| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinhui Guo, Jie Zha. USP22-JMJD8 axis promotes Lenvatinib resistance in hepatocellular carcinoma. Biochimica et biophysica acta. Molecular cell research. 2023-10-28. PMID:37898375. |
under the treatment of lenvatinib, usp22 knockdown inhibited the cell viability of drug-resistant hcc cells and promoted the apoptosis of drug-resistant cells. |
2023-10-28 |
2023-11-08 |
mouse |
| Jinhui Guo, Jie Zha. USP22-JMJD8 axis promotes Lenvatinib resistance in hepatocellular carcinoma. Biochimica et biophysica acta. Molecular cell research. 2023-10-28. PMID:37898375. |
in the rescue experiment, the overexpression of jmjd8 could reduce the apoptosis induced by usp22 knockdown. |
2023-10-28 |
2023-11-08 |
mouse |
| Yanling Li, Jing Gao, Chuntian Liu, Ning Bu, Shuqin Zhan, Haiqin Wu, Ru Zhang, Hong Sun, Hong Fa. USP22 knockdown protects against cerebral ischemia/reperfusion injury via destabilizing PTEN protein and activating the mTOR/TFEB pathway. Naunyn-Schmiedeberg's archives of pharmacology. 2023-05-16. PMID:37191727. |
usp22 shrna was intravenously injected into the mouse brain, and then a middle cerebral artery occlusion/reperfusion (mcao/r) mouse model was constructed, and the infarct volume, neurobehavioral deficit score, cell apoptosis, oxidative stress, and autophagy in vivo were evaluated. |
2023-05-16 |
2023-08-14 |
mouse |
| Yanling Li, Jing Gao, Chuntian Liu, Ning Bu, Shuqin Zhan, Haiqin Wu, Ru Zhang, Hong Sun, Hong Fa. USP22 knockdown protects against cerebral ischemia/reperfusion injury via destabilizing PTEN protein and activating the mTOR/TFEB pathway. Naunyn-Schmiedeberg's archives of pharmacology. 2023-05-16. PMID:37191727. |
the effects of usp22 on proliferation, apoptosis, oxidative stress, and autophagy were explored by cck-8, flow cytometry, elisa, and western blot assays. |
2023-05-16 |
2023-08-14 |
mouse |
| Yanling Li, Jing Gao, Chuntian Liu, Ning Bu, Shuqin Zhan, Haiqin Wu, Ru Zhang, Hong Sun, Hong Fa. USP22 knockdown protects against cerebral ischemia/reperfusion injury via destabilizing PTEN protein and activating the mTOR/TFEB pathway. Naunyn-Schmiedeberg's archives of pharmacology. 2023-05-16. PMID:37191727. |
in vitro, usp22 knockdown strongly improved ogd/r-mediated changes in cell viability, apoptosis, oxidative stress, and lactate dehydrogenase (ldh) production in pc12 cells. |
2023-05-16 |
2023-08-14 |
mouse |
| Yanling Li, Jing Gao, Chuntian Liu, Ning Bu, Shuqin Zhan, Haiqin Wu, Ru Zhang, Hong Sun, Hong Fa. USP22 knockdown protects against cerebral ischemia/reperfusion injury via destabilizing PTEN protein and activating the mTOR/TFEB pathway. Naunyn-Schmiedeberg's archives of pharmacology. 2023-05-16. PMID:37191727. |
pten overexpression reversed the promoting effect of usp22 knockdown on cell viability and the inhibitory effects of usp22 knockdown on apoptosis, oxidative stress, and ldh release rate in pc12 cells subjected to ogd/r. |
2023-05-16 |
2023-08-14 |
mouse |
| Yanling Li, Jing Gao, Chuntian Liu, Ning Bu, Shuqin Zhan, Haiqin Wu, Ru Zhang, Hong Sun, Hong Fa. USP22 knockdown protects against cerebral ischemia/reperfusion injury via destabilizing PTEN protein and activating the mTOR/TFEB pathway. Naunyn-Schmiedeberg's archives of pharmacology. 2023-05-16. PMID:37191727. |
in vivo, usp22 silencing significantly alleviated infarct volume, neurobehavioral impairments, cell apoptosis, oxidative stress, and autophagy in mcao/r mice. |
