| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yunguang Wang, Xinxin He, Hua Zhang, Wei H. Germacrone ameliorates acute lung injury induced by intestinal ischemia-reperfusion by regulating macrophage M1 polarization and mitochondrial defects. Acta biochimica et biophysica Sinica. 2024-10-23. PMID:39439416. |
additionally, ger (ec50: 47.16 μm) ameliorates mitochondrial dysfunction by increasing i/r-ali-induced apoptosis, increasing the expression of sirt1, and reducing the levels of hif1-α, nrf2, and ogg1 in mle-12 cells. |
2024-10-23 |
2024-10-25 |
mouse |
| Yi-Cheng Tsai, Chih-Hui Chang, Yoon Bin Chong, Chieh-Hsin Wu, Hung-Pei Tsai, Tian-Lu Cheng, Chih-Lung Li. MicroRNA-195-5p Inhibits Intracerebral Hemorrhage-Induced Inflammatory Response and Neuron Cell Apoptosis. International journal of molecular sciences. vol 25. issue 19. 2024-10-16. PMID:39408651. |
the mir-195-5p treatment significantly improved neurological function; modulated macrophage polarization by promoting anti-inflammatory marker (cd206 and arg1) production and inhibiting pro-inflammatory marker (cd68 and inos) production; enhanced akt signalling, reduced oxidative stress by increasing sirt1 and nrf2 levels, and attenuated inflammation by decreasing nf-κb activation; inhibited apoptosis via increased bcl-2 and decreased cleaved caspase-3 levels; and regulated synaptic plasticity by modulating nmdar2a, nmdar2b, bdnf, and trkb expression and erk and creb phosphorylation. |
2024-10-16 |
2024-10-18 |
rat |
| Zhang Yaoting, Li Bing, Fu Yu, Cai He, Zheng Yan. Txnip promotes autophagic apoptosis in diabetic cardiomyopathy by upregulating FoxO1 and its acetylation. Cellular signalling. 2024-10-13. PMID:39396562. |
these findings revealed that txnip mediates autophagic apoptosis in dcm by upregulating foxo1 via ros and enhancing foxo1 acetylation through the suppression of sirt1 activity. |
2024-10-13 |
2024-10-16 |
mouse |
| Jie Qiao, Chang Cheng, Gongxu Yang, Chuanqi Zhong, Jun Jin, Bin W. Jiangu Recipe Suppresses ER Stress-Induced Apoptosis and Inhibits Extracellular Matrix Degradation in Chondrocytes through Upregulating SIRT1 Expression. Current pharmaceutical biotechnology. 2024-10-08. PMID:39377404. |
jiangu recipe suppresses er stress-induced apoptosis and inhibits extracellular matrix degradation in chondrocytes through upregulating sirt1 expression. |
2024-10-08 |
2024-10-10 |
Not clear |
| Xiaolei Zhang, Shizhen Wang, Yongting Qin, Hang Gu. Downregulation of microRNA‑221‑3p promotes angiogenesis of lipoprotein(a)‑injured endothelial progenitor cells by targeting silent information regulator 1 to activate the RAF/MEK/ERK signaling pathway. Molecular medicine reports. vol 30. issue 6. 2024-10-04. PMID:39364751. |
in conclusion, mir‑221‑3p inhibitor transfection activated the raf/mek/erk signaling pathway through sirt1, promoted the proliferation, migration, adhesion and angiogenesis of epcs, and reduced apoptosis. |
2024-10-04 |
2024-10-07 |
Not clear |
| Zhongqi Wu, Tianxin Lyu, Leizhen Wu, Hui Yang, Wenqiang L. The Role of SIRT1 in Leukemia. Current treatment options in oncology. 2024-10-02. PMID:39356446. |
recent studies have shown that silent information regulator 1 (sirt1) is involved in the proliferation, apoptosis, metabolism, and senescence of leukemia cells. |
2024-10-02 |
2024-10-04 |
Not clear |
| Samyah T Alanazi, Samir A Salama, Musaad M Althobaiti, Rana A Alotaibi, Ammar A AlAbdullatif, Arafa Musa, Gamaleldin I Haris. Alleviation of Copper-Induced Hepatotoxicity by Bergenin: Diminution of Oxidative Stress, Inflammation, and Apoptosis via Targeting SIRT1/FOXO3a/NF-κB Axes and p38 MAPK Signaling. Biological trace element research. 2024-09-30. PMID:39347884. |
