| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Petak, D M Tillman, J A Houghto. p53 dependence of Fas induction and acute apoptosis in response to 5-fluorouracil-leucovorin in human colon carcinoma cell lines. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 6. issue 11. 2001-05-31. PMID:11106264. |
p53 dependence of fas induction and acute apoptosis in response to 5-fluorouracil-leucovorin in human colon carcinoma cell lines. |
2001-05-31 |
2023-08-12 |
human |
| I Petak, D M Tillman, J A Houghto. p53 dependence of Fas induction and acute apoptosis in response to 5-fluorouracil-leucovorin in human colon carcinoma cell lines. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 6. issue 11. 2001-05-31. PMID:11106264. |
we examined the patterns of induction of apoptosis, fas expression, and the influence of the status of the p53 tumor suppressor gene, in response to treatment of human colon carcinoma cell lines to 5-fluorouracil (fura) combined with leucovorin (lv) under conditions of both dna-directed (ht29, vrc5/c1, and rko) and rna-directed (hct8 and hct116) cytotoxicity. |
2001-05-31 |
2023-08-12 |
human |
| I Petak, D M Tillman, J A Houghto. p53 dependence of Fas induction and acute apoptosis in response to 5-fluorouracil-leucovorin in human colon carcinoma cell lines. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 6. issue 11. 2001-05-31. PMID:11106264. |
transduction of ht29 cells with ad-wtp53 induced elevated fas expression and sensitized the cells to fura-lv-induced apoptosis. |
2001-05-31 |
2023-08-12 |
human |
| I Petak, D M Tillman, J A Houghto. p53 dependence of Fas induction and acute apoptosis in response to 5-fluorouracil-leucovorin in human colon carcinoma cell lines. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 6. issue 11. 2001-05-31. PMID:11106264. |
data indicate that the presence of a wtp53 gene determines fura-lv-induced fas expression, the kinetics of fura-lv-induced apoptosis and not the extent of apoptosis induced, both being independent of the mechanism of fura action. |
2001-05-31 |
2023-08-12 |
human |
| I Petak, D M Tillman, J A Houghto. p53 dependence of Fas induction and acute apoptosis in response to 5-fluorouracil-leucovorin in human colon carcinoma cell lines. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 6. issue 11. 2001-05-31. PMID:11106264. |
therefore, in colon carcinomas that express wtp53, the approach to sensitize tumors to fas-mediated apoptosis may be further enhanced from the effect of fura-lv in elevating fas expression in a p53-dependent manner. |
2001-05-31 |
2023-08-12 |
human |
| I Condo, R Test. Intracellular mediators of programmed cell death initiated at the cell surface receptor Fas. Transplant international : official journal of the European Society for Organ Transplantation. vol 13 Suppl 1. 2001-05-31. PMID:11111951. |
fas (cd95/apo-1) is a member of the "death receptors" family, a group of cell surface proteins that trigger apoptosis upon binding with their natural ligands. |
2001-05-31 |
2023-08-12 |
human |
| R A Schmid, U Stammberger, S Hillinger, A Gaspert, C H Boasquevisque, U Malipiero, A Fontana, W Wede. Fas ligand gene transfer combined with low dose cyclosporine A reduces acute lung allograft rejection. Transplant international : official journal of the European Society for Organ Transplantation. vol 13 Suppl 1. 2001-05-31. PMID:11112024. |
the interaction between fas and its ligand (fasl) induces apoptosis in the fas-expressing cell. |
2001-05-31 |
2023-08-12 |
rat |
| Y Segawa, N Tsuzuike, Y Itokazu, T Omata, N Inoue, M Nagasawa, H Nishioka, Y Nakano, T Kobayashi, T Kand. Effects of a novel hepatoprotective drug, ZNC-2381, on fas-induced hepatocellular caspase-3 activity and apoptosis in mice. Pharmacology. vol 62. issue 2. 2001-05-31. PMID:11174076. |
we examined the effects of znc-2381 (1-(4-aminophenyl)methyl-3-(3-nitrophenyl)-1,3-dihydroimidazo[4,5-b] pyridine-2-one), a new oral hepatoprotective agent, on hepatocellular caspase-3 activity and apoptosis induced by anti-mouse fas antibody (anti-fas ab) in mice. |
2001-05-31 |
2023-08-12 |
mouse |
| T Mammone, D Gan, D Collins, R A Lockshin, K Marenus, D Mae. Successful separation of apoptosis and necrosis pathways in HaCaT keratinocyte cells induced by UVB irradiation. Cell biology and toxicology. vol 16. issue 5. 2001-05-31. PMID:11201053. |
low doses of uvb, 5-20 mj/cm2, increase the levels of apoptosis as shown by increased levels of fragmented dna, fas, parp, and fasl protein, and the number of apoptotic cells as assessed by facs analysis. |
2001-05-31 |
2023-08-12 |
human |
| S Wongweragiat, R F Searle, J N Bulme. Expression of Fas/Fas ligand by decidual leukocytes in hydatidiform mole. Biology of reproduction. vol 64. issue 3. 2001-05-31. PMID:11207192. |
