| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G S Robertson, S J Crocker, D W Nicholson, J B Schul. Neuroprotection by the inhibition of apoptosis. Brain pathology (Zurich, Switzerland). vol 10. issue 2. 2000-06-06. PMID:10764048. |
consistent with the proposal that apoptosis plays a central in role human neurodegenerative disease, caspase-3 activation has recently been observed in stroke, spinal cord trauma, head injury and alzheimer's disease. |
2000-06-06 |
2023-08-12 |
mouse |
| S K Ray, G G Wilford, D C Matzelle, E L Hogan, N L Bani. Calpeptin and methylprednisolone inhibit apoptosis in rat spinal cord injury. Annals of the New York Academy of Sciences. vol 890. 2000-03-15. PMID:10668431. |
calpeptin and methylprednisolone inhibit apoptosis in rat spinal cord injury. |
2000-03-15 |
2023-08-12 |
rat |
| S K Ray, G G Wilford, D C Matzelle, E L Hogan, N L Bani. Calpeptin and methylprednisolone inhibit apoptosis in rat spinal cord injury. Annals of the New York Academy of Sciences. vol 890. 2000-03-15. PMID:10668431. |
we tested calpain involvement in apoptosis in five 1-cm segments of rat spinal cord with injury (40 g-cm) induced at t12 by weight-drop. |
2000-03-15 |
2023-08-12 |
rat |
| L A Peña, Z Fuks, R N Kolesnic. Radiation-induced apoptosis of endothelial cells in the murine central nervous system: protection by fibroblast growth factor and sphingomyelinase deficiency. Cancer research. vol 60. issue 2. 2000-02-28. PMID:10667583. |
beginning at 4 h after single-dose radiation, apoptosis was ongoing for 24 h and peaked at 12 h at an incidence of 0.7-1.4% of the total cells in spinal cord sections. |
2000-02-28 |
2023-08-12 |
mouse |
| R S Ghirnikar, Y L Lee, L F En. Chemokine antagonist infusion attenuates cellular infiltration following spinal cord contusion injury in rat. Journal of neuroscience research. vol 59. issue 1. 2000-02-25. PMID:10658186. |
spinal cord injury is accompanied by an initial inflammatory reaction followed by secondary injury that is caused, in part, by apoptosis. |
2000-02-25 |
2023-08-12 |
rat |
| R S Ghirnikar, Y L Lee, L F En. Chemokine antagonist infusion attenuates cellular infiltration following spinal cord contusion injury in rat. Journal of neuroscience research. vol 59. issue 1. 2000-02-25. PMID:10658186. |
in addition, increased expression of bcl-2 gene, an endogenous inhibitor of apoptosis, was seen in the antagonist infused spinal cord at 7 days post injury. |
2000-02-25 |
2023-08-12 |
rat |
| R S Ghirnikar, Y L Lee, L F En. Chemokine antagonist infusion attenuates cellular infiltration following spinal cord contusion injury in rat. Journal of neuroscience research. vol 59. issue 1. 2000-02-25. PMID:10658186. |
our data suggest that chemokine antagonist infusion post-injury results in limiting the inflammatory response following spinal cord contusion injury, thereby attenuating neuronal loss, possibly due to decreased apoptosis. |
2000-02-25 |
2023-08-12 |
rat |
| F Sedel, C Béchade, A Trille. Nerve growth factor (NGF) induces motoneuron apoptosis in rat embryonic spinal cord in vitro. The European journal of neuroscience. vol 11. issue 11. 1999-12-28. PMID:10583479. |
nerve growth factor (ngf) induces motoneuron apoptosis in rat embryonic spinal cord in vitro. |
1999-12-28 |
2023-08-12 |
rat |
| G L Li, M Farooque, A Holtz, Y Olsso. Apoptosis of oligodendrocytes occurs for long distances away from the primary injury after compression trauma to rat spinal cord. Acta neuropathologica. vol 98. issue 5. 1999-12-10. PMID:10541870. |
apoptosis of oligodendrocytes occurs for long distances away from the primary injury after compression trauma to rat spinal cord. |
1999-12-10 |
2023-08-12 |
rat |
| G L Li, M Farooque, A Holtz, Y Olsso. Apoptosis of oligodendrocytes occurs for long distances away from the primary injury after compression trauma to rat spinal cord. Acta neuropathologica. vol 98. issue 5. 1999-12-10. PMID:10541870. |
in conclusion, compression trauma to rat spinal cord induces signs of apoptosis in glial cells, presumably oligodendrocytes of the long tracts. |
1999-12-10 |
2023-08-12 |
rat |
| L J Martin, A Kaiser, A C Pric. Motor neuron degeneration after sciatic nerve avulsion in adult rat evolves with oxidative stress and is apoptosis. Journal of neurobiology. vol 40. issue 2. 1999-11-04. PMID:10413449. |
we conclude that the retrograde death of motor neurons in the adult spinal cord after sciatic nerve avulsion is apoptosis. |
1999-11-04 |
2023-08-12 |
rat |
| L J Martin, A Kaiser, A C Pric. Motor neuron degeneration after sciatic nerve avulsion in adult rat evolves with oxidative stress and is apoptosis. Journal of neurobiology. vol 40. issue 2. 1999-11-04. PMID:10413449. |
