| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Debashree Mukherjea, Sarvesh Jajoo, Craig Whitworth, Jennifer R Bunch, Jeremy G Turner, Leonard P Rybak, Vickram Ramkuma. Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 49. 2009-01-12. PMID:19052196. |
inhibition of trpv1 by capsazepine or ruthenium red reduced the apoptosis, implicating trpv1 in this process. |
2009-01-12 |
2023-08-12 |
rat |
| Debashree Mukherjea, Sarvesh Jajoo, Craig Whitworth, Jennifer R Bunch, Jeremy G Turner, Leonard P Rybak, Vickram Ramkuma. Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 49. 2009-01-12. PMID:19052196. |
treatment of ub/oc-1 cultures with short interfering rna (sirna) against either trpv1 or nox3 reduced cisplatin-induced apoptosis, while round window application of trpv1 sirna to rats reduced trpv1 expression, decreased damage to outer hair cells and reduced cisplatin-induced hearing loss. |
2009-01-12 |
2023-08-12 |
rat |
| C Amantini, M Mosca, M Nabissi, R Lucciarini, S Caprodossi, A Arcella, F Giangaspero, G Santon. Capsaicin-induced apoptosis of glioma cells is mediated by TRPV1 vanilloid receptor and requires p38 MAPK activation. Journal of neurochemistry. vol 102. issue 3. 2007-10-15. PMID:17442041. |
capsaicin-induced apoptosis of glioma cells is mediated by trpv1 vanilloid receptor and requires p38 mapk activation. |
2007-10-15 |
2023-08-12 |
human |
| C Amantini, M Mosca, M Nabissi, R Lucciarini, S Caprodossi, A Arcella, F Giangaspero, G Santon. Capsaicin-induced apoptosis of glioma cells is mediated by TRPV1 vanilloid receptor and requires p38 MAPK activation. Journal of neurochemistry. vol 102. issue 3. 2007-10-15. PMID:17442041. |
we provide evidence on the expression of the transient receptor potential vanilloid type-1 (trpv1) by glioma cells, and its involvement in capsaicin (cps)-induced apoptosis. |
2007-10-15 |
2023-08-12 |
human |
| Natalia Prevarskaya, Lei Zhang, Greg Barrit. TRP channels in cancer. Biochimica et biophysica acta. vol 1772. issue 8. 2007-09-28. PMID:17616360. |
the drosophila melanogaster, trpl, and the trpv1 and trpm8 proteins, have been used to try to develop strategies to selectively kill cancer cells by activating ca(2+) and na(+) entry, producing a sustained increase in the cytoplasmic concentration of these ions, and subsequent cell death by apoptosis and necrosis. |
2007-09-28 |
2023-08-12 |
drosophila_melanogaster |
| Andriani Athanasiou, Paul A Smith, Sara Vakilpour, Nethia M Kumaran, Amy E Turner, Dimitra Bagiokou, Robert Layfield, David E Ray, Andrew D Westwell, Stephen P H Alexander, David A Kendall, Dileep N Lobo, Susan A Watson, Artitaya Lophatanon, Kenneth A Muir, De-An Guo, Timothy E Bate. Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and biophysical research communications. vol 354. issue 1. 2007-04-06. PMID:17214968. |
time-lapse photomicroscopy of human h460 lung cancer cells demonstrated of the transient receptor potential v1 (trpv1) channel agonists, (e)-capsaicin and resiniferatoxin, and the trpv1 antagonists, capsazepine, and sb366791, were able to bring about morphological changes characteristic of apoptosis and/or necrosis. |
2007-04-06 |
2023-08-12 |
human |
| Andriani Athanasiou, Paul A Smith, Sara Vakilpour, Nethia M Kumaran, Amy E Turner, Dimitra Bagiokou, Robert Layfield, David E Ray, Andrew D Westwell, Stephen P H Alexander, David A Kendall, Dileep N Lobo, Susan A Watson, Artitaya Lophatanon, Kenneth A Muir, De-An Guo, Timothy E Bate. Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and biophysical research communications. vol 354. issue 1. 2007-04-06. PMID:17214968. |
these data support the hypothesis that (e)-capsaicin, resiniferatoxin, capsazepine, and sb366791 are all mitochondrial inhibitors, able to activate apoptosis and/or necrosis via non-receptor mediated mechanisms, and also support the use of trpv1 ligands as anti-cancer agents. |
