| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B A Hultén, A Heath, K Knudsen, G Nyberg, J E Starmark, E Mårtensso. Severe amitriptyline overdose: relationship between toxicokinetics and toxicodynamics. Journal of toxicology. Clinical toxicology. vol 30. issue 2. 1992-06-25. PMID:1588667. |
the level of consciousness correlated with the plasma and unbound amitriptyline both in alpha and beta phase and with red blood cell amitriptyline in alpha phase. |
1992-06-25 |
2023-08-11 |
Not clear |
| G A Head, S Burk. Importance of central noradrenergic and serotonergic pathways in the cardiovascular actions of rilmenidine and clonidine. Journal of cardiovascular pharmacology. vol 18. issue 6. 1992-06-08. PMID:1725893. |
we examined the role of central monoamine neurotransmitters noradrenaline and serotonin in the cardiovascular actions of the alpha 2-adrenoceptor agonist rilmenidine in the conscious rabbit and compared it to clonidine. |
1992-06-08 |
2023-08-11 |
rabbit |
| J L Matheny, K A Westphal, D R Richardson, G I Rot. Macro- and microvascular effects of nitrous oxide in the rat. Anesthesia progress. vol 38. issue 2. 1992-06-04. PMID:1667350. |
systolic blood pressure, heart rat, total tail blood flow, blood cell velocity in subepidermal capillaries of the tail, and percentage of capillaries exhibiting flow were monitored in conscious rats during the administration of n2o before and after administration of clonidine (an alpha 2-adrenergic agonist), prazosin (an alpha 1-adrenergic antagonist) or naloxone (an opioid antagonist). |
1992-06-04 |
2023-08-11 |
rat |
| K Takahashi, K Ando, A Ono, T Shimosawa, E Ogata, T Fujit. Tumor necrosis factor-alpha induces vascular hyporesponsiveness in Sprague-Dawley rats. Life sciences. vol 50. issue 19. 1992-06-02. PMID:1573976. |
because vasodilation is a hallmark of sepsis and decreased vascular responsiveness has been implicated in the pathogenesis of septic shock, we studied the effect of tnf alpha on the mean blood pressure in conscious rats and vascular responsiveness to vasoconstrictors ex vivo using the standard organ bath method. |
1992-06-02 |
2023-08-11 |
rat |
| J F Poyer, B Gabelt, P L Kaufma. The effect of topical PGF2 alpha on uveoscleral outflow and outflow facility in the rabbit eye. Experimental eye research. vol 54. issue 2. 1992-05-13. PMID:1559555. |
pgf2 alpha tromethamine salt (pgf2 alpha-ts) (50 micrograms) applied to one eye of 14 conscious rabbits produced a significant iop fall of 7.4 +/- 0.9 mmhg (p less than 0.001). |
1992-05-13 |
2023-08-11 |
human |
| T Kurz, K A Yamada, S D DaTorre, P B Cor. Alpha 1-adrenergic system and arrhythmias in ischaemic heart disease. European heart journal. vol 12 Suppl F. 1992-05-06. PMID:1666558. |
however, during both early ischaemia and reperfusion there is an enhanced responsivity to alpha-adrenergic stimulation and a potent antiarrhythmic effect of alpha 1-adrenergic blockade in several species including the conscious dog. |
1992-05-06 |
2023-08-11 |
dog |
| C T Frantzides, E A Lianos, D Wittmann, B Greenwood, C E Edmisto. Prostaglandins and modulation of small bowel myoelectric activity. The American journal of physiology. vol 262. issue 3 Pt 1. 1992-04-23. PMID:1347976. |
we explored the effects of prostaglandins (pg) f2 alpha and e2 on the motor and myoelectric activity of the small intestine using closed intra-arterial injections in conscious chronically instrumented dogs. |
1992-04-23 |
2023-08-11 |
Not clear |
| C Hu, P A Flecknell, J H Lile. Fentanyl and medetomidine anaesthesia in the rat and its reversal using atipamazole and either nalbuphine or butorphanol. Laboratory animals. vol 26. issue 1. 1992-04-23. PMID:1548841. |
administration by intraperitoneal injection of atipamezole, a specific alpha 2-adrenoceptor antagonist (1 mg/kg) mixed with a mu antagonist/k agonist opioid (nalbuphine, 2 mg/kg or butorphanol 0.4 mg/kg), resulted in a rapid (less than 8 min) reversal of anaesthesia and the associated respiratory depression, and apparent full recovery of consciousness. |
1992-04-23 |
2023-08-11 |
rat |
| V De Saedeleer, E Wechsung, A Houvenaghe. Influence of PGF2 alpha on gastrointestinal activity in the conscious piglet. Prostaglandins, leukotrienes, and essential fatty acids. vol 45. issue 1. 1992-04-10. PMID:1546068. |
influence of pgf2 alpha on gastrointestinal activity in the conscious piglet. |
1992-04-10 |
2023-08-11 |
Not clear |
| M Reverte, M J Garcia-Barrado, J Moratino. Changes in plasma glucose and lactate evoked by alpha and beta 2-adrenoceptor stimulation in conscious fasted rabbits. Fundamental & clinical pharmacology. vol 5. issue 8. 1992-03-13. PMID:1664409. |
changes in plasma glucose and lactate evoked by alpha and beta 2-adrenoceptor stimulation in conscious fasted rabbits. |
1992-03-13 |
2023-08-11 |
Not clear |
| B S Huang, F H Leene. Brain ouabain and central effects of dietary sodium in spontaneously hypertensive rats. Circulation research. vol 70. issue 2. 1992-03-11. PMID:1735140. |
