| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qingshuang Zhou, Xiaojiang Pu, Zhuang Qian, Haojie Chen, Nannan Wang, Sinian Wang, Zhenhua Feng, Zezhang Zhu, Bin Wang, Yong Qiu, Xu Su. Nuclear receptor Rev-erbα alleviates intervertebral disc degeneration by recruiting NCoR-HDAC3 co-repressor and inhibiting NLRP3 inflammasome. Cell proliferation. 2024-07-24. PMID:39045886. |
rev-erbα deficiency accelerated needle puncture or aging-induced ivd degeneration, characterized by increased extracellular matrix (ecm) catabolism and nucleus pulposus (np) cell apoptosis. |
2024-07-24 |
2024-07-26 |
Not clear |
| Sejal Kundra, Rupinder Kaur, Chirag Pasricha, Pratima Kumari, Thakur Gurjeet Singh, Ravinder Sing. Pathological insights into activin A: Molecular underpinnings and therapeutic prospects in various diseases. International immunopharmacology. vol 139. 2024-07-20. PMID:39032467. |
once triggered, this route leads to gene transcription, differentiation, apoptosis, and extracellular matrix (ecm) formation. |
2024-07-20 |
2024-07-24 |
Not clear |
| T Jin, H Zheng, X Feng, T Wu, K Yang, Y Huan. MiR-539-3p Alleviates Apoptosis and Extracellular Matrix Degradation in Chondrocytes of Childhood-Onset Osteoarthritis by Targeting RUNX2. Physiological research. vol 73. issue 3. 2024-07-19. PMID:39027958. |
mir-539-3p alleviates apoptosis and extracellular matrix degradation in chondrocytes of childhood-onset osteoarthritis by targeting runx2. |
2024-07-19 |
2024-07-21 |
Not clear |
| T Jin, H Zheng, X Feng, T Wu, K Yang, Y Huan. MiR-539-3p Alleviates Apoptosis and Extracellular Matrix Degradation in Chondrocytes of Childhood-Onset Osteoarthritis by Targeting RUNX2. Physiological research. vol 73. issue 3. 2024-07-19. PMID:39027958. |
enhancing mir-539-3p expression or suppressing runx2 expression notably reduced apoptosis, inflammation, and extracellular matrix (ecm) degradation in oa chondrocytes. |
2024-07-19 |
2024-07-21 |
Not clear |
| T Jin, H Zheng, X Feng, T Wu, K Yang, Y Huan. MiR-539-3p Alleviates Apoptosis and Extracellular Matrix Degradation in Chondrocytes of Childhood-Onset Osteoarthritis by Targeting RUNX2. Physiological research. vol 73. issue 3. 2024-07-19. PMID:39027958. |
further experiments demonstrated that mir-539-3p targeting runx2 effectively lessened apoptosis, inflammation, and ecm degradation in oa chondrocytes, accompanied by changes in key molecular markers like reduced caspase-3 and matrix etallopeptidase 13 (mmp-13) levels, and increased b-cell lymphoma 2 (bcl-2) and collagen type x alpha 1 chain (col2a1). |
2024-07-19 |
2024-07-21 |
Not clear |
| Xuyuan Zhang, Ruize Zhang, Yinhai Wang, Liang Li, Zong Zhon. CDK5 Upregulated by ELF3 Transcription Promotes IL-1β-induced Inflammation and Extracellular Matrix Degradation in Human Chondrocytes. Cell biochemistry and biophysics. 2024-07-17. PMID:39020088. |
the levels of inflammatory cytokines were estimated using enzyme-linked immunosorbent assay (elisa) while the expressions of proteins implicated in extracellular matrix (ecm) degradation- and apoptosis were detected using western blot. |
2024-07-17 |
2024-07-20 |
human |
| Jae Gyu Kim, Ashish Ranjan Sharma, Yeon-Hee Lee, Srijan Chatterjee, Yean Jung Choi, Roshani Rajvansh, Chiranjib Chakraborty, Sang-Soo Le. Therapeutic Potential of Quercetin as an Antioxidant for Bone-Muscle-Tendon Regeneration and Aging. Aging and disease. 2024-07-16. PMID:39012676. |
in addition, qc has been shown to have protective effects against oxidative stress, inflammation, apoptosis, and matrix degradation in tendons, helping to maintain the structural integrity and functionality of tendons. |
