| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingjing Cheng, Mengliu Zeng, Biwen Peng, Ping Li, ShiYu Zha. Transient Receptor Potential Vanilloid-1 (TRPV1) Channels act as Suppressors of the Growth of Glioma. Brain research bulletin. 2024-04-17. PMID:38631651. |
in vitro, the activation of trpv1 induced cell apoptosis with decreased migration capability and inhibited proliferation, which was abolished upon trpv1 pharmacological inhibition and silencing. |
2024-04-17 |
2024-04-20 |
mouse |
| Tobias Weihrauch, Natalie Gray, Daniela Wiebe, Martin Schmelz, Maren M Limberg, Ulrike Raa. TRPV1 Channel in Human Eosinophils: Functional Expression and Inflammatory Modulation. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339203. |
trpv1 functionality was analyzed by investigating calcium flux, apoptosis, modulation by cytokines and acidic ph, and cd69 externalization using flow cytometry. |
2024-02-10 |
2024-02-12 |
human |
| Chien-Cheng Chen, Chia-Hua Ke, Chun-Hu Wu, Hung-Fu Lee, Yuan Chao, Min-Chien Tsai, Song-Kun Shyue, Szu-Fu Che. Transient receptor potential vanilloid 1 inhibition reduces brain damage by suppressing neuronal apoptosis after intracerebral hemorrhage. Brain pathology (Zurich, Switzerland). 2024-02-02. PMID:38308041. |
transient receptor potential vanilloid 1 (trpv1), a nonselective cation channel with high calcium permeability, has been implicated in neuronal apoptosis and inflammatory responses. |
2024-02-02 |
2024-02-05 |
mouse |
| Chien-Cheng Chen, Chia-Hua Ke, Chun-Hu Wu, Hung-Fu Lee, Yuan Chao, Min-Chien Tsai, Song-Kun Shyue, Szu-Fu Che. Transient receptor potential vanilloid 1 inhibition reduces brain damage by suppressing neuronal apoptosis after intracerebral hemorrhage. Brain pathology (Zurich, Switzerland). 2024-02-02. PMID:38308041. |
this study used a mouse ich model and neuronal cultures to examine whether trpv1 activation exacerbates brain damage and neurological deficits by promoting neuronal apoptosis and neuroinflammation. |
2024-02-02 |
2024-02-05 |
mouse |
| Ying-Jie Zhu, Hu-Lin Chen, Xin-Jie Cai, Bang-le Zhan, Xiao-Ming Li. Naringin acts as a TRPV1 antagonist to attenuate UVB-induced senescence and damage in HaCaT cells. Chemical biology & drug design. 2023-11-09. PMID:37945519. |
analysis was performed using the mtt assay to assess cell viability, flow cytometry to measure the apoptosis level, sa-β-gal staining to observe cellular senescence, and western blot to assess protein levels of trpv1, p16, p53, p21, matrix metalloproteinase (mmp)-1, and mmp-9. |
2023-11-09 |
2023-11-20 |
human |
| Ying-Jie Zhu, Hu-Lin Chen, Xin-Jie Cai, Bang-le Zhan, Xiao-Ming Li. Naringin acts as a TRPV1 antagonist to attenuate UVB-induced senescence and damage in HaCaT cells. Chemical biology & drug design. 2023-11-09. PMID:37945519. |
both uvb irradiation and capsaicin (cap) treatment upregulated the expression of trpv1 in hacat cells, inhibited cell proliferation, promoted apoptosis, and increased the expression of p16, p53, p21, mmp-1, and mmp-9. |
2023-11-09 |
2023-11-20 |
human |
| Shilin Xu, Keke Hao, Ying Xiong, Rui Xu, Huan Huang, Huiling Wan. Capsaicin alleviates neuronal apoptosis and schizophrenia-like behavioral abnormalities induced by early life stress. Schizophrenia (Heidelberg, Germany). vol 9. issue 1. 2023-11-07. PMID:37935716. |
although the trpv1 agonist capsaicin (cap) has been reported to reduce apoptosis in the central nervous system, its effect in ms models is unclear. |
2023-11-07 |
2023-11-20 |
human |
