| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tetsuo Shukuwa, Ichiro Katayama, Takehiko Koj. Fas-mediated apoptosis of melanoma cells and infiltrating lymphocytes in human malignant melanomas. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 15. issue 4. 2002-05-15. PMID:11950912. |
these findings led us to investigate apoptosis, and to histochemically analyze involvement of fas and fasl in the induction of apoptosis, in human malignant melanoma tissues. |
2002-05-15 |
2023-08-12 |
human |
| Tetsuo Shukuwa, Ichiro Katayama, Takehiko Koj. Fas-mediated apoptosis of melanoma cells and infiltrating lymphocytes in human malignant melanomas. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 15. issue 4. 2002-05-15. PMID:11950912. |
these data reveal that melanoma cells and infiltrating lymphocytes have the potential to induce their own apoptosis regulated by fas and fasl in an autocrine and/or paracrine fashion and that the decline of fas-mediated apoptosis of melanoma cells, rather than the apoptosis of infiltrating lymphocytes, may affect the prognosis of melanoma patients, possibly through the accumulation of more aberrant cells acquiring metastatic activity. |
2002-05-15 |
2023-08-12 |
human |
| A Zisman, C P Ng, A J Pantuck, B Bonavida, A S Belldegru. Actinomycin D and gemcitabine synergistically sensitize androgen-independent prostate cancer cells to Apo2L/TRAIL-mediated apoptosis. Journal of immunotherapy (Hagerstown, Md. : 1997). vol 24. issue 6. 2002-05-14. PMID:11759069. |
the cytotoxic efficacy and kinetics involved in sensitization of apo2l/trail-resistant, androgen-independent prostate cancer cells to apo2l/trail or tumor necrosis factor-alpha or fas ligand-mediated apoptosis were tested using subclinical concentrations of actinomycin d, paclitaxel, cisplatinum, gemcitabine, and radiation in cl-1, lncap, du-145, and pc3 prostate cancer cell lines. |
2002-05-14 |
2023-08-12 |
Not clear |
| Erini Dermitzaki, Christos Tsatsanis, Achille Gravanis, Andrew N Margiori. Corticotropin-releasing hormone induces Fas ligand production and apoptosis in PC12 cells via activation of p38 mitogen-activated protein kinase. The Journal of biological chemistry. vol 277. issue 14. 2002-05-13. PMID:11790788. |
corticotropin-releasing hormone induces fas ligand production and apoptosis in pc12 cells via activation of p38 mitogen-activated protein kinase. |
2002-05-13 |
2023-08-12 |
rat |
| Erini Dermitzaki, Christos Tsatsanis, Achille Gravanis, Andrew N Margiori. Corticotropin-releasing hormone induces Fas ligand production and apoptosis in PC12 cells via activation of p38 mitogen-activated protein kinase. The Journal of biological chemistry. vol 277. issue 14. 2002-05-13. PMID:11790788. |
crh induced fas ligand production and apoptosis. |
2002-05-13 |
2023-08-12 |
rat |
| Erini Dermitzaki, Christos Tsatsanis, Achille Gravanis, Andrew N Margiori. Corticotropin-releasing hormone induces Fas ligand production and apoptosis in PC12 cells via activation of p38 mitogen-activated protein kinase. The Journal of biological chemistry. vol 277. issue 14. 2002-05-13. PMID:11790788. |
these effects were mediated by the crh type 1 receptor because its antagonist antalarmin blocked crh-induced apoptosis and fas ligand expression. |
2002-05-13 |
2023-08-12 |
rat |
| Erini Dermitzaki, Christos Tsatsanis, Achille Gravanis, Andrew N Margiori. Corticotropin-releasing hormone induces Fas ligand production and apoptosis in PC12 cells via activation of p38 mitogen-activated protein kinase. The Journal of biological chemistry. vol 277. issue 14. 2002-05-13. PMID:11790788. |
crh activated p38 mitogen-activated protein kinase, which was found to be essential for crh-induced apoptosis and fas ligand production. |
2002-05-13 |
2023-08-12 |
rat |
| Erini Dermitzaki, Christos Tsatsanis, Achille Gravanis, Andrew N Margiori. Corticotropin-releasing hormone induces Fas ligand production and apoptosis in PC12 cells via activation of p38 mitogen-activated protein kinase. The Journal of biological chemistry. vol 277. issue 14. 2002-05-13. PMID:11790788. |
crh also promoted a rapid and transient activation of erk1/2, which, however, was not necessary for either crh-induced apoptosis or fas ligand production. |
2002-05-13 |
2023-08-12 |
rat |
| Erini Dermitzaki, Christos Tsatsanis, Achille Gravanis, Andrew N Margiori. Corticotropin-releasing hormone induces Fas ligand production and apoptosis in PC12 cells via activation of p38 mitogen-activated protein kinase. The Journal of biological chemistry. vol 277. issue 14. 2002-05-13. PMID:11790788. |
thus, crh promotes pc12 apoptosis via the crh type 1 receptor, which induces fas ligand production via activation of p38. |
2002-05-13 |
2023-08-12 |
rat |
| S J Hall, S E Canfield, Y Yan, W Hassen, W A Selleck, S-H Che. A novel bystander effect involving tumor cell-derived Fas and FasL interactions following Ad.HSV-tk and Ad.mIL-12 gene therapies in experimental prostate cancer. Gene therapy. vol 9. issue 8. 2002-05-13. PMID:11948376. |
