| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Fujishiro, Taiichiro Imanishi, Kaname Onozawa, Masaki Tsushim. Comparison of the anticholinergic effects of the serotonergic antidepressants, paroxetine, fluvoxamine and clomipramine. European journal of pharmacology. vol 454. issue 2-3. 2003-05-06. PMID:12421645. |
to determine whether paroxetine has anticholinergic effects in vivo, we examined the effects of paroxetine on oxotremorine-induced tremor, spontaneous defecation and passive avoidance performance using mice and compared the results with those using fluvoxamine, another selective serotonin reuptake inhibitor, and clomipramine, a tricyclic antidepressant with serotonin selectivity. |
2003-05-06 |
2023-08-12 |
mouse |
| Claus Riemer, Edilio Borroni, Bernard Levet-Trafit, James R Martin, Sonia Poli, Richard H P Porter, Michael Bö. Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. Journal of medicinal chemistry. vol 46. issue 7. 2003-05-02. PMID:12646038. |
by means of in vivo microdialysis in the frontal cortex and a passive avoidance paradigm, where 11 reversed a scopolamine induced retention deficit, a functional correlation between 5-ht(6) receptors and cholinergic neurotransmission could be shown, supporting the therapeutic potential of 5-ht(6) receptors in the treatment of cognitive deficits. |
2003-05-02 |
2023-08-12 |
Not clear |
| Randy L Smith, Craig H Kenned. Increases in avoidance responding produced by REM sleep deprivation or serotonin depletion are reversed by administration of 5-hydroxytryptophan. Behavioural brain research. vol 140. issue 1-2. 2003-04-28. PMID:12644281. |
increases in avoidance responding produced by rem sleep deprivation or serotonin depletion are reversed by administration of 5-hydroxytryptophan. |
2003-04-28 |
2023-08-12 |
rat |
| Randy L Smith, Craig H Kenned. Increases in avoidance responding produced by REM sleep deprivation or serotonin depletion are reversed by administration of 5-hydroxytryptophan. Behavioural brain research. vol 140. issue 1-2. 2003-04-28. PMID:12644281. |
our objective was to directly compare the effects of rapid eye movement (rem) sleep deprivation (remsd) and serotonin 5-hydroxytryptamine (5-ht) depletion on free-operant avoidance behavior in rats. |
2003-04-28 |
2023-08-12 |
rat |
| Randy L Smith, Craig H Kenned. Increases in avoidance responding produced by REM sleep deprivation or serotonin depletion are reversed by administration of 5-hydroxytryptophan. Behavioural brain research. vol 140. issue 1-2. 2003-04-28. PMID:12644281. |
these experiments were designed to determine if declining 5-ht levels observed during remsd might mediate the increases in avoidance responding observed in rem sleep deprived rats. |
2003-04-28 |
2023-08-12 |
rat |
| Randy L Smith, Craig H Kenned. Increases in avoidance responding produced by REM sleep deprivation or serotonin depletion are reversed by administration of 5-hydroxytryptophan. Behavioural brain research. vol 140. issue 1-2. 2003-04-28. PMID:12644281. |
both remsd and 5-ht depletion via pcpa resulted in an increase in avoidance responding that was reversed by administration of 5-htp. |
2003-04-28 |
2023-08-12 |
rat |
| Randy L Smith, Craig H Kenned. Increases in avoidance responding produced by REM sleep deprivation or serotonin depletion are reversed by administration of 5-hydroxytryptophan. Behavioural brain research. vol 140. issue 1-2. 2003-04-28. PMID:12644281. |
remsd and 5-ht depletion via pcpa resulted in increased avoidance efficiency and were reversed by 5-htp administration, but only changes following pcpa injection were statistically significant. |
2003-04-28 |
2023-08-12 |
rat |
| Randy L Smith, Craig H Kenned. Increases in avoidance responding produced by REM sleep deprivation or serotonin depletion are reversed by administration of 5-hydroxytryptophan. Behavioural brain research. vol 140. issue 1-2. 2003-04-28. PMID:12644281. |
decreases in 5-ht levels that occur during remsd likely mediate increases in avoidance responding. |
2003-04-28 |
2023-08-12 |
rat |
| Stéphanie Caillé, Luis Stinus, Emilio F Espejo, Philippe De Deurwaerdère, Umberto Spampinato, George F Koo. Inhibition of 5-HT neurotransmission increases clonidine protective effects on naloxone-induced conditioned place aversion in morphine-dependent rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 2. 2003-04-21. PMID:12589380. |
inhibition of 5-ht neurotransmission increases clonidine protective effects on naloxone-induced conditioned place aversion in morphine-dependent rats. |
2003-04-21 |
2023-08-12 |
rat |
| Stéphanie Caillé, Luis Stinus, Emilio F Espejo, Philippe De Deurwaerdère, Umberto Spampinato, George F Koo. Inhibition of 5-HT neurotransmission increases clonidine protective effects on naloxone-induced conditioned place aversion in morphine-dependent rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 2. 2003-04-21. PMID:12589380. |
an acute serotonin (5-ht) inhibition induced by the specific stimulation of 5-ht1a autoreceptors (8-ohdpat 5-100 microg/kg), on naloxone-induced conditioned place aversion in morphine-dependent rats. |
2003-04-21 |
2023-08-12 |
rat |
