| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manisha R Patil, Anand Bihar. Role of artificial intelligence in cancer detection using protein p53: A Review. Molecular biology reports. vol 52. issue 1. 2024-12-10. PMID:39658610. |
the p53 protein plays a vital role in regulating cell growth, dna repair, and apoptosis (programmed cell death), thereby maintaining the integrity of the genome and preventing the formation of tumors. |
2024-12-10 |
2024-12-13 |
Not clear |
| Yogesh K Chutake, Michele F Mayo, Nancy Dumont, Jessica Filiatrault, Susanne B Breitkopf, Patricia Cho, Dapeng Chen, Vaishali S Dixit, William R Proctor, Eric W Kuhn, Sarah Bollinger Martinez, Alice A McDonald, Jianfeng Qi, Kan-Nian Hu, Rahul Karnik, Joseph D Growney, Kirti Sharma, Stefanie S Schalm, Ashwin M Gollerkeri, Nello Mainolfi, Juliet A Williams, Matthew M Weis. KT-253, A Novel MDM2 Degrader and p53 Stabilizer, Has Superior Potency and Efficacy Than MDM2 Small Molecule Inhibitors. Molecular cancer therapeutics. 2024-12-09. PMID:39648478. |
a single intravenous dose of kt 253 triggered rapid apoptosis and sustained tumor regression in p53 wild-type acute myeloid leukemia (aml) and acute lymphoblastic leukemia (all) xenograft models. |
2024-12-09 |
2024-12-11 |
Not clear |
| Marius Regin, Yingnan Lei, Edouard Couvreu De Deckersberg, Charlotte Janssens, Anfien Huyghebaert, Yves Guns, Pieter Verdyck, Greta Verheyen, Hilde Van de Velde, Karen Sermon, Claudia Spit. Complex aneuploidy triggers autophagy and p53-mediated apoptosis and impairs the second lineage segregation in human preimplantation embryos. eLife. vol 12. 2024-12-09. PMID:39652462. |
rna-sequencing of trophectoderm cells showed activated p53 pathway and apoptosis proportionate to the level of chromosomal imbalance. |
2024-12-09 |
2024-12-12 |
mouse |
| Kim Kobar, Lissandra Tuzi, Jennifer A Fiene, Erin Burnley, Kristianne J C Galpin, Craig Midgen, Brianne Laverty, Vallijah Subasri, Timmy T Wen, Martin Hirst, Michelle Moksa, Annaick Carles, Qi Cao, Adam Shlien, David Malkin, Sergey V Prykhozhij, Jason N Berma. tp53 R217H and R242H mutant zebrafish exhibit dysfunctional p53 hallmarks and recapitulate Li-Fraumeni syndrome phenotypes. Biochimica et biophysica acta. Molecular basis of disease. vol 1871. issue 3. 2024-12-07. PMID:39643218. |
we characterized the first lfs zebrafish hotspot mutants, tp53 r217h and r242h (human r248h and r273h), and found these mutants exhibit partial-to-no activation of p53 target genes, have defective cell-cycle checkpoints, and display partial-to-full resistance to apoptosis, although the r217h mutation has hypomorphic characteristics. |
2024-12-07 |
2024-12-10 |
human |
| Yang Liu, Mengmeng Wang, Fengju Zhang, Jingyao Tang, Xinyue Han, Yiqing H. Effect of 0.05% cyclosporine A eye drops on the healing process of corneal epithelial defects in rats. Experimental eye research. 2024-12-05. PMID:39638277. |
the epithelial healing, tear secretion, epithelial microvilli, expression of apoptosis markers (tunel, p53, and bcl-2 proteins), inflammatory factors (il-1β, tnf-α, and il-6), and epidermal growth factor (egf) were detected in the current study using corneal fluorescein sodium staining, phenol red thread test, transmission electron microscopy (tem), immunofluorescence, and enzyme-linked immunosorbent assay (elisa), respectively. |
2024-12-05 |
2024-12-08 |
rat |
| Honglei Tao, Lei Li, Huiling Li, Tingting Ma, Xinping Zhu, Jili Cao, Yongqiang Zhu, Shengmei Zhu, Mingqian L. The anti-tumor effects of main component (benzethonium chloride) of butorphanol tartrate injection in non-small cell lung cancer. Scientific reports. vol 14. issue 1. 2024-12-05. PMID:39632963. |
bc may regulate the cell cycle, apoptosis and emt signaling pathways by modulating the p53 signaling pathway. |
2024-12-05 |
2024-12-07 |
Not clear |
