| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aman Wang, Zhen Ning, Chang Lu, Wei Gao, Jinxiao Liang, Qiu Yan, Guang Tan, Jiwei Li. USP22 Induces Cisplatin Resistance in Lung Adenocarcinoma by Regulating γH2AX-Mediated DNA Damage Repair and Ku70/Bax-Mediated Apoptosis. Frontiers in pharmacology. vol 8. 2020-09-29. PMID:28567015. |
usp22 induces cisplatin resistance in lung adenocarcinoma by regulating γh2ax-mediated dna damage repair and ku70/bax-mediated apoptosis. |
2020-09-29 |
2023-08-13 |
Not clear |
| Aman Wang, Zhen Ning, Chang Lu, Wei Gao, Jinxiao Liang, Qiu Yan, Guang Tan, Jiwei Li. USP22 Induces Cisplatin Resistance in Lung Adenocarcinoma by Regulating γH2AX-Mediated DNA Damage Repair and Ku70/Bax-Mediated Apoptosis. Frontiers in pharmacology. vol 8. 2020-09-29. PMID:28567015. |
in addition, usp22 decreases the acetylation of ku70 by stabilizing sirt1, thus inhibiting bax-mediated apoptosis and inducing cisplatin resistance. |
2020-09-29 |
2023-08-13 |
Not clear |
| Xiaoou Zhou, Lijun Gan, Jianyun Liu, Xin Xie, Tao Wang, Jianjun Xion. Pirarubicin reduces USP22 expression by inhibiting CREB-1 phosphorylation in HeLa cells. Experimental and therapeutic medicine. vol 17. issue 5. 2020-09-29. PMID:31007754. |
in the current study, treatment with thp induced hela cell apoptosis and decreased usp22 expression in a dose- and time-dependent manner. |
2020-09-29 |
2023-08-13 |
Not clear |
| Xiaoou Zhou, Lijun Gan, Jianyun Liu, Xin Xie, Tao Wang, Jianjun Xion. Pirarubicin reduces USP22 expression by inhibiting CREB-1 phosphorylation in HeLa cells. Experimental and therapeutic medicine. vol 17. issue 5. 2020-09-29. PMID:31007754. |
the present study demonstrated that thp decreased usp22 expression and promoted hela cell apoptosis partially by inhibiting the phosphorylation of creb-1. |
2020-09-29 |
2023-08-13 |
Not clear |
| Gaojun Xu, Jie Cai, Lei Wang, Lianyong Jiang, Jianbing Huang, Rui Hu, Fangbao Din. MicroRNA-30e-5p suppresses non-small cell lung cancer tumorigenesis by regulating USP22-mediated Sirt1/JAK/STAT3 signaling. Experimental cell research. vol 362. issue 2. 2018-10-05. PMID:29174979. |
mir-30e-5p overexpression and usp22 knockdown significantly inhibited tumor growth in vivo and induced cell cycle arrest and apoptosis in nsclc cells in vitro. |
2018-10-05 |
2023-08-13 |
Not clear |
| D Zhou, P Liu, D-W Sun, Z-J Chen, J Hu, S-M Peng, Y-L Li. USP22 down-regulation facilitates human retinoblastoma cell aging and apoptosis via inhibiting TERT/P53 pathway. European review for medical and pharmacological sciences. vol 21. issue 12. 2018-07-23. PMID:28682440. |
usp22 down-regulation facilitates human retinoblastoma cell aging and apoptosis via inhibiting tert/p53 pathway. |
2018-07-23 |
2023-08-13 |
human |
| D Zhou, P Liu, D-W Sun, Z-J Chen, J Hu, S-M Peng, Y-L Li. USP22 down-regulation facilitates human retinoblastoma cell aging and apoptosis via inhibiting TERT/P53 pathway. European review for medical and pharmacological sciences. vol 21. issue 12. 2018-07-23. PMID:28682440. |