accumulation of active mitochondria within the perikaryon and oxidative damage to nucleic acids and proteins may contribute to the mechanisms for apoptosis of motor neurons in the adult spinal cord. |
1999-11-04 |
2023-08-12 |
rat |
| R Goswami, J Kilkus, S A Dawson, G Dawso. Overexpression of Akt (protein kinase B) confers protection against apoptosis and prevents formation of ceramide in response to pro-apoptotic stimuli. Journal of neuroscience research. vol 57. issue 6. 1999-10-19. PMID:10467260. |
an immortalized dorsal root ganglion cell line f-11 exhibits many properties of spinal cord neurons and undergoes apoptosis in response to growth factor withdrawal and the exogenous addition of inhibitors of phosphatidylinositol-3-kinase (pi3k). |
1999-10-19 |
2023-08-12 |
Not clear |
| J E Springer, R D Azbill, P E Knap. Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury. Nature medicine. vol 5. issue 8. 1999-08-26. PMID:10426320. |
the long-term neurological deficits after spinal cord trauma may be due in part to widespread apoptosis of neurons and oligodendroglia in regions distant from and relatively unaffected by the initial injury. |
1999-08-26 |
2023-08-12 |
rat |
| S Wada, K Yone, Y Ishidou, T Nagamine, S Nakahara, T Niiyama, T Sako. Apoptosis following spinal cord injury in rats and preventative effect of N-methyl-D-aspartate receptor antagonist. Journal of neurosurgery. vol 91. issue 1 Suppl. 1999-07-16. PMID:10419375. |
apoptosis following spinal cord injury in rats and preventative effect of n-methyl-d-aspartate receptor antagonist. |
1999-07-16 |
2023-08-12 |
rat |
| P A McCombe, J Harness, M P Pende. Effects of cyclosporin A treatment on clinical course and inflammatory cell apoptosis in experimental autoimmune encephalomyelitis induced in Lewis rats by inoculation with myelin basic protein. Journal of neuroimmunology. vol 97. issue 1-2. 1999-07-12. PMID:10408980. |
this suggests that, while csa treatment caused a non-specific increase in the overall level of t cell apoptosis in the spinal cord, it abrogated the selective apoptosis of vbeta8.2+ encephalitogenic t cells that normally occurs during spontaneous recovery from acute eae. |
1999-07-12 |
2023-08-12 |
rat |
| S Nakahara, K Yone, T Sakou, S Wada, T Nagamine, T Niiyama, H Ichij. Induction of apoptosis signal regulating kinase 1 (ASK1) after spinal cord injury in rats: possible involvement of ASK1-JNK and -p38 pathways in neuronal apoptosis. Journal of neuropathology and experimental neurology. vol 58. issue 5. 1999-05-27. PMID:10331432. |
induction of apoptosis signal regulating kinase 1 (ask1) after spinal cord injury in rats: possible involvement of ask1-jnk and -p38 pathways in neuronal apoptosis. |
1999-05-27 |
2023-08-12 |
rat |
| S Nakahara, K Yone, T Sakou, S Wada, T Nagamine, T Niiyama, H Ichij. Induction of apoptosis signal regulating kinase 1 (ASK1) after spinal cord injury in rats: possible involvement of ASK1-JNK and -p38 pathways in neuronal apoptosis. Journal of neuropathology and experimental neurology. vol 58. issue 5. 1999-05-27. PMID:10331432. |
the aims of this study were to clarify the mechanism of cell death by apoptosis in the spinal cord after traumatic injury, and to examine the role of the mitogen-activated protein kinase (mapk) pathways in the transmission of apoptosis signals. |
1999-05-27 |
2023-08-12 |
rat |
| S Nakahara, K Yone, T Sakou, S Wada, T Nagamine, T Niiyama, H Ichij. Induction of apoptosis signal regulating kinase 1 (ASK1) after spinal cord injury in rats: possible involvement of ASK1-JNK and -p38 pathways in neuronal apoptosis. Journal of neuropathology and experimental neurology. vol 58. issue 5. 1999-05-27. PMID:10331432. |
the rat spinal cord, experimentally injured by extradural static weight-compression, was studied by hematoxylin and eosin staining, nissl-staining, terminal deoxynucleotidyl transferase (tdt) mediated dutp nick-end labeling (tunel) staining, and immunostaining using polyclonal antibodies against apoptosis signal-regulating kinase 1 (ask1), c-jun n-terminal kinase (jnk), and p38 mapk. |
1999-05-27 |
2023-08-12 |
rat |
| S Nakahara, K Yone, T Sakou, S Wada, T Nagamine, T Niiyama, H Ichij. Induction of apoptosis signal regulating kinase 1 (ASK1) after spinal cord injury in rats: possible involvement of ASK1-JNK and -p38 pathways in neuronal apoptosis. Journal of neuropathology and experimental neurology. vol 58. issue 5. 1999-05-27. PMID:10331432. |
these findings suggest the involvement of the stress-activated mapk pathways including ask1 in the transmission of apoptosis signals after spinal cord injury. |
1999-05-27 |
2023-08-12 |
rat |