| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Wang, Yingzi Wang, Xiaona Du, Hailin Zhan. Potassium Channel Conductance Is Involved in Phenylephrine-Induced Spontaneous Firing of Serotonergic Neurons in the Dorsal Raphe Nucleus. Frontiers in cellular neuroscience. vol 16. 2022-06-23. PMID:35734219. |
dysregulation of the activity of 5-ht neurons in the drn is thought to play an important role in emotional disorders. |
2022-06-23 |
2023-08-14 |
Not clear |
| Christian P Mülle. Serotonin and Consciousness-A Reappraisal. Behavioural brain research. 2022-06-18. PMID:35716774. |
serotonin acts in concert with other modulatory systems of the brain stem with some possible specialization on single emotions. |
2022-06-18 |
2023-08-14 |
Not clear |
| Suvarna H Pagire, Haushabhau S Pagire, Kun-Young Park, Eun Jung Bae, Kwang-Eun Kim, Minhee Kim, Jihyeon Yoon, Saravanan Parameswaran, Jun-Ho Choi, Sungmi Park, Jae-Han Jeon, Jin Sook Song, Myung Ae Bae, In-Kyu Lee, Hail Kim, Jae Myoung Suh, Jin Hee Ah. Identification of New Non-BBB Permeable Tryptophan Hydroxylase Inhibitors for Treating Obesity and Fatty Liver Disease. Molecules (Basel, Switzerland). vol 27. issue 11. 2022-06-10. PMID:35684355. |
serotonin (5-hydroxytryptophan) is a hormone that regulates emotions in the central nervous system. |
2022-06-10 |
2023-08-14 |
Not clear |
| Natália Maria Simionato, Janaína da Silva Rocha-Lopes, Ricardo Borges Machado, Deborah Sucheck. Chronic rapid eye movement sleep restriction during juvenility has long-term effects on anxiety-like behaviour and neurotransmission of male Wistar rats. Pharmacology, biochemistry, and behavior. 2022-06-06. PMID:35662652. |
these results suggest that sleep restriction in juvenility and adolescence induces persistent changes in emotional behaviour in adult male rats and that levels of anxiety are correlated with increased serotonin and dopamine metabolism in specific brain areas. |
2022-06-06 |
2023-08-14 |
rat |
| Eleonora Mascheroni, Paola Schiavolin, Isabella Lucia Chiara Mariani Wigley, Roberto Giorda, Uberto Pozzoli, Francesco Morandi, Camilla Fontana, Fabio Mosca, Monica Fumagalli, Rosario Montiross. Serotonin transporter gene methylation and emotional regulation in preschool children born preterm: A longitudinal evaluation of the role of negative emotionality in infancy. Infant mental health journal. 2022-05-27. PMID:35619334. |
the aim of the study was to assess the contribution of negative emotionality at 3 months (t1) and serotonin transporter gene (slc6a4) dna methylation at 4.5 years of age (t2) to emotion regulation in pre-schoolers born very preterm and full-term. |
2022-05-27 |
2023-08-13 |
Not clear |
| A V Wilkinson, A C Swann, D P Graham, M A Patriquin, R Salas, D A Nielsen, T R Koste. Emotional self-regulation, impulsivity, 5-HTTLPR and tobacco use behavior among psychiatric inpatients. Journal of affective disorders. 2022-05-27. PMID:35623482. |
while the serotonin transporter (slc6a4) gene, 5-httlpr, interacts with the social environment to influence both emotional self-regulation and smoking behavior, less is known about interactions between emotional self-regulation and 5-httlpr or their joint influence on tobacco use. |
2022-05-27 |
2023-08-13 |
Not clear |
| Sara Sophia Guedes Linhares, Ywlliane da Silva Rodrigues Meurer, Antonio Aquino, Diego Aquino Câmara, Luiz Eduardo Mateus Brandão, Aline Lima Dierschnabel, Felipe Porto Fiuza, Ramon Hypólito Lima, Rovena Clara Engelberth, Jeferson Souza Cavalcant. Effects of prenatal exposure to fluoxetine on circadian rhythmicity in the locomotor activity and neuropeptide Y and 5-HT expression in male and female adult Wistar rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-04-28. PMID:35481929. |
