| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ester Aso, Andrés Ozaita, Elsa M Valdizán, Catherine Ledent, Angel Pazos, Rafael Maldonado, Olga Valverd. BDNF impairment in the hippocampus is related to enhanced despair behavior in CB1 knockout mice. Journal of neurochemistry. vol 105. issue 2. 2008-05-06. PMID:18047561. |
the endocannabinoid system represents a physiological substrate involved in neuroprotection at both cellular and emotional levels. |
2008-05-06 |
2023-08-12 |
mouse |
| Maria Scherma, Julie Medalie, Walter Fratta, Subramanian K Vadivel, Alexandros Makriyannis, Daniele Piomelli, Eva Mikics, Jozsef Haller, Sevil Yasar, Gianluigi Tanda, Steven R Goldber. The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition. Neuropharmacology. vol 54. issue 1. 2008-04-18. PMID:17904589. |
converging evidence suggests that the endocannabinoid system is an important constituent of neuronal substrates involved in brain reward processes and emotional responses to stress. |
2008-04-18 |
2023-08-12 |
rat |
| Regina A Mangieri, Daniele Piomell. Enhancement of endocannabinoid signaling and the pharmacotherapy of depression. Pharmacological research. vol 56. issue 5. 2008-04-08. PMID:17945507. |
cannabinoids are well known modulators of mood and emotional behavior. |
2008-04-08 |
2023-08-12 |
Not clear |
| Regina A Mangieri, Daniele Piomell. Enhancement of endocannabinoid signaling and the pharmacotherapy of depression. Pharmacological research. vol 56. issue 5. 2008-04-08. PMID:17945507. |
changes in levels of the cannabinoid cb(1) receptor or the endogenous cb(1) receptor ligands, anandamide and 2-ag, are observed both in humans suffering from depression and in animal models of depression, and experimental manipulation of cb(1) receptor signaling has also been shown to affect emotional reactivity in rodents. |
2008-04-08 |
2023-08-12 |
Not clear |
| M Paola Castelli, A Paola Piras, Antonella D'Agostino, Fabio Pibiri, Simona Perra, Gian Luigi Gessa, Mauro Maccarrone, Marco Pisti. Dysregulation of the endogenous cannabinoid system in adult rats prenatally treated with the cannabinoid agonist WIN 55,212-2. European journal of pharmacology. vol 573. issue 1-3. 2008-03-13. PMID:17644084. |
our results show that prenatal exposure to cannabinoid agonist induces a long-term alteration of endocannabinoid system in brain areas involved in learning-memory, motor activity and emotional behavior. |
2008-03-13 |
2023-08-12 |
rat |
| Marco Bortolato, Regina A Mangieri, Jin Fu, Janet H Kim, Oliver Arguello, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia, Daniele Piomell. Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress. Biological psychiatry. vol 62. issue 10. 2008-02-01. PMID:17511970. |
the endocannabinoid anandamide may be involved in the regulation of emotional reactivity. |
2008-02-01 |
2023-08-12 |
rat |
| María-Paz Viveros, Eva-María Marco, Ricardo Llorente, Laura Lamot. The role of the hippocampus in mediating emotional responses to nicotine and cannabinoids: a possible neural substrate for functional interactions. Behavioural pharmacology. vol 18. issue 5-6. 2007-10-23. PMID:17762508. |
the role of the hippocampus in mediating emotional responses to nicotine and cannabinoids: a possible neural substrate for functional interactions. |
2007-10-23 |
2023-08-12 |
human |
| María-Paz Viveros, Eva-María Marco, Ricardo Llorente, Laura Lamot. The role of the hippocampus in mediating emotional responses to nicotine and cannabinoids: a possible neural substrate for functional interactions. Behavioural pharmacology. vol 18. issue 5-6. 2007-10-23. PMID:17762508. |
upon exposure to stressful stimuli, central endocannabinoid and cholinergic systems appear to be activated in key limbic areas such as hippocampus and amygdala, which might contribute to adaptive cognitive and emotional strategies to cope with aversive situations. |
2007-10-23 |
2023-08-12 |
human |
| Ryan J McLaughlin, Matthew N Hill, Anna C Morrish, Boris B Gorzalk. Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effect. Behavioural pharmacology. vol 18. issue 5-6. 2007-10-23. PMID:17762511. |
moreover, the endocannabinoid system in the hippocampus is sensitive to both chronic stress and antidepressant administration, suggesting a potential role of this system in emotional changes associated with these regimens. |
2007-10-23 |
2023-08-12 |
rat |
| María-Paz Viveros, Eva-María Marco, Ricardo Llorente, Meritxell López-Gallard. Endocannabinoid system and synaptic plasticity: implications for emotional responses. Neural plasticity. vol 2007. 2007-09-21. PMID:17641734. |
endocannabinoid system and synaptic plasticity: implications for emotional responses. |
2007-09-21 |
2023-08-12 |
mouse |