to investigate whether dietary sodium-induced changes in brain ola play a functional role, responses of mean arterial pressure (map), heart rate (hr), and renal sympathetic nerve activity (rsna) to intracerebroventricular ouabain and to mental stress and intracerebroventricular alpha 2-adrenoceptor agonist guanabenz alone or preceded by intracerebroventricular ouabain were recorded in conscious shr and wistar-kyoto (wky) rats maintained from 4 to 8 weeks of age on different sodium diets: 1) low sodium intake (lna, 17 mumol), 2) normal sodium intake (nna, 101 mumol), and 3) hna (1,370 mumol). |
1992-03-11 |
2023-08-11 |
rat |
| B B Chen, D P Nyhan, D M Fehr, P A Murra. Halothane anesthesia abolishes pulmonary vascular responses to neural antagonists. The American journal of physiology. vol 262. issue 1 Pt 2. 1992-02-25. PMID:1346355. |
in conscious dogs, sympathetic alpha 1-adrenoreceptor block with prazosin decreased (p less than 0.01) the pulmonary vascular pressure gradient [pulmonary arterial pressure-pulmonary arterial wedge pressure (pap-pawp)] over the entire range of q studied; i.e., inhibition of endogenous alpha 1-adrenoreceptor activity caused pulmonary vasodilation. |
1992-02-25 |
2023-08-11 |
Not clear |
| J S Petersen, M Shalmi, M Bak, N Lomholt, S Christense. Amiloride-sensitive lithium reabsorption during doxazosin-induced blood pressure reduction in rats. Clinical science (London, England : 1979). vol 81. issue 6. 1992-02-19. PMID:1662588. |
the effects of acute systemic alpha 1-adrenoceptor blockade by doxazosin on glomerular filtration rate, urine flow, sodium clearance and lithium clearance were investigated in acutely prepared conscious rats. |
1992-02-19 |
2023-08-11 |
rat |
| C Baylis, C Foulks, L Samsell, K Engel. Short term natriuretic responses in the conscious Zucker obese rat. Clinical and experimental hypertension. Part A, Theory and practice. vol 13. issue 6-7. 1992-02-13. PMID:1836982. |
renal clearance studies were conducted in conscious, chronically catheterized obese and lean zucker rats to investigate the natriuretic responses to i) acute iv infusion of isotonic nacl = 5% of total body weight and ii) iv infusion of alpha rat atrial natriuretic peptide (anp) in a dose of 300 ng/kg/min. |
1992-02-13 |
2023-08-11 |
rat |
| M Reverte, M J García-Barrado, J Moratino. Role of alpha-adrenoceptors in control of plasma potassium in conscious rabbits. Journal of autonomic pharmacology. vol 11. issue 5. 1992-01-21. PMID:1660896. |
in conscious fed rabbits the intravenous infusion of amidephrine (10 micrograms kg-1 min-1), an alpha 1-adrenoceptor agonist, caused a significant increase in plasma potassium levels that was blunted by prazosin (50 micrograms kg-1, s.c.). |
1992-01-21 |
2023-08-11 |
Not clear |
| M Reverte, M J García-Barrado, J Moratino. Role of alpha-adrenoceptors in control of plasma potassium in conscious rabbits. Journal of autonomic pharmacology. vol 11. issue 5. 1992-01-21. PMID:1660896. |
it is concluded that in conscious fed rabbits both alpha 1- and alpha 2-adrenoceptor stimulation induce hyperkalaemia by activation of hepatic ca(2+)-activated k(+)-channels. |
1992-01-21 |
2023-08-11 |
Not clear |
| D P Brooks, M Gellai, P D DePalma, R M Edward. Modulation of vasopressin antidiuretic action by alpha 2-adrenoceptors is species specific. The American journal of physiology. vol 261. issue 5 Pt 2. 1991-12-23. PMID:1659234. |
in the present study, we tested the ability of various alpha 2-adrenoceptor agonists to antagonize vasopressin-induced antidiuresis in the conscious hydrated dog and to inhibit vasopressin-induced adenosine 3',5'-cyclic monophosphate (camp) generation in rat and dog cortical collecting tubules. |
1991-12-23 |
2023-08-11 |
rat |
| Z Y Du, G J Dusting, O L Woodma. Effect of tolerance to glyceryl trinitrate on vascular responses in conscious rabbits. Clinical and experimental pharmacology & physiology. vol 18. issue 6. 1991-11-08. PMID:1914247. |
similarly, in conscious rabbits, pe-induced increases in arterial pressure and hindlimb vascular resistance were significantly enhanced by gtn pretreatment but the responses to the alpha 2-adrenoceptor agonist bht 920 were unaffected. |
1991-11-08 |
2023-08-11 |
rabbit |
| M Thollander, P M Hellström, T H Svensso. Suppression of castor oil-induced diarrhoea by alpha 2-adrenoceptor agonists. Alimentary pharmacology & therapeutics. vol 5. issue 3. 1991-10-17. PMID:1679667. |
the effects of systemic administration of alpha 2-adrenoceptor agonists on migrating myoelectric complexes and castor oil-induced diarrhoea of the small intestine were studied in conscious rats. |
1991-10-17 |
2023-08-11 |
rat |
| W T Schmeling, J P Kampine, D L Roerig, D C Warltie. The effects of the stereoisomers of the alpha 2-adrenergic agonist medetomidine on systemic and coronary hemodynamics in conscious dogs. Anesthesiology. vol 75. issue 3. 1991-10-10. PMID:1679615. |
the effects of the stereoisomers of the alpha 2-adrenergic agonist medetomidine on systemic and coronary hemodynamics in conscious dogs. |
1991-10-10 |
2023-08-11 |
Not clear |