| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marcos Divino Ferreira-Junior, Keilah Valéria Naves Cavalcante, Carlos Henrique Xavier, Emerielle Cristina Vanzela, Antonio Carlos Boschero, Paulo Matafome, Rodrigo Mello Gome. GHSR signalling in perinatal phases is involved in liver metabolism at puberty. The Journal of endocrinology. 2024-07-24. PMID:39045853. |
perinatal ghsr modulation by leap2[1-14] impacts glucose homeostasis in a sex and phase dependent manner, despite no effects on body weight gain or food intake. |
2024-07-24 |
2024-07-26 |
rat |
| Andrea Smith, Brenna MacAulay, Jessica Scheufen, Abagael Hudak, Alfonso Abizai. Chronic social defeat stress increases brain permeability to ghrelin in male mice. eNeuro. 2024-06-27. PMID:38937108. |
the effects of ghrelin on feeding are mediated by the binding of ghrelin to the growth hormone secretagogue receptor (ghsr), a receptor located in hypothalamic and extra-hypothalamic regions important for regulating food intake and metabolic rate. |
2024-06-27 |
2024-06-30 |
mouse |
| b' Mar\\xc3\\xada Paula Cornejo, Gimena Fernandez, Agustina Cabral, Franco Barrile, Florencia Heredia, Guadalupe Garc\\xc3\\xada Romero, Juan Pablo Zubimendi Sampieri, Juan Ignacio Quelas, Sonia Cantel, Jean-Alain Fehrentz, Antonia Alonso, Ramon Pla, Jos\\xc3\\xa9 Luis Ferran, Mar\\xc3\\xada Florencia Andreoli, Pablo Nicolas De Francesco, Mario Perell\\xc3\\xb. GHSR in a Subset of GABA Neurons Controls Food Deprivation-Induced Hyperphagia in Male Mice. Endocrinology. vol 165. issue 7. 2024-06-14. PMID:38815068.' |
the growth hormone secretagogue receptor (ghsr), primarily known as the receptor for the hunger hormone ghrelin, potently controls food intake, yet the specific ghsr-expressing cells mediating the orexigenic effects of this receptor remain incompletely characterized. |
2024-06-14 |
2024-06-16 |
mouse |
| b' Mar\\xc3\\xada Paula Cornejo, Gimena Fernandez, Agustina Cabral, Franco Barrile, Florencia Heredia, Guadalupe Garc\\xc3\\xada Romero, Juan Pablo Zubimendi Sampieri, Juan Ignacio Quelas, Sonia Cantel, Jean-Alain Fehrentz, Antonia Alonso, Ramon Pla, Jos\\xc3\\xa9 Luis Ferran, Mar\\xc3\\xada Florencia Andreoli, Pablo Nicolas De Francesco, Mario Perell\\xc3\\xb. GHSR in a Subset of GABA Neurons Controls Food Deprivation-Induced Hyperphagia in Male Mice. Endocrinology. vol 165. issue 7. 2024-06-14. PMID:38815068.' |
since ghsr is expressed in gamma-aminobutyric acid (gaba)-producing neurons, we sought to investigate whether the selective expression of ghsr in a subset of gaba neurons is sufficient to mediate ghsr's effects on feeding. |
2024-06-14 |
2024-06-16 |
mouse |
| Seohyeon Lee, Wen Ting Cai, Hyung Shin Yoon, Jeong-Hoon Ki. Visualization of the existence of growth hormone secretagogue receptor in the rat nucleus accumbens. Molecular brain. vol 17. issue 1. 2024-06-14. PMID:38872222. |
the potential role of the ghrelin receptor, also known as the growth hormone secretagogue receptor (ghsr), within the nucleus accumbens (nacc) in regulating drug addiction and feeding has been documented; however, the pattern of its expression in this site remains elusive. |
2024-06-14 |
2024-06-16 |
rat |
| András H Lékó, Adriana Gregory-Flores, Renata C N Marchette, Juan L Gomez, Janaina C M Vendruscolo, Vez Repunte-Canonigo, Vicky Choung, Sara L Deschaine, Kimberly E Whiting, Shelley N Jackson, Maria Paula Cornejo, Mario Perello, Zhi-Bing You, Michael Eckhaus, Karuna Rasineni, Kim D Janda, Barry Zorman, Pavel Sumazin, George F Koob, Michael Michaelides, Pietro P Sanna, Leandro F Vendruscolo, Lorenzo Leggi. Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet. Communications biology. vol 7. issue 1. 2024-05-25. PMID:38796563. |
the ghrelin receptor (ghsr) has ligand-independent actions; therefore, ghsr gene deletion may be a reasonable approach to investigate the role of this system in feeding behaviors and diet-induced obesity (dio). |
