| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yongjia Xiang, Rubing Zhou, Yi Yang, Hao Bai, Fan Liang, Hongmei Wang, Xia Wan. A Novel circ_0075829/miR-326/GOT1 ceRNA Crosstalk Regulates the Malignant Phenotypes and Drug Sensitivity of Gemcitabine-Resistant Pancreatic Cancer Cells. Journal of biochemical and molecular toxicology. vol 39. issue 1. 2024-12-18. PMID:39692397. |
knockdown of circ_0075829 impeded the proliferation, invasion, migration, and glutamine metabolism, and promoted cell apoptosis and gem sensitivity of gem-resistant pc cells. |
2024-12-18 |
2024-12-21 |
mouse |
| Zu-Gui Tang, Tie-Mei Chen, Yi Lu, Zhe Wang, Xi-Cheng Wang, Yi Kon. Human bone marrow mesenchymal stem cell-derived exosomes loaded with gemcitabine inhibit pancreatic cancer cell proliferation by enhancing apoptosis. World journal of gastrointestinal oncology. vol 16. issue 9. 2024-10-01. PMID:39350998. |
the study tested the hypothesis that human bone marrow mesenchymal stem cell (msc)-derived exosomes loaded with gem (exo-gem) would have a higher cytotoxicity against human pancreatic cancer cells by enhancing their apoptosis. |
2024-10-01 |
2024-10-03 |
human |
| Qing Zhu, Silue Zeng, Junying Yang, Jiaming Zhuo, Peifeng Wang, Sai Wen, Chihua Fan. Plectin-1-targeted recognition for enhancing comprehensive therapy in pancreatic ductal adenocarcinoma. Nanoscale. 2024-09-18. PMID:39291372. |
gemcitabine (gem), a primary therapeutic option, functions by inhibiting dna synthesis and promoting apoptosis, thereby impeding the progression of pdac. |
2024-09-18 |
2024-09-20 |
Not clear |
| Qing Zhu, Silue Zeng, Junying Yang, Jiaming Zhuo, Peifeng Wang, Sai Wen, Chihua Fan. Plectin-1-targeted recognition for enhancing comprehensive therapy in pancreatic ductal adenocarcinoma. Nanoscale. 2024-09-18. PMID:39291372. |
the approach is applied to enhance chemotherapy, combined with photothermal therapy (ptt), inducing apoptosis in pdac cell lines and improving the pharmacokinetics of gem. |
2024-09-18 |
2024-09-20 |
Not clear |
| Verena Silva Santos, Gabriela Maciel Vieira, Mariana Tannús Ruckert, Pamela Viani de Andrade, Luis Fernando Nagano, Mariângela Ottoboni Brunaldi, José Sebastião Dos Santos, Vanessa Silva Silveir. Atypical phosphatase DUSP11 inhibition promotes nc886 expression and potentiates gemcitabine-mediated cell death through NF-kB modulation. Cancer gene therapy. 2024-07-24. PMID:39048662. |
dusp11 genetic inhibition impaired cell survival and promoted apoptosis, synergistically enhancing gem cytotoxicity. |
2024-07-24 |
2024-07-28 |
human |
| Weiquan Li, Jingchong Liu, Tiexi Yu, Feiyi Lu, Qi Miao, Xiangui Meng, Wen Xiao, Hongmei Yang, Xiaoping Zhan. ZDHHC9-mediated Bip/GRP78 S-palmitoylation inhibits unfolded protein response and promotes bladder cancer progression. Cancer letters. 2024-07-13. PMID:39002690. |
functionally, zdhhc9 knockdown markedly inhibited tumor proliferation, promoted tumor cell apoptosis, and enhanced the efficacy of gemcitabine (gem) and cisplatin (cddp). |
2024-07-13 |
2024-07-16 |
Not clear |
| Kai-Lin Chen, Sai-Wei Huang, Ji-Jin Yao, Shi-Wei He, Sha Gong, Xi-Rong Tan, Ye-Lin Liang, Jun-Yan Li, Sheng-Yan Huang, Ying-Qin Li, Yin Zhao, Han Qiao, Sha Xu, Shengbing Zang, Jun Ma, Na Li. LncRNA DYNLRB2-AS1 promotes gemcitabine resistance of nasopharyngeal carcinoma by inhibiting the ubiquitination degradation of DHX9 protein. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. vol 76. 2024-06-22. PMID:38908233. |
