| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chia-Wen Tsai, Rong-Tzong Tsai, Shih-Ping Liu, Chang-Shi Chen, Min-Chen Tsai, Shao-Hsuan Chien, Huey-Shan Hung, Shinn-Zong Lin, Woei-Cherng Shyu, Ru-Huei F. Neuroprotective Effects of Betulin in Pharmacological and Transgenic Caenorhabditis elegans Models of Parkinson's Disease. Cell transplantation. vol 26. issue 12. 2018-12-11. PMID:29390878. |
moreover, we found that the enhancement of proteasomes activity by promoting rpn1 expression and downregulation of the apoptosis pathway gene, egl-1, may be the molecular mechanism for betulin-mediated protection against pd pathology. |
2018-12-11 |
2023-08-13 |
caenorhabditis_elegans |
| Brittany O'Donnell, Lily Huo, Joseph R Polli, Li Qiu, David N Collier, Baohong Zhang, Xiaoping Pa. From the Cover: ZnO Nanoparticles Enhanced Germ Cell Apoptosis in Caenorhabditis elegans, in Comparison with ZnCl2. Toxicological sciences : an official journal of the Society of Toxicology. vol 156. issue 2. 2018-02-15. PMID:28003440. |
genes involved in the apoptosis pathway (ced-13, ced-3, ced-4, ced-9, cep-1, dpl-1, efl-1, efl-2, egl-1, egl-38, lin-35, pax-2, and sir-2.1) were in general upregulated in response to zno np exposure. |
2018-02-15 |
2023-08-13 |
caenorhabditis_elegans |
| Jerome Teuliere, Gian Garrig. Size Matters: How C. elegans Asymmetric Divisions Regulate Apoptosis. Results and problems in cell differentiation. vol 61. 2017-07-26. PMID:28409303. |
pioneering work defined a conserved apoptosis pathway that is initiated in c. elegans by the bh3-only protein egl-1 and that leads to the activation of the caspase ced-3. |
2017-07-26 |
2023-08-13 |
caenorhabditis_elegans |
| Niladri Mukherjee, Pravat Kumar Parida, Abhishek Santra, Tamashree Ghosh, Ananya Dutta, Kuladip Jana, Anup Kumar Misra, Santi P Sinha Bab. Oxidative stress plays major role in mediating apoptosis in filarial nematode Setaria cervi in the presence of trans-stilbene derivatives. Free radical biology & medicine. vol 93. 2016-12-13. PMID:26849945. |
along with the ros generation and oxidative stress, the decreased expression of anti-apoptotic ced-9 gene and increased expression of nematode specific pro-apoptotic genes, egl-1, ced-4 and ced-3 at the level of transcription and translation level; the up-regulation of caspase-3 activity and involvement of caspase-8,9,3, cytochrome-c and parp were also observed and which denotes the probable existence of both extrinsic and intrinsic pathways apoptosis in parasitic nematodes. |
2016-12-13 |
2023-08-13 |
Not clear |
| Hua Du, Meimei Wang, Lei Wang, Hui Dai, Min Wang, Wei Hong, Xinxin Nie, Lijun Wu, An X. Reproductive Toxicity of Endosulfan: Implication From Germ Cell Apoptosis Modulated by Mitochondrial Dysfunction and Genotoxic Response Genes in Caenorhabditis elegans. Toxicological sciences : an official journal of the Society of Toxicology. vol 145. issue 1. 2016-05-16. PMID:25666835. |
however, the apoptotic effects of endosulfan were blocked in mutants of cep-1(w40), egl-1(n487), and hus-1(op241), indicating conserved genotoxic response genes played an essential role in endosulfan-induced germ cell apoptosis. |
2016-05-16 |
2023-08-13 |
caenorhabditis_elegans |
| Karinna Rubio-Peña, Laura Fontrodona, David Aristizábal-Corrales, Silvia Torres, Eric Cornes, Francisco J García-Rodríguez, Xènia Serrat, David González-Knowles, Sylvain Foissac, Montserrat Porta-De-La-Riva, Julián Ceró. Modeling of autosomal-dominant retinitis pigmentosa in Caenorhabditis elegans uncovers a nexus between global impaired functioning of certain splicing factors and cell type-specific apoptosis. RNA (New York, N.Y.). vol 21. issue 12. 2016-02-26. PMID:26490224. |
