| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tingting Jin, Ziming Wang, Fan Fan, Wandi Wei, Chenming Zhou, Ziyu Zhang, Yue Gao, Wenhui Li, Lin Zhu, Jun Ha. Correction: HDAC1 Promotes Mitochondrial Pathway Apoptosis and Inhibits the Endoplasmic Reticulum Stress Response in High Glucose-Treated Schwann Cells via Decreased U4 Spliceosomal RNA. Neurochemical research. 2024-07-15. PMID:39008242. |
correction: hdac1 promotes mitochondrial pathway apoptosis and inhibits the endoplasmic reticulum stress response in high glucose-treated schwann cells via decreased u4 spliceosomal rna. |
2024-07-15 |
2024-07-18 |
Not clear |
| Tingting Jin, Ziming Wang, Fan Fan, Wandi Wei, Chenming Zhou, Ziyu Zhang, Yue Gao, Wenhui Li, Lin Zhu, Jun Ha. HDAC1 Promotes Mitochondrial Pathway Apoptosis and Inhibits the Endoplasmic Reticulum Stress Response in High Glucose-Treated Schwann Cells via Decreased U4 Spliceosomal RNA. Neurochemical research. 2024-06-25. PMID:38916813. |
hdac1 promotes mitochondrial pathway apoptosis and inhibits the endoplasmic reticulum stress response in high glucose-treated schwann cells via decreased u4 spliceosomal rna. |
2024-06-25 |
2024-06-27 |
mouse |
| Tingting Jin, Ziming Wang, Fan Fan, Wandi Wei, Chenming Zhou, Ziyu Zhang, Yue Gao, Wenhui Li, Lin Zhu, Jun Ha. HDAC1 Promotes Mitochondrial Pathway Apoptosis and Inhibits the Endoplasmic Reticulum Stress Response in High Glucose-Treated Schwann Cells via Decreased U4 Spliceosomal RNA. Neurochemical research. 2024-06-25. PMID:38916813. |
hdac1 expression was increased in diabetic mice and high glucose-cultured rsc96 cells, accompanied by cell apoptosis. |
2024-06-25 |
2024-06-27 |
mouse |
| Tingting Jin, Ziming Wang, Fan Fan, Wandi Wei, Chenming Zhou, Ziyu Zhang, Yue Gao, Wenhui Li, Lin Zhu, Jun Ha. HDAC1 Promotes Mitochondrial Pathway Apoptosis and Inhibits the Endoplasmic Reticulum Stress Response in High Glucose-Treated Schwann Cells via Decreased U4 Spliceosomal RNA. Neurochemical research. 2024-06-25. PMID:38916813. |
in contrast, knockdown of hdac1 inhibited high glucose-promoted mitochondrial pathway apoptosis and suppressed the endoplasmic reticulum response. |
2024-06-25 |
2024-06-27 |
mouse |
| Tingting Jin, Ziming Wang, Fan Fan, Wandi Wei, Chenming Zhou, Ziyu Zhang, Yue Gao, Wenhui Li, Lin Zhu, Jun Ha. HDAC1 Promotes Mitochondrial Pathway Apoptosis and Inhibits the Endoplasmic Reticulum Stress Response in High Glucose-Treated Schwann Cells via Decreased U4 Spliceosomal RNA. Neurochemical research. 2024-06-25. PMID:38916813. |
taken together, these findings indicate that hdac1 promotes mitochondrial pathway-mediated apoptosis and inhibits the endoplasmic reticulum stress response in high glucose-cultured schwann cells by decreasing the u4 spliceosomal rna/ir of rpl21, cdc34, and mtmr11. |
2024-06-25 |
2024-06-27 |
mouse |
| Danna Wei, Xiaoling Liang, Meiling Huang, Caili Wang, Zhangmin Ye, Tianzhuo Zhang, Jingrong Zhan. Targeting histone deacetylase 1 (HDAC1) in the bone marrow stromal cells revers imatinib resistance by modulating IL-6 in Ph + acute lymphoblastic leukemia. Annals of hematology. 2024-06-07. PMID:38847852. |
knockdown of hdac1 within bmscs elevated the im-mediated sup-b15 cell apoptosis, while increasing hdac1 expression had an opposite effect. |
2024-06-07 |
2024-06-10 |
Not clear |
| Sara Rossi, Vanessa Tatangelo, Maria Dichiara, Stefania Butini, Sandra Gemma, Simone Brogi, Silvia Pasquini, Martina Cappello, Fabrizio Vincenzi, Katia Varani, Ludovica Lopresti, Margherita Malchiodi, Chiara Carrara, Alessandro Gozzetti, Monica Bocchia, Giuseppe Marotta, Laura Patrussi, Gabriele Carullo, Cosima T Baldari, Giuseppe Campian. A novel potent class I HDAC inhibitor reverses the STAT4/p66Shc apoptotic defect in B cells from chronic lymphocytic leukemia patients. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 174. 2024-04-05. PMID:38579402. |