| Lijuan Ma, Boyi Li, Jinchen Ma, Chunyuan Wu, Nan Li, Kailin Zhou, Yun Yan, Mingshuang Li, Xiaoyan Hu, Hao Yan, Qi Wang, Yanfei Zheng, Zhisheng W. Novel discovery of schisandrin A regulating the interplay of autophagy and apoptosis in oligoasthenospermia by targeting SCF/c-kit and TRPV1 Acta pharmaceutica Sinica. B. vol 13. issue 6. 2023-07-10. PMID:37425035. |
novel discovery of schisandrin a regulating the interplay of autophagy and apoptosis in oligoasthenospermia by targeting scf/c-kit and trpv1 oligoasthenospermia is the primary cause of infertility. |
2023-07-10 |
2023-08-14 |
Not clear |
| Lijuan Ma, Boyi Li, Jinchen Ma, Chunyuan Wu, Nan Li, Kailin Zhou, Yun Yan, Mingshuang Li, Xiaoyan Hu, Hao Yan, Qi Wang, Yanfei Zheng, Zhisheng W. Novel discovery of schisandrin A regulating the interplay of autophagy and apoptosis in oligoasthenospermia by targeting SCF/c-kit and TRPV1 Acta pharmaceutica Sinica. B. vol 13. issue 6. 2023-07-10. PMID:37425035. |
in this study, stem cell factor (scf), c-kit, and transient receptor potential vanilloid 1 (trpv1) biosensors were successfully established and applied to studying apoptosis and autophagy mechanisms. |
2023-07-10 |
2023-08-14 |
Not clear |
| Betül Yazğan, Yener Yazğan, Mustafa Nazıroğl. Alpha-lipoic acid modulates the diabetes mellitus-mediated neuropathic pain via inhibition of the TRPV1 channel, apoptosis, and oxidative stress in rats. Journal of bioenergetics and biomembranes. 2023-06-25. PMID:37357235. |
alpha-lipoic acid modulates the diabetes mellitus-mediated neuropathic pain via inhibition of the trpv1 channel, apoptosis, and oxidative stress in rats. |
2023-06-25 |
2023-08-14 |
rat |
| Federica Maggi, Maria Beatrice Morelli, Cristina Aguzzi, Laura Zeppa, Massimo Nabissi, Carlo Polidori, Giorgio Santoni, Consuelo Amantin. Calcium influx, oxidative stress, and apoptosis induced by TRPV1 in chronic myeloid leukemia cells: Synergistic effects with imatinib. Frontiers in molecular biosciences. vol 10. 2023-03-06. PMID:36876044. |
calcium influx, oxidative stress, and apoptosis induced by trpv1 in chronic myeloid leukemia cells: synergistic effects with imatinib. |
2023-03-06 |
2023-08-14 |
Not clear |
| Yusuf Dal, Mustafa Nazıroğlu, Mehmet Okan Özkay. Low molecular weight heparin treatment reduced apoptosis and oxidative cytotoxicity in the thrombocytes of patients with recurrent pregnancy loss and thrombophilia: Involvements of TRPM2 and TRPV1 channels. The journal of obstetrics and gynaecology research. 2023-02-22. PMID:36807656. |
low molecular weight heparin treatment reduced apoptosis and oxidative cytotoxicity in the thrombocytes of patients with recurrent pregnancy loss and thrombophilia: involvements of trpm2 and trpv1 channels. |
2023-02-22 |
2023-08-14 |
Not clear |
| Meng-Yang Sun, Xue Zhang, Peng-Cheng Yu, Di Liu, Yang Yang, Wen-Wen Cui, Xiao-Na Yang, Yun-Tao Lei, Xing-Hua Li, Wen-Hui Wang, Peng Cao, Heng-Shan Wang, Michael X Zhu, Chang-Zhu Li, Rui Wang, Ying-Zhe Fan, Ye Y. Vanilloid agonist-mediated activation of TRPV1 channels requires coordinated movement of the S1-S4 bundle rather than a quiescent state. Science bulletin. vol 67. issue 10. 2022-12-22. PMID:36546250. |
covalent occupation of vcf-identified sites, single-channel recording, cell apoptosis analysis, and exploration of the role of psfl828, a novel non-vanilloid agonist we identified, have collectively confirmed the essential role of this coordinated s1-s4 motility in capsaicin-mediated activation of trpv1. |
2022-12-22 |
2023-08-14 |
Not clear |