2007-04-06 |
2023-08-12 |
human |
| Eniko Bodó, Tamás Bíró, Andrea Telek, Gabriella Czifra, Zoltán Griger, Balázs I Tóth, Alessandra Mescalchin, Taisuke Ito, Albrecht Bettermann, László Kovács, Ralf Pau. A hot new twist to hair biology: involvement of vanilloid receptor-1 (VR1/TRPV1) signaling in human hair growth control. The American journal of pathology. vol 166. issue 4. 2005-05-17. PMID:15793280. |
in organ culture, trpv1 activation by capsaicin resulted in a dose-dependent and trpv1-specific inhibition of hair shaft elongation, suppression of proliferation, induction of apoptosis, premature hf regression (catagen), and up-regulation of intrafollicular transforming growth factor-beta(2). |
2005-05-17 |
2023-08-12 |
human |
| Eniko Bodó, Tamás Bíró, Andrea Telek, Gabriella Czifra, Zoltán Griger, Balázs I Tóth, Alessandra Mescalchin, Taisuke Ito, Albrecht Bettermann, László Kovács, Ralf Pau. A hot new twist to hair biology: involvement of vanilloid receptor-1 (VR1/TRPV1) signaling in human hair growth control. The American journal of pathology. vol 166. issue 4. 2005-05-17. PMID:15793280. |
cultured human ors keratinocytes also expressed functional trpv1, whose stimulation inhibited proliferation, induced apoptosis, elevated intracellular calcium concentration, up-regulated known endogenous hair growth inhibitors (interleukin-1beta, transforming growth factor-beta(2)), and down-regulated known hair growth promoters (hepatocyte growth factor, insulin-like growth factor-i, stem cell factor). |
2005-05-17 |
2023-08-12 |
human |
| N Agopyan, J Head, S Yu, S A Simo. TRPV1 receptors mediate particulate matter-induced apoptosis. American journal of physiology. Lung cellular and molecular physiology. vol 286. issue 3. 2004-03-26. PMID:14633515. |
trpv1 receptors mediate particulate matter-induced apoptosis. |
2004-03-26 |
2023-08-12 |
mouse |
| N Agopyan, J Head, S Yu, S A Simo. TRPV1 receptors mediate particulate matter-induced apoptosis. American journal of physiology. Lung cellular and molecular physiology. vol 286. issue 3. 2004-03-26. PMID:14633515. |
to understand some of these mechanisms, we measured pm-induced apoptosis and necrosis in normal human airway epithelial cells and sensory neurons from both wild-type mice and mice lacking trpv1 receptors using alexa fluor 488-conjugated annexin v and propidium iodide labeling, respectively. |
2004-03-26 |
2023-08-12 |
mouse |
| N Agopyan, J Head, S Yu, S A Simo. TRPV1 receptors mediate particulate matter-induced apoptosis. American journal of physiology. Lung cellular and molecular physiology. vol 286. issue 3. 2004-03-26. PMID:14633515. |
exposure of environmental pms containing residual oil fly ash and ash from mount st. helens was found to induce apoptosis, but not necrosis, as a consequence of sustained calcium influx through trpv1 receptors. |
2004-03-26 |
2023-08-12 |
mouse |
| N Agopyan, J Head, S Yu, S A Simo. TRPV1 receptors mediate particulate matter-induced apoptosis. American journal of physiology. Lung cellular and molecular physiology. vol 286. issue 3. 2004-03-26. PMID:14633515. |
apoptosis was completely prevented by inhibiting trpv1 receptors with capsazepine or by removing extracellular calcium or in sensory neurons from trpv1(-/-) mice. |
2004-03-26 |
2023-08-12 |
mouse |
| N Agopyan, J Head, S Yu, S A Simo. TRPV1 receptors mediate particulate matter-induced apoptosis. American journal of physiology. Lung cellular and molecular physiology. vol 286. issue 3. 2004-03-26. PMID:14633515. |
in summary, it was found that inhibiting trpv1 receptors prevents pm-induced apoptosis, thereby providing a potential mechanism to reduce their toxicity. |
2004-03-26 |
2023-08-12 |
mouse |