| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Akubuiro, M Bridget Zimmerman, L L Boles Ponto, S A Walsh, J Sunderland, L McCormick, M Sing. Hyperactive hypothalamus, motivated and non-distractible chronic overeating in ADAR2 transgenic mice. Genes, brain, and behavior. vol 12. issue 3. 2013-09-23. PMID:23323881. |
the results indicate that adar2 transgenic mice exhibit, (1) a food preference for diets with higher fat content, (2) significantly increased food intake that is non-distractible in a competing reward environment, (3) significantly increased messenger rna (mrna) expressions of adar2, serotonin 2c receptor (5ht2c r), d1, d2 and mu opioid receptors and no change in corticotropin-releasing hormone mrnas and significantly reduced adar2 protein expression in the hypothalamus, (4) significantly increased d1 receptor and altered bioamines with no change in adar2, mu opioid and d2 receptor mrna expression in the striatum and (5) significantly greater glucose metabolism in the hypothalamus, brain stem, right hippocampus, left and right mid brain regions and suprascapular peripheral tissue than controls. |
2013-09-23 |
2023-08-12 |
mouse |
| Y Ichihara, T Wada, Y Soeda, Y Ishii, M Sasahara, H Tsuneki, T Sasaok. SH2-containing inositol 5'-phosphatase 2 selectively impairs hypothalamic insulin signalling and regulation of food intake in mice. Journal of neuroendocrinology. vol 25. issue 4. 2013-09-16. PMID:23286299. |
these results suggest that ship2 contributes to the regulation of food intake mainly via the attenuation of insulin signalling in the hypothalamus of mice. |
2013-09-16 |
2023-08-12 |
mouse |
| Szilvia Vas, Csaba Ádori, Katalin Könczöl, Zita Kátai, Dorottya Pap, Rege S Papp, György Bagdy, Miklós Palkovits, Zsuzsanna E Tót. Nesfatin-1/NUCB2 as a potential new element of sleep regulation in rats. PloS one. vol 8. issue 4. 2013-09-16. PMID:23560056. |
melanin-concentrating hormone (mch) and nesfatin-1/nucb2 (nesfatin) are strongly co - expressed in the hypothalamus and are involved both in food intake regulation and depression. |
2013-09-16 |
2023-08-12 |
rat |
| Marta Librán-Pérez, Marcos A López-Patiño, Jesús M Míguez, José L Soenga. Oleic acid and octanoic acid sensing capacity in rainbow trout Oncorhynchus mykiss is direct in hypothalamus and Brockmann bodies. PloS one. vol 8. issue 3. 2013-09-11. PMID:23533628. |
in a first set of experiments, we evaluated in hypothalamus and bb exposed to increased oleic acic or octanoic acid concentrations changes in parameters related to fa metabolism, fa transport, nuclear receptors and transcription factors, reactive oxygen species (ros) effectors, components of the katp channel, and (in hypothalamus) neuropeptides related to food intake. |
2013-09-11 |
2023-08-12 |
Not clear |
| Nobuko Sakurazawa, Asuka Mano-Otagiri, Takahiro Nemoto, Tamotsu Shibasak. Effects of intracerebroventricular ghrelin on food intake and Fos expression in the arcuate nucleus of the hypothalamus in female rats vary with estrous cycle phase. Neuroscience letters. vol 541. 2013-09-03. PMID:23435434. |
effects of intracerebroventricular ghrelin on food intake and fos expression in the arcuate nucleus of the hypothalamus in female rats vary with estrous cycle phase. |
2013-09-03 |
2023-08-12 |
rat |
| Nobuko Sakurazawa, Asuka Mano-Otagiri, Takahiro Nemoto, Tamotsu Shibasak. Effects of intracerebroventricular ghrelin on food intake and Fos expression in the arcuate nucleus of the hypothalamus in female rats vary with estrous cycle phase. Neuroscience letters. vol 541. 2013-09-03. PMID:23435434. |
intracerebroventricular (icv) injection of ghrelin increases food intake via activation of neuropeptide y (npy)/agouti-related protein (agrp) neurons, which express growth hormone secretagogue receptor type 1a (ghs-r1a), in the arcuate nucleus of the hypothalamus (arc) in male rats. |
2013-09-03 |
2023-08-12 |
rat |
| Mardi S Byerly, Roy D Swanson, Nina N Semsarzadeh, Patrick S McCulloh, Kiwook Kwon, Susan Aja, Timothy H Moran, G William Wong, Seth Blacksha. Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite. American journal of physiology. Regulatory, integrative and comparative physiology. vol 304. issue 12. 2013-08-30. PMID:23576617. |
disruption of finely coordinated neuropeptide signals in the hypothalamus can result in altered food intake and body weight. |
2013-08-30 |
2023-08-12 |
mouse |
| Takakazu Yagi, Akihiro Asakawa, Hirotaka Ueda, Satoshi Ikeda, Shouichi Miyawaki, Akio Inu. The role of zinc in the treatment of taste disorders. Recent patents on food, nutrition & agriculture. vol 5. issue 1. 2013-08-26. PMID:23305423. |
orally administered zinc has been shown to directly stimulate food intake via neuropeptide in the hypothalamus. |
2013-08-26 |
2023-08-12 |
Not clear |
| Teresa C Delgad. Glutamate and GABA in Appetite Regulation. Frontiers in endocrinology. vol 4. 2013-08-22. PMID:23966982. |
glutamate and gaba dominate synaptic transmission in the hypothalamus and administration of their receptors agonists into hypothalamic nuclei stimulates feeding. |
