| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W T Chance, A Balasubramaniam, H Thompson, B Mohapatra, J Ramo, J E Fische. Assessment of feeding response of tumor-bearing rats to hypothalamic injection and infusion of neuropeptide Y. Peptides. vol 17. issue 5. 1997-02-19. PMID:8844769. |
daily injection of increasing doses of npy stimulated ad lib feeding in non-tb rats, while having no effect on tb rats. |
1997-02-19 |
2023-08-12 |
rat |
| W T Chance, A Balasubramaniam, H Thompson, B Mohapatra, J Ramo, J E Fische. Assessment of feeding response of tumor-bearing rats to hypothalamic injection and infusion of neuropeptide Y. Peptides. vol 17. issue 5. 1997-02-19. PMID:8844769. |
desensitization to npy-induced feeding following daily injections of the peptide was suggested by the loss of feeding response to a dose (500 ng) of npy that increased food intake prior to the daily npy treatments. |
1997-02-19 |
2023-08-12 |
rat |
| W T Chance, A Balasubramaniam, H Thompson, B Mohapatra, J Ramo, J E Fische. Assessment of feeding response of tumor-bearing rats to hypothalamic injection and infusion of neuropeptide Y. Peptides. vol 17. issue 5. 1997-02-19. PMID:8844769. |
these results suggest that hypothalamic npy feeding systems are refractory in tb rats, even before they exhibit anorexia. |
1997-02-19 |
2023-08-12 |
rat |
| W T Chance, A Balasubramaniam, H Thompson, B Mohapatra, J Ramo, J E Fische. Assessment of feeding response of tumor-bearing rats to hypothalamic injection and infusion of neuropeptide Y. Peptides. vol 17. issue 5. 1997-02-19. PMID:8844769. |
in addition, a rapid loss of the feeding response occurred in rats with constant infusion of npy into hypothalamic tissue or with daily intrahypothalamic injections of the peptide, suggesting possible npy receptor-mediated alterations. |
1997-02-19 |
2023-08-12 |
rat |
| W T Chance, A Balasubramaniam, H Thompson, B Mohapatra, J Ramo, J E Fische. Assessment of feeding response of tumor-bearing rats to hypothalamic injection and infusion of neuropeptide Y. Peptides. vol 17. issue 5. 1997-02-19. PMID:8844769. |
therefore, control of obesity or anorexia through npy feeding mechanisms may prove difficult due to rapid compensatory receptor changes. |
1997-02-19 |
2023-08-12 |
rat |
| A Sainsbury, I Cusin, F Rohner-Jeanrenaud, B Jeanrenau. Adrenalectomy prevents the obesity syndrome produced by chronic central neuropeptide Y infusion in normal rats. Diabetes. vol 46. issue 2. 1997-02-12. PMID:9000696. |
neuropeptide y (npy) in the hypothalamus plays an important role in the regulation of food intake and body weight and seems to be implicated in the etiology of obesity. |
1997-02-12 |
2023-08-12 |
rat |
| S J Choi, K Meeran, D O'Shea, P D Lambert, S R Bloo. Weight loss in rats treated with intracerebroventricular cobalt protoporphyrin is not specific to the neuropeptide Y system. Brain research. vol 729. issue 2. 1997-02-07. PMID:8876991. |
the 2 h feeding response (copp vs. vehicle-treated) to 10 micrograms neuropeptide y (npy) (4.0 vs. 7.1 g; p < 0.05), the 1 h feeding response to 10 micrograms galanin (1.3 vs. 3.2 g; p < 0.05) and 30 micrograms norepinephrine (0.6 vs. 1.9 g; p < 0.05) in copp-treated animals were all reduced compared to the vehicle-treated group. |
1997-02-07 |
2023-08-12 |
rat |
| L Pickavance, S Dryden, D Hopkins, C Bing, H Frankish, Q Wang, R G Vernon, G William. Relationships between hypothalamic neuropeptide Y and food intake in the lactating rat. Peptides. vol 17. issue 4. 1997-01-24. PMID:8804064. |
we have explored further the relationship between hypothalamic npy and food intake in lactation and tested the hypothesis that hypoinsulinemia is the stimulus to npy neuronal activity. |
1997-01-24 |
2023-08-12 |
rat |
| L Pickavance, S Dryden, D Hopkins, C Bing, H Frankish, Q Wang, R G Vernon, G William. Relationships between hypothalamic neuropeptide Y and food intake in the lactating rat. Peptides. vol 17. issue 4. 1997-01-24. PMID:8804064. |
lactating rats (n = 8) that were restricted to control rats' food intake for 3 days showed generally higher hypothalamic npy levels, with significantly higher concentrations than controls (p < 0.05) in the arc, mpo, pvn, and lateral hypothalamic area (lha); npy mrna levels were also significantly increased (p < 0.05). |
1997-01-24 |
2023-08-12 |
rat |
| R Munglani, M J Hudspith, S P Hun. The therapeutic potential of neuropeptide Y. Analgesic, anxiolytic and antihypertensive. Drugs. vol 52. issue 3. 1997-01-24. PMID:8875128. |
perhaps best appreciated is the role of npy in the control of systemic blood pressure, together with its effects on feeding, anxiety and memory. |
1997-01-24 |
2023-08-12 |
Not clear |
| D O'Shea, D G Morgan, K Meeran, C M Edwards, M D Turton, S J Choi, M M Heath, I Gunn, G M Taylor, J K Howard, C I Bloom, C J Small, O Haddo, J J Ma, W Callinan, D M Smith, M A Ghatei, S R Bloo. Neuropeptide Y induced feeding in the rat is mediated by a novel receptor. Endocrinology. vol 138. issue 1. 1997-01-23. PMID:8977404. |