2023-05-16 |
2023-08-14 |
mouse |
| Zhao Hui Li, Yin Yu, Chao Du, Hong Fu, Jian Wang, Yu Tia. [Retracted] RNA interference‑mediated USP22 gene silencing promotes human brain glioma apoptosis and induces cell cycle arrest. Oncology letters. vol 25. issue 4. 2023-03-24. PMID:36960193. |
[retracted] rna interference‑mediated usp22 gene silencing promotes human brain glioma apoptosis and induces cell cycle arrest. |
2023-03-24 |
2023-08-14 |
human |
| Bo Tang, Yang Li, Shengguang Yuan, Stephen Tomlinson, Songqing H. [Retracted] Upregulation of the δ opioid receptor in liver cancer promotes liver cancer progression both International journal of oncology. vol 62. issue 5. 2023-03-17. PMID:36928526. |
[retracted] upregulation of the δ opioid receptor in liver cancer promotes liver cancer progression both following the publication of the above paper, it was drawn to the editor's attention by a concerned reader that the western blotting data shown in fig. 1c on p. 1284 for the control β‑actin protein bands were strikingly similar to bands appearing in another article written by different authors at different research institutes, which had already been submitted for consideration for publication (li zh, yu y, du c, fu h, wang j and tian y: rna interference‑mediated usp22 gene silencing promotes human brain glioma apoptosis and induces cell cycle arrest. |
2023-03-17 |
2023-08-14 |
human |
| Shan Song, Yang Wang, Hai-Yan Wang, Long-Long Gu. Role of sevoflurane in myocardial ischemia-reperfusion injury via the ubiquitin-specific protease 22/lysine-specific demethylase 3A axis. Bioengineered. vol 13. issue 5. 2023-01-26. PMID:36700466. |
usp 22, kdm3a, and yap1 were found to be down-regulated in mi/ri and spc protected mi/ri rats, as evidenced by up-regulated expressions of usp22, kdm3a, and yap1, reduced pathological injury in the myocardium, myocardial infarction areas, apoptosis, and levels of ck-mb, ctni, and ldh, and enhanced h9c2 cell viability; while the protective effects of sevo were counteracted by silencing of usp22, kdm3a, and spc upregulated usp22, which stabilized kdm3a protein levels via deubiquitination, and kdm3a inhibited histone 3 lysine 9 di-methylation (h3k9me2) levels in the yap1 promoter to encourage yap1 transcription, to reduce mi/ri. |
2023-01-26 |
2023-08-14 |
rat |
| Yanqi Li, Yuan He, Yuan Chen, Zhaocai He, Fan Yang, Chungen Xin. Contribution of microRNA-30d to the prevention of the thyroid cancer occurrence and progression: mechanism and implications. Apoptosis : an international journal on programmed cell death. 2023-01-25. PMID:36695983. |
accordingly, mir-30d inhibited proliferation and promoted apoptosis of thyroid cancer cells by suppressing usp22 through sirt1/foxo3a/puma axis. |
2023-01-25 |
2023-08-14 |
Not clear |
| Zhao Hui Li, Yin Yu, Chao DU, Hong Fu, Jian Wang, Yu Tia. RNA interference-mediated USP22 gene silencing promotes human brain glioma apoptosis and induces cell cycle arrest. Oncology letters. vol 5. issue 4. 2021-10-21. PMID:23599781. |
rna interference-mediated usp22 gene silencing promotes human brain glioma apoptosis and induces cell cycle arrest. |
2021-10-21 |
2023-08-12 |
human |
| Zhao Hui Li, Yin Yu, Chao DU, Hong Fu, Jian Wang, Yu Tia. RNA interference-mediated USP22 gene silencing promotes human brain glioma apoptosis and induces cell cycle arrest. Oncology letters. vol 5. issue 4. 2021-10-21. PMID:23599781. |