dynlrb2-as1 was shown to function as contain an oncogenic lncrna that promoted npc gem resistance, cell proliferation, but inhibited cell apoptosis. |
2024-06-22 |
2024-06-25 |
Not clear |
| Prakash Shrestha, Yashwardhan Ghanwatkar, Sohan Mahto, Nilkamal Pramanik, Ram I Mahat. Gemcitabine-Lipid Conjugate and ONC201 Combination Therapy Effectively Treats Orthotopic Pancreatic Tumor-Bearing Mice. ACS applied materials & interfaces. vol 16. issue 23. 2024-06-12. PMID:38813771. |
moreover, the pancreatic cancer cells that were able to bypass apoptosis after treatment of onc201 get arrested in the g1-phase, which makes them highly sensitive to gem. |
2024-06-12 |
2024-06-14 |
mouse |
| Chander Parkash Dora, Varun Kushwah, Vivek Yadav, Kaushik Kuche, Sanyog Jai. Gemcitabine-Phospholipid Complex Loaded Lipid Nanoparticles for Improving Drug Loading, Stability, and Efficacy against Pancreatic Cancer. Molecular pharmaceutics. 2024-05-15. PMID:38747900. |
moreover, gem-nps exhibited enhanced cytotoxicity, apoptosis, and cell uptake in panc-2 and mia paca cells compared to the free gem. |
2024-05-15 |
2024-05-27 |
Not clear |
| Hanyi Song, Xinjie Yao, Yuqi Zheng, Long Zho. Helicobacter pylori infection induces POU5F1 upregulation and SPP1 activation to promote chemoresistance and T cell inactivation in gastric cancer cells. Biochemical pharmacology. 2024-05-03. PMID:38701869. |
hp infection in ags and mkn-74 cells promoted proliferation, migration and invasion, apoptosis resistance, and tumorigenic activity of cells under cisplatin (ddp) plus gemcitabine (gem) treatment. |
2024-05-03 |
2024-05-06 |
Not clear |
| Hongfu Liu, Dongdong Zhou, Dongqin Liu, Xi Xu, Kai Zhang, Ruxia Hu, Peng Xiong, Changxin Wang, Xiangfu Zeng, Liefeng Wang, Shuyong Zhan. Synergistic antitumor activity between HER2 antibody-drug conjugate and chemotherapy for treating advanced colorectal cancer. Cell death & disease. vol 15. issue 3. 2024-03-05. PMID:38443386. |
the results revealed that combination treatment of rc48 and gem regulated multiple signaling pathways, such as pi3k-akt, mapk, p53, foxo, apoptosis, cell cycle and cell senescence, etc., to exert its antitumor activity in crc cells. |
2024-03-05 |
2024-03-08 |
Not clear |
| Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xi. Lipid-like gemcitabine diester-loaded liposomes for improved chemotherapy of pancreatic cancer. Journal of controlled release : official journal of the Controlled Release Society. 2023-11-19. PMID:37981050. |
compared to free gem, lipodmgem showed enhanced cellular uptake and cell apoptosis, improved inhibition of cell migration on aspc-1 cells and a greatly extended half-life (7.22 vs. 1.78 h). |
2023-11-19 |
2023-11-29 |
Not clear |
| Aliva Prity Minz, Debasish Mohapatra, Madhuri Dutta, Manisha Sethi, Deepti Parida, Amlan Priyadarshee Mohapatra, Swayambara Mishra, Salona Kar, Prakash K Sasmal, Shantibhusan Senapat. Statins abrogate gemcitabine-induced PD-L1 expression in pancreatic cancer-associated fibroblasts and cancer cells with improved therapeutic outcome. Cancer immunology, immunotherapy : CII. 2023-11-05. PMID:37926727. |
upregulation of pd-l1 in pscs/cafs upon gem treatment caused t cell inactivation and apoptosis in vitro. |
2023-11-05 |
2023-11-08 |
mouse |
