All Relations between apoptosis and p53

Publication Sentence Publish Date Extraction Date Species
Yafei Duan, Yukai Yang, Hua Li, Zhe Zhang, Xiaoying Chen, Meng Xiao, Yuxiu Na. The toxic effects of tetracycline exposure on the physiological homeostasis of the gut-liver axis in grouper. Environmental research. 2024-06-12. PMID:38866314. further, intestinal health was also affected, including the damaged intestinal mucosa, the decreased mrna expression levels of tight junction proteins (zo-1, occludin, and claudin-3), along with the increased gene expression levels of inflammation (il-1β, il-8, tnf-α) and apoptosis (casp-3 and p53). 2024-06-12 2024-06-15 Not clear
Aswathi R K, Suresh Arumugam, Natrajan Muninathan, Kuppusamy Baskar, Deepthi S, Dinesh Roy . P53 Gene as a Promising Biomarker and Potential Target for the Early Diagnosis of Reproductive Cancers. Cureus. vol 16. issue 5. 2024-06-12. PMID:38864057. p53 is a key tumor suppressor that recognizes the carcinogenic biological pathways and eradicates them by apoptosis. 2024-06-12 2024-06-14 Not clear
Oleg A Kuchur, Sofya S Pogodaeva, Anna V Shcherbakova, Segrey A Tsymba. Atox1-cyclin D1 loop activity is critical for survival of tumor cells with inactivated TP53. Bioscience reports. vol 44. issue 6. 2024-06-11. PMID:38813981. the p53 protein plays an important role in regulating processes such as apoptosis, repair, and cell division, and the loss of its functionality often accompanies various types of tumors and contributes to the development of chemoresistance. 2024-06-11 2024-06-14 Not clear
Zeling Du, Meiqi Lin, Qiaohua Li, Dan Guo, Yanna Xue, Wei Liu, Hong Shi, Taiping Chen, Jiameng Da. The totipotent 2C-like state safeguards genomic stability of mouse embryonic stem cells. Journal of cellular physiology. 2024-06-11. PMID:38860420. unexpectedly, p53 deficiency results in defective response to dna damage, leading to early accumulation of dna damage, micronuclei, indicative of genomic instability, cell apoptosis, and reduced self-renewal capacity of escs when devoid of 2clcs in cultures. 2024-06-11 2024-06-14 mouse
Fazeleh Ranjbar-Niavol, Niloufar Rezaei, Ying Zhao, Hamed Mirzaei, Moustapha Hassan, Massoud Vosoug. P53/NANOG balance; the leading switch between poorly to well differentiated status in liver cancer cells. Frontiers in oncology. vol 14. 2024-06-08. PMID:38846985. enforcing a well-differentiated state on cells requires tumor suppressor p53 activation as a key player in apoptosis induction and well differentiation. 2024-06-08 2024-06-10 Not clear
Xiangying Zhang, Ling Xu, Zihao Fan, Yao Gao, Yuan Tian, Yaling Cao, Dexi Chen, Feng Re. Enhancing ASPP2 promotes acute liver injury via an inflammatory immunoregulatory mechanism. Frontiers in immunology. vol 15. 2024-06-06. PMID:38840923. apoptosis stimulating protein of p53-2 (aspp2) is a proapoptotic member of the p53 binding protein family. 2024-06-06 2024-06-08 Not clear
Lei Chen, Fengju Duan, Fangfang Ge, Lu Tian, Yuanyuan Li, Ying Li, Qing Zhu, Qiong Zhou, Hong Li. Inhibitor of apoptosis stimulating protein of p53 protects against MPP Metabolic brain disease. 2024-06-06. PMID:38842662. inhibitor of apoptosis stimulating protein of p53 protects against mpp inhibitor of apoptosis stimulating protein of p53 (iaspp) is related to the pathogenesis of several neurological disorders by affecting the oxidative stress and survival of neurons. 2024-06-06 2024-06-08 Not clear
