| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nan Zhao, Jun Chu, Jieying Liu, Liangkun Ma, Ning Ma, Wei Song, Tianshu Su. Prenatal exposure to Benzo[a]pyrene affects maternal-fetal outcomes via placental apoptosis. Scientific reports. vol 14. issue 1. 2024-07-23. PMID:39043924. |
we additionally observed elevated p53-mediated placental apoptosis in higher bap exposure groups, with altered expression levels of p53 and bax/bcl-2. |
2024-07-23 |
2024-07-26 |
mouse |
| Mahdieh Ahmadi Kamalabadi, Hamid Ostadebrahimi, Fereshteh Koosha, Asieh Fatemidokht, Iman Menbari Oskuie, Fatemeh Amin, Amin Shiralizadeh Dezful. Gd-GQDs as nanotheranostic platform for the treatment of HPV-positive oropharyngeal cancer. Medical oncology (Northwood, London, England). vol 41. issue 8. 2024-07-22. PMID:39037549. |
in contrast, the combination group exhibited a significant increase in bax protein expression, suggesting that cells could undergo apoptosis independent of the p53 pathway. |
2024-07-22 |
2024-07-24 |
Not clear |
| Jie Dai, Renjin Chen, Jie Wang, Ping Zhou, BiQiong Wang, Jianmei Li, Yun Lu, Xianlun Pang, ShaoZhi F. Intraperitoneal administration of doxorubicin-encapsulated Brucea javanica oil nanoemulsion against malignant ascites. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2024-07-21. PMID:39033885. |
bjo significantly induced apoptosis of s180 cells by upregulating the expression of p53 and caspase-3 (cleaved). |
2024-07-21 |
2024-07-24 |
mouse |
| Xiu-Li Zhang, Jia-Peng Li, Mei-Zhu Wu, Jin-Kong Wu, Shu-Yu He, Yao Lu, Qi-Hang Ding, Ying Wen, Lin-Zi Long, Chang-Geng Fu, Ali Farman, A-Ling Shen, Jun Pen. Quercetin protects against hypertensive renal injury by attenuating apoptosis: an integrated approach using network pharmacology and RNA-Seq. Journal of cardiovascular pharmacology. 2024-07-19. PMID:39027976. |
network pharmacology analysis identified multiple potential candidate targets (including tp53, bcl-2 and bax) and enriched signaling pathways (including apoptosis and p53 signaling pathway). |
2024-07-19 |
2024-07-21 |
mouse |
| Xiu-Li Zhang, Jia-Peng Li, Mei-Zhu Wu, Jin-Kong Wu, Shu-Yu He, Yao Lu, Qi-Hang Ding, Ying Wen, Lin-Zi Long, Chang-Geng Fu, Ali Farman, A-Ling Shen, Jun Pen. Quercetin protects against hypertensive renal injury by attenuating apoptosis: an integrated approach using network pharmacology and RNA-Seq. Journal of cardiovascular pharmacology. 2024-07-19. PMID:39027976. |
quercetin treatment significantly alleviated the pathological changes in renal tissues of ang ii-infused mice and reversed 464 differentially expressed transcripts (dets), as well as enriched several signaling pathways, including those related apoptosis and p53 pathway. |
2024-07-19 |
2024-07-21 |
mouse |
| Xiu-Li Zhang, Jia-Peng Li, Mei-Zhu Wu, Jin-Kong Wu, Shu-Yu He, Yao Lu, Qi-Hang Ding, Ying Wen, Lin-Zi Long, Chang-Geng Fu, Ali Farman, A-Ling Shen, Jun Pen. Quercetin protects against hypertensive renal injury by attenuating apoptosis: an integrated approach using network pharmacology and RNA-Seq. Journal of cardiovascular pharmacology. 2024-07-19. PMID:39027976. |
quercetin treatment significantly attenuated hypertensive renal injury and cell apoptosis in renal tissues of ang ii-infused mice and ang ii-stimulated nrk-52e cells, and by targeting p53 may be one of the potential underlying mechanisms. |
2024-07-19 |
