| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hai Wang, Zhongming Huang, Xin Zhao, Boda Guo, Zhigang J. miR-4270 regulates cell proliferation and apoptosis in patients with Sertoli cell-only syndrome by targeting GADD45A and inactivating the NOTCH signaling pathway. American journal of translational research. vol 12. issue 9. 2020-10-13. PMID:33042452. |
elisa and flow cytometry assays indicated that mir-4270 knockdown prominently suppressed the apoptosis of human sc and tm4 cells. |
2020-10-13 |
2023-08-13 |
human |
| Hai Wang, Zhongming Huang, Xin Zhao, Boda Guo, Zhigang J. miR-4270 regulates cell proliferation and apoptosis in patients with Sertoli cell-only syndrome by targeting GADD45A and inactivating the NOTCH signaling pathway. American journal of translational research. vol 12. issue 9. 2020-10-13. PMID:33042452. |
taken together, our data demonstrated that mir-4270 regulates proliferation and apoptosis in sc of scos patients by inactivating notch signaling pathway via gadd45a gene, which may offer a new insight into the development of human sc and provide a promising biomarker for the treatment of scos. |
2020-10-13 |
2023-08-13 |
human |
| Shanika Karunasagara, Geum-Lan Hong, Da-Young Jung, Kyung-Hyun Kim, Kyoungwon Cho, Ju-Young Jun. Protective effects of combination of Stauntonia hexaphylla and Cornus officinalis on testosterone-induced benign prostatic hyperplasia through inhibition of 5α- reductase type 2 and induced cell apoptosis. PloS one. vol 15. issue 8. 2020-10-02. PMID:32790676. |
furthermore, sc treatment significantly decreased the bcl-2/bax ratio, indicating induced prostate cell apoptosis in tp-induced bph rats. |
2020-10-02 |
2023-08-13 |
human |
| Shanika Karunasagara, Geum-Lan Hong, Da-Young Jung, Kyung-Hyun Kim, Kyoungwon Cho, Ju-Young Jun. Protective effects of combination of Stauntonia hexaphylla and Cornus officinalis on testosterone-induced benign prostatic hyperplasia through inhibition of 5α- reductase type 2 and induced cell apoptosis. PloS one. vol 15. issue 8. 2020-10-02. PMID:32790676. |
thus, our findings demonstrated that sc extract protects against bph by inhibiting 5α-reductase type 2 and inducing prostate cell apoptosis. |
2020-10-02 |
2023-08-13 |
human |
| Kuan-Hung Chen, Chih-Hung Chen, Christopher Glenn Wallace, Yen-Ta Chen, Chih-Chao Yang, Pei-Hsun Sung, Hsin-Ju Chiang, Yi-Ling Chen, Sarah Chua, Hon-Kan Yip, Jiin-Tsuey Chen. Combined therapy with melatonin and exendin-4 effectively attenuated the deterioration of renal function in rat cardiorenal syndrome. American journal of translational research. vol 9. issue 2. 2020-10-01. PMID:28337255. |
the kidney protein expressions of inflammation (tnf-α/nf-κb/mmp-9/inos/rantes), oxidative stress (nox-1/nox-2/nox-4/oxidized protein), apoptosis (cleaved caspase-3/cleaved parp/bax), dna-damaged marker (γ-h2ax) and fibrosis (p-mad3/tfg-β) showed identical patterns of creatinine level, whereas kidney protein expressions of glp-1r showed a progressive increase from sc to crs-mel-ex4 (all p<0.0001). |
2020-10-01 |
2023-08-13 |
rat |
| Yuting Li, Yuhua Sun, Min Cai, Huanhuan Zhang, Nannan Gao, Huiwei Huang, Shusen Cui, Dengbing Ya. Fas Ligand Gene (Faslg) Plays an Important Role in Nerve Degeneration and Regeneration After Rat Sciatic Nerve Injury. Frontiers in molecular neuroscience. vol 11. 2020-10-01. PMID:29970988. |
silencing or overexpression of faslg affected sc proliferation, migration, and apoptosis through β-catenin, nuclear factor-κb (nf-κb), and caspase-3 pathways |
2020-10-01 |
2023-08-13 |
rat |
