| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chaoqun Feng, Ziang Hu, Min Zhao, Chuan Leng, Guangye Li, Fei Yang, Xiaohong Fa. Region-specific mitophagy in nucleus pulposus, annulus fibrosus, and cartilage endplate of intervertebral disc degeneration: mechanisms and therapeutic strategies. Frontiers in pharmacology. vol 16. 2025-04-18. PMID:40248091. |
in the nucleus pulposus (np), impaired mitochondria lead to apoptosis, oxidative stress, senescence, extracellular matrix degradation and synthesis, excessive autophagy, inflammation, mitochondrial instability, and pyroptosis, with key regulatory targets including ampk, pgc-1α, sirt1, sirt3, progerin, p65, mfn2, foxo3, ndufa4l2, slc39a7, itgα5/β1, nrf2, and nlrp3 inflammasome. |
2025-04-18 |
2025-04-20 |
Not clear |
| Hanlin Ding, Danyong Liu, Jianfeng He, Dongcheng Zhou, Chan Wang, Changming Yang, Zhongyuan Xi. The Role of the Sirt1/Foxo3a Pathway in Mitigating Myocardial Ischemia-Reperfusion Injury by Dexmedetomidine. Chemical biology & drug design. vol 105. issue 4. 2025-04-15. PMID:40230274. |
additionally, dex significantly reduced the expression of bcl-2-associated x protein/b-cell lymphoma 2 (bax/bcl-2), cleaved caspase-3, beclin-1, and microtubule-associated protein 1a/1b-light chain 3b (lc3b), inhibiting apoptosis and autophagy while increasing the expression of p62, sirt1, and foxo3a. |
2025-04-15 |
2025-04-17 |
mouse |
| Zhiyun Shu, Wenqing Zhang, Mengze Sun, Zixu Huyan, Shishun Xie, Hongyuan Cheng, Xiangjun L. Dehydrodiisoeugenol Alleviates Sodium Palmitate-Induced Mitochondrial Dysfunction and Activates Autophagy in VSMCs via the SIRT1/Nrf2 Axis. Cell biochemistry and function. vol 43. issue 4. 2025-04-15. PMID:40231935. |
bioinformatics and molecular docking studies identified key targets of deh in treating atherosclerosis (as), exploring its role in activating autophagy and inhibiting apoptosis through modulation of sirt1. |
2025-04-15 |
2025-04-17 |
Not clear |
| Zhiyun Shu, Wenqing Zhang, Mengze Sun, Zixu Huyan, Shishun Xie, Hongyuan Cheng, Xiangjun L. Dehydrodiisoeugenol Alleviates Sodium Palmitate-Induced Mitochondrial Dysfunction and Activates Autophagy in VSMCs via the SIRT1/Nrf2 Axis. Cell biochemistry and function. vol 43. issue 4. 2025-04-15. PMID:40231935. |
compared to deh administration alone, the combination of deh with sirt1 overexpression (oe) further enhanced the proliferation, migration and autophagy of vsmcs while inhibiting oxidative stress, mitochondrial dysfunction, and apoptosis. |
2025-04-15 |
2025-04-17 |
Not clear |
| Jing Wang, Yiqiong Yang, Yang Xu, Zhipeng Xu, Xiaozhi Zhao, Ruipeng Jia, Yutian Da. Correction to: Long noncoding RNA XIST inhibition promotes Leydig cell apoptosis by acting as a competing endogenous RNA for microRNA‑145a‑5p that targets SIRT1 in late‑onset hypogonadism. Cell and tissue research. 2025-04-03. PMID:40178571. |
correction to: long noncoding rna xist inhibition promotes leydig cell apoptosis by acting as a competing endogenous rna for microrna‑145a‑5p that targets sirt1 in late‑onset hypogonadism. |
2025-04-03 |
2025-04-04 |
Not clear |
| Weiming Wang, Gang Yuan, Guang Li, Tingting Zhao, Yue Chen, Youhua X. Cigarette smoking extract induces mitochondrial dysfunction and apoptosis in HUVECs via the Sirt1-SHH axis. Human & experimental toxicology. vol 44. 2025-04-02. PMID:40170556. |
atherosclerosis was evaluated by oil red o staining in apoe-ko mice after cigarette smoke exposure.resultscse decreased sirt1 and sonic hedgehog (shh) expression, leading to mitochondrial dysfunction and apoptosis in huvecs. |
2025-04-02 |
2025-04-04 |
mouse |
| Weiming Wang, Gang Yuan, Guang Li, Tingting Zhao, Yue Chen, Youhua X. Cigarette smoking extract induces mitochondrial dysfunction and apoptosis in HUVECs via the Sirt1-SHH axis. Human & experimental toxicology. vol 44. 2025-04-02. PMID:40170556. |