| Safura Pournajaf, Nastaran Afsordeh, Hadi Bayat, Mohammad Hossein Pourgholam. Fingolimod Inhibits C6 Rat Glioma Proliferation and Migration, Induces Sub-G1 Cell Cycle Arrest, Mitochondrial and Extrinsic Apoptosis In Vitro and Reduces Tumour Growth In Vivo. Clinical and experimental pharmacology & physiology. vol 52. issue 1. 2024-12-03. PMID:39623929. |
cell shrinkage coupled with ao/eb and pi staining of the fingolimod-treated cells indicated apoptosis, subsequently confirmed by measuring the expression levels of the candidate genes involved in apoptosis and cell cycle, such as bax/bcl2, p53, cytochrome c and caspases 9/3, fas, fadd, tnfrsf1a, cdkn1a, and ccnd1, at rna and protein levels, indicating both extrinsic and mitochondrial apoptosis and cell cycle arrest at sub-g1 phase in fingolimod-treated cells. |
2024-12-03 |
2024-12-06 |
rat |
| W U Shuang, L I Qiao, Zhu Xieying, Zhang Taoyua. 2-hydroxy-3-methyl anthraquinone promotes apoptosis and inhibits invasion of human hepatocellular carcinoma cells by targeting nicotinamide adenine dinucleotide-dependent protein deacetylase sirtuin-1/cellular tumor antigen p53 signaling pathway. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. vol 44. issue 6. 2024-12-02. PMID:39617695. |
2-hydroxy-3-methyl anthraquinone promotes apoptosis and inhibits invasion of human hepatocellular carcinoma cells by targeting nicotinamide adenine dinucleotide-dependent protein deacetylase sirtuin-1/cellular tumor antigen p53 signaling pathway. |
2024-12-02 |
2024-12-06 |
human |
| Cunjie Li, Yuxin Xiao, Jieling Zhou, Shifeng Liu, Ligang Zhang, Xinran Song, Xinhua Guo, Qifang Song, Jianfu Zhao, Ning Den. Knockout of onecut2 inhibits proliferation and promotes apoptosis of tumor cells through SKP2-mediated p53 acetylation in hepatocellular carcinoma. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-11-28. PMID:39609269. |
knockout of onecut2 inhibits proliferation and promotes apoptosis of tumor cells through skp2-mediated p53 acetylation in hepatocellular carcinoma. |
2024-11-28 |
2024-12-01 |
mouse |
| Cunjie Li, Yuxin Xiao, Jieling Zhou, Shifeng Liu, Ligang Zhang, Xinran Song, Xinhua Guo, Qifang Song, Jianfu Zhao, Ning Den. Knockout of onecut2 inhibits proliferation and promotes apoptosis of tumor cells through SKP2-mediated p53 acetylation in hepatocellular carcinoma. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-11-28. PMID:39609269. |
moreover, downregulating the expression of oc2 and skp2 could release p300, promote the acetylation of p53, increase the expression of p21 and p27, and promote the apoptosis of hcc cells. |
2024-11-28 |
2024-12-01 |
mouse |
| Cunjie Li, Yuxin Xiao, Jieling Zhou, Shifeng Liu, Ligang Zhang, Xinran Song, Xinhua Guo, Qifang Song, Jianfu Zhao, Ning Den. Knockout of onecut2 inhibits proliferation and promotes apoptosis of tumor cells through SKP2-mediated p53 acetylation in hepatocellular carcinoma. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-11-28. PMID:39609269. |
moreover, the overexpression of oc2 or skp2 in the knockout hcc cell line clearly inhibited the acetylation level of p53 and reduced cell apoptosis. |
2024-11-28 |
2024-12-01 |
mouse |
| Yudi Zhang, Yi Liu, Xueyan Xing, Haibin Liu, Wuxiang Gua. Genome-Wide Analysis of p53 Targets Reveals SCN2A as a Novel Player in p53-Induced Cell Arrest in HPV-Positive Cells. Viruses. vol 16. issue 11. 2024-11-27. PMID:39599840. |
the host transcription factor p53 is a critical tumor suppressor in hpv-induced carcinogenesis, regulating target genes involved in cell cycle arrest and apoptosis. |
2024-11-27 |
2024-11-29 |
Not clear |
| Ilter Ilhan, Halil Asci, Ibrahim Aydın Candan, Mehtap Savran, Orhan Berk Imeci, Mehmet Abdulkadir Sevu. Cannabidiol mitigates methotrexate-induced hepatic injury via SIRT-1/p53 signaling and mitochondrial pathways: reduces oxidative stress and inflammation. Drug and chemical toxicology. 2024-11-27. PMID:39603835. |