collectively, these findings highlight the alleviating activity of bergenin against the copper-induced hepatotoxicity via controlling oxidative stress, inflammation, and apoptosis potentially through upregulation of sirt1, activation of foxo3a along with suppression of nf-κb and p38 mapk signaling. |
2024-09-30 |
2024-10-02 |
rat |
| Xiaoli Yang, Lixin Han, Di Zhang, Cuixiang Xu, Zhankui Jin, Yongmin Xion. Downregulated Expression and Hypermethylation of SIRT1 in Patients with Kashin-Beck Disease-Mediated Chondrocyte Apoptosis May Potentially Be Ameliorated by Selenium Supplement. Biological trace element research. 2024-09-23. PMID:39312125. |
downregulated expression and hypermethylation of sirt1 in patients with kashin-beck disease-mediated chondrocyte apoptosis may potentially be ameliorated by selenium supplement. |
2024-09-23 |
2024-09-26 |
Not clear |
| Xiaoli Yang, Lixin Han, Di Zhang, Cuixiang Xu, Zhankui Jin, Yongmin Xion. Downregulated Expression and Hypermethylation of SIRT1 in Patients with Kashin-Beck Disease-Mediated Chondrocyte Apoptosis May Potentially Be Ameliorated by Selenium Supplement. Biological trace element research. 2024-09-23. PMID:39312125. |
this study aims to elucidate the role of silent information regulator 2 homologue 1 (sirt1) in cartilage damage in kashin-beck disease (kbd) by exploring the correlation between sirt1 and kbd and the potential effect of sirt1 expression and methylation on chondrocyte apoptosis. |
2024-09-23 |
2024-09-26 |
Not clear |
| Xiaoli Yang, Lixin Han, Di Zhang, Cuixiang Xu, Zhankui Jin, Yongmin Xion. Downregulated Expression and Hypermethylation of SIRT1 in Patients with Kashin-Beck Disease-Mediated Chondrocyte Apoptosis May Potentially Be Ameliorated by Selenium Supplement. Biological trace element research. 2024-09-23. PMID:39312125. |
furthermore, apoptosis rates, dnmt1 mrna level, and sirt1 methylation level were increased in chondrocytes treated with se deficiency and t-2 toxin, but sirt1 mrna level was downregulated, whereas the opposite trend was observed in chondrocytes treated with se supplement. |
2024-09-23 |
2024-09-26 |
Not clear |
| Xiaoli Yang, Lixin Han, Di Zhang, Cuixiang Xu, Zhankui Jin, Yongmin Xion. Downregulated Expression and Hypermethylation of SIRT1 in Patients with Kashin-Beck Disease-Mediated Chondrocyte Apoptosis May Potentially Be Ameliorated by Selenium Supplement. Biological trace element research. 2024-09-23. PMID:39312125. |
low sirt1 expression and cpg hypermethylation in kbd patients are associated with increased disease risk, which mediated chondrocyte apoptosis can be ameliorated by se supplement. |
2024-09-23 |
2024-09-26 |
Not clear |
| Zhihang Zhang, Yalan Luo, Xijing Zhuang, Haifeng Gao, Qi Yang, Hailong Che. Emodin alleviates lung injury via the miR-217-5p/Sirt1 axis in rats with severe acute pancreatitis. Journal of pharmacological sciences. vol 156. issue 3. 2024-09-23. PMID:39313277. |
in conclusion, mir-217-5p inhibition exerts protective effects on sap-ali in vitro and in vivo by repressing apoptosis, inflammation, and oxidative stress through sirt1 activation. |
2024-09-23 |
2024-09-26 |
rat |
| Papitcha Jongwachirachai, Waralee Ruankham, Setthawut Apiraksattayakul, Saruta Intharakham, Veda Prachayasittikul, Wilasinee Suwanjang, Virapong Prachayasittikul, Supaluk Prachayasittikul, Kamonrat Phopi. Neuroprotective Properties of Coriander-Derived Compounds on Neuronal Cell Damage under Oxidative Stress-Induced SH-SY5Y Neuroblastoma and in Silico ADMET Analysis. Neurochemical research. 2024-09-19. PMID:39298035. |
the results showed that linalool, linalyl acetate, and geranyl acetate elicited their neuroprotection against oxidative stress via protecting cell death, reducing ros production, preventing cell apoptosis, and modulating sirt1 longevity. |
2024-09-19 |
2024-09-22 |
Not clear |
| Xiang Qin, Xi Chen, Fan Wang, Fangfang Zhong, Yan Zeng, Wenjun Li. Huaier inhibits autophagy and promotes apoptosis in T-cell acute lymphoblastic leukemia by down-regulating SIRT1. Heliyon. vol 10. issue 17. 2024-09-17. PMID:39286166. |
