| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y M Chan, W Wu, H K Yip, K F So, R W Oppenhei. Caspase inhibitors promote the survival of avulsed spinal motoneurons in neonatal rats. Neuroreport. vol 12. issue 3. 2001-06-07. PMID:11234760. |
because caspases are important mediators of apoptosis, we have investigated the effects of the caspase inhibitors, benzyloxycarbonyl-asp(ome)fluoromethylketone (boc-d-fmk), and n-acetyl-asp-glu-val-asp aldehyde (ac-devd-cho) on the survival of neonatal and adult spinal motoneurons after root avulsion of the c7 spinal cord. |
2001-06-07 |
2023-08-12 |
rat |
| S Casha, W R Yu, M G Fehling. Oligodendroglial apoptosis occurs along degenerating axons and is associated with FAS and p75 expression following spinal cord injury in the rat. Neuroscience. vol 103. issue 1. 2001-05-24. PMID:11311801. |
oligodendroglial apoptosis occurs along degenerating axons and is associated with fas and p75 expression following spinal cord injury in the rat. |
2001-05-24 |
2023-08-12 |
rat |
| S Casha, W R Yu, M G Fehling. Oligodendroglial apoptosis occurs along degenerating axons and is associated with FAS and p75 expression following spinal cord injury in the rat. Neuroscience. vol 103. issue 1. 2001-05-24. PMID:11311801. |
in the present study, we used the extradural clip compression model in the rat to examine the cellular distribution of apoptosis following cervical spinal cord injury, the relationship between glial apoptosis and post-traumatic axonal degeneration and the possible role of apo[apoptosis]-1, cd95 (fas) and p75 in initiating post-traumatic glial apoptosis. |
2001-05-24 |
2023-08-12 |
rat |
| S Casha, W R Yu, M G Fehling. Oligodendroglial apoptosis occurs along degenerating axons and is associated with FAS and p75 expression following spinal cord injury in the rat. Neuroscience. vol 103. issue 1. 2001-05-24. PMID:11311801. |
we conclude that axonal degeneration after traumatic spinal cord injury is associated with glial, in particular oligodendroglial, apoptosis. |
2001-05-24 |
2023-08-12 |
rat |
| M Yamada, A Natsume, M Mata, T Oligino, J Goss, J Glorioso, D J Fin. Herpes simplex virus vector-mediated expression of Bcl-2 protects spinal motor neurons from degeneration following root avulsion. Experimental neurology. vol 168. issue 2. 2001-05-10. PMID:11259110. |
features characteristic of both necrosis and apoptosis have been described in motor neurons of the spinal cord following proximal avulsion of the ventral roots. |
2001-05-10 |
2023-08-12 |
rat |
| M Zurita, J Vaquero, I Zurit. Presence and significance of CD-95 (Fas/APO1) expression after spinal cord injury. Journal of neurosurgery. vol 94. issue 2 Suppl. 2001-04-26. PMID:11302628. |
based on the hypothesis that apoptosis is related to cell death after spinal cord injury (sci), the authors studied the presence and distribution of cd95 (fas/apo1)-positive cells in injured spinal cord tissue for the purpose of determining the significance of this protein during the early phases of sci. |
2001-04-26 |
2023-08-12 |
Not clear |
| A G Basnak'ian, A V Baskov, N N Sokolov, I A Borshchenk. [Apoptosis during spinal cord trauma: prospects for pharmacological correction]. Voprosy meditsinskoi khimii. vol 46. issue 5. 2001-04-05. PMID:11204623. |
[apoptosis during spinal cord trauma: prospects for pharmacological correction]. |
2001-04-05 |
2023-08-12 |
Not clear |
| A G Basnak'ian, A V Baskov, N N Sokolov, I A Borshchenk. [Apoptosis during spinal cord trauma: prospects for pharmacological correction]. Voprosy meditsinskoi khimii. vol 46. issue 5. 2001-04-05. PMID:11204623. |
in this review, the basic stages of apoptosis in spinal cord, biochemical regulation of this process, and methods for its detection are considered. |
2001-04-05 |
2023-08-12 |
Not clear |
| R Garrido, M P Mattson, B Hennig, M Tobore. Nicotine protects against arachidonic-acid-induced caspase activation, cytochrome c release and apoptosis of cultured spinal cord neurons. Journal of neurochemistry. vol 76. issue 5. 2001-04-05. PMID:11238724. |
nicotine protects against arachidonic-acid-induced caspase activation, cytochrome c release and apoptosis of cultured spinal cord neurons. |
2001-04-05 |
2023-08-12 |
Not clear |
| R Garrido, M P Mattson, B Hennig, M Tobore. Nicotine protects against arachidonic-acid-induced caspase activation, cytochrome c release and apoptosis of cultured spinal cord neurons. Journal of neurochemistry. vol 76. issue 5. 2001-04-05. PMID:11238724. |
in order to determine potential mechanisms of apoptosis induced by arachidonic acid, activation of caspases -3, -8, and -9, as well as the release of cytochrome c into the cytoplasm were measured in cultured spinal cord neurons exposed to 10 microm of this fatty acid. |
