| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y B Lee, T Y Yune, S Y Baik, Y H Shin, S Du, H Rhim, E B Lee, Y C Kim, M L Shin, G J Markelonis, T H O. Role of tumor necrosis factor-alpha in neuronal and glial apoptosis after spinal cord injury. Experimental neurology. vol 166. issue 1. 2000-12-07. PMID:11031095. |
we investigated the role of tumor necrosis factor (tnf)-alpha in the onset of neuronal and glial apoptosis after traumatic spinal cord crush injury in rats. |
2000-12-07 |
2023-08-12 |
rat |
| Y B Lee, T Y Yune, S Y Baik, Y H Shin, S Du, H Rhim, E B Lee, Y C Kim, M L Shin, G J Markelonis, T H O. Role of tumor necrosis factor-alpha in neuronal and glial apoptosis after spinal cord injury. Experimental neurology. vol 166. issue 1. 2000-12-07. PMID:11031095. |
these results suggest that: (i) tnf-alpha may function as an external signal initiating apoptosis in neurons and oligodendrocytes after spinal cord injury; and (ii) tnf-alpha-initiated apoptosis may be mediated in part by no as produced by a nos expressed in response to tnf-alpha. |
2000-12-07 |
2023-08-12 |
rat |
| E Fujita, K Urase, J Egashira, Y Miho, K Isahara, Y Uchiyama, A Isoai, H Kumagai, K Kuida, N Motoyama, T Momo. Detection of caspase-9 activation in the cell death of the Bcl-x-deficient mouse embryo nervous system by cleavage sites-directed antisera. Brain research. Developmental brain research. vol 122. issue 2. 2000-11-13. PMID:10960682. |
we show that bcl-xl protects against caspase-9- and/or caspase-3-dependent apoptosis in the caudal portion of the ventral hindbrain, anterior horn cells, and dorsal root ganglia neurons of the normal mouse embryos and against caspase-9/caspase-3-independent apoptosis in the dorsal region of the nervous system including the dorsal spinal cord. |
2000-11-13 |
2023-08-12 |
mouse |
| C Puerta, I Martínez, P Baranda, M R Blasco, R Castejón, J A Vargas, A García-Merin. Aminoguanidine reduces apoptosis of circulating V Beta 8.2 T lymphocytes in Lewis rats with actively induced experimental autoimmune encephalomyelitis. Association with persistent inflammation of the central nervous system and lack of recovery. Journal of neuroimmunology. vol 110. issue 1-2. 2000-11-13. PMID:11024544. |
in the periphery of aminoguanidine-treated animals, t lymphocytes showed increased proliferation against myelin basic protein, and the percentage of vbeta 8.2(+) t lymphocytes undergoing early apoptosis was markedly decreased, although it was unchanged in vbeta 8.2(+) t cells isolated from the spinal cord. |
2000-11-13 |
2023-08-12 |
rat |
| O Ohya, H Ikeda, U Tomaru, I Yamashita, T Kasai, K Morita, A Wakisaka, T Yoshik. Human T-lymphocyte virus type I (HTLV-I)-induced myeloneuropathy in rats: oligodendrocytes undergo apoptosis in the presence of HTLV-I. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 108. issue 6. 2000-10-25. PMID:11028810. |
in the thoracic spinal cord of rats with htlv-i infection, the first event was the appearance of apoptosis of oligodendrocytes beginning at 7 months after induced infection, thereafter followed by the appearance of white matter degeneration, increase of macrophages/activated microglia and of gemistocytic astrocytes at 12, 15 and 20 months, respectively. |
2000-10-25 |
2023-08-12 |
human |
| B M Chow, Y Q Li, C S Won. Radiation-induced apoptosis in the adult central nervous system is p53-dependent. Cell death and differentiation. vol 7. issue 8. 2000-10-20. PMID:10918445. |
radiation-induced apoptosis was preceded by an increase in nuclear p53 expression in glial cells of the spinal cord and subependymal cells of the brain. |
2000-10-20 |
2023-08-12 |
mouse |
| B M Chow, Y Q Li, C S Won. Radiation-induced apoptosis in the adult central nervous system is p53-dependent. Cell death and differentiation. vol 7. issue 8. 2000-10-20. PMID:10918445. |
there was no evidence of radiation-induced apoptosis in the spinal cord and subependymal region of p53-/- animals. |
2000-10-20 |
2023-08-12 |
mouse |
| F H Yi, C Lautrette, C Vermot-Desroches, D Bordessoule, P Couratier, J Wijdenes, J L Preud'homme, M O Jaubertea. In vitro induction of neuronal apoptosis by anti-Fas antibody-containing sera from amyotrophic lateral sclerosis patients. Journal of neuroimmunology. vol 109. issue 2. 2000-10-12. PMID:10996223. |
in mixed cultures of rat embryonic brain and spinal cord cells, als sera (and agonistic anti-fas monoclonal antibodies and soluble fas-ligand) induced the apoptosis of a subpopulation of neurons. |
2000-10-12 |
