 |
human |
| Muhammad S Aldhshan, Tooru M Mizun. Environmental enrichment accentuates glucose-induced feeding suppression and glial cell line-derived neurotrophic factor gene expression in the hypothalamus of mice. Nutritional neuroscience. 2023-01-12. PMID:36634108. |
environmental enrichment accentuates glucose-induced feeding suppression and glial cell line-derived neurotrophic factor gene expression in the hypothalamus of mice. |
2023-01-12 |
2023-08-14 |
mouse |
| Muhammad S Aldhshan, Tooru M Mizun. Environmental enrichment accentuates glucose-induced feeding suppression and glial cell line-derived neurotrophic factor gene expression in the hypothalamus of mice. Nutritional neuroscience. 2023-01-12. PMID:36634108. |
the hypothalamus controls food intake by integrating nutrient signals, of which one of the most important is glucose. |
2023-01-12 |
2023-08-14 |
mouse |
| Xiangyang Xie, Jessica Houtz, Guey-Ying Liao, Yuting Chen, Baoji X. Genetic Val66Met BDNF Variant Increases Hyperphagia on Fat-rich Diets in Mice. Endocrinology. 2023-01-11. PMID:36631165. |
furthermore, we found that refeeding after fasting or nocturnal feeding with hfd activated trkb more strongly than with chow in the hypothalamus of wt mice, whereas trkb activation under these two conditions was greatly attenuated in bdnfmet/met mice. |
2023-01-11 |
2023-08-14 |
mouse |
| Isadora C Furigo, Laura Dearde. Mechanisms mediating the impact of maternal obesity on offspring hypothalamic development and later function. Frontiers in endocrinology. vol 13. 2023-01-09. PMID:36619540. |
the hypothalamus is the primary site in the brain for maintaining energy homeostasis, which it coordinates by sensing whole body nutrient status and appropriately adjusting parameters including food intake. |
2023-01-09 |
2023-08-14 |
Not clear |
| Jessica L Swanson, Joshua Ortiz-Guzman, Snigdha Srivastava, Pey-Shyuan Chin, Sean W Dooling, Elizabeth Hanson Moss, Mikhail Y Kochukov, Patrick J Hunt, Jay M Patel, Brandon T Pekarek, Qingchun Tong, Benjamin R Arenkie. Activation of basal forebrain-to-lateral habenula circuitry drives reflexive aversion and suppresses feeding behavior. Scientific reports. vol 12. issue 1. 2022-12-21. PMID:36543829. |
the hypothalamus has been extensively investigated for its role in homeostatic feeding. |
2022-12-21 |
2023-08-14 |
Not clear |