2024-07-16 |
2024-07-18 |
human |
| Sneha Kumari, Rishika Dhapola, Prajjwal Sharma, Pushank Nagar, Bikash Medhi, Dibbanti HariKrishnaRedd. The impact of cytokines in neuroinflammation-mediated stroke. Cytokine & growth factor reviews. 2024-07-14. PMID:39004599. |
cytokines can directly induce neuronal injury and death through various mechanisms, including excitotoxicity, oxidative stress, hpa-axis activation, secretion of matrix metalloproteinase and apoptosis. |
2024-07-14 |
2024-07-18 |
Not clear |
| Morena Fasano, Mario Pirozzi, Chiara Carmen Miceli, Mariateresa Cocule, Michele Caraglia, Mariarosaria Boccellino, Pasquale Vitale, Vincenzo De Falco, Stefano Farese, Alessia Zotta, Fortunato Ciardiello, Raffaele Adde. TGF-β Modulated Pathways in Colorectal Cancer: New Potential Therapeutic Opportunities. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000507. |
tgf-β signaling plays a crucial role in various cellular processes, including growth, differentiation, apoptosis, epithelial-mesenchymal transition (emt), regulation of the extracellular matrix, angiogenesis, and immune responses. |
2024-07-13 |
2024-07-15 |
Not clear |
| Fang Fang, Borong Wang, Xiang Lu, Li Wang, Xiangjun Chen, Guanghui Wang, Yifan Yan. miR-126a-5p inhibits H1N1-induced inflammation and matrix protease secretion in lung fibroblasts by targeting ADAMTS-4. Archives of virology. vol 169. issue 8. 2024-07-11. PMID:38990242. |
inflammatory factors and matrix protease levels were examined using elisa kits, and cell apoptosis was assessed by measuring the levels of apoptosis-related proteins. |
2024-07-11 |
2024-07-13 |
Not clear |
| Fang Fang, Borong Wang, Xiang Lu, Li Wang, Xiangjun Chen, Guanghui Wang, Yifan Yan. miR-126a-5p inhibits H1N1-induced inflammation and matrix protease secretion in lung fibroblasts by targeting ADAMTS-4. Archives of virology. vol 169. issue 8. 2024-07-11. PMID:38990242. |
overexpression of mir-126a-5p attenuated the cellular inflammatory response, apoptosis, matrix protease secretion, and virus replication. |
2024-07-11 |
2024-07-13 |
Not clear |
| Fang Fang, Borong Wang, Xiang Lu, Li Wang, Xiangjun Chen, Guanghui Wang, Yifan Yan. miR-126a-5p inhibits H1N1-induced inflammation and matrix protease secretion in lung fibroblasts by targeting ADAMTS-4. Archives of virology. vol 169. issue 8. 2024-07-11. PMID:38990242. |
further experiments showed that overexpression of adamts-4 significantly reversed the inhibitory effects of mir-126a-5p on fibroblast inflammation, apoptosis, matrix protease secretion, and virus replication. |
2024-07-11 |
2024-07-13 |
Not clear |
| Fang Fang, Borong Wang, Xiang Lu, Li Wang, Xiangjun Chen, Guanghui Wang, Yifan Yan. miR-126a-5p inhibits H1N1-induced inflammation and matrix protease secretion in lung fibroblasts by targeting ADAMTS-4. Archives of virology. vol 169. issue 8. 2024-07-11. PMID:38990242. |
upregulation of mir-126a-5p inhibits h1n1-induced apoptosis, inflammatory factors, and matrix protease secretion, as well as virus replication in lung fibroblasts. |
2024-07-11 |
2024-07-13 |
Not clear |
| Mingwei- Wang, Qiaohui- Ying, Ru Ding, Yuncan- Xing, Jue Wang, Yiming- Pan, Bo Pan, Guifen- Xiang, Zhong Li. Elucidating prognosis in cervical squamous cell carcinoma and endocervical adenocarcinoma: a novel anoikis-related gene signature model. Frontiers in oncology. vol 14. 2024-07-11. PMID:38988712. |
anoikis, a specialized form of apoptosis induced by loss of cell adhesion to the extracellular matrix, plays a critical role. |
2024-07-11 |
2024-07-13 |
Not clear |