new selective class i hdac inhibitors (hdacis, 6a-g) were developed with increased potency over existing agents and preferentially interfering with the cll-relevant isoform hdac1, to unveil the role of class i hdacs in the upregulation of stat4 expression, which upregulates p66shc expression and hence normalizes cll cell apoptosis. |
2024-04-05 |
2024-04-10 |
Not clear |
| Guiping Ren, Xiaoqian Gu, Lu Zhang, Shimin Gong, Shuang Song, Shunkai Chen, Zhenjing Chen, Xiaoyan Wang, Zhanbiao Li, Yingshui Zhou, Longxi Li, Jiao Yang, Fan Lai, Yunkun Dan. Ribosomal frameshifting at normal codon repeats recodes functional chimeric proteins in human. Nucleic acids research. 2024-01-28. PMID:38281188. |
finally, we show a crfs-derived trans-frame protein (hdac1-fs) functions by antagonizing the activities of hdac1, thus affecting cell migration and apoptosis. |
2024-01-28 |
2024-01-31 |
human |
| Xiaofeng Zhou, Yingting He, Hongyan Quan, Xiangchun Pan, Yinqi Zhou, Zhe Zhang, Xiaolong Yuan, Jiaqi L. Cells. vol 12. issue 23. 2023-12-09. PMID:38067162. |
using the mouse model, we showed that trichostatin a (tsa), a histone deacetylase (hdac) inhibitor, downregulated the protein level of hdac1 in ovaries to promote the apoptosis of granulosa cells (gcs), and thus arrested follicular development and delayed sexual maturity. |
2023-12-09 |
2023-12-17 |
mouse |
| Li Liu, Ke Gu, Dong Hu. HDAC1 suppresses radiotherapy sensitivity in cervical cancer via regulating HIF-1α/VEGF signaling pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 11. 2023-11-28. PMID:38015530. |
in vivo, we found that hdac1 silence hindered tumor growth and cell proliferation and promoted tumor cell apoptosis in nude mice after radiotherapy. |
2023-11-28 |
2023-11-29 |
mouse |
| Carter A Wright, Emily R Gordon, Sara J Coope. Genomic analysis reveals HDAC1 regulates clinically relevant transcriptional programs in Pancreatic cancer. BMC cancer. vol 23. issue 1. 2023-11-26. PMID:37996815. |
integrative genomic analysis shows that hdac1 overexpression promotes activation of key resistance pathways including epithelial to mesenchymal transition, cell cycle, and apoptosis through global chromatin remodeling. |
2023-11-26 |
2023-11-28 |
Not clear |
| Yao Chen, Shuangqian Zhang, Zhijia Li, Bo Yin, Yi Liu, Lan Zhan. Discovery of a dual-target inhibitor of CDK7 and HDAC1 that induces apoptosis and inhibits migration in colorectal cancer. ChemMedChem. 2023-10-11. PMID:37821774. |
discovery of a dual-target inhibitor of cdk7 and hdac1 that induces apoptosis and inhibits migration in colorectal cancer. |
2023-10-11 |
2023-10-15 |
Not clear |
| Kaushik Kumar Bharadwaj, Iqrar Ahmad, Siddhartha Pati, Arabinda Ghosh, Bijuli Rabha, Tanmay Sarkar, Dorothy Bhattacharjya, Harun Patel, Debabrat Baishy. Screening of Phytocompounds for Identification of Prospective Histone Deacetylase 1 (HDAC1) Inhibitor: An In Silico Molecular Docking, Molecular Dynamics Simulation, and MM-GBSA Approach. Applied biochemistry and biotechnology. 2023-09-30. PMID:37776441. |
hdac1 inhibitors have thus emerged as possible therapeutic approaches against a variety of human malignancies, as they can inhibit the activity of certain hdacs, repair the overexpression of tumour suppressor genes, and induce cell differentiation, cell cycle arrest, and apoptosis. |
2023-09-30 |
2023-10-07 |