2024-07-21 |
mouse |
| Expression of concern: Acrolein induces apoptosis through the death receptor pathway in A549 lung cells: role of p53. Canadian journal of physiology and pharmacology. 2024-07-19. PMID:39029946. |
expression of concern: acrolein induces apoptosis through the death receptor pathway in a549 lung cells: role of p53. |
2024-07-19 |
2024-07-22 |
Not clear |
| Yanqing Li, Chi Zhang, Haicheng Cheng, LinYan Lv, Xinning Zhu, Menghui Ma, Zhenhan Xu, Junxian He, Yun Xie, Xing Yang, Xiaoyan Liang, Chunhua Deng, Guihua Li. FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells. Experimental gerontology. 2024-07-18. PMID:39025385. |
upon activation, it binds p53 in the nucleus, preventing senescent cell apoptosis and maintaining senescent cells in situ. |
2024-07-18 |
2024-07-21 |
mouse |
| Yanqing Li, Chi Zhang, Haicheng Cheng, LinYan Lv, Xinning Zhu, Menghui Ma, Zhenhan Xu, Junxian He, Yun Xie, Xing Yang, Xiaoyan Liang, Chunhua Deng, Guihua Li. FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells. Experimental gerontology. 2024-07-18. PMID:39025385. |
in this study, we observed that foxo4-dri, a specific foxo4- p53 binding blocker, induced apoptosis in senescent leydig cells, reduced the secretion of certain senescence-associated secretory phenotype and improved the proliferation of cocultured gc-1 spg cells. |
2024-07-18 |
2024-07-21 |
mouse |
| Marek Rusi. The p53 protein - not only the guardian of the genome. Postepy biochemii. vol 70. issue 1. 2024-07-17. PMID:39016231. |
the p53 tumor suppressor protein is best known as an activator of cell cycle arrest and apoptosis. |
2024-07-17 |
2024-07-19 |
mouse |
| Marek Rusi. The p53 protein - not only the guardian of the genome. Postepy biochemii. vol 70. issue 1. 2024-07-17. PMID:39016231. |
surprisingly, in mouse models, the activation of the best-studied p53 target genes encoding the inhibitor of the cell cycle (cdkn1a) or the inducers of apoptosis (e.g. noxa, puma) is dispensable for protection against cancers. |
2024-07-17 |
2024-07-19 |
mouse |
| Xiaobing Tian, Praveen R Srinivasan, Vida Tajiknia, Ashley F Sanchez Sevilla Uruchurtu, Attila A Seyhan, Benedito A Carneiro, Arielle De La Cruz, Maximilian Pinho-Schwermann, Andrew George, Shuai Zhao, Jillian Strandberg, Francesca Di Cristofano, Shengliang Zhang, Lanlan Zhou, Alexander G Raufi, Arunasalam Navaraj, Yiqun Zhang, Nataliia Verovkina, Maryam Ghandali, Dinara Ryspayeva, Wafik S El-Deir. Targeting apoptotic pathways for cancer therapy. The Journal of clinical investigation. vol 134. issue 14. 2024-07-15. PMID:39007268. |
apoptosis pathways also interact with other signaling mechanisms, such as the p53 signaling pathway and the integrated stress response (isr) pathway. |
2024-07-15 |
2024-07-18 |
Not clear |
| Koanhoi Kim, Hyok-Rae Cho, Yonghae So. Astaxanthin Induces Apoptosis in MCF-7 Cells through a p53-Dependent Pathway. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000216. |
to elucidate the connection between apoptosis and p53, the levels of p53 and p21 proteins were assessed. |
2024-07-13 |
2024-07-15 |
human |
| Jonathan K M Lim, Arash Samiei, Alberto Delaidelli, Jessica Oliveira de Santis, Vanessa Brinkmann, Christopher J Carnie, Daniel Radiloff, Laura Hruby, Alisa Kahler, Jordan Cran, Gabriel Leprivier, Poul H Sorense. The eEF2 kinase coordinates the DNA damage response to cisplatin by supporting p53 activation. Cell death & disease. vol 15. issue 7. 2024-07-13. PMID:39003251. |
