| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhenghong Lin, Heeyoung Yang, Qingfei Kong, Jinping Li, Sang-Myeong Lee, Beixue Gao, Hongxin Dong, Jianjun Wei, Jianxun Song, Donna D Zhang, Deyu Fan. USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Molecular cell. vol 46. issue 4. 2012-07-27. PMID:22542455. |
in contrast, depletion of endogenous usp22 by rna interference destabilizes sirt1, inhibits sirt1-mediated deacetylation of p53 and elevates p53-dependent apoptosis. |
2012-07-27 |
2023-08-12 |
mouse |
| Zhenghong Lin, Heeyoung Yang, Qingfei Kong, Jinping Li, Sang-Myeong Lee, Beixue Gao, Hongxin Dong, Jianjun Wei, Jianxun Song, Donna D Zhang, Deyu Fan. USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Molecular cell. vol 46. issue 4. 2012-07-27. PMID:22542455. |
our study elucidates a molecular mechanism in suppression of cell apoptosis by stabilizing sirt1 in response to dna damage and reveals a critical physiological function of usp22 in mouse embryonic development. |
2012-07-27 |
2023-08-12 |
mouse |
| Gennadi V Glinsk. Genomic models of metastatic cancer: functional analysis of death-from-cancer signature genes reveals aneuploid, anoikis-resistant, metastasis-enabling phenotype with altered cell cycle control and activated Polycomb Group (PcG) protein chromatin silencing pathway. Cell cycle (Georgetown, Tex.). vol 5. issue 11. 2006-08-18. PMID:16760651. |
this analysis predicts that cancer cells manifesting a stem cell-like expression profile of a death-from-cancer signature would exhibit the following features: a concomitantly increased expression of certain members of inhibitor of apoptosis protein (iap) family (survivin and xiap); activation of mitotic spindle check point proteins (bub1, bub3, kntc2, mad2, plk1, plk4, stk6/aurora a); and elevated levels of certain cell cycle control/marker proteins (ccnb1, ccnb2, ccnd1, ccna2, cdc2, cdc25, ki67, usp22). |
2006-08-18 |
2023-08-12 |
Not clear |