5-ht promotes essential brain changes throughout its development, which include neuron migration, differentiation, and organization of neural circuitries related to emotional, cognitive, and circadian behavior. |
2022-04-28 |
2023-08-13 |
rat |
| Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Eiko Fujita, Toshiya Matsushima, Koichi J Homma, Shinji Yamaguch. Chick Hippocampal Formation Displays Subdivision- and Layer-Selective Expression Patterns of Serotonin Receptor Subfamily Genes. Frontiers in physiology. vol 13. 2022-04-25. PMID:35464081. |
in hf neural circuits, serotonin receptors (5-htrs) modulate functions related to cognition and emotion. |
2022-04-25 |
2023-08-13 |
chicken |
| Błażej D Pędzich, Sarah Rubens, Mehdi Sekssaoui, Anouk Pierre, Andries Van Schuerbeek, Philippe Marin, Joel Bockaert, Emmanuel Valjent, Carine Bécamel, Dimitri De Bunde. Effects of a psychedelic 5-HT2A receptor agonist on anxiety-related behavior and fear processing in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-04-22. PMID:35449450. |
the serotonin 2a (5-ht2a) receptor is a key target underlying the effects of psychedelics on emotional arousal but its role in fear processing remains controversial. |
2022-04-22 |
2023-08-13 |
mouse |
| Bo Bi, Dongfang Che, Yuyin Ba. Neural network of bipolar disorder: Toward integration of neuroimaging and neurocircuit-based treatment strategies. Translational psychiatry. vol 12. issue 1. 2022-04-06. PMID:35383150. |
based on the reported data, we hypothesized that (i) the core neuropathology in bd is damage in fronto-limbic network, which is associated with emotional dysfunction; (ii) changes in intrinsic brain network, such as sensorimotor network, salience network, default-mode network, central executive network are associated with impaired cognition function; and (iii) beyond the dopaminergic-driven basal ganglia-thalamo-cortical motor circuit modulated by other neurotransmitter systems, such as serotonin (subcortical-cortical modulation), the sensorimotor network and related motor function modulated by other non-motor networks such as the default-mode network are involved in psychomotor function. |
2022-04-06 |
2023-08-13 |
Not clear |
| Aqeela Zahra, Le Du, Meng Jia, Muhammad Umar Butt, Qun Wang, Yunfu Wang, Jianping W. Prenatal exposure of citalopram elicits depression-like and anxiety-like behaviors and alteration of morphology and protein expression of medial prefrontal cortex in young adult mice. Journal of integrative neuroscience. vol 21. issue 2. 2022-04-01. PMID:35364649. |
treatment of major depression disorder with selective serotonin reuptake inhibitors (ssris), such as citalopram (ctm), during pregnancy effects on the neurological trajectory of the offspring and induces enduring consequences, notably emotional and cognitive impairment. |
2022-04-01 |
2023-08-13 |
mouse |
| Hiroko Miyagishi, Minoru Tsuji, Kazuya Miyagawa, Kazuhiro Kurokawa, Atsumi Mochida-Saito, Kohei Takahashi, Yasuhiro Kosuge, Kumiko Ishige, Hiroshi Taked. Possible role of transcriptional regulation of 5-HT Brain research. 2022-03-04. PMID:35245487. |
moreover, this emotional abnormality was alleviated by chronic treatment with flesinoxan, a serotonin (5-ht) |
2022-03-04 |
2023-08-13 |
mouse |
| Lluis Miquel-Rio, Diana Alarcón-Arís, María Torres-López, Valentín Cóppola-Segovia, Rubén Pavia-Collado, Verónica Paz, Esther Ruiz-Bronchal, Leticia Campa, Carme Casal, Andrés Montefeltro, Miquel Vila, Francesc Artigas, Raquel Revilla, Analia Bortolozz. Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy. Translational psychiatry. vol 12. issue 1. 2022-02-25. PMID:35210396. |
altogether, our findings show that α-synucleinopathy in 5-ht neurons negatively affects brain circuits that control mood and emotions, resembling the expression of neuropsychiatric symptoms occurring at the onset of pd. |
