| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H D McCarthy, P E McKibbin, B Holloway, R Mayers, G William. Hypothalamic neuropeptide Y receptor characteristics and NPY-induced feeding responses in lean and obese Zucker rats. Life sciences. vol 49. issue 20. 1991-12-13. PMID:1658513. |
at two higher doses (235 pmol and 2.35 nmol), npy was equipotent in both genotypes over 1 and 2 hours but npy-induced feeding was attenuated over 3 hours in the obese rat. |
1991-12-13 |
2023-08-11 |
rat |
| R R Schick, V Schusdziarra, C Nussbaumer, M Classe. Neuropeptide Y and food intake in fasted rats: effect of naloxone and site of action. Brain research. vol 552. issue 2. 1991-10-31. PMID:1913187. |
central administration of neuropeptide y (npy) induces food intake in freely feeding animals and this effect is mediated by hypothalamic sites. |
1991-10-31 |
2023-08-11 |
rat |
| R R Schick, V Schusdziarra, C Nussbaumer, M Classe. Neuropeptide Y and food intake in fasted rats: effect of naloxone and site of action. Brain research. vol 552. issue 2. 1991-10-31. PMID:1913187. |
little is known, however, about the effect of npy on food intake and site of action in food-deprived animals. |
1991-10-31 |
2023-08-11 |
rat |
| R R Schick, V Schusdziarra, C Nussbaumer, M Classe. Neuropeptide Y and food intake in fasted rats: effect of naloxone and site of action. Brain research. vol 552. issue 2. 1991-10-31. PMID:1913187. |
during the first 40 min food intake was not different with or without npy. |
1991-10-31 |
2023-08-11 |
rat |
| R R Schick, V Schusdziarra, C Nussbaumer, M Classe. Neuropeptide Y and food intake in fasted rats: effect of naloxone and site of action. Brain research. vol 552. issue 2. 1991-10-31. PMID:1913187. |
the opioid receptor antagonist naloxone significantly augmented latency to feed, both in the absence and presence of npy (8.0 vs 1.7 min or 14.7 vs 2.8 min, respectively) and abolished the npy-induced increase in food intake. |
1991-10-31 |
2023-08-11 |
rat |
| R R Schick, V Schusdziarra, C Nussbaumer, M Classe. Neuropeptide Y and food intake in fasted rats: effect of naloxone and site of action. Brain research. vol 552. issue 2. 1991-10-31. PMID:1913187. |
following intrahypothalamic injection of npy, an increase in food intake (greater than 20%) was observed in 50% of the histologically identified lh and vmh sites, but only in 15% of the injection sites outside the lh/vmh. |
1991-10-31 |
2023-08-11 |
rat |
| U Pesonen, J Rouru, R Huupponen, M Koul. Effects of repeated administration of mifepristone and 8-OH-DPAT on expression of preproneuropeptide Y mRNA in the arcuate nucleus of obese Zucker rats. Brain research. Molecular brain research. vol 10. issue 3. 1991-10-07. PMID:1653393. |
neuropeptide y (npy) is an important hypothalamic regulator of feeding behavior. |
1991-10-07 |
2023-08-11 |
rat |
| A Inui, M Okita, M Nakajima, T Inoue, N Sakatani, M Oya, H Morioka, Y Okimura, K Chihara, S Bab. Neuropeptide regulation of feeding in dogs. The American journal of physiology. vol 261. issue 3 Pt 2. 1991-10-04. PMID:1716066. |
norepinephrine and four families of neuropeptides, namely, neuropeptide y (npy), opioid peptides, galanin, and growth hormone-releasing factor (grh), have been shown to stimulate feeding after central administration. |
1991-10-04 |
2023-08-11 |
human |
| A Inui, M Okita, M Nakajima, T Inoue, N Sakatani, M Oya, H Morioka, Y Okimura, K Chihara, S Bab. Neuropeptide regulation of feeding in dogs. The American journal of physiology. vol 261. issue 3 Pt 2. 1991-10-04. PMID:1716066. |
surprisingly, neither intracerebroventricular injections of npy and peptide yy nor intracerebroventricular pretreatment with anti-hnpy gamma-globulin modulated feeding, stressing the species differences in the feeding response to exogenous substances and the underlying physiology. |
1991-10-04 |
2023-08-11 |
human |
| E Moore, Z Merali, R J Beninge. Neuropeptide Y and behaviour: effects of intrastriatal NPY on circling behaviour of rats. Polish journal of pharmacology and pharmacy. vol 42. issue 6. 1991-10-03. PMID:2103003. |
npy dose-dependently stimulates food intake when administered icv into the paraventricular hypothalamic nucleus of rats. |