| Milad Ashrafizadeh, Kuo Luo, Wei Zhang, Amir Reza Aref, Xianbin Zhan. Acquired and intrinsic gemcitabine resistance in pancreatic cancer therapy: Environmental factors, molecular profile and drug/nanotherapeutic approaches. Environmental research. 2023-10-20. PMID:37863168. |
moreover, supportive autophagy inhibits apoptosis and stimulates gem resistance in pc cells. |
2023-10-20 |
2023-11-08 |
Not clear |
| Jing Cui, Yao Guo, Tao Yin, Shanmiao Gou, Jiongxin Xiong, Xueyi Liang, Chong Lu, Tao Pen. USP8 promotes gemcitabine resistance of pancreatic cancer via deubiquitinating and stabilizing Nrf2. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 166. 2023-08-28. PMID:37639742. |
furthermore, usp8 was found to promote gem resistance both in vivo and in vitro via regulating cell viability and apoptosis. |
2023-08-28 |
2023-09-07 |
Not clear |
| Pan Xi, Xiaojuan Ma, Fuquan Hu, Liang Li, Huijuan Liu, Jing Zhou, Wenan W. ROS-Sp1 axis is involved in thermochemotherapy-enhanced sensitivity of pancreatic cancer cells to gemcitabine. Cell biology international. 2023-08-07. PMID:37545170. |
pancreatic cancer cells panc-1 and aspc-1 were either treated with gem or thermochemotherapy, then cell viability, apoptosis, migration, invasion, reactive oxygen species (ros) production, and sp1 expression were evaluated. |
2023-08-07 |
2023-08-14 |
Not clear |
| Pan Xi, Xiaojuan Ma, Fuquan Hu, Liang Li, Huijuan Liu, Jing Zhou, Wenan W. ROS-Sp1 axis is involved in thermochemotherapy-enhanced sensitivity of pancreatic cancer cells to gemcitabine. Cell biology international. 2023-08-07. PMID:37545170. |
gem caused significant cell apoptosis and proapoptotic genes of both cancer cells, and thermochemotherapy further promoted apoptosis and genes transcription, accompanied by excessive ros production. |
2023-08-07 |
2023-08-14 |
Not clear |
| Zeru Li, Cheng Qin, Bangbo Zhao, Yuanyang Wang, Tianyu Li, Yutong Zhao, Weibin Wan. DHX38 restricts chemoresistance by regulating the alternative pre-mRNA splicing of RELL2 in pancreatic ductal adenocarcinoma. PLoS genetics. vol 19. issue 7. 2023-07-28. PMID:37506056. |
firstly, we found that rell2 plays an anti-oncogenic role in pdac by performing in vitro functional assays including cell proliferation, gem cytotoxicity assay and apoptosis. |
2023-07-28 |
2023-08-14 |
Not clear |
| Yi-Ru Pan, Chiao-En Wu, Shih-Ming Jung, Shih-Chiang Huang, Sheng-Hsuan Lin, Wen-Chi Chou, Yu-Chan Chang, Ming-Huang Chen, Tsai-Hsien Hung, Alice L Yu, Wen-Kuan Huang, Chun-Nan Ye. Mucin 4 Confers Gemcitabine Resistance and an Unfavorable Prognosis in Patients with Cholangiocarcinoma via AKT Activation. International journal of biological sciences. vol 19. issue 9. 2023-06-16. PMID:37324940. |
the muc4-akt axis induced bax s184 phosphorylation to inhibit apoptosis and downregulated gem transporter human equilibrative nucleoside transporter 1 (hent1) expression. |
2023-06-16 |
2023-08-14 |
human |
| Sharad S Singhal, Rachana Garg, Atish Mohanty, Pankaj Garg, Sravani Keerthi Ramisetty, Tamara Mirzapoiazova, Raffaella Soldi, Sunil Sharma, Prakash Kulkarni, Ravi Salgi. Recent Advancement in Breast Cancer Research: Insights from Model Organisms-Mouse Models to Zebrafish. Cancers. vol 15. issue 11. 2023-06-11. PMID:37296923. |
the currently available gem models have been employed to assess specific genetic changes that underlay many features of carcinogenesis, including variations in tumor cell proliferation, apoptosis, invasion, metastasis, angiogenesis, and drug resistance. |
2023-06-11 |
2023-08-14 |
mouse |