2022-02-25 |
2023-08-13 |
mouse |
| Lluis Miquel-Rio, Diana Alarcón-Arís, María Torres-López, Valentín Cóppola-Segovia, Rubén Pavia-Collado, Verónica Paz, Esther Ruiz-Bronchal, Leticia Campa, Carme Casal, Andrés Montefeltro, Miquel Vila, Francesc Artigas, Raquel Revilla, Analia Bortolozz. Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy. Translational psychiatry. vol 12. issue 1. 2022-02-25. PMID:35210396. |
dysfunction of the serotonergic (5-ht) system, which regulates mood and emotional pathways, occurs during the premotor phase of pd and contributes to a variety of non-motor symptoms. |
2022-02-25 |
2023-08-13 |
mouse |
| Tian Tian, Jia Li, Guiling Zhang, Jian Wang, Dong Liu, Changhua Wan, Jicheng Fang, Di Wu, Yiran Zhou, Yuanyuan Qin, Wenzhen Zh. Default Mode Network Alterations Induced by Childhood Trauma Correlate With Emotional Function and SLC6A4 Expression. Frontiers in psychiatry. vol 12. 2022-02-14. PMID:35153849. |
the serotonin transporter gene was identified and might suggest the biological underpinning of the relationship between childhood trauma, dmn, and emotion regulation. |
2022-02-14 |
2023-08-13 |
Not clear |
| Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Eiko Fujita, Toshiya Matsushima, Koichi J Homma, Shinji Yamaguch. Serotonergic Neurons in the Chick Brainstem Express Various Serotonin Receptor Subfamily Genes. Frontiers in physiology. vol 12. 2022-02-03. PMID:35111079. |
in mammals, 5-ht plays an important role in the regulation of many mental states and the processing of emotions in the central nervous system. |
2022-02-03 |
2023-08-13 |
chicken |
| Carolina Ramos de Mendonça, Raul Manhães-de-Castro, Bárbara Juacy Rodrigues Costa de Santana, Luana Olegário da Silva, Ana Elisa Toscano, Omar Guzmán-Quevedo, Lígia Cristina Monteiro Galind. Effects of flavonols on emotional behavior and compounds of the serotonergic system: A preclinical systematic review. European journal of pharmacology. 2021-12-26. PMID:34954234. |
an imbalance of 5-ht in the brain can modulate emotional behavior such as depression and anxiety. |
2021-12-26 |
2023-08-13 |
Not clear |
| Anna Haduch, Przemysław J Danek, Wojciech Kuban, Renata Pukło, Natalia Alenina, Joanna Gołębiowska, Piotr Popik, Michael Bader, Władysława A Danie. Cytochrome P450 2D (CYP2D) enzyme dysfunction associated with aging and serotonin deficiency in the brain and liver of female Dark Agouti rats. Neurochemistry international. vol 152. 2021-12-11. PMID:34780807. |
in summary, the aging process and tph2 deficit affect the cyp2d activity and protein level in female rats, which may have a negative impact on the compensatory capacity of cyp2d in the synthesis of serotonin and dopamine in cerebral structures involved in cognitive and emotional functions. |
2021-12-11 |
2023-08-13 |
rat |
| Hidenao Kimijima, Kazuya Miyagawa, Kazuhiro Kurokawa, Atsumi Mochida-Saito, Kohei Takahashi, Hiroshi Takeda, Minoru Tsuj. Trichostatin A, a histone deacetylase inhibitor, alleviates the emotional abnormality induced by maladaptation to stress in mice. Neuroscience letters. vol 766. 2021-12-01. PMID:34774702. |
these findings suggest that an hdac inhibitor may have a beneficial effect on stress adaptation by affecting 5-ht neural function in the brain and alleviate the emotional abnormality under conditions of excessive stress. |
2021-12-01 |
2023-08-13 |
mouse |
| Mathilde Baudat, Anne R de Kort, Daniel L A van den Hove, Elbert A J Jooste. Early-life exposure to selective serotonin reuptake inhibitors: long-term effects on pain and affective comorbidities. The European journal of neuroscience. 2021-11-29. PMID:34841582. |
serotonin, beside its role in regulating pain and emotions, promotes neuronal network formation. |
2021-11-29 |
2023-08-13 |
Not clear |