Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Xinjing Luo, Baoguo Chen, Rui Zheng, Peng Lin, Jicheng Li, Haixiao Che. Hydrogen peroxide induces apoptosis through the mitochondrial pathway in rat Schwann cells. Neuroscience letters. vol 485. issue 1. 2011-01-04. PMID:20813162. |
it has been shown that hydrogen peroxide (h(2)o(2)) induces apoptosis in several kinds of cells; however, the role of h(2)o(2) in the apoptosis of schwann cells (scs) is currently unclear. |
2011-01-04 |
2023-08-12 |
rat |
Xinjing Luo, Baoguo Chen, Rui Zheng, Peng Lin, Jicheng Li, Haixiao Che. Hydrogen peroxide induces apoptosis through the mitochondrial pathway in rat Schwann cells. Neuroscience letters. vol 485. issue 1. 2011-01-04. PMID:20813162. |
the objective of this study was to determine whether h(2)o(2) is capable of inducing apoptosis in scs and whether or not such an effect is associated with the activation of mitochondrial pathway. |
2011-01-04 |
2023-08-12 |
rat |
Xinjing Luo, Baoguo Chen, Rui Zheng, Peng Lin, Jicheng Li, Haixiao Che. Hydrogen peroxide induces apoptosis through the mitochondrial pathway in rat Schwann cells. Neuroscience letters. vol 485. issue 1. 2011-01-04. PMID:20813162. |
we demonstrated that h(2)o(2) induces apoptosis in scs, and is associated with increased release of cytochrome c from mitochondria and the activation of caspase-3 and -9 by up-regulation of bax and down-regulation of bcl-2. |
2011-01-04 |
2023-08-12 |
rat |
Yiorgos Apidianakis, Chrysoula Pitsouli, Norbert Perrimon, Laurence Rahm. Synergy between bacterial infection and genetic predisposition in intestinal dysplasia. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 49. 2010-09-08. PMID:19934041. |
this, in turn, causes apoptosis of enterocytes, the largest class of differentiated intestinal cells, and promotes a dramatic proliferation of scs and progenitors that serves as a homeostatic compensatory mechanism to replenish the apoptotic enterocytes. |
2010-09-08 |
2023-08-12 |
human |
Yongwei Qin, Chun Cheng, Haibo Wang, Xiaoyi Shao, Yongjing Gao, Aiguo She. TNF-alpha as an autocrine mediator and its role in the activation of Schwann cells. Neurochemical research. vol 33. issue 6. 2008-07-24. PMID:18205044. |
furthermore, tnf-alpha is involved in the induction of apoptosis through binding to tnfr in scs. |
2008-07-24 |
2023-08-12 |
Not clear |
Matthew J Provenzano, Ningyong Xu, Mark R Ver Meer, J Jason Clark, Marlan R Hanse. p75NTR and sortilin increase after facial nerve injury. The Laryngoscope. vol 118. issue 1. 2008-02-25. PMID:18090258. |
after axotomy, schwann cells (scs), required for successful nerve regeneration, undergo a number of cellular changes including dedifferentiation, proliferation, expression of molecules that support axon growth, and apoptosis. |
2008-02-25 |
2023-08-12 |
Not clear |
Biju Parekkadan, Daan van Poll, Zaki Megeed, Naoya Kobayashi, Arno W Tilles, François Berthiaume, Martin L Yarmus. Immunomodulation of activated hepatic stellate cells by mesenchymal stem cells. Biochemical and biophysical research communications. vol 363. issue 2. 2007-11-26. PMID:17869217. |
indirect coculture of mscs and activated scs led to a significant decrease in collagen deposition and proliferation, while inducing apoptosis of activated scs. |
2007-11-26 |
2023-08-12 |
Not clear |
Biju Parekkadan, Daan van Poll, Zaki Megeed, Naoya Kobayashi, Arno W Tilles, François Berthiaume, Martin L Yarmus. Immunomodulation of activated hepatic stellate cells by mesenchymal stem cells. Biochemical and biophysical research communications. vol 363. issue 2. 2007-11-26. PMID:17869217. |
in addition, release of hgf by mscs was responsible for the marked induction of apoptosis in scs as determined by antibody-neutralization studies. |
2007-11-26 |
2023-08-12 |
Not clear |
Caitlin E Hill, Andres Hurtado, Bas Blits, Ben A Bahr, Patrick M Wood, Mary Bartlett Bunge, Martin Oudeg. Early necrosis and apoptosis of Schwann cells transplanted into the injured rat spinal cord. The European journal of neuroscience. vol 26. issue 6. 2007-11-20. PMID:17880386. |
to assess the extent and temporal profile of transplanted cell death, and the contributions of necrosis and apoptosis to this cell death following spinal cord injury, different concentrations of schwann cells (scs), lentivirally transduced to express green fluorescent protein (gfp), were transplanted into a 1-week-old moderate contusion of the adult rat thoracic spinal cord. |
2007-11-20 |
2023-08-12 |
rat |
Caitlin E Hill, Andres Hurtado, Bas Blits, Ben A Bahr, Patrick M Wood, Mary Bartlett Bunge, Martin Oudeg. Early necrosis and apoptosis of Schwann cells transplanted into the injured rat spinal cord. The European journal of neuroscience. vol 26. issue 6. 2007-11-20. PMID:17880386. |
six times more scs died during the first week after transplantation by necrosis than apoptosis, with the majority of cell death occurring within the first 24 h. the early death of transplanted scs indicates that factors present, even 1 week after a moderate contusion, are capable of inducing substantial transplanted cell death. |