| María-Paz Viveros, Eva-María Marco, Ricardo Llorente, Meritxell López-Gallard. Endocannabinoid system and synaptic plasticity: implications for emotional responses. Neural plasticity. vol 2007. 2007-09-21. PMID:17641734. |
brain regions such as the amygdala, hippocampus and cortex, which are directly involved in the regulation of emotional behavior, contain high densities of cannabinoid cb1 receptors. |
2007-09-21 |
2023-08-12 |
mouse |
| María-Paz Viveros, Eva-María Marco, Ricardo Llorente, Meritxell López-Gallard. Endocannabinoid system and synaptic plasticity: implications for emotional responses. Neural plasticity. vol 2007. 2007-09-21. PMID:17641734. |
thus, the endocannabinoid system appears to play a pivotal role in the regulation of emotional states. |
2007-09-21 |
2023-08-12 |
mouse |
| Matthew N Hill, Eda S Karacabeyli, Boris B Gorzalk. Estrogen recruits the endocannabinoid system to modulate emotionality. Psychoneuroendocrinology. vol 32. issue 4. 2007-07-03. PMID:17391861. |
collectively, these data demonstrate that estrogen may elicit changes in emotional behavior through an endocannabinoid mechanism, and suggest that inhibition of faah represents a therapeutic target for anxiety and depression in women. |
2007-07-03 |
2023-08-12 |
human |
| M Konings, Hari D Maharaj. Cannabis use and mood disorders: patterns of clinical presentations among adolescents in a developing country. International journal of adolescent medicine and health. vol 18. issue 2. 2006-11-29. PMID:16894861. |
further research is needed on the effect of cannabinoids on emotions, behaviour and thinking and its relationship to mental disorders. |
2006-11-29 |
2023-08-12 |
Not clear |
| Maria Rutkowska, Joanna Jamontt, Halina Glinia. Effects of cannabinoids on the anxiety-like response in mice. Pharmacological reports : PR. vol 58. issue 2. 2006-10-26. PMID:16702621. |
several pieces of anatomical, biochemical and pharmacological evidence indicate that the endocannabinoid system via cb1 receptors is implicated in the control of emotional behavior. |
2006-10-26 |
2023-08-12 |
mouse |
| Anna Lisa Muntoni, Giuliano Pillolla, Miriam Melis, Simona Perra, Gian Luigi Gessa, Marco Pisti. Cannabinoids modulate spontaneous neuronal activity and evoked inhibition of locus coeruleus noradrenergic neurons. The European journal of neuroscience. vol 23. issue 9. 2006-10-06. PMID:16706846. |
in addition, exogenous cannabinoids, as well as pharmacological and genetic manipulation of the endocannabinoid system, are known to influence emotional states (e.g. |
2006-10-06 |
2023-08-12 |
rat |
| Anna Lisa Muntoni, Giuliano Pillolla, Miriam Melis, Simona Perra, Gian Luigi Gessa, Marco Pisti. Cannabinoids modulate spontaneous neuronal activity and evoked inhibition of locus coeruleus noradrenergic neurons. The European journal of neuroscience. vol 23. issue 9. 2006-10-06. PMID:16706846. |
cognitive and attention deficits, anxiety reactions), as well as a role for cannabinoid receptors in basic brain activities sustaining arousal and emotional states. |
2006-10-06 |
2023-08-12 |
rat |
| Steven R Laviolette, Anthony A Grac. Cannabinoids Potentiate Emotional Learning Plasticity in Neurons of the Medial Prefrontal Cortex through Basolateral Amygdala Inputs. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 24. 2006-07-11. PMID:16775133. |
we report that systemic activation or blockade of cannabinoid cb1 receptors modulates emotional associative learning and memory formation in a subpopulation of neurons in the mammalian medial prefrontal cortex (mpfc) that receives functional input from the basolateral amygdala (bla). |
2006-07-11 |
2023-08-12 |
rat |
| Tiziana Antonelli, Maria Cristina Tomasini, Maria Tattoli, Tommaso Cassano, Sergio Tanganelli, Simone Finetti, Elisa Mazzoni, Luigia Trabace, Luca Steardo, Vincenzo Cuomo, Luca Ferrar. Prenatal exposure to the CB1 receptor agonist WIN 55,212-2 causes learning disruption associated with impaired cortical NMDA receptor function and emotional reactivity changes in rat offspring. Cerebral cortex (New York, N.Y. : 1991). vol 15. issue 12. 2006-01-10. PMID:15788701. |
the aim of this study was to investigate whether prenatal exposure to the cannabinoid cb1 receptor agonist win 55,212-2 (win) at a daily dose devoid of overt signs of toxicity and/or gross malformations (0.5 mg/kg, gestation days 5-20), influences cortical glutamatergic neurotransmission, learning and emotional reactivity in rat offspring. |
2006-01-10 |
2023-08-12 |
rat |
| Olga Valverd. Participation of the cannabinoid system in the regulation of emotional-like behaviour. Current pharmaceutical design. vol 11. issue 26. 2005-12-20. PMID:16250845. |
this paper reviews the results obtained in different animal models used to investigate emotional states after the manipulation of the endocannabinoid system. |
2005-12-20 |
2023-08-12 |
mouse |