| Stéphanie Caillé, Luis Stinus, Emilio F Espejo, Philippe De Deurwaerdère, Umberto Spampinato, George F Koo. Inhibition of 5-HT neurotransmission increases clonidine protective effects on naloxone-induced conditioned place aversion in morphine-dependent rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 2. 2003-04-21. PMID:12589380. |
acute neuropharmacological blockade of serotonin transmission also potentiated the clonidine effects on naloxone-induced conditioned place aversion. |
2003-04-21 |
2023-08-12 |
rat |
| Cheryl L Limebeer, Linda A Parke. The 5-HT1A agonist 8-OH-DPAT dose-dependently interferes with the establishment and the expression of lithium-induced conditioned rejection reactions in rats. Psychopharmacology. vol 166. issue 2. 2003-04-02. PMID:12552358. |
the present experiments evaluated the potential of the 5-ht(1a )agonist, 8-oh-dpat (dpat), which reduces serotonin availability, to interfere with both the establishment and with the expression of lithium-induced conditioned rejection reactions (experiment 1) and lithium-induced taste avoidance (experiment 2). |
2003-04-02 |
2023-08-12 |
rat |
| F S Hall, X F Li, I Sora, F Xu, M Caron, K P Lesch, D L Murphy, G R Uh. Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions. Neuroscience. vol 115. issue 1. 2003-02-05. PMID:12401330. |
cocaine blocks uptake by neuronal plasma membrane transporters for dopamine, serotonin and norepinephrine, producing subjective effects in humans that are both euphoric/rewarding and also fearful, jittery and aversive. |
2003-02-05 |
2023-08-12 |
mouse |
| F S Hall, X F Li, I Sora, F Xu, M Caron, K P Lesch, D L Murphy, G R Uh. Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions. Neuroscience. vol 115. issue 1. 2003-02-05. PMID:12401330. |
one explanation for these observations could be that cocaine produces aversive or anhedonic effects by serotonin or norepinephrine receptor blockade in wildtype mice that are removed in serotonin or norepinephrine receptor knockouts, increasing net cocaine reward. |
2003-02-05 |
2023-08-12 |
mouse |
| F S Hall, X F Li, I Sora, F Xu, M Caron, K P Lesch, D L Murphy, G R Uh. Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions. Neuroscience. vol 115. issue 1. 2003-02-05. PMID:12401330. |
they are consistent with emerging hypotheses that actions at the three primary brain molecular targets for cocaine each provide distinct contributions to cocaine reward and cocaine aversion in wildtype mice, and that this balance changes in mice that develop without dopamine, norepinephrine or serotonin transporters. |
2003-02-05 |
2023-08-12 |
mouse |
| Carlos Eduardo Macedo, Vanessa Moreno Castilho, Maria Angélica de Souza e Silva, Marcus L Brandã. Dual 5-HT mechanisms in basolateral and central nuclei of amygdala in the regulation of the defensive behavior induced by electrical stimulation of the inferior colliculus. Brain research bulletin. vol 59. issue 3. 2003-01-17. PMID:12431748. |
it is likely that aversive information ascending from the inferior colliculus may receive either inhibitory or excitatory influences of 5-ht mechanisms in the bla or cea, respectively. |
2003-01-17 |
2023-08-12 |
rat |
| Cláudia A Jacob, Alfredo H C L Cabral, Leandro P Almeida, Valeska Magierek, Patrício L Ramos, Janaína M Zanoveli, Jesus Landeira-Fernandez, Hélio Zangrossi, Regina L Nogueir. Chronic imipramine enhances 5-HT(1A) and 5-HT(2) receptors-mediated inhibition of panic-like behavior in the rat dorsal periaqueductal gray. Pharmacology, biochemistry, and behavior. vol 72. issue 4. 2003-01-08. PMID:12062564. |
treatment with imipramine did not change the basal threshold of aversive electrical stimulation measured before intra-dpag injection of the 5-ht agonists. |
2003-01-08 |
2023-08-12 |
rat |
| A N Talalaenko, Iu V Babiĭ, N N Perch, S A Vozdvigin, V Iu Panfilo. [Neurochemical analysis of the amygdala basolateral nucleus of rats during anxiety tests]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 83. issue 3. 2003-01-06. PMID:12436687. |
chlordiazepoxid, phenibut, indoter, campiron, campironin, when administered into the amygdala, improve the anxiety condition of rats in avoidance tests and resemble by their effects dophamine, gaba, or serotonin. |
2003-01-06 |
2023-08-12 |
rat |
| F Miranda, G Orozco, D N Velázquez-Martíne. Full substitution of the discriminative cue of a 5-HT(1A/1B/2C) agonist with the combined administration of a 5-HT(1B/2C) and a 5-HT(1A) agonist. Behavioural pharmacology. vol 13. issue 4. 2002-12-24. PMID:12218511. |
the present study examined whether animals attend to the individual components of the cue produced by a drug that stimulates different 5-hydroxytryptamine (5-ht) receptor populations, using a drug discrimination task based on the conditioned taste aversion (cta) procedure. |
2002-12-24 |
2023-08-12 |
human |
| Soraya Seedat, Dan J Stein, Carl Ziervogel, Tessa Middleton, Deborah Kaminer, Robin A Emsley, Wendy Rossou. Comparison of response to a selective serotonin reuptake inhibitor in children, adolescents, and adults with posttraumatic stress disorder. Journal of child and adolescent psychopharmacology. vol 12. issue 1. 2002-11-13. PMID:12014594. |
the efficacy of the selective serotonin reuptake inhibitors (ssris) in treating essential symptoms (re-experiencing, avoidance, numbing, hyperarousal) in both adults and children is likely to involve potentiation of this neurotransmitter. |
2002-11-13 |
2023-08-12 |
Not clear |