| Xiang Lu Ji, Ming H. Sodium cantharidate targets STAT3 and abrogates EGFR inhibitor resistance in osteosarcoma. Aging. vol 11. issue 15. 2020-08-19. PMID:31422383. |
we found that sc repressed cell viability and migration and induced apoptosis in vitro, while combined sc and erlotinib treatment enhanced osteosarcoma growth suppression by preventing feedback activation of stat3. |
2020-08-19 |
2023-08-13 |
mouse |
| Wen Li, Yonghan He, Rongping Zhang, Guangrong Zheng, Daohong Zho. The curcumin analog EF24 is a novel senolytic agent. Aging. vol 11. issue 2. 2020-04-03. PMID:30694217. |
mechanistically, ef24 selectively kills scs by inducing sc apoptosis in a reactive oxygen species (ros) production independent manner but associated with an increase in the proteasome degradation of the bcl-2 anti-apoptotic protein family proteins known to play an important role in protecting scs from apoptosis. |
2020-04-03 |
2023-08-13 |
Not clear |
| Jung Lim Kim, Seong Hye Park, Soyeon Jeong, Bo Ram Kim, Yoo Jin Na, Min Jee Jo, Yoon A Jeong, Hye Kyeong Yun, Dae Yeong Kim, Bu Gyeom Kim, SangGuan You, Sang Cheul Oh, Dae-Hee Le. Sea Cucumber ( Nutrients. vol 11. issue 5. 2019-11-28. PMID:31083595. |
sc fractions and trail alone did not affect apoptosis; however, combined treatment dramatically induced the apoptosis of crc cells, but not of normal colon cells. |
2019-11-28 |
2023-08-13 |
Not clear |
| Jung Lim Kim, Seong Hye Park, Soyeon Jeong, Bo Ram Kim, Yoo Jin Na, Min Jee Jo, Yoon A Jeong, Hye Kyeong Yun, Dae Yeong Kim, Bu Gyeom Kim, SangGuan You, Sang Cheul Oh, Dae-Hee Le. Sea Cucumber ( Nutrients. vol 11. issue 5. 2019-11-28. PMID:31083595. |
altogether, our results demonstrate that the sc f2 fraction may sensitize crc cells to trail-induced apoptosis through xiap ubiquitination and er stress. |
2019-11-28 |
2023-08-13 |
Not clear |
| Jiao Jiao Zhang, Xian Zhong Wang, Huynh Luong Do, Nisansala Chandimali, Tae Yoon Kang, Nameun Kim, Mrinmoy Ghosh, Sang Baek Lee, Young Sun Mok, Seong Bong Kim, Taeho Kwon, Dong Kee Jeon. MicroRNA-7450 regulates non-thermal plasma-induced chicken Sertoli cell apoptosis via adenosine monophosphate-activated protein kinase activation. Scientific reports. vol 8. issue 1. 2019-10-22. PMID:29884805. |
results showed that plasma treatment increased sc apoptosis in a time- and dose-dependent manner. |
2019-10-22 |
2023-08-13 |
chicken |
| Jiao Jiao Zhang, Xian Zhong Wang, Huynh Luong Do, Nisansala Chandimali, Tae Yoon Kang, Nameun Kim, Mrinmoy Ghosh, Sang Baek Lee, Young Sun Mok, Seong Bong Kim, Taeho Kwon, Dong Kee Jeon. MicroRNA-7450 regulates non-thermal plasma-induced chicken Sertoli cell apoptosis via adenosine monophosphate-activated protein kinase activation. Scientific reports. vol 8. issue 1. 2019-10-22. PMID:29884805. |
plasma-induced sc apoptosis possibly resulted from the excess production of reactive oxygen species via the suppression of antioxidant defense systems and decreased cellular energy metabolism through the inhibition of adenosine triphosphate (atp) release and respiratory enzyme activity in the mitochondria. |
2019-10-22 |
2023-08-13 |
chicken |
| Jiao Jiao Zhang, Xian Zhong Wang, Huynh Luong Do, Nisansala Chandimali, Tae Yoon Kang, Nameun Kim, Mrinmoy Ghosh, Sang Baek Lee, Young Sun Mok, Seong Bong Kim, Taeho Kwon, Dong Kee Jeon. MicroRNA-7450 regulates non-thermal plasma-induced chicken Sertoli cell apoptosis via adenosine monophosphate-activated protein kinase activation. Scientific reports. vol 8. issue 1. 2019-10-22. PMID:29884805. |
our findings suggest that mir-7450 is involved in the regulation of plasma-induced sc apoptosis through the activation of ampkα and the further inhibition of mtor signaling pathway. |