Yong-Kyu Lee, Hyeon Ho Heo, Nackhyoung Kim, Ui-Hyun Park, Hyesook Youn, Eun-Yi Moon, Eun-Joo Kim, Soo-Jong U. Tumor antigen PRAME is a potential therapeutic target of p53 activation in melanoma cells. BMB reports. 2024-06-05. PMID:38835116. the tumor suppressor p53 is a transcriptional regulator that mediates cell cycle arrest and apoptosis in response to stress signals. 2024-06-05 2024-06-07 human
Hyeon Jin Kim, Mi Suk Jeong, Se Bok Jan. Identification and structure of AIMP2-DX2 for therapeutic perspectives. BMB reports. 2024-06-05. PMID:38835119. in response to dna damage, a component of aimp2 separates from the multi-trna synthetase complex, binds to p53, and prevents its degradation by mdm2, inducing apoptosis. 2024-06-05 2024-06-07 Not clear
Qiuyue Jin, Xiaohui Zhou, Xiaomin Niu, Canqi Ping, Xiaozhou Dong, Danyu Duan, Rongrong Wang, Yi Chen, Fei Pan, Fan Yang, Xihua Yang, Guoshun Zhang, Ruili Wang, Shuqiu Zhang, Guolian Re. Co-delivery of doxorubicin-dihydroartemisinin prodrug/TEPP-46 nano-liposomes for improving antitumor and decreasing cardiotoxicity in B16-F10 tumor-bearing mice. Colloids and surfaces. B, Biointerfaces. vol 241. 2024-06-04. PMID:38833960. the presence of tepp-46 increased the content of p53 protein, which further induced tumor cell apoptosis. 2024-06-04 2024-06-07 mouse
Micheline Kirsch-Volders, Miroslav Mišík, Jacques de Gerlach. Tetraploidy as a metastable state towards malignant cell transformation within a systemic approach of cancer development. Mutation research. Genetic toxicology and environmental mutagenesis. vol 896. 2024-05-31. PMID:38821671. the available data shows that stress-induced tetraploidisation/polyploidisation leads to p53 stabilisation, cell cycle arrest, followed by cellular senescence or apoptosis, suppressing the proliferation of tetraploid cells. 2024-05-31 2024-06-02 Not clear
Feng-Ling Zhou, Bin Yuan, Yi-Xian Ye, Shu-Ye Deng, Jing Ma, Hong Liu, Yuan-Zheng Ma, Yan-Fei We. [Effects of plumbagin on proliferation and apoptosis of human hepatocellular carcinoma cells based on CKB/p53 signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 9. 2024-05-30. PMID:38812135. in conclusion, plumbagin significantly inhibited the proliferative ability of huh-7 cells, and the mechanism may be related to the inhibition of ckb expression, activation of the p53 signaling pathway, and regulation of the expression of mitochondrial-associated apoptotic proteins, ultimately inducing cell apoptosis. 2024-05-30 2024-06-08 mouse
Zihuan Wang, Xu Zhang, Yuchen Luo, Yijiang Song, Cheng Xiang, Yilin He, Kejin Wang, Yingnan Yu, Zhen Wang, Wenxuan Peng, Yi Ding, Side Liu, Changjie W. Therapeutic targeting of ARID1A-deficient cancer cells with RITA (Reactivating p53 and inducing tumor apoptosis). Cell death & disease. vol 15. issue 5. 2024-05-29. PMID:38811536. therapeutic targeting of arid1a-deficient cancer cells with rita (reactivating p53 and inducing tumor apoptosis). 2024-05-29 2024-06-02 Not clear
Zihuan Wang, Xu Zhang, Yuchen Luo, Yijiang Song, Cheng Xiang, Yilin He, Kejin Wang, Yingnan Yu, Zhen Wang, Wenxuan Peng, Yi Ding, Side Liu, Changjie W. Therapeutic targeting of ARID1A-deficient cancer cells with RITA (Reactivating p53 and inducing tumor apoptosis). Cell death & disease. vol 15. issue 5. 2024-05-29. PMID:38811536. in this study, we observed that arid1a-deficient colorectal cancer (crc) cells showed synthetic lethal effects with a p53 activator, rita (reactivating p53 and inducing tumor apoptosis). 2024-05-29 2024-06-02 Not clear
