| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guoyuan Qi, Zhigang Liu, Rong Fan, Ziru Yin, Yashi Mi, Bo Ren, Xuebo Li. Athyrium multidentatum (Doll.) Ching extract induce apoptosis via mitochondrial dysfunction and oxidative stress in HepG2 cells. Scientific reports. vol 7. issue 1. 2019-01-09. PMID:28536473. |
also, amc strongly inhibited the cell growth and induced apoptosis and cell cycle arrest in hepg2 cells by significantly upregulating the protein expressions of fas, fas-l, bax/bcl-2, cyto-c, cleaved caspase-3, and parp in a dose-dependent manner, which indicates amc induces apoptosis in hepg2 cells through both intrinsic and extrinsic pathways. |
2019-01-09 |
2023-08-13 |
Not clear |
| Johanna Ebmeyer, Jessica Behrend, Mario Lorenz, Georgia Günther, Raymond Reif, Jan G Hengstler, Albert Braeuning, Alfonso Lampen, Stefanie Hessel-Pra. Pyrrolizidine alkaloid-induced alterations of prostanoid synthesis in human endothelial cells. Chemico-biological interactions. vol 298. 2019-01-09. PMID:30465738. |
initial molecular effect screening using a pcr array with genes associated with endothelial cell biology showed pa-induced upregulation of the fas receptor, which is involved in extrinsic apoptosis, and regulation of a number of interleukins, as well as of different enzymes relevant for prostanoid synthesis. |
2019-01-09 |
2023-08-13 |
human |
| Sheng-Bing Liu, Xue-Ping Lin, Ying Xu, Zhong-Fei Shen, Wei-Wei Pa. DAXX promotes ovarian cancer ascites cell proliferation and migration by activating the ERK signaling pathway. Journal of ovarian research. vol 11. issue 1. 2018-12-28. PMID:30336783. |
the death-domain-associated protein (daxx) was originally identified as a protein that binds to the transmembrane death receptor fas and enhances both fas-induced and transforming growth factor-β-dependent apoptosis. |
2018-12-28 |
2023-08-13 |
mouse |
| Diana Díaz-García, Diana Cenariu, Yolanda Pérez, Paula Cruz, Isabel Del Hierro, Sanjiv Prashar, Eva Fischer-Fodor, Santiago Gómez-Rui. Modulation of the mechanism of apoptosis in cancer cell lines by treatment with silica-based nanostructured materials functionalized with different metallodrugs. Dalton transactions (Cambridge, England : 2003). vol 47. issue 35. 2018-12-12. PMID:30112529. |
in addition, mechanistic aspects of the apoptosis triggered by the synthesized materials have been studied in vitro in tumour cell lines derived from three distinct types of cancer in order to elucidate their growth inhibition and interference with the expression of tumour necrosis factor alfa (tnf-α) and the first apoptosis signal receptor (fas or tumour necrosis factor receptor 6). |
2018-12-12 |
2023-08-13 |
Not clear |
| Xiao-Yan He, Bo-Ya Liu, Jin-Long Wu, Shu-Lun Ai, Ren-Xi Zhuo, Si-Xue Chen. A Dual Macrophage Targeting Nanovector for Delivery of Oligodeoxynucleotides To Overcome Cancer-Associated Immunosuppression. ACS applied materials & interfaces. vol 9. issue 49. 2018-12-11. PMID:29160061. |
nevertheless, upregulated fas as well as fas ligand (fasl) may induce fas/fasl-mediated apoptosis, which results in the increased expressions of caspases in tumor cells. |
2018-12-11 |
2023-08-13 |
Not clear |
| Li Liao, Yang Yu, Bingyi Shao, Xiaoxia Su, Han Wang, Huijuan Kuang, Huan Jing, Yi Shuai, Deqin Yang, Yan Ji. Redundant let-7a suppresses the immunomodulatory properties of BMSCs by inhibiting the Fas/FasL system in osteoporosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 32. issue 4. 2018-12-11. PMID:29203591. |
in vivo and in vitro assays revealed that the capacity of osteoporotic bmscs to induce t-cell apoptosis declined as a result of decreased fas and fasl protein. |
2018-12-11 |
2023-08-13 |
Not clear |