the up-regulation of atl-1 correlates with the ectopic expression of the pro-apoptotic gene egl-1 and apoptosis in hypodermal cells, which produce the cuticle, but not in other cell types. |
2016-02-26 |
2023-08-13 |
human |
| Alice L Ye, J Matthew Ragle, Barbara Conradt, Needhi Bhall. Differential regulation of germline apoptosis in response to meiotic checkpoint activation. Genetics. vol 198. issue 3. 2015-07-07. PMID:25217053. |
in caenorhabditis elegans, germline apoptosis is promoted by egl-1 and ced-13 in response to meiotic checkpoint activation. |
2015-07-07 |
2023-08-13 |
caenorhabditis_elegans |
| Alice L Ye, J Matthew Ragle, Barbara Conradt, Needhi Bhall. Differential regulation of germline apoptosis in response to meiotic checkpoint activation. Genetics. vol 198. issue 3. 2015-07-07. PMID:25217053. |
we also identify a regulatory region of egl-1 required to inhibit germline apoptosis in response to dna damage incurred during meiotic recombination. |
2015-07-07 |
2023-08-13 |
caenorhabditis_elegans |
| Jinbo Wang, Jyothsna Chitturi, Qinglan Ge, Valeriya Laskova, Wei Wang, Xia Li, Mei Ding, Mei Zhen, Xun Huan. The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID lineage. Development (Cambridge, England). vol 142. issue 8. 2015-07-06. PMID:25790851. |
during embryogenesis, the rid progenitor cell gives rise to the rid neuron and rid sister cell; the latter undergoes apoptosis shortly after cell division upon expression of the pro-apoptotic gene egl-1. |
2015-07-06 |
2023-08-13 |
caenorhabditis_elegans |
| Yue-Mi Chen, Shih-Ping Liu, Hsin-Lien Lin, Ming-Chia Chan, Yen-Chuan Chen, Yu-Ling Huang, Min-Chen Tsai, Ru-Huei F. Irisflorentin improves α-synuclein accumulation and attenuates 6-OHDA-induced dopaminergic neuron degeneration, implication for Parkinson's disease therapy. BioMedicine. vol 5. issue 1. 2015-06-02. PMID:25705584. |
irisflorentin may exert its effects by promoting rpn-3 expression to enhance the activity of proteasomes and down-regulating egl-1 expression to block apoptosis pathways. |
2015-06-02 |
2023-08-13 |
caenorhabditis_elegans |
| Joseph Ryan Polli, Yanqiong Zhang, Xiaoping Pa. Dispersed crude oil amplifies germ cell apoptosis in Caenorhabditis elegans, followed a CEP-1-dependent pathway. Archives of toxicology. vol 88. issue 3. 2015-05-12. PMID:24496467. |
genes involved in the apoptosis pathway were dysregulated, which include ced-13, ced-3, ced-4, ced-9, cep-1, dpl-1, efl-1, efl-2, egl-1, egl-38, lin-35, pax-2, and sir-2.1. |
2015-05-12 |
2023-08-12 |
human |
| Bo Yan, Nadin Memar, Julia Gallinger, Barbara Conrad. Coordination of cell proliferation and cell fate determination by CES-1 snail. PLoS genetics. vol 9. issue 10. 2015-02-19. PMID:24204299. |
by repressing the transcription of the bh3-only gene egl-1, ces-1 can also suppress apoptosis in the daughters of the nsm neuroblasts. |
2015-02-19 |
2023-08-12 |
caenorhabditis_elegans |
| Ru-Huei Fu, Yu-Chi Wang, Chang-Shi Chen, Rong-Tzong Tsai, Shih-Ping Liu, Wen-Lin Chang, Hsin-Lien Lin, Chia-Hui Lu, Jing-Rong Wei, Zih-Wan Wang, Woei-Cherng Shyu, Shinn-Zong Li. Acetylcorynoline attenuates dopaminergic neuron degeneration and α-synuclein aggregation in animal models of Parkinson's disease. Neuropharmacology. vol 82. 2015-01-09. PMID:23973292. |
