| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura Rubbia-Brandt, Sophia Taylor, Patrizia Gindre, Rafael Quadri, Karim Abid, Laurent Spahr, Francesco Negr. Lack of in vivo blockade of Fas- and TNFR1-mediated hepatocyte apoptosis by the hepatitis C virus. The Journal of pathology. vol 197. issue 5. 2002-09-23. PMID:12210081. |
furthermore, when patients expressing either fas or tnfr1 were stratified according to serum hcv rna levels, cases with detectable hepatocyte apoptosis had higher hcv viraemias. |
2002-09-23 |
2023-08-12 |
Not clear |
| G Z Feuerstei. Apoptosis--new opportunities for novel therapeutics for heart diseases. Cardiovascular drugs and therapy. vol 15. issue 6. 2002-09-20. PMID:11916364. |
among the most potent stimuli that elicit cardiomyocyte apoptosis are: oxygen radicals (including no), cytokines, (e.g., tnfalpha, fas) neurohormonal factors (angiotension ii), cardiotoxic drugs (e.g., doxorubicin) and mechanical, stretch situations. |
2002-09-20 |
2023-08-12 |
human |
| Kåre Kemp, Helle Bruunsgaard, Peter Skinhøj, Bente Klarlund Pederse. Pneumococcal infections in humans are associated with increased apoptosis and trafficking of type 1 cytokine-producing T cells. Infection and immunity. vol 70. issue 9. 2002-09-18. PMID:12183548. |
in fact, increased activation-induced apoptosis in the remaining peripheral lymphocytes and elevated levels of soluble fas ligand were detected at admission to the hospital. |
2002-09-18 |
2023-08-12 |
Not clear |
| Randy W Jackson, Richard Gelinas, Ted A Baughman, Thomas Cox, J Jeffry Howbert, Kristin A Kucera, John A Latham, Fred Ramsdell, Devinder Singh, Ihab S Darwis. Benzobicyclooctanes as novel inhibitors of TNF-alpha signaling. Bioorganic & medicinal chemistry letters. vol 12. issue 7. 2002-09-17. PMID:11909725. |
additionally, they are selective for tnf-alpha as they do not inhibit apoptosis induced by soluble fas ligand. |
2002-09-17 |
2023-08-12 |
Not clear |
| Lina Musallam, Chantal Ethier, Pierre Selim Haddad, Francine Denizeau, Marc Bilodea. Resistance to Fas-induced apoptosis in hepatocytes: role of GSH depletion by cell isolation and culture. American journal of physiology. Gastrointestinal and liver physiology. vol 283. issue 3. 2002-09-17. PMID:12181187. |
results show that the capacity of fas to activate caspase-8 and to induce apoptosis requires important intracellular glutathione levels and high gsh/total glutathione ratio. |
2002-09-17 |
2023-08-12 |
mouse |
| Shaobo Zhang, Guangyuan Zeng, Chinghai Kao, Thomas Gardner, Christopher Sweeney, Ning-Sun Yang, John N Eble, Liang Chen. Fas-Fas ligand signaling pathway mediates an interleukin-12-induced rejection of a murine prostate tumor system. The Prostate. vol 53. issue 1. 2002-09-17. PMID:12210482. |
fas (apo-1/cd95) is a type i membrane protein that is capable of initiating an apoptosis signaling pathway when bound to its ligand (fasl). |
2002-09-17 |
2023-08-12 |
Not clear |
| Ahmed A Samatar, Luquan Wang, Asra Mirza, Sandra Koseoglu, Suxing Liu, Chandra C Kuma. Transforming growth factor-beta 2 is a transcriptional target for Akt/protein kinase B via forkhead transcription factor. The Journal of biological chemistry. vol 277. issue 31. 2002-09-16. PMID:12011061. |
akt/protein kinase b phosphorylates forkhead transcription factors and prevents their nuclear localization, leading to repression of genes involved in apoptosis, such as fas ligand (fasl). |
2002-09-16 |
2023-08-12 |
human |
| Jin Hong Liu, Sheng Wei, Thierry Lamy, Yongxiang Li, P K Epling-Burnette, Julie Y Djeu, Thomas P Loughra. Blockade of Fas-dependent apoptosis by soluble Fas in LGL leukemia. Blood. vol 100. issue 4. 2002-09-12. PMID:12149230. |
blockade of fas-dependent apoptosis by soluble fas in lgl leukemia. |
2002-09-12 |
2023-08-12 |
mouse |
| Jin Hong Liu, Sheng Wei, Thierry Lamy, Yongxiang Li, P K Epling-Burnette, Julie Y Djeu, Thomas P Loughra. Blockade of Fas-dependent apoptosis by soluble Fas in LGL leukemia. Blood. vol 100. issue 4. 2002-09-12. PMID:12149230. |
in lpr/lpr mice and children with autoimmune lymphoproliferative syndrome, defective apoptosis is due to fas mutations. |
2002-09-12 |
2023-08-12 |
mouse |
| Jin Hong Liu, Sheng Wei, Thierry Lamy, Yongxiang Li, P K Epling-Burnette, Julie Y Djeu, Thomas P Loughra. Blockade of Fas-dependent apoptosis by soluble Fas in LGL leukemia. Blood. vol 100. issue 4. 2002-09-12. PMID:12149230. |
leukemic lgls are resistant to fas-dependent apoptosis despite expressing high levels of fas. |