| Gerd Meyer Zu Horste, Dariusz Przybylski, Markus A Schramm, Chao Wang, Alexandra Schnell, Youjin Lee, Raymond Sobel, Aviv Regev, Vijay K Kuchro. Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1. Immunity. vol 48. issue 3. 2018-11-27. PMID:29562202. |
the death receptor fas removes activated lymphocytes through apoptosis. |
2018-11-27 |
2023-08-13 |
mouse |
| Min Zhang, HaiLing Xia, Min Yu, LiJin Zhu, Li Ju, JunQiang Chen, JiaJun Zhao, Yun Xiao, Kun Che. N-acetylcysteine prevents cytotoxic effects induced by man-made mineral fibers in a human bronchial epithelial cell line. Toxicology in vitro : an international journal published in association with BIBRA. vol 53. 2018-11-26. PMID:30145358. |
furthermore, our results showed that apoptosis induced by mmmfs was mediated by the mitochondrial apoptotic pathway and fas death receptor pathway. |
2018-11-26 |
2023-08-13 |
human |
| S P Sergeeva, A A Savin, P F Litvitski. [A role of the Fas system in the pathogenesis of ischemic stroke]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 116. issue 3 Pt 2. 2018-11-05. PMID:27296794. |
the fas system can promote several biological effects due to their activation after ischemic stroke: apoptosis, inflammation, proliferation, differentiation. |
2018-11-05 |
2023-08-13 |
Not clear |
| S P Sergeeva, A A Savin, P F Litvitski. [A role of the Fas system in the pathogenesis of ischemic stroke]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 116. issue 3 Pt 2. 2018-11-05. PMID:27296794. |
fas interacts with adapter proteins activating a number of signaling pathways, including mapk, nfkb, jnk, erk, phosphorylation of cytoskeletal proteins, and caspase-dependent apoptosis. |
2018-11-05 |
2023-08-13 |
Not clear |
| S P Sergeeva, A A Savin, P F Litvitski. [A role of the Fas system in the pathogenesis of ischemic stroke]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 116. issue 3 Pt 2. 2018-11-05. PMID:27296794. |
fas expressed by neuronal progenitor cells from the subventricular zone does not induce apoptosis in healthy adult humans. |
2018-11-05 |
2023-08-13 |
Not clear |
| Peng Du, Shi-Jun Li, David M Ojcius, Kai-Xuan Li, Wei-Lin Hu, Xu'ai Lin, Ai-Hua Sun, Jie Ya. A novel Fas-binding outer membrane protein and lipopolysaccharide of Leptospira interrogans induce macrophage apoptosis through the Fas/FasL-caspase-8/-3 pathway. Emerging microbes & infections. vol 7. issue 1. 2018-11-02. PMID:30061622. |
in the present study, we found that l. interrogans caused apoptosis of phagocytosis-inhibited macrophages, and the product of the l. interrogans lb047 gene (lep-omp047) was the unique protein captured by mouse and human fas proteins. |
2018-11-02 |
2023-08-13 |
mouse |
| Amos E Dodi, Iyabode O Ajayi, Christine Chang, Meghan Beard, Shanna L Ashley, Steven K Huang, Victor J Thannickal, Daniel J Tschumperlin, Thomas H Sisson, Jeffrey C Horowit. Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli. Respiratory research. vol 19. issue 1. 2018-10-29. PMID:29747634. |
fibroblasts from fibrotic lungs of humans and mice demonstrate resistance to apoptosis induced by fas-ligand and prior studies have shown that susceptibility to apoptosis is enhanced when fas (cd95) expression is increased in these cells. |
2018-10-29 |
2023-08-13 |
mouse |
| Tuo Zhao, Rong Li, Xin Tan, Jun Zhang, Cuihong Fan, Qin Zhao, Yulin Deng, Aizhang Xu, Kiven Erique Lukong, Harald Genth, Jim Xian. Simulated Microgravity Reduces Focal Adhesions and Alters Cytoskeleton and Nuclear Positioning Leading to Enhanced Apoptosis via Suppressing FAK/RhoA-Mediated mTORC1/NF-κB and ERK1/2 Pathways. International journal of molecular sciences. vol 19. issue 7. 2018-10-24. PMID:29986550. |
furthermore, the fak/rhoa activator, toxin cytotoxic necrotizing factor-1 (cnf1), reduces cell apoptosis, restores the cytoskeleton, fas, neps, and nuclear positioning, and converts all of the above smg-induced changes in molecular signaling in cells under smg. |