| Enhui Yao, Lili Luo, Chenxi Lin, Jing Wen, Yanglongfei Li, Tong Ren, Yujie Chen, Jinhua Huang, Xin Ji. OEA alleviates apoptosis in diabetic rats with myocardial ischemia/reperfusion injury by regulating the PI3K/Akt signaling pathway through activation of TRPV1. Frontiers in pharmacology. vol 13. 2022-12-01. PMID:36452230. |
oea alleviates apoptosis in diabetic rats with myocardial ischemia/reperfusion injury by regulating the pi3k/akt signaling pathway through activation of trpv1. |
2022-12-01 |
2023-08-14 |
rat |
| Gulin Ozdamar Unal, Arif Demirdas, Mustafa Nazıroglu, Ishak Suat Ove. Agomelatine attenuates calcium signaling and apoptosis via the inhibition of TRPV1 channel in the hippocampal neurons of rats with chronic mild stress depression model. Behavioural brain research. 2022-08-01. PMID:35914635. |
agomelatine attenuates calcium signaling and apoptosis via the inhibition of trpv1 channel in the hippocampal neurons of rats with chronic mild stress depression model. |
2022-08-01 |
2023-08-14 |
rat |
| Ahmi Öz, Ramazan Çinar, Mustafa Naziroğl. TRPV1 stimulation increased oxidative neurotoxicity and apoptosis in the glia cell membrane but not in the perinuclear area: An evidence of TRPV1 subtype. Metabolic brain disease. 2022-07-01. PMID:35776390. |
trpv1 stimulation increased oxidative neurotoxicity and apoptosis in the glia cell membrane but not in the perinuclear area: an evidence of trpv1 subtype. |
2022-07-01 |
2023-08-14 |
Not clear |
| Chiara Valenti, Monia Billi, Gian Luca Pancrazi, Elena Calabria, Niccolò Giuseppe Armogida, Gregorio Tortora, Stefano Pagano, Paolo Barnaba, Lorella Marinucc. Biological Effects of Cannabidiol on Human Cancer Cells: Systematic Review of the Literature. Pharmacological research. 2022-06-01. PMID:35643249. |
cb1 receptor has been related to viability effects, cb2 to apoptosis and trpv1 to inflammation and invasiveness. |
2022-06-01 |
2023-08-13 |
human |
| Man Long, Zhigang Wang, Luyao Shao, Jing Bi, Zebin Chen, Nina Yi. Electroacupuncture Pretreatment Attenuates Cerebral Ischemia-Reperfusion Injury in Rats Through Transient Receptor Potential Vanilloid 1-Mediated Anti-apoptosis via Inhibiting NF-κB Signaling Pathway. Neuroscience. 2021-12-20. PMID:34929338. |
then, infarct volume, nerve cell injury, neuronal apoptosis, nf-κb signaling activation, and expression of trpv1 were evaluated by ttc staining, hematoxylin-eosin staining, transmission electron microscopy, immunochemistry, immunofluorescence, and western blot, respectively. |
2021-12-20 |
2023-08-13 |
rat |
| Man Long, Zhigang Wang, Luyao Shao, Jing Bi, Zebin Chen, Nina Yi. Electroacupuncture Pretreatment Attenuates Cerebral Ischemia-Reperfusion Injury in Rats Through Transient Receptor Potential Vanilloid 1-Mediated Anti-apoptosis via Inhibiting NF-κB Signaling Pathway. Neuroscience. 2021-12-20. PMID:34929338. |
by contrast, enhancement of trpv1 expression accompanying capsaicin application, the specific trpv1 agonists, markedly accelerated nerve cell damage, aggravated neuronal apoptosis, prompted nuclear translocation of nf-κb (p65), resulting in the reversion of ea pretreatment-evoked neuroprotective effect in mcao rats. |
2021-12-20 |
2023-08-13 |
rat |
| Jing Luo, Jialei Chen, Changhong Yang, Junyi Tan, Jing Zhao, Ning Jiang, Yong Zha. 6-Gingerol protects against cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1 / FAF1 complex dissociation-mediated autophagy. International immunopharmacology. vol 100. 2021-10-27. PMID:34537481. |
6-gingerol protects against cerebral ischemia/reperfusion injury by inhibiting nlrp3 inflammasome and apoptosis via trpv1 / faf1 complex dissociation-mediated autophagy. |
2021-10-27 |
2023-08-13 |
Not clear |