| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nat L Pernick, Fazlul H Sarkar, Pam Tabaczka, Glenn Kotcher, John Frank, N Volkan Adsa. Fas and Fas ligand expression in pancreatic adenocarcinoma. Pancreas. vol 25. issue 3. 2002-11-27. PMID:12370548. |
fas and fas ligand (fasl) mediate apoptosis of tumor cells in immune surveillance, and expression of fasl by tumors may mediate their counterattack on cytotoxic lymphocytes. |
2002-11-27 |
2023-08-12 |
human |
| Iris Motta, Mathieu Gissot, Jean M Kanellopoulos, David M Ojciu. Absence of weight loss during Cryptosporidium infection in susceptible mice deficient in Fas-mediated apoptosis. Microbes and infection. vol 4. issue 8. 2002-11-26. PMID:12270729. |
we now test the possibility that fas (apo-1/cd95)-dependent apoptosis of uninfected cells, due to enhanced expression of the fas ligand (fasl) on infected cells, may contribute to the pathology of cryptosporidiosis. |
2002-11-26 |
2023-08-12 |
mouse |
| Vera Sobek, Sandra Balkow, Heinrich Körner, Markus M Simo. Antigen-induced cell death of T effector cells in vitro proceeds via the Fas pathway, requires endogenous interferon-gamma and is independent of perforin and granzymes. European journal of immunology. vol 32. issue 9. 2002-11-20. PMID:12207333. |
by using in vitro-polyclonally activated or ex vivo-derived virus-induced t cell populations from mice with mutations or targeted gene defects in one or more components of the two key cytolytic pathways we now show that tcr-induced apoptosis is only impaired in the absence of fasl and/or fas, but not in the absence of perforin and/or granzymes. |
2002-11-20 |
2023-08-12 |
mouse |
| Yasunari Nakamoto, Shuichi Kaneko, Hong Fan, Takashi Momoi, Hiroko Tsutsui, Kenji Nakanishi, Kenichi Kobayashi, Takashi Sud. Prevention of hepatocellular carcinoma development associated with chronic hepatitis by anti-fas ligand antibody therapy. The Journal of experimental medicine. vol 196. issue 8. 2002-11-19. PMID:12391022. |
here, using a unique animal model of chronic hepatitis that induces hepatocellular carcinogenesis, we demonstrate that neutralization of the activity of fas ligand prevented hepatocyte apoptosis, proliferation, liver inflammation, and the eventual development of hepatocellular carcinoma. |
2002-11-19 |
2023-08-12 |
Not clear |
| James K Pru, Isabel R Hendry, John S Davis, Bo R Rued. Soluble Fas ligand activates the sphingomyelin pathway and induces apoptosis in luteal steroidogenic cells independently of stress-activated p38(MAPK). Endocrinology. vol 143. issue 11. 2002-11-19. PMID:12399431. |
soluble fas ligand activates the sphingomyelin pathway and induces apoptosis in luteal steroidogenic cells independently of stress-activated p38(mapk). |
2002-11-19 |
2023-08-12 |
cattle |
| Bridget T Heelan, Vincent Tormey, Peter Amlot, Elspeth Payne, Atul Mehta, A David B Webste. Effect of anti-CD20 (rituximab) on resistant thrombocytopenia in autoimmune lymphoproliferative syndrome. British journal of haematology. vol 118. issue 4. 2002-11-18. PMID:12199788. |
fas (cd95) plays an important role in apoptosis. |
2002-11-18 |
2023-08-12 |
Not clear |
| Liliana Guzman-Rojas, Jennifer C Sims-Mourtada, Roberto Rangel, Hector Martinez-Valde. Life and death within germinal centres: a double-edged sword. Immunology. vol 107. issue 2. 2002-11-18. PMID:12383195. |
within germinal centres, b lymphocytes are destined to die by apoptosis via fas signalling, unless they are positively rescued by antigen and by signals initiated by cd40-cd154 interactions. |
2002-11-18 |
2023-08-12 |
Not clear |
| Maowu Guo, Eimei Sato, Xiang Li, Etsuko Mori, Shigeru Saito, Tsuneatsu Mor. Induction of apoptosis mediated by fas receptor and activation of caspase-3 in MRL-+/+ or MRL-lpr/lpr murine oocytes. Zygote (Cambridge, England). vol 10. issue 1. 2002-11-15. PMID:11964087. |
induction of apoptosis mediated by fas receptor and activation of caspase-3 in mrl-+/+ or mrl-lpr/lpr murine oocytes. |
2002-11-15 |
2023-08-12 |
Not clear |
| Maowu Guo, Eimei Sato, Xiang Li, Etsuko Mori, Shigeru Saito, Tsuneatsu Mor. Induction of apoptosis mediated by fas receptor and activation of caspase-3 in MRL-+/+ or MRL-lpr/lpr murine oocytes. Zygote (Cambridge, England). vol 10. issue 1. 2002-11-15. PMID:11964087. |
these findings indicate that the induction of apoptosis in mrl/lpr murine oocytes did not occur in the presence of a defective fas receptor lacking the death domain to trigger the caspase cascade, suggesting a failure to induce ovarian follicular atresia. |
2002-11-15 |
2023-08-12 |
Not clear |
| L M Goga, O M Vasiliu, C R Ionesc. [Molecular mechanisms of apoptosis. Fas and TNF systems. ICE protease system. Bcl-2 family]. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi. vol 105. issue 1. 2002-11-14. PMID:12092154. |