Zihuan Wang, Xu Zhang, Yuchen Luo, Yijiang Song, Cheng Xiang, Yilin He, Kejin Wang, Yingnan Yu, Zhen Wang, Wenxuan Peng, Yi Ding, Side Liu, Changjie W. Therapeutic targeting of ARID1A-deficient cancer cells with RITA (Reactivating p53 and inducing tumor apoptosis). Cell death & disease. vol 15. issue 5. 2024-05-29. PMID:38811536. arid1a loss exhibits an opposing effect on p53 targets, leading to decreased p21 expression and increased levels of proapoptotic genes, puma and noxa, which is further potentiated by rita treatment, ultimately inducing cell apoptosis. 2024-05-29 2024-06-02 Not clear
b' Mohammad Mijanur Rahman, Huixin Wu, Trygve O Tollefsbo. A novel combinatorial approach using\xa0sulforaphane- and withaferin A-rich extracts for prevention of estrogen receptor-negative breast cancer through epigenetic and gut microbial mechanisms. Scientific reports. vol 14. issue 1. 2024-05-27. PMID:38802425.' at the molecular level, the bsp and ash combination upregulated tumor suppressors (p53, p57) along with apoptosis associated proteins (bax, puma) and bax:bcl-2 ratio. 2024-05-27 2024-05-31 mouse
Adrian I Abdo, Zlatko Kopeck. Comparing Redox and Intracellular Signalling Responses to Cold Plasma in Wound Healing and Cancer. Current issues in molecular biology. vol 46. issue 5. 2024-05-26. PMID:38785562. at higher cp exposures, inactivation, apoptosis, and autophagy of malignant cells can occur via the degradation of the pi3k/akt and mitogen-activated protein kinase (mapk)-dependent and -independent activation of the master tumour suppressor p53, leading to caspase-mediated cell death. 2024-05-26 2024-05-27 Not clear
Jannatul Ferdoush, Rizwaan Abdul Kadir, Matthew Ogle, Ayan Sah. Regulation of eukaryotic transcription initiation in response to cellular stress. Gene. vol 924. 2024-05-26. PMID:38795856. several transcription factors such as p53, c/ebp homologous protein (chop), activating transcription factor 6 (atf6α), e2f, transforming growth factor (tgf)-β, adenomatous polyposis coli (apc), smad, and myc have been implicated in regulation of transcription of target genes involved in cell cycle progression, apoptosis, and dna damage repair pathways. 2024-05-26 2024-05-31 human
Kirti S Prabhu, Serah Jessy, Shilpa Kuttikrishnan, Farina Mujeeb, Zahwa Mariyam, Ummu Habeeba, Nuha Ahmad, Ajaz A Bhat, Shahab Uddi. Anticancer Potential and Molecular Targets of Pristimerin in Human Malignancies. Pharmaceuticals (Basel, Switzerland). vol 17. issue 5. 2024-05-25. PMID:38794148. ps modulates several key cellular processes, including apoptosis, autophagy, cell migration and invasion, angiogenesis, and resistance to chemotherapy, targeting crucial signaling pathways such as those involving nf-κb, p53, and stat3, among others. 2024-05-25 2024-05-27 human
Lyudmila Boyanova, José Medeiros, Daniel Yordanov, Raina Gergova, Rumyana Markovsk. Turmeric and curcumin as adjuncts in controlling Helicobacter pylori-associated diseases: A narrative review. Letters in applied microbiology. 2024-05-25. PMID:38794899. curcumin also displayed numerous anticancer activities such as apoptosis induction, anti-inflammatory and anti-angiogenic effects, caspase-3 upregulation, bax protein enhancement, p53 gene activation, and chemosensitization. 2024-05-25 2024-05-27 Not clear