overexpressing sirt1 or activating the shh signaling pathway attenuated cse-induced apoptosis and mitochondrial dysfunction. |
2025-04-02 |
2025-04-04 |
mouse |
| Weiming Wang, Gang Yuan, Guang Li, Tingting Zhao, Yue Chen, Youhua X. Cigarette smoking extract induces mitochondrial dysfunction and apoptosis in HUVECs via the Sirt1-SHH axis. Human & experimental toxicology. vol 44. 2025-04-02. PMID:40170556. |
however, inhibiting the shh signaling axis attenuated the protective effect of sirt1 overexpression on cse-induced apoptosis and mitochondrial dysfunction. |
2025-04-02 |
2025-04-04 |
mouse |
| Weiming Wang, Gang Yuan, Guang Li, Tingting Zhao, Yue Chen, Youhua X. Cigarette smoking extract induces mitochondrial dysfunction and apoptosis in HUVECs via the Sirt1-SHH axis. Human & experimental toxicology. vol 44. 2025-04-02. PMID:40170556. |
this study confirms that cse can induce mitochondrial dysfunction and apoptosis of huvecs by reducing sirt1 expression and inhibiting shh signaling activation. |
2025-04-02 |
2025-04-04 |
mouse |
| Peiming Sang, Yanyan Ma, Xie Zhang, Binhui Chen, Fan He, Neng Shen, Jiangang Zha. BMAL1 attenuates intervertebral disc degeneration by activating the SIRT1/PGC-1α pathway: evidence from vitro studies. Scientific reports. vol 15. issue 1. 2025-03-21. PMID:40113885. |
the overexpression of bmal1 was achieved with the pcdna3.1, the expression of sirt1 and pgc-1α were increased, the inflammatory response, the ros, the level of apoptosis and senescence were decreased, however, the level of mitophagy, the activity and density of np cell were enhanced. |
2025-03-21 |
2025-03-23 |
Not clear |
| Yafen Chen, Shuyao Shan, Qiqi Xue, Yan Ren, Qihong Wu, Jiawei Chen, Ke Yang, Jiumei Ca. Sirtuin1 mitigates hypoxia-induced cardiomyocyte apoptosis in myocardial infarction via PHD3/HIF-1α. Molecular medicine (Cambridge, Mass.). vol 31. issue 1. 2025-03-15. PMID:40087582. |
sirtuin 1 (sirt1) has emerged as a key regulator of cell survival and apoptosis, particularly under hypoxic conditions. |
2025-03-15 |
2025-03-18 |
Not clear |
| Shasha Ye, Jingjing Lin, Yujie Zhang, Jiana Li, Yichen Wang, Fei Liang, Junyi Wu, Yifan Xu, Li Lin, Yeli Zha. RhFGF21 protects the skin from UVB irradiation in diabetic mice through the inhibition of epidermal cell apoptosis and macrophage-mediated inflammation via the SIRT1 signaling pathway. Biochimica et biophysica acta. Molecular basis of disease. vol 1871. issue 4. 2025-02-28. PMID:40020529. |
rhfgf21 protects the skin from uvb irradiation in diabetic mice through the inhibition of epidermal cell apoptosis and macrophage-mediated inflammation via the sirt1 signaling pathway. |
2025-02-28 |
2025-03-04 |
mouse |
| Fei Ran, Kailang Mu, Lingli Zhou, Leqiang Peng, Gang Liu, Yuchen Liu, Yuxin Pang, Guo Feng, Changmao Guo, Tianjian Wang, Qiumei Lu. Plant-Derived B-CGT Hydrogel Accelerates Diabetic Wound Healing Through Multitarget Modulation of Inflammation, Angiogenesis, and Tissue Remodeling. Gels (Basel, Switzerland). vol 11. issue 2. 2025-02-25. PMID:39996646. |
network pharmacology and molecular docking analyses suggest that b-cgt may regulate key mechanisms, such as apoptosis, inflammation, and matrix remodeling, through core targets including sirt1, casp8, and mmp8. |
2025-02-25 |
2025-02-27 |
mouse |
| Chon-Seng Hong, Nan-Chun Wu, Yu-Wen Lin, You-Cheng Lin, Jhih-Yuan Shih, Ko-Chi Niu, Mao-Tsun Lin, Ching-Ping Chang, Zhih-Cherng Chen, Wei-Chih Kan, Wei-Ting Chan. Hyperbaric oxygen therapy attenuated limb ischemia in mice with high-fat diet by restoring Sirtuin 1 and mitochondrial function. Free radical biology & medicine. 2025-02-16. PMID:39956474. |