fas ligand and tumor necrosis factor bind to their receptors and induce apoptosis. |
2002-11-14 |
2023-08-12 |
Not clear |
| J Furuzawa-Carballeda, R Rodríquez-Calderón, L Díaz de León, J Alcocer-Varel. Mediators of inflammation are down-regulated while apoptosis is up-regulated in rheumatoid arthritis synovial tissue by polymerized collagen. Clinical and experimental immunology. vol 130. issue 1. 2002-11-13. PMID:12296865. |
meanwhile, timp-1 (36 +/- 7 versus 57 +/- 11) and fas expression (20 +/- 10 versus 55 +/- 13) and apoptosis (14 +/- 3 versus 55 +/- 5) were up-regulated in treated cultures compared with controls. |
2002-11-13 |
2023-08-12 |
Not clear |
| Yun-Sook Lim, Hong-Seob So, Myung-Sunny Kim, Gu Moon, Jin-Hee Won, Seung-Wha Baek, Sun-Rock Moon, Sei-Hoon Yang, Byoung-Ju Kim, Chang-Bo Ko, Raekil Par. Palgin sensitizes the adriamycin-induced apoptosis via the enhancement of Fas/Fas ligand expression. Life sciences. vol 71. issue 20. 2002-11-12. PMID:12231400. |
interestingly, a synergistic increase in apoptosis by the combination of two drugs was accompanied by the enhancement of fas and fas ligand (fasl) expression in chang cells. |
2002-11-12 |
2023-08-12 |
Not clear |
| Yimin Qin, Blanca Camoretti-Mercado, Lyubov Blokh, Catherine G Long, Franklin D Ko, Kimm J Haman. Fas resistance of leukemic eosinophils is due to activation of NF-kappa B by Fas ligation. Journal of immunology (Baltimore, Md. : 1950). vol 169. issue 7. 2002-11-12. PMID:12244143. |
although activation of nf-kappab by ligation of fas (cd95/apo-1), a member of the tnfr family, has been observed in a few studies, fas-mediated nf-kappab activation has not previously been shown to protect cells from apoptosis. |
2002-11-12 |
2023-08-12 |
Not clear |
| Remco van Doorn, Remco Dijkman, Maarten H Vermeer, Theo M Starink, Rein Willemze, Cornelis P Tense. A novel splice variant of the Fas gene in patients with cutaneous T-cell lymphoma. Cancer research. vol 62. issue 19. 2002-11-08. PMID:12359741. |
an important mediator of apoptosis in t cells is the fas receptor. |
2002-11-08 |
2023-08-12 |
Not clear |
| Tracy Vargo-Gogola, Barbara Fingleton, Howard C Crawford, Lynn M Matrisia. Matrilysin (matrix metalloproteinase-7) selects for apoptosis-resistant mammary cells in vivo. Cancer research. vol 62. issue 19. 2002-11-08. PMID:12359768. |
in cell culture models, acute exposure of cells coexpressing fas and fas ligand (fasl) to matrilysin induces apoptosis, whereas chronic exposure to matrilysin selects for apoptosis-resistant cells. |
2002-11-08 |
2023-08-12 |
mouse |
| Michelle J Muessel, Robert M Klein, Angela M Wilson, Nancy E J Berma. Ablation of the chemokine monocyte chemoattractant protein-1 delays retrograde neuronal degeneration, attenuates microglial activation, and alters expression of cell death molecules. Brain research. Molecular brain research. vol 103. issue 1-2. 2002-11-06. PMID:12106688. |
investigation of bcl-2, bax, fas, fas ligand (fasl) and activated caspase-3, key regulators of apoptosis that can be modulated by cytokines, revealed complex alterations of mrna and protein levels in mcp-1(-/-) and ccr2(-/-) mice. |
2002-11-06 |
2023-08-12 |
mouse |
| O A Seidi, M K Sharie. The expression of apoptosis-regulatory proteins in B lymphocytes from patients with multiple sclerosis. Journal of neuroimmunology. vol 130. issue 1-2. 2002-11-04. PMID:12225903. |
cellular commitment to apoptosis is partly regulated by the cell death receptor fas, and the anti-apoptosis proteins bcl-2 and flip. |
2002-11-04 |
2023-08-12 |
Not clear |
| Juan A Garcia-Velasco, Naciye Mulayim, Umit A Kayisli, Aydin Aric. Elevated soluble Fas ligand levels may suggest a role for apoptosis in women with endometriosis. Fertility and sterility. vol 78. issue 4. 2002-11-04. PMID:12372468. |
elevated soluble fas ligand levels may suggest a role for apoptosis in women with endometriosis. |
2002-11-04 |
2023-08-12 |
Not clear |
| Joon Song, Thomas Rutherford, Frederick Naftolin, Santiago Brown, Gil Mo. Hormonal regulation of apoptosis and the Fas and Fas ligand system in human endometrial cells. Molecular human reproduction. vol 8. issue 5. 2002-10-30. PMID:11994542. |
hormonal regulation of apoptosis and the fas and fas ligand system in human endometrial cells. |
2002-10-30 |
2023-08-12 |
human |
| Joon Song, Thomas Rutherford, Frederick Naftolin, Santiago Brown, Gil Mo. Hormonal regulation of apoptosis and the Fas and Fas ligand system in human endometrial cells. Molecular human reproduction. vol 8. issue 5. 2002-10-30. PMID:11994542. |
apoptosis was determined by 3-[4,5-dimethylthiazol-2-yl]-2,5-dephenyl tetrazolium bromide (mtt) assay and propidium iodide staining, while fas and fasl expression were evaluated by western blot analysis. |
2002-10-30 |
2023-08-12 |
human |