2007-11-20 |
2023-08-12 |
rat |
Bhupinder P S Vohra, Jason S Groshong, Roberto Zayas, Robert L Wollmann, Christopher M Gome. Activation of apoptotic pathways at muscle fiber synapses is circumscribed and reversible in a slow-channel syndrome model. Neurobiology of disease. vol 23. issue 2. 2006-11-27. PMID:16815027. |
we hypothesized that scs represents a limited form of apoptosis. |
2006-11-27 |
2023-08-12 |
mouse |
Bhupinder P S Vohra, Jason S Groshong, Roberto Zayas, Robert L Wollmann, Christopher M Gome. Activation of apoptotic pathways at muscle fiber synapses is circumscribed and reversible in a slow-channel syndrome model. Neurobiology of disease. vol 23. issue 2. 2006-11-27. PMID:16815027. |
identification of extrasynaptic factors that prevent the spread of apoptosis in scs muscle fibers may aid in developing treatments for neurological disorders characterized by excitotoxicity or apoptosis. |
2006-11-27 |
2023-08-12 |
mouse |
Bhupinder P S Vohra, Jason S Groshong, Roberto Zayas, Robert L Wollmann, Christopher M Gome. Activation of apoptotic pathways at muscle fiber synapses is circumscribed and reversible in a slow-channel syndrome model. Neurobiology of disease. vol 23. issue 2. 2006-11-27. PMID:16815027. |
these results demonstrate that in scs processes leading to apoptosis may remain compartmentalized and reversible. |
2006-11-27 |
2023-08-12 |
mouse |
Christopher R Hayworth, Susan E Moody, Lewis A Chodosh, Paul Krieg, Mendell Rimer, Wesley J Thompso. Induction of neuregulin signaling in mouse schwann cells in vivo mimics responses to denervation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 25. 2006-07-11. PMID:16793894. |
last, induction of the active receptor is sufficient to rescue scs in neonatal muscle from denervation-induced apoptosis. |
2006-07-11 |
2023-08-12 |
mouse |
Rosane B Oliveira, Elizabeth P Sampaio, Fernando Aarestrup, Rosane M B Teles, Tatiana P Silva, Ariane L Oliveira, Paulo R Z Antas, Euzenir N Sarn. Cytokines and Mycobacterium leprae induce apoptosis in human Schwann cells. Journal of neuropathology and experimental neurology. vol 64. issue 10. 2005-11-03. PMID:16215460. |
it is possible that cytokine production and apoptosis of schwann cells (scs) directly affect nerve degeneration and regeneration leading to injury of the myelin sheath and axon. |
2005-11-03 |
2023-08-12 |
human |
Michiru Fukunaga, Satoshi Miyata, Satomi Higo, Yasuhiro Hamada, Shigemitsu Ueyama, Masato Kasug. Methylglyoxal induces apoptosis through oxidative stress-mediated activation of p38 mitogen-activated protein kinase in rat Schwann cells. Annals of the New York Academy of Sciences. vol 1043. 2005-10-27. PMID:16037234. |
we found that mg was capable of inducing apoptosis in peripheral nerve-derived schwann cells (scs) in a time- and dose-dependent manner, accompanied by a reduction of intracellular glutathione content. |
2005-10-27 |
2023-08-12 |
rat |
Michiru Fukunaga, Satoshi Miyata, Bing Fen Liu, Hiroyuki Miyazaki, Yushi Hirota, Satomi Higo, Yasuhiro Hamada, Shigemitsu Ueyama, Masato Kasug. Methylglyoxal induces apoptosis through activation of p38 MAPK in rat Schwann cells. Biochemical and biophysical research communications. vol 320. issue 3. 2004-08-26. PMID:15240103. |
inhibiting the p38 mapk activation by sb203580 successfully suppressed the mg-induced apoptosis in scs. |
2004-08-26 |
2023-08-12 |
rat |
Michiru Fukunaga, Satoshi Miyata, Bing Fen Liu, Hiroyuki Miyazaki, Yushi Hirota, Satomi Higo, Yasuhiro Hamada, Shigemitsu Ueyama, Masato Kasug. Methylglyoxal induces apoptosis through activation of p38 MAPK in rat Schwann cells. Biochemical and biophysical research communications. vol 320. issue 3. 2004-08-26. PMID:15240103. |
we examined whether mg was capable of inducing apoptosis in schwann cells (scs), since recent studies have suggested a potential involvement of apoptotic cell death in the development of diabetic neuropathy. |
2004-08-26 |
2023-08-12 |
rat |
Michiru Fukunaga, Satoshi Miyata, Bing Fen Liu, Hiroyuki Miyazaki, Yushi Hirota, Satomi Higo, Yasuhiro Hamada, Shigemitsu Ueyama, Masato Kasug. Methylglyoxal induces apoptosis through activation of p38 MAPK in rat Schwann cells. Biochemical and biophysical research communications. vol 320. issue 3. 2004-08-26. PMID:15240103. |
mg induced apoptosis in scs in a dose-dependent manner, accompanied by a reduction of intracellular glutathione content and activation of the p38 mapk. |
2004-08-26 |
2023-08-12 |
rat |
Bhupinder P S Vohra, Jason S Groshong, Ricardo A Maselli, M Anthony Verity, Robert L Wollmann, Christopher M Gome. Focal caspase activation underlies the endplate myopathy in slow-channel syndrome. Annals of neurology. vol 55. issue 3. 2004-04-12. PMID:14991812. |
using antisera specific for the activated forms of caspases, the family of cysteine proteases that underlies apoptosis, we demonstrated that active forms of initiator and effector caspases are selectively localized at the nmj in scs. |
2004-04-12 |
2023-08-12 |
human |