usp22 is one of the important targets for inhibiting tumor growth, but clear illustration regarding its effects of telomerase, tumor cell immortality and retinoblastoma cell aging or apoptosis via suppressing tert/p53 signal pathway remains to be elusive. |
2018-07-23 |
2023-08-13 |
human |
| Hua-Dong Zhao, Hai-Li Tang, Ning-Ning Liu, Ya-Li Zhao, Qin-Qin Liu, Xiao-Shan Zhu, Lin-Tao Jia, Chun-Fang Gao, An-Gang Yang, Jun-Tang L. Targeting ubiquitin-specific protease 22 suppresses growth and metastasis of anaplastic thyroid carcinoma. Oncotarget. vol 7. issue 21. 2018-01-18. PMID:27145278. |
in vitro assays showed that usp22 depletion suppressed atc cell survival and proliferation by decreasing rb phosphorylation and cyclin d2, inactivating akt, and simultaneously upregulating rb; usp22 silencing restrained cell migration and invasion by inhibiting epithelial-mesenchymal transition; usp22 knockdown promoted mitochondrion- mediated and caspase-dependent apoptosis by upregulating bax and bid and promoting caspase-3 activation. |
2018-01-18 |
2023-08-13 |
Not clear |
| Jian-Xia Shi, Qi-Jin Wang, Hui Li, Qin Huan. Silencing of USP22 suppresses high glucose-induced apoptosis, ROS production and inflammation in podocytes. Molecular bioSystems. vol 12. issue 5. 2017-07-24. PMID:26953552. |
silencing of usp22 suppresses high glucose-induced apoptosis, ros production and inflammation in podocytes. |
2017-07-24 |
2023-08-13 |
rat |
| Jian-Xia Shi, Qi-Jin Wang, Hui Li, Qin Huan. Silencing of USP22 suppresses high glucose-induced apoptosis, ROS production and inflammation in podocytes. Molecular bioSystems. vol 12. issue 5. 2017-07-24. PMID:26953552. |
ubiquitin-specific protease 22 (usp22) has been reported to mediate various cellular processes, including cell proliferation and apoptosis. |
2017-07-24 |
2023-08-13 |
rat |
| Jian-Xia Shi, Qi-Jin Wang, Hui Li, Qin Huan. Silencing of USP22 suppresses high glucose-induced apoptosis, ROS production and inflammation in podocytes. Molecular bioSystems. vol 12. issue 5. 2017-07-24. PMID:26953552. |
silencing of usp22 in podocytes attenuated high d-glucose-induced apoptosis and inflammatory responses, evidenced by increases in proliferation and mmp levels and decreases in the apoptotic rate, ros production, the bax/bcl-2 ratio, caspase-3 expression and secretion of tnf-α, il-1β, il-6 and tgf-β1. |
2017-07-24 |
2023-08-13 |
rat |
| Jian-Xia Shi, Qi-Jin Wang, Hui Li, Qin Huan. Silencing of USP22 suppresses high glucose-induced apoptosis, ROS production and inflammation in podocytes. Molecular bioSystems. vol 12. issue 5. 2017-07-24. PMID:26953552. |
in addition, podocytes with usp22 overexpression significantly enhanced the effect of high d-glucose-induced apoptosis and inflammatory responses. |
2017-07-24 |
2023-08-13 |
rat |
| Jian-Xia Shi, Qi-Jin Wang, Hui Li, Qin Huan. Silencing of USP22 suppresses high glucose-induced apoptosis, ROS production and inflammation in podocytes. Molecular bioSystems. vol 12. issue 5. 2017-07-24. PMID:26953552. |
notably, silencing of usp22 in diabetic rats conferred a similar protective effect against high glucose-induced apoptosis and inflammation. |
2017-07-24 |
2023-08-13 |
rat |
