| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Berangere Pinan-Lucarre, Christopher V Gabel, Christopher P Reina, S Elizabeth Hulme, Sergey S Shevkoplyas, R Daniel Slone, Jian Xue, Yujie Qiao, Sarah Weisberg, Kevin Roodhouse, Lin Sun, George M Whitesides, Aravinthan Samuel, Monica Driscol. The core apoptotic executioner proteins CED-3 and CED-4 promote initiation of neuronal regeneration in Caenorhabditis elegans. PLoS biology. vol 10. issue 5. 2012-08-24. PMID:22629231. |
the ced-3 activator, ced-4/apaf-1, similarly promotes regeneration, but the upstream regulators of apoptosis ced-9/bcl2 and bh3-domain proteins egl-1 and ced-13 are not essential. |
2012-08-24 |
2023-08-12 |
caenorhabditis_elegans |
| E Pourkarimi, S Greiss, A Gartne. Evidence that CED-9/Bcl2 and CED-4/Apaf-1 localization is not consistent with the current model for C. elegans apoptosis induction. Cell death and differentiation. vol 19. issue 3. 2012-06-08. PMID:21886181. |
in c. elegans, the bh3-only domain protein egl-1, the apaf-1 homolog ced-4 and the ced-3 caspase are required for apoptosis induction, whereas the bcl-2 homolog ced-9 prevents apoptosis. |
2012-06-08 |
2023-08-12 |
caenorhabditis_elegans |
| Takashi Hirose, Brendan D Galvin, H Robert Horvit. Six and Eya promote apoptosis through direct transcriptional activation of the proapoptotic BH3-only gene egl-1 in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 35. 2010-11-15. PMID:20713707. |
six and eya promote apoptosis through direct transcriptional activation of the proapoptotic bh3-only gene egl-1 in caenorhabditis elegans. |
2010-11-15 |
2023-08-12 |
human |
| R Nehme, P Grote, T Tomasi, S Löser, H Holzkamp, R Schnabel, B Conrad. Transcriptional upregulation of both egl-1 BH3-only and ced-3 caspase is required for the death of the male-specific CEM neurons. Cell death and differentiation. vol 17. issue 8. 2010-10-26. PMID:20150917. |
furthermore, in these cells, the pro-caspase proced-3 is inherited from progenitors and the transcriptional upregulation of the bh3-only gene egl-1 is thought to be sufficient for apoptosis induction. |
2010-10-26 |
2023-08-12 |
caenorhabditis_elegans |
| R Nehme, P Grote, T Tomasi, S Löser, H Holzkamp, R Schnabel, B Conrad. Transcriptional upregulation of both egl-1 BH3-only and ced-3 caspase is required for the death of the male-specific CEM neurons. Cell death and differentiation. vol 17. issue 8. 2010-10-26. PMID:20150917. |
we found that in the cems, the transcriptional activation of both the egl-1 and ced-3 gene is necessary for apoptosis induction. |
2010-10-26 |
2023-08-12 |
caenorhabditis_elegans |
| Cai Kezhou, Ren Chong, Yu Zenglian. Nickel-induced apoptosis and relevant signal transduction pathways in Caenorhabditis elegans. Toxicology and industrial health. vol 26. issue 4. 2010-06-09. PMID:20237193. |
the results presented here demonstrated that nickel-induced apoptosis was independent of the dna damage response gene, such as hus-1, p53/cep-1 and egl-1. |
2010-06-09 |
2023-08-12 |
caenorhabditis_elegans |
| Ren Chong, Cai Ke-zhou, Yu Zeng-lian. Induction of germline apoptosis by cobalt and relevant signal transduction pathways in Caenorhabditis elegans. Toxicology mechanisms and methods. vol 19. issue 9. 2010-01-22. PMID:19839723. |
the results presented here demonstrated that cobalt-induced apoptosis was independent of the dna damage response gene, such as hus-1, p53/cep-1, and egl-1. |
2010-01-22 |
2023-08-12 |
caenorhabditis_elegans |
| Mei Yang, Jianwei Sun, Xiaojuan Sun, Qinfang Shen, Zhiyang Gao, Chonglin Yan. Caenorhabditis elegans protein arginine methyltransferase PRMT-5 negatively regulates DNA damage-induced apoptosis. PLoS genetics. vol 5. issue 6. 2009-08-28. PMID:19521535. |
we show that inactivation of c. elegans prmt-5 leads to excessive apoptosis in germline following ionizing irradiation, which is due to a cep-1/p53-dependent up-regulation of the cell death initiator egl-1. |