it activates antioxidant defenses via sirt-1 upregulation, suppresses inflammation by reducing tnf-α, and prevents apoptosis by modulating p53, bcl-2, and bax gene expressions. |
2024-11-27 |
2024-11-30 |
rat |
| Jinming Wang, Quanwei Li, Yunfei Huo, Xiaoni Liu, Ying Shi, Bangxiang Xi. ASPP2 deficiency promotes the progression of metabolic dysfunction-associated steatohepatitis via ACSL4 upregulation. Scientific reports. vol 14. issue 1. 2024-11-26. PMID:39587161. |
as a member of the p53-binding protein family, apoptosis-stimulating protein p53 2 (aspp2) is closely related to autophagy and apoptosis. |
2024-11-26 |
2024-11-28 |
mouse |
| Zhe Bai, Hui Li, Baoping Jia. Potential Therapeutic Effect of Sinigrin on Diethylnitrosamine-Induced Liver Cancer in Mice: Exploring the Involvement of Nrf-2/HO-1, PI3K-Akt-mTOR Signaling Pathways, and Apoptosis. ACS omega. vol 9. issue 46. 2024-11-25. PMID:39583716. |
sinigrin also activated the intrinsic mitochondrial apoptosis pathway mediated by p53, downregulated antiapoptotic proteins (bcl-2), up-regulated pro-apoptosis regulatory proteins like bax and caspase-3. |
2024-11-25 |
2024-11-27 |
mouse |
| Lingjing Wei, Congyan Yu, Shan Xiao, Kang Liu, Yudian Lu, Baojiang Gan, Peng Zhu, Sheng Zhan. Effects of hypoxia on survival, apoptosis, and the transcriptome of the Chinese yellow pond turtle (Mauremys mutica). Gene. 2024-11-25. PMID:39586519. |
and the degs were enriched in the inflammation, apoptosis, sugar transport, antioxidant, fructose, and mannose metabolism, arginine and proline metabolism, glycosaminoglycan biosynthesis, p53, and mapk signaling pathways. |
2024-11-25 |
2024-11-28 |
Not clear |
| M A Darenskaya, A A Semendyaev, D A Stupin, S I Kolesnikov, N V Semenova, D V Tukhieva, A V Shcherbatykh, L I Kolesnikov. Expression of Immunohistochemical Markers in the Walls of Pelvic Varicose Veins in Women. Bulletin of experimental biology and medicine. 2024-11-25. PMID:39585595. |
the expression of markers of proliferation (ki-67), apoptosis (p53), and angiogenesis (cd31, cd34), as well as estrogen and progesterone receptors in women with pelvic varicose veins was assessed by the immunohistochemical method. |
2024-11-25 |
2024-11-27 |
Not clear |
| M A Darenskaya, A A Semendyaev, D A Stupin, S I Kolesnikov, N V Semenova, D V Tukhieva, A V Shcherbatykh, L I Kolesnikov. Expression of Immunohistochemical Markers in the Walls of Pelvic Varicose Veins in Women. Bulletin of experimental biology and medicine. 2024-11-25. PMID:39585595. |
a decrease in the median expression of the proliferation marker (ki-67) and estrogen and progesterone receptors and simultaneous increase in the expression of apoptosis marker (p53) and activation of angiogenesis processes (markers cd31 and cd34) were observed with increasing the severity of the disease. |
2024-11-25 |
2024-11-27 |
Not clear |
| Shaonan Yang, Lu Jiang, Ling Deng, Jingjing Luo, Xiaoling Zhang, Sha Chen, Zhi Don. Chaperone-Mediated Autophagy Alleviates Cerebral Ischemia-Reperfusion Injury by Inhibiting P53-Mediated Mitochondria-Associated Apoptosis. Neurochemical research. vol 50. issue 1. 2024-11-22. PMID:39576398. |
the p53 activator, nutlin-3, not only reversed the inhibitory effect of cma on apoptosis, but also significantly weakened the protective effect of cma on ogd/r and mcao/r. |
2024-11-22 |
2024-11-24 |
Not clear |
| Yuanyuan Jia, Xinyue Zhang, Yiqing Cai, Hanghui Yu, Guohua Cao, Enyong Dai, Rui Kang, Daolin Tang, Nanjun Hu, Leng Ha. OSGIN1 promotes ferroptosis resistance by directly enhancing GCLM activity. Biochemical and biophysical research communications. vol 740. 2024-11-21. PMID:39571229. |
oxidative stress induced growth inhibitor 1 (osgin1) is a tumor protein p53 (tp53)-target gene involved in the oxidative stress response and promotes apoptosis. |
2024-11-21 |
2024-11-24 |
human |