2001-04-05 |
2023-08-12 |
Not clear |
| R Garrido, M P Mattson, B Hennig, M Tobore. Nicotine protects against arachidonic-acid-induced caspase activation, cytochrome c release and apoptosis of cultured spinal cord neurons. Journal of neurochemistry. vol 76. issue 5. 2001-04-05. PMID:11238724. |
in addition, because nicotine can exert a variety of neuroprotective effects, we hypothesized that it can prevent arachidonic acid induced apoptosis of spinal cord neurons. |
2001-04-05 |
2023-08-12 |
Not clear |
| K Satake, Y Matsuyama, M Kamiya, H Kawakami, H Iwata, K Adachi, K Kiuch. Nitric oxide via macrophage iNOS induces apoptosis following traumatic spinal cord injury. Brain research. Molecular brain research. vol 85. issue 1-2. 2001-03-08. PMID:11146113. |
nitric oxide via macrophage inos induces apoptosis following traumatic spinal cord injury. |
2001-03-08 |
2023-08-12 |
rat |
| M S Beattie, A A Farooqui, J C Bresnaha. Review of current evidence for apoptosis after spinal cord injury. Journal of neurotrauma. vol 17. issue 10. 2001-03-01. PMID:11063057. |
review of current evidence for apoptosis after spinal cord injury. |
2001-03-01 |
2023-08-12 |
Not clear |
| S Vukosavic, L Stefanis, V Jackson-Lewis, C Guégan, N Romero, C Chen, M Dubois-Dauphin, S Przedborsk. Delaying caspase activation by Bcl-2: A clue to disease retardation in a transgenic mouse model of amyotrophic lateral sclerosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 24. 2001-02-22. PMID:11124989. |
activated caspase-3 and its produced beta-actin cleavage fragments are found in apoptotic neurons in the anterior horn of the spinal cord of affected transgenic msod1 mice; although such neurons are few, their scarcity should not undermine the potential importance of apoptosis in the overall msod1-related neurodegeneration. |
2001-02-22 |
2023-08-12 |
mouse |
| S K Ray, D D Matzelle, G G Wilford, E L Hogan, N L Bani. Increased calpain expression is associated with apoptosis in rat spinal cord injury: calpain inhibitor provides neuroprotection. Neurochemical research. vol 25. issue 9-10. 2001-02-15. PMID:11059793. |
increased calpain expression is associated with apoptosis in rat spinal cord injury: calpain inhibitor provides neuroprotection. |
2001-02-15 |
2023-08-12 |
rat |
| B A Citron, I V Smirnova, P M Arnold, B W Festof. Upregulation of neurotoxic serine proteases, prothrombin, and protease-activated receptor 1 early after spinal cord injury. Journal of neurotrauma. vol 17. issue 12. 2001-02-08. PMID:11186232. |
apoptosis, well-established in development and now also in degenerative disease, occurs with regularity in several cell compartments early after controlled contusion spinal cord injury (sci). |
2001-02-08 |
2023-08-12 |
human |
| B A Citron, I V Smirnova, P M Arnold, B W Festof. Upregulation of neurotoxic serine proteases, prothrombin, and protease-activated receptor 1 early after spinal cord injury. Journal of neurotrauma. vol 17. issue 12. 2001-02-08. PMID:11186232. |
they imply the possibility of using specific, tissue-directed serine protease inhibition at translational or transcriptional levels, and offer a potential paradigm shift in drug discovery for sci to limit the extent of apoptosis, and consequent functional loss, in the human spinal cord. |
2001-02-08 |
2023-08-12 |
human |
| R Götz, C Karch, M R Digby, J Troppmair, U R Rapp, M Sendtne. The neuronal apoptosis inhibitory protein suppresses neuronal differentiation and apoptosis in PC12 cells. Human molecular genetics. vol 9. issue 17. 2000-12-22. PMID:11030753. |
the human neuronal apoptosis inhibitory protein (naip) gene has been discovered as a candidate gene for spinal muscular atrophy, a genetic disorder characterized by motor neuron loss in the spinal cord. |
2000-12-22 |
2023-08-12 |
mouse |
| G L Li, M Farooque, Y Olsso. Changes of Fas and Fas ligand immunoreactivity after compression trauma to rat spinal cord. Acta neuropathologica. vol 100. issue 1. 2000-12-07. PMID:10912923. |
fas-fasl interactions may for instance be involved in apoptosis of oligodendrocytes which occurs as a delayed phenomenon after trauma to the spinal cord. |
2000-12-07 |
2023-08-12 |
rat |
| Y B Lee, T Y Yune, S Y Baik, Y H Shin, S Du, H Rhim, E B Lee, Y C Kim, M L Shin, G J Markelonis, T H O. Role of tumor necrosis factor-alpha in neuronal and glial apoptosis after spinal cord injury. Experimental neurology. vol 166. issue 1. 2000-12-07. PMID:11031095. |
role of tumor necrosis factor-alpha in neuronal and glial apoptosis after spinal cord injury. |
2000-12-07 |
2023-08-12 |
rat |