mechanistically, eef2k deficiency blunts the activation of the dna damage response associated atm and atr pathways, in turn preventing p53 activation and therefore compromising induction of cisplatin-induced apoptosis. |
2024-07-13 |
2024-07-16 |
caenorhabditis_elegans |
| Sanaa Musa, Noor Amara, Adan Selawi, Junbiao Wang, Cristina Marchini, Abed Agbarya, Jamal Mahajn. Overcoming Chemoresistance in Cancer: The Promise of Crizotinib. Cancers. vol 16. issue 13. 2024-07-13. PMID:39001541. |
crizotinib can cause the degradation of the p53 mutant, sensitizing these cancer cells to dna-damaging substances and triggering apoptosis. |
2024-07-13 |
2024-07-15 |
Not clear |
| Cai-Jing Mo, Xiao-Yuan Deng, Ru-Lan Ma, Kun Zhu, Lei Shi, Kang L. Sm-like 5 knockdown inhibits proliferation and promotes apoptosis of colon cancer cells by upregulating p53, CDKN1A and TNFRSF10B. World journal of gastrointestinal oncology. vol 16. issue 6. 2024-07-12. PMID:38994171. |
sm-like 5 knockdown inhibits proliferation and promotes apoptosis of colon cancer cells by upregulating p53, cdkn1a and tnfrsf10b. |
2024-07-12 |
2024-07-14 |
Not clear |
| Zijie Lin, Zhiying Cai, Lingling Li, Yekai Wei, Qufei Lin. c-Jun N-terminal kinase 1/P53 signaling mediates intrinsic apoptosis of largemouth bass (Micropterus salmoides) hepatocytes under heat stress. The Science of the total environment. 2024-07-12. PMID:38997017. |
these results not only confirm that heat stress led to intrinsic apoptosis of hepatocytes but also indicated that jnk1 could mediate p53 expression and activate caspase-dependent intrinsic apoptosis in largemouth bass hepatocytes under such conditions. |
2024-07-12 |
2024-07-15 |
Not clear |
| Han Zhang, Taotao Zheng, Chuan Qin, Xinyue Zhang, Han Lin, Xiaoping Huang, Qiang Liu, Shichuan Chang, Li Zhang, Jing Guo, Yao Zhang, Chunxiang Bian, Huawen Li. CCT6A promotes cell proliferation in colon cancer by targeting BIRC5 associated with p53 status. Cancer gene therapy. 2024-07-12. PMID:38997438. |
cct6a plays a role in cellular process, including the cell cycle, p53, and apoptosis signaling pathways. |
2024-07-12 |
2024-07-15 |
Not clear |
| B Haridevamuthu, S P Ramya Ranjan Nayak, Raghul Murugan, Gokul Sudhakaran, Raman Pachaiappan, K Manikandan, Vellapandian Chitra, Mikhlid H Almutairi, Bader O Almutairi, M K Kathiravan, Jesu Arockiara. Co-occurrence of azorubine and bisphenol A in beverages increases the risk of developmental toxicity: A study in zebrafish model. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-07-11. PMID:38992409. |
critical genes related to the antioxidant response elements (nrf2, ho1, and nqo1), apoptosis activation (bcl2, bax, and p53), and pro/anti-inflammatory cytokines (nfkb, tnfa, il1b, tgfb, il10, and il12) displayed substantial changes, highlighting the molecular mechanisms. |
2024-07-11 |
2024-07-14 |
zebrafish |
| Yide He, Jun Hu, Rosa Freitas, Jie Gu, Guixiang Ji, Yongjun Zhan. Trace-level Gabapentin can Induce Cardiovascular Developmental Toxicity through Apoptosis in Zebrafish Larvae. Environmental pollution (Barking, Essex : 1987). 2024-07-11. PMID:38992826. |
the vascular cell apoptosis was promoted through genes like p53, bad, and bcl2. |
2024-07-11 |
2024-07-14 |
zebrafish |