2002-09-12 |
2023-08-12 |
mouse |
| Jin Hong Liu, Sheng Wei, Thierry Lamy, Yongxiang Li, P K Epling-Burnette, Julie Y Djeu, Thomas P Loughra. Blockade of Fas-dependent apoptosis by soluble Fas in LGL leukemia. Blood. vol 100. issue 4. 2002-09-12. PMID:12149230. |
supernatants from cells transfected with these fas variants blocked fas-dependent apoptosis of leukemic lgls. |
2002-09-12 |
2023-08-12 |
mouse |
| Jin Hong Liu, Sheng Wei, Thierry Lamy, Yongxiang Li, P K Epling-Burnette, Julie Y Djeu, Thomas P Loughra. Blockade of Fas-dependent apoptosis by soluble Fas in LGL leukemia. Blood. vol 100. issue 4. 2002-09-12. PMID:12149230. |
these results suggest that blockade of fas-signaling by soluble fas may be a mechanism leading to apoptosis resistance in leukemic lgls. |
2002-09-12 |
2023-08-12 |
mouse |
| Valeria M Borges, Marcela F Lopes, Haroldo Falcão, José Henrique Leite-Júnior, Patricia R M Rocco, Wendy F Davidson, Rafael Linden, Walter A Zin, George A DosRei. Apoptosis underlies immunopathogenic mechanisms in acute silicosis. American journal of respiratory cell and molecular biology. vol 27. issue 1. 2002-09-11. PMID:12091249. |
cd4(+) t cell death was mediated by fas ligand, because cd4(+) t cells from fas ligand-deficient gld mice did not undergo activation-induced apoptosis. |
2002-09-11 |
2023-08-12 |
mouse |
| J Fleming, A Ghose, P R Harriso. Molecular mechanisms of cancer prevention by selenium compounds. Nutrition and cancer. vol 40. issue 1. 2002-09-10. PMID:11799922. |
our recent work has shown that primary cultures of oral carcinoma biopsies are significantly more sensitive than normal oral mucosa cultures to induction of apoptosis by a natural selenium metabolite [selenodiglutathione (sdg)], and this is associated with induction of fas ligand, a well-known mediator of apoptosis in other contexts, and activation of so-called stress kinase signaling pathways, particularly the jun nh2-terminal kinase (jnk). |
2002-09-10 |
2023-08-12 |
Not clear |
| J Fleming, A Ghose, P R Harriso. Molecular mechanisms of cancer prevention by selenium compounds. Nutrition and cancer. vol 40. issue 1. 2002-09-10. PMID:11799922. |
the selective activation of the fas pathway in carcinomas could be responsible directly for their destruction by apoptosis or target them for attack by immunologic responses. |
2002-09-10 |
2023-08-12 |
Not clear |
| Michelle Embree-Ku, Deborah Venturini, Kim Boekelheid. Fas is involved in the p53-dependent apoptotic response to ionizing radiation in mouse testis. Biology of reproduction. vol 66. issue 5. 2002-09-10. PMID:11967210. |
these results indicate that apoptosis and up-regulation of fas following radiation are both p53-dependent events. |
2002-09-10 |
2023-08-12 |
mouse |
| Michelle Embree-Ku, Deborah Venturini, Kim Boekelheid. Fas is involved in the p53-dependent apoptotic response to ionizing radiation in mouse testis. Biology of reproduction. vol 66. issue 5. 2002-09-10. PMID:11967210. |
although fas is necessary, in part, for radiation-induced p53-dependent apoptosis, fasl is not. |
2002-09-10 |
2023-08-12 |
mouse |
| Y-L Chen, J-Y Wang, S-H Chen, B-C Yan. Granulocytes mediates the Fas-L-associated apoptosis during lung metastasis of melanoma that determines the metastatic behaviour. British journal of cancer. vol 87. issue 3. 2002-09-10. PMID:12177809. |
in murine melanoma model, activation of fas (cd95, apo-1) signal in tumour cells reduces their lung metastasis potential, which may be associated with an induction of apoptosis in tumours. |
2002-09-10 |
2023-08-12 |
mouse |
| Bin Lu, Liying Wang, Djordje Medan, David Toledo, Chuanshu Huang, Fei Chen, Xianglin Shi, Yon Rojanasaku. Regulation of Fas (CD95)-induced apoptosis by nuclear factor-kappaB and tumor necrosis factor-alpha in macrophages. American journal of physiology. Cell physiology. vol 283. issue 3. 2002-09-09. PMID:12176740. |
regulation of fas (cd95)-induced apoptosis by nuclear factor-kappab and tumor necrosis factor-alpha in macrophages. |
2002-09-09 |
2023-08-12 |
Not clear |
| Jan Schulze-Luehrmann, Brigitte Santner-Nanan, Mithilesh Kumar Jha, Anneliese Schimpl, Andris Avots, Edgar Serflin. Hematopoietic progenitor kinase 1 supports apoptosis of T lymphocytes. Blood. vol 100. issue 3. 2002-09-06. PMID:12130508. |
when hpk1 was overexpressed in murine cd4(+) t cells, a substantial increase was observed in spontaneous and tcr/cd3-mediated apoptosis as well as in fas ligand (fasl) expression. |
2002-09-06 |
2023-08-12 |
Not clear |