silencing the usp22 gene was found to effectively inhibit proliferation of human brain glioma cells, resulting in cell apoptosis and cell cycle arrest at the g |
2021-10-21 |
2023-08-12 |
human |
| Junbo Rong, Zhigang Li, Limin Xu, Lijuan Lang, Guangying Zhen. microRNA-362-3p targets USP22 to retard retinoblastoma growth via reducing deubiquitination of LSD1. Cell cycle (Georgetown, Tex.). vol 20. issue 3. 2021-06-03. PMID:33475455. |
restoring mir-362-3p and depleting usp22 attenuated invasion, proliferation and migration, and facilitated apoptosis of rb cells. |
2021-06-03 |
2023-08-13 |
Not clear |
| Junbo Rong, Zhigang Li, Limin Xu, Lijuan Lang, Guangying Zhen. microRNA-362-3p targets USP22 to retard retinoblastoma growth via reducing deubiquitination of LSD1. Cell cycle (Georgetown, Tex.). vol 20. issue 3. 2021-06-03. PMID:33475455. |
it is revealed that mir-362-3p targets usp22 and then restrains invasion, proliferation and migration while promotes apoptosis of rb via reducing lsd1 modified by deubiquitination. |
2021-06-03 |
2023-08-13 |
Not clear |
| Jens Roedig, Lisa Kowald, Thomas Juretschke, Rebekka Karlowitz, Behnaz Ahangarian Abhari, Heiko Roedig, Simone Fulda, Petra Beli, Sjoerd Jl van Wij. USP22 controls necroptosis by regulating receptor-interacting protein kinase 3 ubiquitination. EMBO reports. vol 22. issue 2. 2021-05-31. PMID:33369872. |
apart from apoptosis, the relevance of usp22 in other programmed cell death pathways still remains unclear. |
2021-05-31 |
2023-08-13 |
human |
| Jens Roedig, Lisa Kowald, Thomas Juretschke, Rebekka Karlowitz, Behnaz Ahangarian Abhari, Heiko Roedig, Simone Fulda, Petra Beli, Sjoerd Jl van Wij. USP22 controls necroptosis by regulating receptor-interacting protein kinase 3 ubiquitination. EMBO reports. vol 22. issue 2. 2021-05-31. PMID:33369872. |
loss of usp22 expression significantly delays tnfα/smac mimetic/zvad.fmk (tbz)-induced necroptosis, without affecting tnfα-mediated nf-κb activation or extrinsic apoptosis. |
2021-05-31 |
2023-08-13 |
human |
| Wei Liu, Dunwei Wang, Lidi Liu, Lin Wang, Ming Ya. miR-140 inhibits osteosarcoma progression by impairing USP22-mediated LSD1 stabilization and promoting p21 expression. Molecular therapy. Nucleic acids. vol 24. 2021-04-21. PMID:33868787. |
overexpression of mir-140 inhibited cell proliferation, migration, and invasion and promoted cell apoptosis by directly targeting usp22, resulting in its decreased expression. |
2021-04-21 |
2023-08-13 |
Not clear |
| Bing Han, Yue Sun, Dongdong Yang, Huijuan Zhang, Steven Mo, Xuesong Chen, Hailing Lu, Xueyan Mao, Jing H. USP22 promotes development of lung adenocarcinoma through ubiquitination and immunosuppression. Aging. vol 12. issue 8. 2021-02-23. PMID:32294625. |
more than that, knocking down usp22 can up-regulate stat1 to activate jak1-stat1-caspase pathway, and promote apoptosis of tumor cell. |
2021-02-23 |
2023-08-13 |
Not clear |
| Yong Liao, Xingsi Liang, Wenjin Liang, Zeming Li, Yan Wang, Lin Wang, Siqi Zhen, Bo Tang, Zhenran Wan. High expression of ubiquitin carboxyl-terminal hydrolase 22 is associated with poor prognosis in hepatitis B virus-associated liver cancer. Oncology letters. vol 17. issue 6. 2020-09-30. PMID:31186731. |
additionally, investigation into the underlying mechanism, using small interfering rna, revealed that the downregulation of usp22 inhibited proliferation and promoted apoptosis though the phosphoinositide 3-kinase/protein kinase b signaling pathway. |
2020-09-30 |
2023-08-13 |
Not clear |