after demonstrating that ad.hsv-tk/gcv and ad.mil-12-induced ifn-gamma independently up-regulated expression of fasl and fas, respectively, studies examined tumor cell-mediated death through fas/fasl-induced apoptosis as a mechanism of primary tumor growth suppression. |
2002-05-13 |
2023-08-12 |
mouse |
| S J Hall, S E Canfield, Y Yan, W Hassen, W A Selleck, S-H Che. A novel bystander effect involving tumor cell-derived Fas and FasL interactions following Ad.HSV-tk and Ad.mIL-12 gene therapies in experimental prostate cancer. Gene therapy. vol 9. issue 8. 2002-05-13. PMID:11948376. |
in vivo co-inoculation of an adenovirus expressing soluble fas resulted in combination therapy-treated tumors, which were three times larger than expected, and a reduction in apoptosis to baseline levels. |
2002-05-13 |
2023-08-12 |
mouse |
| S J Hall, S E Canfield, Y Yan, W Hassen, W A Selleck, S-H Che. A novel bystander effect involving tumor cell-derived Fas and FasL interactions following Ad.HSV-tk and Ad.mIL-12 gene therapies in experimental prostate cancer. Gene therapy. vol 9. issue 8. 2002-05-13. PMID:11948376. |
therefore, the combination of ad.hsv-tk/gcv + ad.mil-12 results in enhanced local growth control via apoptosis due to tumor cell expression of fas and fasl and improved anti-metastatic activity secondary to a strong nk response. |
2002-05-13 |
2023-08-12 |
mouse |
| D Eaton, D E Gilham, A O'Neill, R E Hawkin. Retroviral transduction of human peripheral blood lymphocytes with Bcl-X(L) promotes in vitro lymphocyte survival in pro-apoptotic conditions. Gene therapy. vol 9. issue 8. 2002-05-13. PMID:11948378. |
we show that jurkat cells transduced with bcl-x(l) retrovirus were partially resistant to fas (cd95) antibody-induced apoptosis. |
2002-05-13 |
2023-08-12 |
mouse |
| H Takahashi, A Ishida-Yamamoto, H Iizuk. Ultraviolet B irradiation induces apoptosis of keratinocytes by direct activation of Fas antigen. The journal of investigative dermatology. Symposium proceedings. vol 6. issue 1. 2002-05-10. PMID:11764289. |
ultraviolet b irradiation induces apoptosis of keratinocytes by direct activation of fas antigen. |
2002-05-10 |
2023-08-12 |
mouse |
| H Takahashi, A Ishida-Yamamoto, H Iizuk. Ultraviolet B irradiation induces apoptosis of keratinocytes by direct activation of Fas antigen. The journal of investigative dermatology. Symposium proceedings. vol 6. issue 1. 2002-05-10. PMID:11764289. |
keratinocytes derived from mrl/lpr mice, which have mutated fas antigen, showed diminished uvb-induced apoptosis suggesting that fas antigen is significantly involved in uvb-induced apoptosis. |
2002-05-10 |
2023-08-12 |
mouse |
| H Takahashi, A Ishida-Yamamoto, H Iizuk. Ultraviolet B irradiation induces apoptosis of keratinocytes by direct activation of Fas antigen. The journal of investigative dermatology. Symposium proceedings. vol 6. issue 1. 2002-05-10. PMID:11764289. |
these results indicate that uvb irradiation induces multimerization of fas antigen that results in apoptosis without the fas ligand. |
2002-05-10 |
2023-08-12 |
mouse |
| R S Biswas, H J Cha, J M Hardwick, R K Srivastav. Inhibition of drug-induced Fas ligand transcription and apoptosis by Bcl-XL. Molecular and cellular biochemistry. vol 225. issue 1-. 2002-05-09. PMID:11716366. |
inhibition of drug-induced fas ligand transcription and apoptosis by bcl-xl. |
2002-05-09 |
2023-08-12 |
Not clear |
| R S Biswas, H J Cha, J M Hardwick, R K Srivastav. Inhibition of drug-induced Fas ligand transcription and apoptosis by Bcl-XL. Molecular and cellular biochemistry. vol 225. issue 1-. 2002-05-09. PMID:11716366. |
inhibition of fas/fasl pathway by anti-fasl antibody, mutant fas or a dominant negative fadd blocks paclitaxel-induced apoptosis. |
2002-05-09 |
2023-08-12 |
Not clear |
| R L Nolsøe, O P Kristiansen, Z M Larsen, J Johannesen, F Pociot, T Mandrup-Poulse. Complete mutation scan of the human Fas ligand gene: linkage studies in Type I diabetes mellitus families. Diabetologia. vol 45. issue 1. 2002-05-09. PMID:11845233. |
there is evidence that the apoptosis inducing t-cell effector, fas ligand (fasl) could be involved in the pathogenesis of type i diabetes, probably because fasl-mediated apoptosis is important in maintaining peripheral self-tolerance and in down-regulating an immune response. |
2002-05-09 |
2023-08-12 |
human |
| L H B Boechat, C A Vilella, R L Zollne. Effect of iodide on Fas, Fas-ligand and Bcl-w mRNA expression in thyroid of NOD mice pretreated with methimazole. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 35. issue 3. 2002-05-09. PMID:11887206. |
some authors have proposed that iodide, given after methimazole or propylthiouracil, is capable of inducing apoptosis in thyroid cells and that anti-thyroid drugs can modulate the expression of apoptosis components such as fas and its ligand (fas-l). |
2002-05-09 |
2023-08-12 |
mouse |