fas ligand (fasl) expression by placental trophoblast may induce apoptosis of fas+ lymphocytes, thereby facilitating immune tolerance and survival of the molar trophoblast. |
2001-05-31 |
2023-08-12 |
Not clear |
| T Koji, Y Hishikawa, H Ando, Y Nakanishi, N Kobayash. Expression of Fas and Fas ligand in normal and ischemia-reperfusion testes: involvement of the Fas system in the induction of germ cell apoptosis in the damaged mouse testis. Biology of reproduction. vol 64. issue 3. 2001-05-31. PMID:11207212. |
expression of fas and fas ligand in normal and ischemia-reperfusion testes: involvement of the fas system in the induction of germ cell apoptosis in the damaged mouse testis. |
2001-05-31 |
2023-08-12 |
mouse |
| T Koji, Y Hishikawa, H Ando, Y Nakanishi, N Kobayash. Expression of Fas and Fas ligand in normal and ischemia-reperfusion testes: involvement of the Fas system in the induction of germ cell apoptosis in the damaged mouse testis. Biology of reproduction. vol 64. issue 3. 2001-05-31. PMID:11207212. |
the aim of this study was to examine the possible involvement of the fas and fas ligand (fasl) system in the induction of germ cell apoptosis in normal and ischemia-reperfusion testes of adult mice. |
2001-05-31 |
2023-08-12 |
mouse |
| T Koji, Y Hishikawa, H Ando, Y Nakanishi, N Kobayash. Expression of Fas and Fas ligand in normal and ischemia-reperfusion testes: involvement of the Fas system in the induction of germ cell apoptosis in the damaged mouse testis. Biology of reproduction. vol 64. issue 3. 2001-05-31. PMID:11207212. |
apoptosis of germ cells was identified in the normal testis especially around stages xi and xii, whereas the expression of fas and fasl was largely confined to leydig cells and sertoli cells, respectively. |
2001-05-31 |
2023-08-12 |
mouse |
| T Koji, Y Hishikawa, H Ando, Y Nakanishi, N Kobayash. Expression of Fas and Fas ligand in normal and ischemia-reperfusion testes: involvement of the Fas system in the induction of germ cell apoptosis in the damaged mouse testis. Biology of reproduction. vol 64. issue 3. 2001-05-31. PMID:11207212. |
injection of anti-fas antibody, which blocks the interaction between fas and fasl, inhibited apoptosis, as indicated by the reduced number of tunel-positive cells, except for apoptosis at stages xi and xii. |
2001-05-31 |
2023-08-12 |
mouse |
| K Hoshimoto, M Hayashi, T Ohkur. Plasma levels of soluble Fas during normal pregnancy. Gynecologic and obstetric investigation. vol 51. issue 2. 2001-05-31. PMID:11223701. |
however, there are few reports on soluble fas (sfas) which is an inhibitor of apoptosis during normal pregnancy. |
2001-05-31 |
2023-08-12 |
human |
| K Tobiume, A Matsuzawa, T Takahashi, H Nishitoh, K Morita, K Takeda, O Minowa, K Miyazono, T Noda, H Ichij. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO reports. vol 2. issue 3. 2001-05-31. PMID:11266364. |
apoptosis signal-regulating kinase (ask) 1 is activated in response to various cytotoxic stresses including tnf, fas and reactive oxygen species (ros) such as h(2)o(2), and activates c-jun nh(2)-terminal kinase (jnk) and p38. |
2001-05-31 |
2023-08-12 |
mouse |
| P Bossù, E del Grosso, M P Cesaroni, G Maurizi, N Balestro, A Stoppacciaro, E del Giudice, P Ruggiero, D Borasch. Balance between autocrine interleukin-1beta and caspases defines life versus death of polymorphonuclear cells. European cytokine network. vol 12. issue 1. 2001-05-31. PMID:11282563. |
upon fas triggering, pmn apoptosis is greatly accelerated, in correlation with increased caspase activity, whereas il-1beta production is not augmented. |
2001-05-31 |
2023-08-12 |
human |
| T Tsubata, T Honj. B cell tolerance and autoimmunity. Reviews in immunogenetics. vol 2. issue 1. 2001-05-31. PMID:11324689. |
since all of these molecules regulate b cell apoptosis mediated by either the antigen receptor or fas, b cell apoptosis may play a role in the induction and maintenance of b cell tolerance. |
2001-05-31 |
2023-08-12 |
Not clear |
| F Aoudjit, K Vuor. Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis. The Journal of cell biology. vol 152. issue 3. 2001-05-24. PMID:11157988. |
matrix attachment modulates fas-mediated apoptosis at two different levels: by regulating the expression level of fas, and by regulating the expression level of c-flip, an endogenous antagonist of caspase-8. |
2001-05-24 |
2023-08-12 |
Not clear |
| F Aoudjit, K Vuor. Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis. The Journal of cell biology. vol 152. issue 3. 2001-05-24. PMID:11157988. |
these studies identify matrix attachment as a survival factor against death receptor-mediated apoptosis and provide a molecular mechanism for anoikis and previously observed fas resistance in endothelial cells. |
2001-05-24 |
2023-08-12 |
Not clear |