2019-10-22 |
2023-08-13 |
chicken |
| Huanhuan Zhang, Zhiwei Shao, Yun Zhu, Lingyu Shi, Zhihao Li, Rui Hou, Chunwang Zhang, Dengbing Ya. Toll-Like Receptor 4 (TLR4) Expression Affects Schwann Cell Behavior in vitro. Scientific reports. vol 8. issue 1. 2019-10-21. PMID:30046125. |
enhanced or silenced expression of tlr4 affected sc proliferation, migration, apoptosis and relative gene expression. |
2019-10-21 |
2023-08-13 |
rat |
| Oluwaseun Adebayo Bamodu, Kuang-Tai Kuo, Li-Ping Yuan, Wei-Hong Cheng, Wei-Hwa Lee, Yuan-Soon Ho, Tsu-Yi Chao, Chi-Tai Ye. HDAC inhibitor suppresses proliferation and tumorigenicity of drug-resistant chronic myeloid leukemia stem cells through regulation of hsa-miR-196a targeting BCR/ABL1. Experimental cell research. vol 370. issue 2. 2019-09-30. PMID:30017934. |
this hsa-mir-196a-mediated sc-limiting effect of saha is dose-dependent, low-dosed, cell cycle-modulating and accompanied by leukemic sc apoptosis. |
2019-09-30 |
2023-08-13 |
mouse |
| Hamid Sattar, Jie Yang, Xia Zhao, Jingzeng Cai, Qi Liu, Muhammad Ishfaq, Zijiang Yang, Menghao Chen, Ziwei Zhang, Shiwen X. Selenoprotein-U (SelU) knockdown triggers autophagy through PI3K-Akt-mTOR pathway inhibition in rooster Sertoli cells. Metallomics : integrated biometal science. vol 10. issue 7. 2019-08-16. PMID:29961786. |
to investigate the role of selu in testis autophagic and/or apoptosis cell death mechanisms, we established a sertoli cell (sc) model isolated from 45 day old layer roosters. |
2019-08-16 |
2023-08-13 |
chicken |
| Mansi Shukla, Nirmalya Ganguli, Souvik Sen Sharma, Subeer S Majumda. Sertoli cell specific decline in NOR-1 leads to germ cell apoptosis and reduced fertility. Journal of cellular biochemistry. vol 119. issue 8. 2019-05-16. PMID:29363789. |
this disruption of sc maturation resulted in gc apoptosis. |
2019-05-16 |
2023-08-13 |
mouse |
| Xinyu Hu, Shanshan Teng, Jiawei He, Xiaoqi Sun, Mingzhao Du, Ling Kou, Xiaofeng Wan. Pharmacological basis for application of scutellarin in Alzheimer's disease: Antioxidation and antiapoptosis. Molecular medicine reports. vol 18. issue 5. 2019-01-29. PMID:30221730. |
the protective effects of sc on ad were investigated using an l‑glutamic acid (l‑glu)‑damaged ht22 cell apoptosis model and an aluminum chloride plus d‑galactose‑induced ad mouse model. |
2019-01-29 |
2023-08-13 |
mouse |
| Xinyu Hu, Shanshan Teng, Jiawei He, Xiaoqi Sun, Mingzhao Du, Ling Kou, Xiaofeng Wan. Pharmacological basis for application of scutellarin in Alzheimer's disease: Antioxidation and antiapoptosis. Molecular medicine reports. vol 18. issue 5. 2019-01-29. PMID:30221730. |
in l‑glu‑damaged ht22 cells, sc significantly increased cell viability, inhibited lactate dehydrogenase release, reduced caspase‑3 activity and suppressed apoptosis, which were determined via an mtt assay, an in vitro toxicology assay kit, a caspase‑3 activity assay kit, and propidium iodide and annexin v staining. |
2019-01-29 |
2023-08-13 |
mouse |
| Houlei Wang, Jingping Wu, Xinchao Zhang, Lei Ding, Qingmin Zen. Microarray analysis of the expression profile of lncRNAs reveals the key role of lncRNA BC088327 as an agonist to heregulin‑1β‑induced cell proliferation in peripheral nerve injury. International journal of molecular medicine. vol 41. issue 6. 2018-09-10. PMID:29568963. |
according to these findings, the role of bc088327 in peripheral nerve injury was further assessed by detecting the cell viability, cell cycle and apoptosis in a hypoxic sc cell model after suppressing the expression of bc088327 using specific small interfering rna. |
2018-09-10 |
2023-08-13 |
rat |