acetylcorynoline may exert its effects by decreasing egl-1 expression to suppress apoptosis pathways and by increasing rpn5 expression to enhance the activity of proteasomes. |
2015-01-09 |
2023-08-12 |
human |
| Yun Wang, Shunchang Wang, Xun Luo, Yanan Yang, Fenglei Jian, Xuemin Wang, Lucheng Xi. The roles of DNA damage-dependent signals and MAPK cascades in tributyltin-induced germline apoptosis in Caenorhabditis elegans. Chemosphere. vol 108. 2014-10-22. PMID:24534158. |
tbt-induced apoptosis was blocked in the bcl-2 gain-of-function strain ced-9(n1950), whereas tbt induced a minor increase in the bh3-only protein egl-1 mutated strain egl-1(n1084n3082). |
2014-10-22 |
2023-08-12 |
caenorhabditis_elegans |
| Carlos Giovanni Silva-García, Rosa Estela Navarr. The C. elegans TIA-1/TIAR homolog TIAR-1 is required to induce germ cell apoptosis. Genesis (New York, N.Y. : 2000). vol 51. issue 10. 2014-04-25. PMID:23913578. |
the bh3-only protein egl-1 induces germ cell apoptosis when animals are exposed to pathogens or agents that produce dna damage. |
2014-04-25 |
2023-08-12 |
caenorhabditis_elegans |
| Carlos Giovanni Silva-García, Rosa Estela Navarr. The C. elegans TIA-1/TIAR homolog TIAR-1 is required to induce germ cell apoptosis. Genesis (New York, N.Y. : 2000). vol 51. issue 10. 2014-04-25. PMID:23913578. |
previously, we found that heat shock, oxidative, and osmotic stresses induce germ cell apoptosis through an egl-1 and cep-1 independent mechanism that requires the mapkk pathway. |
2014-04-25 |
2023-08-12 |
caenorhabditis_elegans |
| N Silva, A Adamo, P Santonicola, E Martinez-Perez, A La Volp. Pro-crossover factors regulate damage-dependent apoptosis in the Caenorhabditis elegans germ line. Cell death and differentiation. vol 20. issue 9. 2014-03-31. PMID:23832114. |
although ionizing radiation fails to induce apoptosis in msh-4/5-mutant backgrounds, it induces transcriptional activation of the apoptosis-activator egl-1, which is controlled by the caenorhabditis elegans p53 orthologue cep-1. |
2014-03-31 |
2023-08-12 |
caenorhabditis_elegans |
| T H Morthorst, A Olse. Cell-nonautonomous inhibition of radiation-induced apoptosis by dynein light chain 1 in Caenorhabditis elegans. Cell death & disease. vol 4. 2014-03-12. PMID:24030151. |
we show that dlc-1 mediates apoptosis through the genes lin-35, egl-1 and ced-13, which are all involved in the response to ionising radiation (ir)-induced apoptosis. |
2014-03-12 |
2023-08-12 |
caenorhabditis_elegans |
| Takashi Hirose, H Robert Horvit. An Sp1 transcription factor coordinates caspase-dependent and -independent apoptotic pathways. Nature. vol 500. issue 7462. 2013-09-24. PMID:23851392. |
sptf-3 directly drives the transcription of the gene egl-1, which encodes a bh3-only protein that promotes apoptosis through the activation of the ced-3 caspase. |
2013-09-24 |
2023-08-12 |
caenorhabditis_elegans |
| Michael Chiorazzi, Lixin Rui, Yandan Yang, Michele Ceribelli, Nima Tishbi, Carine W Maurer, Stella M Ranuncolo, Hong Zhao, Weihong Xu, Wing-Chung C Chan, Elaine S Jaffe, Randy D Gascoyne, Elias Campo, Andreas Rosenwald, German Ott, Jan Delabie, Lisa M Rimsza, Shai Shaham, Louis M Staud. Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 10. 2013-05-02. PMID:23431138. |
dre-1 functions in parallel to egl-1, requires ced-9 for activity, and binds to ced-9, suggesting that dre-1 promotes apoptosis by inactivating ced-9. |
2013-05-02 |
2023-08-12 |
human |