2024-05-25 |
2024-05-31 |
mouse |
| András H Lékó, Adriana Gregory-Flores, Renata C N Marchette, Juan L Gomez, Janaina C M Vendruscolo, Vez Repunte-Canonigo, Vicky Choung, Sara L Deschaine, Kimberly E Whiting, Shelley N Jackson, Maria Paula Cornejo, Mario Perello, Zhi-Bing You, Michael Eckhaus, Karuna Rasineni, Kim D Janda, Barry Zorman, Pavel Sumazin, George F Koob, Michael Michaelides, Pietro P Sanna, Leandro F Vendruscolo, Lorenzo Leggi. Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet. Communications biology. vol 7. issue 1. 2024-05-25. PMID:38796563. |
our main findings are that the ghsr gene deletion protects against dio and decreases food intake during hfd in male but not in female rats. |
2024-05-25 |
2024-05-31 |
mouse |
| András H Lékó, Adriana Gregory-Flores, Renata C N Marchette, Juan L Gomez, Janaina C M Vendruscolo, Vez Repunte-Canonigo, Vicky Choung, Sara L Deschaine, Kimberly E Whiting, Shelley N Jackson, Maria Paula Cornejo, Mario Perello, Zhi-Bing You, Michael Eckhaus, Karuna Rasineni, Kim D Janda, Barry Zorman, Pavel Sumazin, George F Koob, Michael Michaelides, Pietro P Sanna, Leandro F Vendruscolo, Lorenzo Leggi. Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet. Communications biology. vol 7. issue 1. 2024-05-25. PMID:38796563. |
central administration of a novel ghsr inverse agonist, pf-5190457, attenuates ghrelin-induced food intake, but only in male, not in female mice. |
2024-05-25 |
2024-05-31 |
mouse |
| Andrea Smith, Trevor Rodrigues, Caroline Wallace, Karen Mezher, Brenna MacAulay, Rebecca Prowse, Lindsay Hyland, Alfonso Abizai. Growth hormone secretagogue receptor (GHSR) signaling in the ventral tegmental area (VTA) mediates feeding produced by chronic social defeat stress in male mice. Neuroscience. 2024-04-07. PMID:38583506. |
growth hormone secretagogue receptor (ghsr) signaling in the ventral tegmental area (vta) mediates feeding produced by chronic social defeat stress in male mice. |
2024-04-07 |
2024-04-10 |
mouse |
| Andrea Smith, Trevor Rodrigues, Caroline Wallace, Karen Mezher, Brenna MacAulay, Rebecca Prowse, Lindsay Hyland, Alfonso Abizai. Growth hormone secretagogue receptor (GHSR) signaling in the ventral tegmental area (VTA) mediates feeding produced by chronic social defeat stress in male mice. Neuroscience. 2024-04-07. PMID:38583506. |
ghrelin, a hormone secreted by the stomach, binds to the growth hormone secretagogue receptor (ghsr) in various brain regions to produce a number of behavioral effects that include increased feeding motivation. |
2024-04-07 |
2024-04-10 |
mouse |
| Andrea Smith, Trevor Rodrigues, Caroline Wallace, Karen Mezher, Brenna MacAulay, Rebecca Prowse, Lindsay Hyland, Alfonso Abizai. Growth hormone secretagogue receptor (GHSR) signaling in the ventral tegmental area (VTA) mediates feeding produced by chronic social defeat stress in male mice. Neuroscience. 2024-04-07. PMID:38583506. |
here we examined the role of ghsr signaling in the vta in feeding behavior in mice exposed to social defeat stress. |
2024-04-07 |
2024-04-10 |
mouse |
| Andrea Smith, Trevor Rodrigues, Caroline Wallace, Karen Mezher, Brenna MacAulay, Rebecca Prowse, Lindsay Hyland, Alfonso Abizai. Growth hormone secretagogue receptor (GHSR) signaling in the ventral tegmental area (VTA) mediates feeding produced by chronic social defeat stress in male mice. Neuroscience. 2024-04-07. PMID:38583506. |
socially defeated ghsr ko mice failed to increase their caloric intake in response to this stressor but rescue of ghsr expression in the vta restored feeding responses. |
2024-04-07 |
2024-04-10 |
mouse |
| Haruka Saito, Hiroyuki Watanabe, Masahiro On. Synthesis and biological evaluation of novel Bioorganic & medicinal chemistry letters. 2024-01-22. PMID:38253227. |