| Ying-Li Liu, Jie Zheng, Li-Juan Tang, Wei Han, Jian-Min Wang, Dian-Wu Liu, Qing-Bao Tia. The deubiquitinating enzyme activity of USP22 is necessary for regulating HeLa cell growth. Gene. vol 572. issue 1. 2015-12-04. PMID:26143114. |
ubiquitin-specific protease 22 (usp22) can regulate the cell cycle and apoptosis in many cancer cell types, while it is still unclear whether the deubiquitinating enzyme activity of usp22 is necessary for these processes. |
2015-12-04 |
2023-08-13 |
Not clear |
| Ying-Li Liu, Jie Zheng, Li-Juan Tang, Wei Han, Jian-Min Wang, Dian-Wu Liu, Qing-Bao Tia. The deubiquitinating enzyme activity of USP22 is necessary for regulating HeLa cell growth. Gene. vol 572. issue 1. 2015-12-04. PMID:26143114. |
in this study, we demonstrate that usp22 can regulate cell cycle but not apoptosis in hela cell. |
2015-12-04 |
2023-08-13 |
Not clear |
| Ning Ao, Yanyan Liu, Hailiang Feng, Xiaocui Bian, Zhanwen Li, Bei Gu, Xiaomei Zhao, Yuqin Li. Ubiquitin-specific peptidase USP22 negatively regulates the STAT signaling pathway by deubiquitinating SIRT1. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 33. issue 6. 2015-09-21. PMID:24969755. |
the ubiquitin-specific peptidase usp22 mediates various cellular and organismal processes, such as cell growth, apoptosis, and tumor malignancy. |
2015-09-21 |
2023-08-13 |
Not clear |
| Fangbao Ding, Chunrong Bao, Yue Tian, Haibo Xiao, Mingsong Wang, Xiao Xie, Fengqing Hu, Ju Me. USP22 promotes NSCLC tumorigenesis via MDMX up-regulation and subsequent p53 inhibition. International journal of molecular sciences. vol 16. issue 1. 2015-08-28. PMID:25547493. |
usp22 silencing by shrna inhibits proliferation, induces apoptosis and arrests cells at the g0/g1 phases in nsclc cells and curbs human nsclc tumor growth in a mouse xenograft model. |
2015-08-28 |
2023-08-13 |
mouse |
| Fangbao Ding, Chunrong Bao, Yue Tian, Haibo Xiao, Mingsong Wang, Xiao Xie, Fengqing Hu, Ju Me. USP22 promotes NSCLC tumorigenesis via MDMX up-regulation and subsequent p53 inhibition. International journal of molecular sciences. vol 16. issue 1. 2015-08-28. PMID:25547493. |
furthermore, mdmx silencing leads to growth arrest and apoptosis in nsclc cells, and over-expression of mdmx reverses the usp22 silencing-induced effects. |
2015-08-28 |
2023-08-13 |
mouse |
| Jianjun Xiong, Xiaoyuan Xu, Xiaou Zhou, Jianyun Liu, Zhen Gong, Ping Wu, Weidong L. USP22 transcriptional activity is negatively regulated by the histone deacetylase inhibitor trichostatin A. Molecular medicine reports. vol 10. issue 6. 2015-06-19. PMID:25323692. |
in addition, the overexpression of usp22 was observed to attenuate tsa‑induced apoptosis in hela cells. |
2015-06-19 |
2023-08-13 |
Not clear |
| Zhenghong Lin, Heeyoung Yang, Qingfei Kong, Jinping Li, Sang-Myeong Lee, Beixue Gao, Hongxin Dong, Jianjun Wei, Jianxun Song, Donna D Zhang, Deyu Fan. USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Molecular cell. vol 46. issue 4. 2012-07-27. PMID:22542455. |
usp22 antagonizes p53 transcriptional activation by deubiquitinating sirt1 to suppress cell apoptosis and is required for mouse embryonic development. |
2012-07-27 |
2023-08-12 |
mouse |