huaier inhibits autophagy and promotes apoptosis in t-cell acute lymphoblastic leukemia by down-regulating sirt1. |
2024-09-17 |
2024-09-19 |
Not clear |
| Suleiman Ibrahim Shelash Mohammad, Asokan Vasudevan, Felix Oghenemaro Enwa, Jaya Bansal, Mamata Chahar, Mamdouh Eldesoqui, Muhammad Ikram Ullah, Zhanna R Gardanova, Hanen Mahmod Hulail, Ahmed Hussein Zwame. The Sirt1/Nrf2 pathway is a key factor for drug therapy in chemotherapy-induced cardiotoxicity: a Mini-Review. Medical oncology (Northwood, London, England). vol 41. issue 10. 2024-09-11. PMID:39259412. |
reports suggest that the sirtuin-1 (sirt1)/nuclear factor e2-associated factor 2 (nrf2) signaling pathway has been considered an alternative path for counteracting cardiotoxicity by suppressing oxidative stress, inflammation, and apoptosis. |
2024-09-11 |
2024-09-13 |
Not clear |
| Mengru Ma, Lian Yi, Yifei Pei, Qimin Zhang, Chao Tong, Manyu Zhao, Yuanhong Chen, Jinghan Zhu, Wanguang Zhang, Fan Yao, Pengyuan Yang, Peijing Zhan. USP26 as a hepatitis B virus-induced deubiquitinase primes hepatocellular carcinogenesis by epigenetic remodeling. Nature communications. vol 15. issue 1. 2024-09-09. PMID:39251623. |
hbx consequently promotes the association of usp26 with sirt1 to synergistically stabilize sirt1 by deubiquitination, which promotes cell proliferation and impedes cell apoptosis to accelerate hcc tumorigenesis. |
2024-09-09 |
2024-09-13 |
human |
| Yaping Zhao, Li Wang, Yu Huang, Paul C Evans, Peter J Little, Xiaoyu Tian, Jianping Weng, Suowen X. Anthocyanins in Vascular Health and Disease: Mechanisms of Action and Therapeutic Potential. Journal of cardiovascular pharmacology. vol 84. issue 3. 2024-09-06. PMID:39240726. |
at the cellular and molecular level, anthocyanins and their metabolites could protect endothelial cells from senescence, apoptosis, and inflammation by activating the phosphoinositide 3-kinase/protein kinase b/endothelial nitric oxide synthases, silent information regulator 1 (sirt1), or nuclear factor erythroid2-related factor 2 pathways and inhibiting the nuclear factor kappa b, bax, or p38 mitogen-activated protein kinase pathways. |
2024-09-06 |
2024-09-09 |
Not clear |
| Jiawei Chen, Kebin Chen, Shuai Zhang, Xiaopeng Huan. SIRT1 silencing ameliorates malignancy of non-small cell lung cancer via activating FOXO1. Scientific reports. vol 14. issue 1. 2024-08-29. PMID:39198693. |
the depletion of sirt1 retarded the capabilities of proliferation, migration and invasion, while enhancing apoptosis in nsclc cells. |
2024-08-29 |
2024-09-01 |
human |
| Swapnil Tripathi, Dharati Parmar, Samir Raval, Rajeev Mishra, Gyanendra Sing. Attenuation of chromium (VI) and arsenic (III)-induced oxidative stress and hepatic apoptosis by phloretin, biochanin-A, and coenzyme Q10 via activation of SIRT1/Nrf2/HO-1/NQO1 signaling. Journal of biochemical and molecular toxicology. vol 38. issue 9. 2024-08-23. PMID:39177155. |
importantly, the treatment with nutraceuticals not only restored the antioxidant activity but also favorably altered the expressions of sirt1, nrf2, ho-1, and nqo1 signaling and apoptosis markers. |
2024-08-23 |
2024-08-25 |
mouse |
| Swapnil Tripathi, Dharati Parmar, Samir Raval, Rajeev Mishra, Gyanendra Sing. Attenuation of chromium (VI) and arsenic (III)-induced oxidative stress and hepatic apoptosis by phloretin, biochanin-A, and coenzyme Q10 via activation of SIRT1/Nrf2/HO-1/NQO1 signaling. Journal of biochemical and molecular toxicology. vol 38. issue 9. 2024-08-23. PMID:39177155. |
by averting the triggered apoptosis in conjunction with oxidative stress, this combination increases the sirt1, nrf2, ho-1, and nqo1 signaling, thereby reassuringly maintaining the cellular equilibrium. |
2024-08-23 |
2024-08-25 |
mouse |