there are now six recognized neuropeptide y (npy) receptor subtypes (y1-y4 and two recently cloned distinct receptors labeled y5), of which y1 and one of the y5's have been suggested could mediate the effect of npy on feeding. |
1997-01-23 |
2023-08-12 |
rat |
| D O'Shea, D G Morgan, K Meeran, C M Edwards, M D Turton, S J Choi, M M Heath, I Gunn, G M Taylor, J K Howard, C I Bloom, C J Small, O Haddo, J J Ma, W Callinan, D M Smith, M A Ghatei, S R Bloo. Neuropeptide Y induced feeding in the rat is mediated by a novel receptor. Endocrinology. vol 138. issue 1. 1997-01-23. PMID:8977404. |
the fragments npy(2-36) and npy(3-36), which bind y1 only poorly, were injected intracerebroventricularly (icv) and found to have similar dose-response relationships to npy in the stimulation of feeding. |
1997-01-23 |
2023-08-12 |
rat |
| D O'Shea, D G Morgan, K Meeran, C M Edwards, M D Turton, S J Choi, M M Heath, I Gunn, G M Taylor, J K Howard, C I Bloom, C J Small, O Haddo, J J Ma, W Callinan, D M Smith, M A Ghatei, S R Bloo. Neuropeptide Y induced feeding in the rat is mediated by a novel receptor. Endocrinology. vol 138. issue 1. 1997-01-23. PMID:8977404. |
however npy (13-36), which stimulates both y2 and y5, caused no increase in food intake, even at high doses. |
1997-01-23 |
2023-08-12 |
rat |
| D O'Shea, D G Morgan, K Meeran, C M Edwards, M D Turton, S J Choi, M M Heath, I Gunn, G M Taylor, J K Howard, C I Bloom, C J Small, O Haddo, J J Ma, W Callinan, D M Smith, M A Ghatei, S R Bloo. Neuropeptide Y induced feeding in the rat is mediated by a novel receptor. Endocrinology. vol 138. issue 1. 1997-01-23. PMID:8977404. |
the novel fragment [pro34]-npy(3-36) is as effective at stimulating food intake as the classical y1 analogue [pro34]-npy but bound to the y1 receptor with only 1/20th of the affinity of npy and failed to inhibit adenylyl cyclase through this receptor. |
1997-01-23 |
2023-08-12 |
rat |
| D O'Shea, D G Morgan, K Meeran, C M Edwards, M D Turton, S J Choi, M M Heath, I Gunn, G M Taylor, J K Howard, C I Bloom, C J Small, O Haddo, J J Ma, W Callinan, D M Smith, M A Ghatei, S R Bloo. Neuropeptide Y induced feeding in the rat is mediated by a novel receptor. Endocrinology. vol 138. issue 1. 1997-01-23. PMID:8977404. |
coadministration of high dose npy(13-36) and [pro34]npy did not enhance feeding compared with [pro34]-npy alone. |
1997-01-23 |
2023-08-12 |
rat |
| D O'Shea, D G Morgan, K Meeran, C M Edwards, M D Turton, S J Choi, M M Heath, I Gunn, G M Taylor, J K Howard, C I Bloom, C J Small, O Haddo, J J Ma, W Callinan, D M Smith, M A Ghatei, S R Bloo. Neuropeptide Y induced feeding in the rat is mediated by a novel receptor. Endocrinology. vol 138. issue 1. 1997-01-23. PMID:8977404. |
in addition, the npy y1 receptor antagonist bibp-3226, which does not bind y2, y4, or y5 receptors, significantly reduced npy induced feeding. |
1997-01-23 |
2023-08-12 |
rat |
| D O'Shea, D G Morgan, K Meeran, C M Edwards, M D Turton, S J Choi, M M Heath, I Gunn, G M Taylor, J K Howard, C I Bloom, C J Small, O Haddo, J J Ma, W Callinan, D M Smith, M A Ghatei, S R Bloo. Neuropeptide Y induced feeding in the rat is mediated by a novel receptor. Endocrinology. vol 138. issue 1. 1997-01-23. PMID:8977404. |
these results indicate that the feeding effect of icv npy involves a novel receptor and that it is functionally distinct from the recognized receptor subtypes. |
1997-01-23 |
2023-08-12 |
rat |
| H Shimizu, K Ohtani, Y Kato, Y Tanaka, M Mor. Withdrawal of [corrected] estrogen increases hypothalamic neuropeptide Y (NPY) mRNA expression in ovariectomized obese rat . Neuroscience letters. vol 204. issue 1-2. 1997-01-17. PMID:8929983. |
the present findings indicated that hypothalamic npy mrna expression, which involves the regulation of feeding behavior, are in parallel with circulating estrogen levels. |
1997-01-17 |
2023-08-12 |
rat |
| A J Sipols, D P Figlewicz, R J Seeley, M Chavez, S C Woods, D Port. Intraventricular neuropeptide Y does not stimulate food intake in the baboon. Physiology & behavior. vol 60. issue 3. 1997-01-16. PMID:8873242. |
in the present study, we examined the ability of the orexigenic peptide neuropeptide y (npy) to stimulate feeding when administered into the lateral ventricle of baboons. |
1997-01-16 |
2023-08-12 |
Not clear |
| A Tomaszuk, C Simpson, G William. Neuropeptide Y, the hypothalamus and the regulation of energy homeostasis. Hormone research. vol 46. issue 2. 1997-01-14. PMID:8871182. |
ultimately, characterization of the specific "feeding' receptors which mediate npy's central effects on energy homeostasis may provide opportunities for designing drugs to manipulate and appetite and energy balance in man, notably obesity and the cachexia commonly associated with malignancy and chronic infection. |
1997-01-14 |
2023-08-12 |
Not clear |