this study explored the impact of hbo on angiogenesis and apoptosis in high-fat diet (hfd)-fed mice with limb ischemia, focusing on the role of sirtuin 1 (sirt1). |
2025-02-16 |
2025-02-23 |
mouse |
| Chon-Seng Hong, Nan-Chun Wu, Yu-Wen Lin, You-Cheng Lin, Jhih-Yuan Shih, Ko-Chi Niu, Mao-Tsun Lin, Ching-Ping Chang, Zhih-Cherng Chen, Wei-Chih Kan, Wei-Ting Chan. Hyperbaric oxygen therapy attenuated limb ischemia in mice with high-fat diet by restoring Sirtuin 1 and mitochondrial function. Free radical biology & medicine. 2025-02-16. PMID:39956474. |
collectively, these findings suggest that hbo enhances angiogenesis and reduces apoptosis in both in vivo and in vitro ischemia models, primarily through sirt1 activation. |
2025-02-16 |
2025-02-23 |
mouse |
| Ayaho Yamamoto, Peter D Sly, Lavrent Khachatryan, Nelufa Begum, Abrey J Yeo, Paul D Robinson, Stephania A Cormier, Emmanuelle Fantin. Astaxanthin protects against environmentally persistent free radical-induced oxidative stress in well-differentiated respiratory epithelium. Redox biology. vol 81. 2025-02-14. PMID:39952200. |
we found that epfr exposure induced mitochondrial reactive oxygen species (mtros) production; increased mitochondrial dna copy number; down-regulated mucus production gene, mucin-5ac (muc5ac); up-regulated detoxifying gene, cytochrome p450 1a1 (cyp1a1), nuclear factor erythroid 2-related factor 2 (nrf2)-regulated antioxidant pathways including sirtuin 1 (sirt1)-forkhead box o3 (foxo3), mitophagy, pten-induced kinase 1 (pink1), apoptosis, cyclin-dependent kinase inhibitor p21 (p21), and inflammation, c-c motif chemokine ligand 5 (ccl5). |
2025-02-14 |
2025-02-18 |
human |
| Shi-Tao Zhao, Zhi-Cong Qiu, Zhi-Qiang Xu, En-De Tao, Rong-Bin Qiu, Han-Zhi Peng, Lian-Fen Zhou, Rui-Yuan Zeng, Song-Qing Lai, Li Wa. Curcumin attenuates myocardial ischemia‑reperfusion‑induced autophagy‑dependent ferroptosis via Sirt1/AKT/FoxO3a signaling. International journal of molecular medicine. vol 55. issue 3. 2025-02-11. PMID:39930816. |
miri decreased silent information regulator 1 (sirt1), decreased akt and forkhead box o3a (foxo3a) phosphorylation, leading to foxo3a entry into the nucleus to activate translation of autophagy‑related genes and inducing ferroptosis, apoptosis and autophagy. |
2025-02-11 |
2025-02-13 |
rat |
| Shi-Tao Zhao, Zhi-Cong Qiu, Zhi-Qiang Xu, En-De Tao, Rong-Bin Qiu, Han-Zhi Peng, Lian-Fen Zhou, Rui-Yuan Zeng, Song-Qing Lai, Li Wa. Curcumin attenuates myocardial ischemia‑reperfusion‑induced autophagy‑dependent ferroptosis via Sirt1/AKT/FoxO3a signaling. International journal of molecular medicine. vol 55. issue 3. 2025-02-11. PMID:39930816. |
however, cur pretreatment activated akt and foxo3a phosphorylation via sirt1, thereby transporting foxo3a out of the nucleus, reducing autophagy‑related gene translation and attenuating miri‑induced ferroptosis, apoptosis and autophagy. |
2025-02-11 |
2025-02-13 |
rat |
| Jing Zhu, Youming Guo, Lingling Luo, Xin Huang, Tianqi Wei, Baiyi Zuo, Guanying Liu, Wenbo Bu, Chengrang L. Sirtuin1 Deficiency Could Exacerbate Melanocyte Apoptosis Under Endoplasmic Reticulum Stress. Inflammation. 2025-02-08. PMID:39921788. |
thus, we explored how sirt1 modulates er stress-induced melanocyte apoptosis in vitro and in vivo. |
2025-02-08 |
2025-02-11 |
mouse |
| Jing Zhu, Youming Guo, Lingling Luo, Xin Huang, Tianqi Wei, Baiyi Zuo, Guanying Liu, Wenbo Bu, Chengrang L. Sirtuin1 Deficiency Could Exacerbate Melanocyte Apoptosis Under Endoplasmic Reticulum Stress. Inflammation. 2025-02-08. PMID:39921788. |
our results showed that sirt1 affected er stress-induced apoptosis of melanocyte apoptosis when upon to er stress in vitro. |
2025-02-08 |
2025-02-11 |
mouse |