| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sebastian Greiss, Björn Schumacher, Kaj Grandien, Jonathan Rothblatt, Anton Gartne. Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family. BMC genomics. vol 9. 2008-08-20. PMID:18627611. |
egl-1 and ced-13 proteins inactivate bcl-2 like ced-9 to trigger ced-4 and ced-3 caspase dependent germ cell apoptosis. |
2008-08-20 |
2023-08-12 |
caenorhabditis_elegans |
| Claus Schertel, Barbara Conrad. C. elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions. Development (Cambridge, England). vol 134. issue 20. 2008-02-15. PMID:17881492. |
finally, we demonstrate that lin-35, dpl-1 and efl-2, but not efl-1, function either downstream of or in parallel to cep-1 p53 (also known as tp53) and egl-1 bh3-only to cause dna damage-induced germ cell apoptosis. |
2008-02-15 |
2023-08-12 |
human |
| Hillel T Schwartz, H Robert Horvit. The C. elegans protein CEH-30 protects male-specific neurons from apoptosis independently of the Bcl-2 homolog CED-9. Genes & development. vol 21. issue 23. 2008-01-04. PMID:18056428. |
the established mechanism for the regulation of specific programmed cell deaths in c. elegans is the transcriptional control of the bh3-only gene egl-1, which inhibits the bcl-2 homolog ced-9; similarly, most regulation of vertebrate apoptosis involves the bcl-2 superfamily. |
2008-01-04 |
2023-08-12 |
mouse |
| Erin Peden, Elizabeth Kimberly, Keiko Gengyo-Ando, Shohei Mitani, Ding Xu. Control of sex-specific apoptosis in C. elegans by the BarH homeodomain protein CEH-30 and the transcriptional repressor UNC-37/Groucho. Genes & development. vol 21. issue 23. 2008-01-04. PMID:18056429. |
ceh-30 encodes a barh homeodomain protein that acts downstream from the terminal sex determination gene tra-1, but upstream of, or in parallel to, the cell-death-initiating gene egl-1 to protect cem neurons from undergoing apoptosis in males. |
2008-01-04 |
2023-08-12 |
caenorhabditis_elegans |
| L S Salinas, E Maldonado, R E Navarr. Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans. Cell death and differentiation. vol 13. issue 12. 2007-02-02. PMID:16729024. |
the dna damage-induced germ cell apoptosis occurs in response to genotoxic agents and involves the proteins egl-1 and ced-13, and the dna damage response protein p53. |
2007-02-02 |
2023-08-12 |
caenorhabditis_elegans |
| L S Salinas, E Maldonado, R E Navarr. Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans. Cell death and differentiation. vol 13. issue 12. 2007-02-02. PMID:16729024. |
germ cell apoptosis can also be induced in response to pathogen infection through an egl-1 dependent pathway. |
2007-02-02 |
2023-08-12 |
caenorhabditis_elegans |
| L S Salinas, E Maldonado, R E Navarr. Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans. Cell death and differentiation. vol 13. issue 12. 2007-02-02. PMID:16729024. |
we found that oxidative, osmotic, heat shock and starvation stresses induce germ cell apoptosis through a p53 and egl-1 independent pathway. |
2007-02-02 |
2023-08-12 |
caenorhabditis_elegans |
| Yonatan B Tzur, Ayelet Margalit, Naomi Melamed-Book, Yosef Gruenbau. Matefin/SUN-1 is a nuclear envelope receptor for CED-4 during Caenorhabditis elegans apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 36. 2006-10-19. PMID:16938876. |
induction of apoptosis begins when the proapoptotic protein egl-1 is expressed and binds ced-9. |
2006-10-19 |
2023-08-12 |
caenorhabditis_elegans |
| W D Fairlie, M A Perugini, M Kvansakul, L Chen, D C S Huang, P M Colma. CED-4 forms a 2 : 2 heterotetrameric complex with CED-9 until specifically displaced by EGL-1 or CED-13. Cell death and differentiation. vol 13. issue 3. 2006-04-20. PMID:16167070. |
in cells undergoing apoptosis, the bcl-2 homology domain 3 (bh3)-only protein egl-1 binds to ced-9 at the mitochondrial membrane to cause the release of ced-4, which oligomerises and facilitates the activation of the caspase ced-3. |
2006-04-20 |
2023-08-12 |
caenorhabditis_elegans |
| B Schumacher, C Schertel, N Wittenburg, S Tuck, S Mitani, A Gartner, B Conradt, S Shaha. C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage. Cell death and differentiation. vol 12. issue 2. 2005-09-26. PMID:15605074. |
our studies suggest that in addition to the bh3-only protein egl-1, ced-13 might also promote apoptosis in the c. elegans germ line in response to p53 activation. |
2005-09-26 |
2023-08-12 |
caenorhabditis_elegans |
| Nieng Yan, Lichuan Gu, David Kokel, Jijie Chai, Wenyu Li, Aidong Han, Lin Chen, Ding Xue, Yigong Sh. Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4. Molecular cell. vol 15. issue 6. 2004-10-29. PMID:15383288. |
these data suggest a working mechanism for the release of ced-4 from the ced-4/ced-9 complex upon egl-1 binding and provide a mechanistic framework for understanding apoptosis activation in c. elegans. |
2004-10-29 |
2023-08-12 |
caenorhabditis_elegans |
| G V Putcha, E M Johnso. Men are but worms: neuronal cell death in C elegans and vertebrates. Cell death and differentiation. vol 11. issue 1. 2004-08-25. PMID:14647239. |
their studies of lineage determination in worms established the 'central dogma' of apoptosis: the bh3-only protein egl-1 is induced in cells destined to die, interacts with the bcl-2-like inhibitor ced-9, displacing the adaptor ced-4, which then promotes activation of the caspase ced-3. |
2004-08-25 |
2023-08-12 |
human |
| L del Peso, V M Gonzalez, N Inohara, R E Ellis, G Núñe. Disruption of the CED-9.CED-4 complex by EGL-1 is a critical step for programmed cell death in Caenorhabditis elegans. The Journal of biological chemistry. vol 275. issue 35. 2000-10-03. PMID:10846174. |
finally, the ability of egl-1 to promote apoptosis is impaired by the replacement of wild-type ced-9 with ced-9g169e, and this effect is correlated with the inability of egl-1 to induce the displacement of ced-4 from the ced-9.ced-4 complex. |
2000-10-03 |
2023-08-12 |
caenorhabditis_elegans |
| T L Gumienny, E Lambie, E Hartwieg, H R Horvitz, M O Hengartne. Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline. Development (Cambridge, England). vol 126. issue 5. 1999-04-02. PMID:9927601. |
however, this machinery is activated by a distinct pathway, as loss of egl-1 function, which inhibits somatic cell death, does not affect germ cell apoptosis. |
1999-04-02 |
2023-08-12 |
caenorhabditis_elegans |