2018-10-24 |
2023-08-13 |
human |
| Tuo Zhao, Rong Li, Xin Tan, Jun Zhang, Cuihong Fan, Qin Zhao, Yulin Deng, Aizhang Xu, Kiven Erique Lukong, Harald Genth, Jim Xian. Simulated Microgravity Reduces Focal Adhesions and Alters Cytoskeleton and Nuclear Positioning Leading to Enhanced Apoptosis via Suppressing FAK/RhoA-Mediated mTORC1/NF-κB and ERK1/2 Pathways. International journal of molecular sciences. vol 19. issue 7. 2018-10-24. PMID:29986550. |
therefore, our data demonstrate that smg reduces fas and alters the cytoskeleton and nuclear positioning, leading to enhanced cell apoptosis via suppressing the fak/rhoa-regulated mtorc1/nf-κb and erk1/2 pathways. |
2018-10-24 |
2023-08-13 |
human |
| Tian-Hua Yao, Parekejiang Pataer, Krishna Prasad Regmi, Xi-Wen Gu, Quan-Yan Li, Jing-Ting Du, Su-Meng Ge, Jun-Bo T. Propranolol induces hemangioma endothelial cell apoptosis via a p53‑BAX mediated pathway. Molecular medicine reports. vol 18. issue 1. 2018-10-19. PMID:29767244. |
the expression levels of downstream proteins regulated by p53 [tumour necrosis factor receptor superfamily member 6 (fas), p53‑induced death domain‑containing protein (pidd), death receptor 5 (dr5), bh3‑interacting domain death agonist (bid), apoptosis regulator bax (bax), p53 unregulated modulator of apoptosis (puma), phosphatidylinositol‑glycan biosynthesis class s protein (pigs), and insulin‑like growth factor‑binding protein 3 (igf‑bp3)] were revealed in the experimental and control groups via western blotting. |
2018-10-19 |
2023-08-13 |
Not clear |
| Bingyi Shao, Xiaohui Fu, Yang Yu, Deqin Yan. Regulatory effects of miRNA‑181a on FasL expression in bone marrow mesenchymal stem cells and its effect on CD4+T lymphocyte apoptosis in estrogen deficiency‑induced osteoporosis. Molecular medicine reports. vol 18. issue 1. 2018-10-19. PMID:29845202. |
in our previous study, it was demonstrated that estrogen promotes bone marrow mesenchymal stem cell (bmmsc)‑induced osteoclast apoptosis through downregulation of microrna (mir)‑181a and subsequent fas ligand (fasl) protein accumulation. |
2018-10-19 |
2023-08-13 |
mouse |
| Yuanxin Zhang, Yakun Ge, Xie Ping, Ming Yu, Dawei Lou, Wei Sh. Synergistic apoptotic effects of silibinin in enhancing paclitaxel toxicity in human gastric cancer cell lines. Molecular medicine reports. vol 18. issue 2. 2018-10-18. PMID:29901126. |
furthermore, upregulation of the ratio of apoptosis regulator bcl‑2/apoptosis regulator bax and tumor necrosis factor receptor superfamily member 6 (fas)/fas ligand indicated that the silibinin‑paclitaxel combination activated the death receptor‑mediated pathway in sgc‑7901 cells. |
2018-10-18 |
2023-08-13 |
human |
| Hongliang Yu, Jian He, Qian Lu, Da Huo, Shanmei Yuan, Zhengyang Zhou, Peipei Xu, Yong H. Anti-Fas Antibody Conjugated Nanoparticles Enhancing the Antitumor Effect of Camptothecin by Activating the Fas-FasL Apoptotic Pathway. ACS applied materials & interfaces. vol 8. issue 44. 2018-10-16. PMID:27754664. |
emerging evidence suggest that the introduction of fas ligand (fasl) can enhance the fas-dependent apoptosis and induce durable immune responses against tumor. |
2018-10-16 |
2023-08-13 |
Not clear |
| Hongliang Yu, Jian He, Qian Lu, Da Huo, Shanmei Yuan, Zhengyang Zhou, Peipei Xu, Yong H. Anti-Fas Antibody Conjugated Nanoparticles Enhancing the Antitumor Effect of Camptothecin by Activating the Fas-FasL Apoptotic Pathway. ACS applied materials & interfaces. vol 8. issue 44. 2018-10-16. PMID:27754664. |
due to the high level of mmp expressed by tumor cells inside the tumor tissue, these nps would shed their peg layers, resulting in the exposure of anti-fas antibody to bind the fas receptor and triggering the apoptosis of tumor cells. |
2018-10-16 |
2023-08-13 |
Not clear |