| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Claus Schertel, Barbara Conrad. C. elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions. Development (Cambridge, England). vol 134. issue 20. 2008-02-15. PMID:17881492. |
finally, we demonstrate that lin-35, dpl-1 and efl-2, but not efl-1, function either downstream of or in parallel to cep-1 p53 (also known as tp53) and egl-1 bh3-only to cause dna damage-induced germ cell apoptosis. |
2008-02-15 |
2023-08-12 |
human |
| Hillel T Schwartz, H Robert Horvit. The C. elegans protein CEH-30 protects male-specific neurons from apoptosis independently of the Bcl-2 homolog CED-9. Genes & development. vol 21. issue 23. 2008-01-04. PMID:18056428. |
the established mechanism for the regulation of specific programmed cell deaths in c. elegans is the transcriptional control of the bh3-only gene egl-1, which inhibits the bcl-2 homolog ced-9; similarly, most regulation of vertebrate apoptosis involves the bcl-2 superfamily. |
2008-01-04 |
2023-08-12 |
mouse |
| Erin Peden, Elizabeth Kimberly, Keiko Gengyo-Ando, Shohei Mitani, Ding Xu. Control of sex-specific apoptosis in C. elegans by the BarH homeodomain protein CEH-30 and the transcriptional repressor UNC-37/Groucho. Genes & development. vol 21. issue 23. 2008-01-04. PMID:18056429. |
ceh-30 encodes a barh homeodomain protein that acts downstream from the terminal sex determination gene tra-1, but upstream of, or in parallel to, the cell-death-initiating gene egl-1 to protect cem neurons from undergoing apoptosis in males. |
2008-01-04 |
2023-08-12 |
caenorhabditis_elegans |
| L S Salinas, E Maldonado, R E Navarr. Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans. Cell death and differentiation. vol 13. issue 12. 2007-02-02. PMID:16729024. |
the dna damage-induced germ cell apoptosis occurs in response to genotoxic agents and involves the proteins egl-1 and ced-13, and the dna damage response protein p53. |
2007-02-02 |
2023-08-12 |
caenorhabditis_elegans |
| L S Salinas, E Maldonado, R E Navarr. Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans. Cell death and differentiation. vol 13. issue 12. 2007-02-02. PMID:16729024. |
germ cell apoptosis can also be induced in response to pathogen infection through an egl-1 dependent pathway. |
2007-02-02 |
2023-08-12 |
caenorhabditis_elegans |
| L S Salinas, E Maldonado, R E Navarr. Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans. Cell death and differentiation. vol 13. issue 12. 2007-02-02. PMID:16729024. |
we found that oxidative, osmotic, heat shock and starvation stresses induce germ cell apoptosis through a p53 and egl-1 independent pathway. |
2007-02-02 |
2023-08-12 |
caenorhabditis_elegans |
| Yonatan B Tzur, Ayelet Margalit, Naomi Melamed-Book, Yosef Gruenbau. Matefin/SUN-1 is a nuclear envelope receptor for CED-4 during Caenorhabditis elegans apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 36. 2006-10-19. PMID:16938876. |
induction of apoptosis begins when the proapoptotic protein egl-1 is expressed and binds ced-9. |
2006-10-19 |
2023-08-12 |
caenorhabditis_elegans |
| W D Fairlie, M A Perugini, M Kvansakul, L Chen, D C S Huang, P M Colma. CED-4 forms a 2 : 2 heterotetrameric complex with CED-9 until specifically displaced by EGL-1 or CED-13. Cell death and differentiation. vol 13. issue 3. 2006-04-20. PMID:16167070. |
in cells undergoing apoptosis, the bcl-2 homology domain 3 (bh3)-only protein egl-1 binds to ced-9 at the mitochondrial membrane to cause the release of ced-4, which oligomerises and facilitates the activation of the caspase ced-3. |
2006-04-20 |
2023-08-12 |
caenorhabditis_elegans |
| B Schumacher, C Schertel, N Wittenburg, S Tuck, S Mitani, A Gartner, B Conradt, S Shaha. C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage. Cell death and differentiation. vol 12. issue 2. 2005-09-26. PMID:15605074. |
our studies suggest that in addition to the bh3-only protein egl-1, ced-13 might also promote apoptosis in the c. elegans germ line in response to p53 activation. |
2005-09-26 |
2023-08-12 |
caenorhabditis_elegans |
| Nieng Yan, Lichuan Gu, David Kokel, Jijie Chai, Wenyu Li, Aidong Han, Lin Chen, Ding Xue, Yigong Sh. Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4. Molecular cell. vol 15. issue 6. 2004-10-29. PMID:15383288. |
these data suggest a working mechanism for the release of ced-4 from the ced-4/ced-9 complex upon egl-1 binding and provide a mechanistic framework for understanding apoptosis activation in c. elegans. |
2004-10-29 |
2023-08-12 |
caenorhabditis_elegans |
| G V Putcha, E M Johnso. Men are but worms: neuronal cell death in C elegans and vertebrates. Cell death and differentiation. vol 11. issue 1. 2004-08-25. PMID:14647239. |
their studies of lineage determination in worms established the 'central dogma' of apoptosis: the bh3-only protein egl-1 is induced in cells destined to die, interacts with the bcl-2-like inhibitor ced-9, displacing the adaptor ced-4, which then promotes activation of the caspase ced-3. |
2004-08-25 |
2023-08-12 |
human |
| L del Peso, V M Gonzalez, N Inohara, R E Ellis, G Núñe. Disruption of the CED-9.CED-4 complex by EGL-1 is a critical step for programmed cell death in Caenorhabditis elegans. The Journal of biological chemistry. vol 275. issue 35. 2000-10-03. PMID:10846174. |
finally, the ability of egl-1 to promote apoptosis is impaired by the replacement of wild-type ced-9 with ced-9g169e, and this effect is correlated with the inability of egl-1 to induce the displacement of ced-4 from the ced-9.ced-4 complex. |
2000-10-03 |
2023-08-12 |
caenorhabditis_elegans |
| T L Gumienny, E Lambie, E Hartwieg, H R Horvitz, M O Hengartne. Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline. Development (Cambridge, England). vol 126. issue 5. 1999-04-02. PMID:9927601. |
however, this machinery is activated by a distinct pathway, as loss of egl-1 function, which inhibits somatic cell death, does not affect germ cell apoptosis. |
1999-04-02 |
2023-08-12 |
caenorhabditis_elegans |