| Anton W Roodnat, Breedge Callaghan, Chelsey Doyle, Neeru A Vallabh, Sarah D Atkinson, Colin E Willoughb. Genome-wide RNA sequencing of ocular fibroblasts from glaucomatous and normal eyes: Implications for glaucoma management. PloS one. vol 19. issue 7. 2024-07-11. PMID:38990974. |
tenon's ocular fibroblasts from glaucomatous eyes showed signs of fibrosis with fibroblast to myofibroblast transdifferentiation and associated changes in mitochondrial fission, remodeling of the extracellular matrix, proliferation, unfolded protein response, inflammation and apoptosis which may relate to the pathogenesis of glaucoma or the detrimental effects of topical glaucoma therapies. |
2024-07-11 |
2024-07-14 |
human |
| Alexander Morelli-Batters, Hannah C Lamont, Mirna Elghobashy, Imran Masood, Lisa J Hil. The role of Vitamin D3 in ocular fibrosis and its therapeutic potential for the glaucomatous trabecular meshwork. Frontiers in ophthalmology. vol 2. 2024-07-10. PMID:38983544. |
increased outflow resistance is partly due to tm/sc dysregulation, including loss of normal trabecular meshwork cell (tmc) function, following increased levels of oxidative stress within tmc, dysregulated extracellular matrix (ecm) deposition and remodeling alongside alterations in tmc phenotype and apoptosis. |
2024-07-10 |
2024-07-12 |
Not clear |
| Archoo Sajeeda, Haroon Rashid, Tanveer Ahmad Malik, Raghu Rai Sharma, Aalim Maqsood Bhat, Amit Kumar, Shahid Hussain Naikoo, Tasduq Abdullah Sheik. Seabuckthorn pulp extract alleviates UV-B-induced skin photo-damage by significantly reducing oxidative stress-mediated endoplasmic reticulum stress and DNA Damage in human primary skin fibroblasts and Balb/c mice skin. Environmental science and pollution research international. 2024-07-10. PMID:38985420. |
the uv-b irradiation-induced ros generation led to the degradation of the extracellular matrix, inflammation, dna damage, endoplasmic reticulum (er) stress, and apoptosis. |
2024-07-10 |
2024-07-12 |
mouse |
| Rijiang Chen, Yan Tong, Xiunian Hu, Wantao Wang, Fake Lia. circSLTM knockdown attenuates chondrocyte inflammation, apoptosis and ECM degradation in osteoarthritis by regulating the miR-515-5p/VAPB axis. International immunopharmacology. vol 138. 2024-07-09. PMID:38981227. |
circular rnas (circrnas) have emerged as pivotal players in oa progression, orchestrating various biological processes such as proliferation, apoptosis, inflammation, and extracellular matrix (ecm) reorganization. |
2024-07-09 |
2024-07-12 |
mouse |
| Rijiang Chen, Yan Tong, Xiunian Hu, Wantao Wang, Fake Lia. circSLTM knockdown attenuates chondrocyte inflammation, apoptosis and ECM degradation in osteoarthritis by regulating the miR-515-5p/VAPB axis. International immunopharmacology. vol 138. 2024-07-09. PMID:38981227. |
loss-of-function assays were conducted, demonstrating that silencing circsltm via shrnas mitigated lps-induced effects on chondrocytes, as evidenced by enhanced proliferation, reduced apoptosis, and inflammatory factors, and altered expression of extracellular matrix proteins. |
2024-07-09 |
2024-07-12 |
mouse |
| Chinmay S Sankhe, Jessica L Sacco, Jacob Lawton, Ryan A Fair, David Vidotto Rezende Soares, Mohammed K R Aldahdooh, Enrique D Gomez, Esther W Gome. Breast Cancer Cells Exhibit Mesenchymal-Epithelial Plasticity Following Dynamic Modulation of Matrix Stiffness. Advanced biology. 2024-07-08. PMID:38977422. |
a reduction in matrix stiffness attenuates the expression of integrin-linked kinase, and inhibition of integrin-linked kinase impacts proliferation, apoptosis, and gene expression in cells cultured on stiff and dynamic hydrogels. |
2024-07-08 |
2024-07-12 |
Not clear |