2023-08-12 |
human |
| J L González de Aguilar, J W Gordon, F René, M de Tapia, B Lutz-Bucher, C Gaiddon, J P Loeffle. Alteration of the Bcl-x/Bax ratio in a transgenic mouse model of amyotrophic lateral sclerosis: evidence for the implication of the p53 signaling pathway. Neurobiology of disease. vol 7. issue 4. 2000-10-11. PMID:10964611. |
these findings provide evidence that the p53 signaling pathway is activated in sod1-linked familial als and may play a causative role in spinal cord neuron apoptosis by modulating the bcl-x/bax ratio. |
2000-10-11 |
2023-08-12 |
mouse |
| Y Q Li, C S Won. Radiation-induced apoptosis in the neonatal and adult rat spinal cord. Radiation research. vol 154. issue 3. 2000-09-28. PMID:10956432. |
radiation-induced apoptosis in the neonatal and adult rat spinal cord. |
2000-09-28 |
2023-08-12 |
rat |
| Y Q Li, C S Won. Radiation-induced apoptosis in the neonatal and adult rat spinal cord. Radiation research. vol 154. issue 3. 2000-09-28. PMID:10956432. |
this study was designed to characterize radiation-induced apoptosis in the spinal cord of the neonatal and young adult rat. |
2000-09-28 |
2023-08-12 |
rat |
| Y Q Li, C S Won. Radiation-induced apoptosis in the neonatal and adult rat spinal cord. Radiation research. vol 154. issue 3. 2000-09-28. PMID:10956432. |
the time course of radiation-induced apoptosis in 1- or 2-week-old rat spinal cord was similar to that in the young adult rat spinal cord. |
2000-09-28 |
2023-08-12 |
rat |
| Y Q Li, C S Won. Radiation-induced apoptosis in the neonatal and adult rat spinal cord. Radiation research. vol 154. issue 3. 2000-09-28. PMID:10956432. |
a peak response was observed at about 8 h after irradiation, and the apoptosis index returned to the levels in nonirradiated spinal cords at 24 h. the neonatal rat spinal cord demonstrated increased apoptosis compared to the adult. |
2000-09-28 |
2023-08-12 |
rat |
| Y Q Li, C S Won. Radiation-induced apoptosis in the neonatal and adult rat spinal cord. Radiation research. vol 154. issue 3. 2000-09-28. PMID:10956432. |
values for total yield of apoptosis over 24 h induced by 8 gy in the neonatal rat spinal cord were significantly greater than that in the adult. |
2000-09-28 |
2023-08-12 |
rat |
| Y Q Li, C S Won. Radiation-induced apoptosis in the neonatal and adult rat spinal cord. Radiation research. vol 154. issue 3. 2000-09-28. PMID:10956432. |
we conclude that the neonatal spinal cord demonstrates a greater level of apoptosis after exposure to ionizing radiation than the young adult spinal cord. |
2000-09-28 |
2023-08-12 |
rat |
| Y Q Li, C S Won. Radiation-induced apoptosis in the neonatal and adult rat spinal cord. Radiation research. vol 154. issue 3. 2000-09-28. PMID:10956432. |
this increase in apoptosis may be associated in part with the greater percentage of proliferating cells in the neonatal spinal cord, which demonstrate a greater level of radiation-induced apoptosis than nonproliferating cells. |
2000-09-28 |
2023-08-12 |
rat |
| J Lu, K W Ashwell, P Wait. Advances in secondary spinal cord injury: role of apoptosis. Spine. vol 25. issue 14. 2000-08-31. PMID:10888960. |
advances in secondary spinal cord injury: role of apoptosis. |
2000-08-31 |
2023-08-12 |
Not clear |
| J Schmidt, R Gold, L Schönrock, U K Zettl, H P Hartung, K V Toyk. T-cell apoptosis in situ in experimental autoimmune encephalomyelitis following methylprednisolone pulse therapy. Brain : a journal of neurology. vol 123 ( Pt 7). 2000-08-07. PMID:10869055. |
t-cell apoptosis was assessed on spinal cord cross-sections by morphology and tunel staining. |
2000-08-07 |
2023-08-12 |
rat |
| S K Ray, D C Matzelle, G G Wilford, E L Hogan, N L Bani. E-64-d prevents both calpain upregulation and apoptosis in the lesion and penumbra following spinal cord injury in rats. Brain research. vol 867. issue 1-2. 2000-08-04. PMID:10837800. |
e-64-d prevents both calpain upregulation and apoptosis in the lesion and penumbra following spinal cord injury in rats. |
2000-08-04 |
2023-08-12 |
rat |
| G Simic, D Seso-Simic, P J Lucassen, A Islam, Z Krsnik, A Cviko, D Jelasic, N Barisic, B Winblad, I Kostovic, B Krusli. Ultrastructural analysis and TUNEL demonstrate motor neuron apoptosis in Werdnig-Hoffmann disease. Journal of neuropathology and experimental neurology. vol 59. issue 5. 2000-07-19. PMID:10888370. |
a significant number of motor neurons in the spinal cord of children with whd were shown to die by apoptosis. |
2000-07-19 |
2023-08-12 |
Not clear |