2013-08-22 |
2023-08-12 |
mouse |
| Jin Kwon Jeong, Sabrina Dian. Prolyl carboxypeptidase and its inhibitors in metabolism. Trends in endocrinology and metabolism: TEM. vol 24. issue 2. 2013-08-20. PMID:23245768. |
proopiomelanocortin (pomc)-expressing neurons in the hypothalamus integrate a variety of central and peripheral metabolic inputs, and regulate energy homeostasis by controlling energy expenditure and food intake. |
2013-08-20 |
2023-08-12 |
Not clear |
| Subashini Karunakaran, Akiff Manji, Chenhua Serena Yan, Zi-Jun John Wu, Susanne M Cle. Moo1 obesity quantitative trait locus in BTBR T+ Itpr3tf/J mice increases food intake. Physiological genomics. vol 45. issue 5. 2013-08-20. PMID:23341217. |
the expression levels of the main molecular mediators of food intake in the hypothalamus were not altered, suggesting this locus affects an independent pathway, consistent with its identification in mice lacking functional leptin. |
2013-08-20 |
2023-08-12 |
mouse |
| Dong-Hoon Kim, Stephen C Woods, Randy J Seele. Hypothalamic Akt/PKB signaling in regulation of food intake. Frontiers in bioscience (Scholar edition). vol 4. 2013-08-05. PMID:22202102. |
the hypothalamus is a center for regulation of food intake and npy/agrp and pomc neurons are key regulators of food intake in the arcuate nucleus. |
2013-08-05 |
2023-08-12 |
Not clear |
| Dong-Hoon Kim, Stephen C Woods, Randy J Seele. Hypothalamic Akt/PKB signaling in regulation of food intake. Frontiers in bioscience (Scholar edition). vol 4. 2013-08-05. PMID:22202102. |
a variety of signals originating from peripheral organs to sense the status of energy converge on the hypothalamus and diverse neurons in the hypothalamus are involved in determining the output of signal to regulate food intake. |
2013-08-05 |
2023-08-12 |
Not clear |
| Tadahiro Kitamur. [Obesity and the central regulation of energy metabolism]. Nihon rinsho. Japanese journal of clinical medicine. vol 71. issue 2. 2013-07-30. PMID:23631196. |
the hypothalamus is the center of controlling food intake and energy expenditure by integrating information from hormones and nutrients. |
2013-07-30 |
2023-08-12 |
Not clear |
| Christiane E Koch, Simon Göddeke, Manon Krüger, Alexander Tup. Effect of central and peripheral leucine on energy metabolism in the Djungarian hamster (Phodopus sungorus). Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. vol 183. issue 2. 2013-07-12. PMID:22843139. |
branched-chain amino acids, particularly leucine, are thought to activate nutrient sensing pathways in the hypothalamus that regulate food intake and energy homeostasis. |
2013-07-12 |
2023-08-12 |
Not clear |
| Zhao He, Sharon S Zhang, Qingyuan Meng, Shuangwei Li, Helen H Zhu, Marie-Astrid Raquil, Nazilla Alderson, Hai Zhang, Jiarui Wu, Liangyou Rui, Dongsheng Cai, Gen-Sheng Fen. Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals. Molecular and cellular biology. vol 32. issue 10. 2013-07-05. PMID:22431513. |
in mammals, leptin regulates food intake and energy balance mainly through the activation of leprb in the hypothalamus, and estrogen has a leptin-like effect in the hypothalamic control of metabolism. |
2013-07-05 |
2023-08-12 |
mouse |
| Xin-Ling Fang, Gang Shu, Jian-Jian Yu, Li-Na Wang, Jing Yang, Qing-Jie Zeng, Xiao Cheng, Zhi-Qi Zhang, Song-Bo Wang, Ping Gao, Xiao-Tong Zhu, Qian-Yun Xi, Yong-Liang Zhang, Qing-Yan Jian. The anorexigenic effect of serotonin is mediated by the generation of NADPH oxidase-dependent ROS. PloS one. vol 8. issue 1. 2013-07-05. PMID:23326391. |
it has been recently demonstrated that reactive oxygen species (ros) in the hypothalamus are a crucial integrative target for the regulation of food intake. |
2013-07-05 |
2023-08-12 |
mouse |
| Daniel A Lee, Seth Blacksha. Functional implications of hypothalamic neurogenesis in the adult mammalian brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 8. 2013-07-01. PMID:22867732. |
numerous studies, however, have also reported adult neurogenesis in the hypothalamus, a brain structure that serves as a central homeostatic regulator of numerous physiological and behavioral functions, such as feeding, metabolism, body temperature, thirst, fatigue, aggression, sleep, circadian rhythms, and sexual behavior. |
2013-07-01 |
2023-08-12 |
Not clear |
| Ikuo Kimura, Yoshiaki Nakayama, Ying Zhao, Morichika Konishi, Nobuyuki Ito. Neurotrophic effects of neudesin in the central nervous system. Frontiers in neuroscience. vol 7. 2013-06-28. PMID:23805070. |
neudesin is also an anorexigenic factor that suppresses food intake in the hypothalamus. |
2013-06-28 |
2023-08-12 |
Not clear |
| X L Ma, L W Zheng, L T Mao, L B Zhou, A L Wan. Neuropeptide Y in black seabream Acanthopagrus schlegelii: identification, distribution and mRNA expression responses to ghrelin. Journal of fish biology. vol 82. issue 4. 2013-06-24. PMID:23557320. |
treatment with acylated ghrelin significantly up-regulated npy mrna level in the hypothalamus, suggesting that npy may be involved in regulating food intake of a. schlegelii. |
2013-06-24 |
2023-08-12 |
Not clear |