1991-10-03 |
2023-08-11 |
rat |
| P Rogers, P E McKibbin, G William. Acute fenfluramine administration reduces neuropeptide Y concentrations in specific hypothalamic regions of the rat: possible implications for the anorectic effect of fenfluramine. Peptides. vol 12. issue 2. 1991-08-14. PMID:2067977. |
neuropeptide y (npy), a powerful central appetite stimulant, coexists in several hypothalamic areas with serotonin, which suppresses feeding. |
1991-08-14 |
2023-08-11 |
rat |
| C L McLaughlin, J S Tou, G J Rogan, C A Bail. Full amino acid sequence of centrally administered NPY required for maximal food intake response. Physiology & behavior. vol 49. issue 3. 1991-08-08. PMID:2062928. |
full amino acid sequence of centrally administered npy required for maximal food intake response. |
1991-08-08 |
2023-08-11 |
rat |
| C L McLaughlin, J S Tou, G J Rogan, C A Bail. Full amino acid sequence of centrally administered NPY required for maximal food intake response. Physiology & behavior. vol 49. issue 3. 1991-08-08. PMID:2062928. |
central administration of npy (1-36) potently increases food intake and it has been hypothesized that biological activities of npy are related to its ability to form an alpha-helix, represented by the fragment npy (14-31). |
1991-08-08 |
2023-08-11 |
rat |
| C L McLaughlin, J S Tou, G J Rogan, C A Bail. Full amino acid sequence of centrally administered NPY required for maximal food intake response. Physiology & behavior. vol 49. issue 3. 1991-08-08. PMID:2062928. |
two-h fasted male rats were administered 0, 0.2, 1.0 or 5.0 nmol npy (1-36) or npy fragments in 5 microliters saline icv and intake of lab chow pellets was measured for 22 h. fragments containing all or part of the polyproline-like helix [npy (1-8)] antiparallel to the alpha-helix dose-relatedly increased food intake for 4 hours after injection. |
1991-08-08 |
2023-08-11 |
rat |
| C L McLaughlin, J S Tou, G J Rogan, C A Bail. Full amino acid sequence of centrally administered NPY required for maximal food intake response. Physiology & behavior. vol 49. issue 3. 1991-08-08. PMID:2062928. |
five nmol npy (1-36) and npy (2-36) increased 4-hour food intake 486 and 219%, respectively (p less than 0.05). |
1991-08-08 |
2023-08-11 |
rat |
| C L McLaughlin, J S Tou, G J Rogan, C A Bail. Full amino acid sequence of centrally administered NPY required for maximal food intake response. Physiology & behavior. vol 49. issue 3. 1991-08-08. PMID:2062928. |
five nmol npy (9-36) and npy (14-36) increased 4-hour food intake 128% (p = 0.02) and 62% (ns), respectively. |
1991-08-08 |
2023-08-11 |
rat |
| C L McLaughlin, J S Tou, G J Rogan, C A Bail. Full amino acid sequence of centrally administered NPY required for maximal food intake response. Physiology & behavior. vol 49. issue 3. 1991-08-08. PMID:2062928. |
substitution of dpro for lpro in position 2 increased potency but not efficacy of npy since food intake was increased at the 0.2 and 1.0 but not 5.0 nmol doses and the percent increase was not more than to 5 nmol npy (1-36). |
1991-08-08 |
2023-08-11 |
rat |
| C L McLaughlin, J S Tou, G J Rogan, C A Bail. Full amino acid sequence of centrally administered NPY required for maximal food intake response. Physiology & behavior. vol 49. issue 3. 1991-08-08. PMID:2062928. |
thus the maximum food intake response to npy requires both c-terminal and n-terminal fragments as well as the alpha-helix. |
1991-08-08 |
2023-08-11 |
rat |
| X Paez, J W Nyce, R D Myer. Differential feeding responses evoked in the rat by NPY and NPY1-27 injected intracerebroventricularly. Pharmacology, biochemistry, and behavior. vol 38. issue 2. 1991-07-31. PMID:2057507. |
differential feeding responses evoked in the rat by npy and npy1-27 injected intracerebroventricularly. |
1991-07-31 |
2023-08-11 |
rat |
| X Paez, J W Nyce, R D Myer. Differential feeding responses evoked in the rat by NPY and NPY1-27 injected intracerebroventricularly. Pharmacology, biochemistry, and behavior. vol 38. issue 2. 1991-07-31. PMID:2057507. |
neuropeptide y (npy) given by the intracerebroventricular (icv) route in the rat evokes hyperphagic-like feeding. |
1991-07-31 |
2023-08-11 |
rat |