human |
| Shuai Wang, Zhonghao Cui, Jian Zhu, Peng Zhou, Xianjiao Cao, Xiaolei Li, Yunhan Ma, Qingqing H. Colchicine inhibits the proliferation and promotes the apoptosis of papillary thyroid carcinoma cells likely due to the inhibitory effect on HDAC1. Biochemical and biophysical research communications. vol 679. 2023-09-10. PMID:37690423. |
colchicine inhibits the proliferation and promotes the apoptosis of papillary thyroid carcinoma cells likely due to the inhibitory effect on hdac1. |
2023-09-10 |
2023-10-07 |
Not clear |
| Shuai Wang, Zhonghao Cui, Jian Zhu, Peng Zhou, Xianjiao Cao, Xiaolei Li, Yunhan Ma, Qingqing H. Colchicine inhibits the proliferation and promotes the apoptosis of papillary thyroid carcinoma cells likely due to the inhibitory effect on HDAC1. Biochemical and biophysical research communications. vol 679. 2023-09-10. PMID:37690423. |
we then used cck-8, colony formation, mitochondrial membrane potential and apoptosis assays to confirm that colchicine could inhibit the proliferation and promote the apoptosis of ptc cells and verified by rt‒qpcr, western blot, and cellular immunofluorescence assays that colchicine could inhibit the expression of hdac1 in ptc cells. |
2023-09-10 |
2023-10-07 |
Not clear |
| Shuai Wang, Zhonghao Cui, Jian Zhu, Peng Zhou, Xianjiao Cao, Xiaolei Li, Yunhan Ma, Qingqing H. Colchicine inhibits the proliferation and promotes the apoptosis of papillary thyroid carcinoma cells likely due to the inhibitory effect on HDAC1. Biochemical and biophysical research communications. vol 679. 2023-09-10. PMID:37690423. |
we then applied an hdac1 inhibitor, pyroxamide, to verify that inhibition of hdac1 inhibits proliferation and promotes apoptosis in ptc cells. |
2023-09-10 |
2023-10-07 |
Not clear |
| Shuai Wang, Zhonghao Cui, Jian Zhu, Peng Zhou, Xianjiao Cao, Xiaolei Li, Yunhan Ma, Qingqing H. Colchicine inhibits the proliferation and promotes the apoptosis of papillary thyroid carcinoma cells likely due to the inhibitory effect on HDAC1. Biochemical and biophysical research communications. vol 679. 2023-09-10. PMID:37690423. |
therefore, we conclude that colchicine can inhibit the proliferation and promote the apoptosis of ptc cells likely due to its inhibitory effect on hdac1. |
2023-09-10 |
2023-10-07 |
Not clear |
| Chao Wen, Xiaoliang Lu, Yingyin Sun, Qi Li, Jing Liao, Lin L. Naringenin induces the cell apoptosis of acute myeloid leukemia cells by regulating the lncRNA XIST/miR-34a/HDAC1 signaling. Heliyon. vol 9. issue 5. 2023-05-19. PMID:37206002. |
here, we found that nar induced the apoptosis, decreased the expression of lncrna xist and hdac1, and increased the expression of microrna-34a in hl60 cells. |
2023-05-19 |
2023-08-14 |
Not clear |
| Changsheng Wang, Xiaobo Zhang, Xitian Zhu, Rongsheng Chen, Nancheng Lia. The RNA binding protein HuR promotes neuronal apoptosis in rats with spinal cord injury via the HDAC1/RAD21 axis. Neuroscience. 2023-05-10. PMID:37164303. |
the injection of hur shrna in tail vein of sci rats increased basso, beattie, and bresnahan score, relieved sci, reduced hur and hdac1 expression, elevated rad21 expression, and decreased neuronal-like apoptosis. |
2023-05-10 |
2023-08-14 |
rat |
| Changsheng Wang, Xiaobo Zhang, Xitian Zhu, Rongsheng Chen, Nancheng Lia. The RNA binding protein HuR promotes neuronal apoptosis in rats with spinal cord injury via the HDAC1/RAD21 axis. Neuroscience. 2023-05-10. PMID:37164303. |
in conclusion, down-regulation of hur alleviated sci and neuronal apoptosis in rats by suppressing hdac1 expression and promoting rad21 expression. |
2023-05-10 |
2023-08-14 |
rat |