synthesis and biological evaluation of novel the ghrelin receptor (ghsr) is known to regulate various physiological processes including appetite, food intake, and growth hormone release. |
2024-01-22 |
2024-01-25 |
Not clear |
| Da Mi Kim, Jong Han Lee, Quan Pan, Hye Won Han, Zheng Shen, Sahar Eshghjoo, Chia-Shan Wu, Wanbao Yang, Ji Yeon Noh, David W Threadgill, Shaodong Guo, Gus Wright, Robert Alaniz, Yuxiang Su. Nutrient-sensing growth hormone secretagogue receptor in macrophage programming and meta-inflammation. Molecular metabolism. 2023-12-13. PMID:38092245. |
growth hormone secretagogue receptor (ghsr) is known to mediate the effects of nutrient-sensing hormone ghrelin in food intake and fat deposition. |
2023-12-13 |
2023-12-17 |
mouse |
| M Alex Thomas, Xin Cui, Liana R Artinian, Qiang Cao, Jia Jing, Felipe C Silva, Shirong Wang, Jeffrey M Zigman, Yuxiang Sun, Hang Shi, Bingzhong Xu. Crosstalk between Gut Sensory Ghrelin Signaling and Adipose Tissue Sympathetic Outflow Regulates Metabolic Homeostasis. bioRxiv : the preprint server for biology. 2023-12-11. PMID:38076894. |
remarkably, sensory neuron ghsr deletion attenuates dio through increased energy expenditure and sympathetic outflow to adipose tissue independent of food intake. |
2023-12-11 |
2023-12-17 |
Not clear |
| Ivana Maric, Lorena López-Ferreras, Yashaswini Bhat, Mohammed Asker, Stina Börchers, Lauren Bellfy, Suyeun Byun, Janine L Kwapis, Karolina P Skibick. From the stomach to locus coeruleus: new neural substrate for ghrelin's effects on ingestive, motivated and anxiety-like behaviors. Frontiers in pharmacology. vol 14. 2023-12-01. PMID:38026980. |
to pursue this idea, we examined the effects of lc ghsr stimulation and blockade on food intake, operant responding for a palatable food reward and, anxiety-like behavior in the open field (of) and acoustic startle response (asr) tests in male and female rats. |
2023-12-01 |
2023-12-10 |
rat |
| Omprakash Singh, Sean B Ogden, Salil Varshney, Kripa Shankar, Deepali Gupta, Subhojit Paul, Sherri Osborne-Lawrence, Corine P Richard, Nathan P Metzger, Connor Lawrence, Luis León-Mercado, Jeffrey M Zigma. Ghrelin-responsive mediobasal hypothalamic neurons mediate exercise-associated food intake and exercise endurance. JCI insight. 2023-11-14. PMID:37962950. |
also, ghsr (ghrelin receptor)-null mice exhibit decreased food intake following hiie and a diminished running distance (time until exhaustion) during a longer, step-wise exercise endurance protocol. |
2023-11-14 |
2023-11-20 |
mouse |
| Anna Katrina Jógvansdóttir Gradel, Stephanie K Holm, Sarah Byberg, Myrte Merkestein, Wouter Frederik Johan Hogendorf, Mari Lilith Lund, Jesse Arnold Buijink, Jesper Damgaard, Jens Lykkesfeldt, Birgitte Hols. The dietary regulation of LEAP2 depends on meal composition in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 6. 2023-04-27. PMID:37104087. |
upon activation of the growth hormone secretagogue receptor (ghsr), ghrelin increases blood glucose levels, food intake, and promotes weight gain. |
2023-04-27 |
2023-08-14 |
mouse |
| Hallie S Wald, Misgana Y Ghidewon, Matthew R Hayes, Harvey J Gril. Hindbrain ghrelin and LEAP2, ligands for GHSR, bidirectionally control food intake. American journal of physiology. Regulatory, integrative and comparative physiology. 2023-02-27. PMID:36847494. |
hindbrain ghrelin and leap2, ligands for ghsr, bidirectionally control food intake. |
2023-02-27 |
2023-08-14 |
Not clear |
| Hallie S Wald, Misgana Y Ghidewon, Matthew R Hayes, Harvey J Gril. Hindbrain ghrelin and LEAP2, ligands for GHSR, bidirectionally control food intake. American journal of physiology. Regulatory, integrative and comparative physiology. 2023-02-27. PMID:36847494. |
hindbrain growth hormone secretagogue receptor (ghsr) agonism increases food intake, yet the underlying neural mechanisms remain unclear. |
2023-02-27 |
2023-08-14 |
Not clear |