2009-08-28 |
2023-08-12 |
human |
| Mei Yang, Jianwei Sun, Xiaojuan Sun, Qinfang Shen, Zhiyang Gao, Chonglin Yan. Caenorhabditis elegans protein arginine methyltransferase PRMT-5 negatively regulates DNA damage-induced apoptosis. PLoS genetics. vol 5. issue 6. 2009-08-28. PMID:19521535. |
importantly, down-regulation of cbp-1 significantly suppresses dna damage-induced egl-1 expression and apoptosis in prmt-5 mutant worms. |
2009-08-28 |
2023-08-12 |
human |
| David G Breckenridge, Byung-Ho Kang, Ding Xu. Bcl-2 proteins EGL-1 and CED-9 do not regulate mitochondrial fission or fusion in Caenorhabditis elegans. Current biology : CB. vol 19. issue 9. 2009-08-11. PMID:19327994. |
to better understand the potential roles of bcl-2 family proteins in regulating mitochondrial dynamics, we carried out a detailed analysis of mitochondria in animals that either lose or have increased activity of egl-1 and ced-9, two bcl-2 family genes that induce and inhibit apoptosis in c. elegans, respectively. |
2009-08-11 |
2023-08-12 |
caenorhabditis_elegans |
| Qinfang Shen, Fengsong Qin, Zhiyang Gao, Jie Cui, Hui Xiao, Zhiheng Xu, Chonglin Yan. Adenine nucleotide translocator cooperates with core cell death machinery to promote apoptosis in Caenorhabditis elegans. Molecular and cellular biology. vol 29. issue 14. 2009-07-13. PMID:19414600. |
in cells destined to die, egl-1 binds to ced-9 and results in the release of ced-4 from the mitochondrion-tethered ced-9-ced-4 complex to the perinucleus, which facilitates processing of the ced-3 caspase to cause apoptosis. |
2009-07-13 |
2023-08-12 |
caenorhabditis_elegans |
| Shunchang Wang, Lijun Wu, Yun Wang, Xun Luo, Yun L. Copper-induced germline apoptosis in Caenorhabditis elegans: the independent roles of DNA damage response signaling and the dependent roles of MAPK cascades. Chemico-biological interactions. vol 180. issue 2. 2009-06-26. PMID:19497412. |
the knockout of checkpoint genes hus-1, clk-2, the bcl-2 homolog ced-9, and the bh3-only domain egl-1 did not prevent cells of the germline from copper-induced apoptosis. |
2009-06-26 |
2023-08-12 |
caenorhabditis_elegans |
| Xinzhu Deng, Xianglei Yin, Richard Allan, Diane D Lu, Carine W Maurer, Adriana Haimovitz-Friedman, Zvi Fuks, Shai Shaham, Richard Kolesnic. Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans. Science (New York, N.Y.). vol 322. issue 5898. 2008-10-21. PMID:18832646. |
these studies define cep-1 (the worm homolog of the tumor suppressor p53)-mediated accumulation of egl-1 and ceramide synthase-mediated generation of ceramide through parallel pathways that integrate at mitochondrial membranes to regulate stress-induced apoptosis. |
2008-10-21 |
2023-08-12 |
caenorhabditis_elegans |
| Bei Pei, Shunchang Wang, Xiaoyin Guo, Jun Wang, Gen Yang, Haiying Hang, Lijun W. Arsenite-induced germline apoptosis through a MAPK-dependent, p53-independent pathway in Caenorhabditis elegans. Chemical research in toxicology. vol 21. issue 8. 2008-10-09. PMID:18597494. |
our results showed that the loss-of-function mutations of p53/ cep-1 and dna damage response (ddr) genes hus-1, clk-2, and egl-1 exhibited significant increase in germline apoptosis under arsenite exposure, whereas arsenite-induced germline apoptosis was blocked in loss-of-function alleles of extracellular signal-regulated kinase (erk) (lin-45 (ku51), mek-2 (n1989), and mpk-1 (ku1)), c-jun n-terminal kinase (jnk) (jkk-1 (km2), mek-1 (ks54), jnk-1 (gk7), mkk-4 (ju91)), and p38 ( nsy-1 (ag3), sek-1 (ag1), and pmk-1 (km25)) mapk cascades. |
2008-10-09 |
2023-08-12 |
caenorhabditis_elegans |
| Bei Pei, Shunchang Wang, Xiaoyin Guo, Jun Wang, Gen Yang, Haiying Hang, Lijun W. Arsenite-induced germline apoptosis through a MAPK-dependent, p53-independent pathway in Caenorhabditis elegans. Chemical research in toxicology. vol 21. issue 8. 2008-10-09. PMID:18597494. |
these results suggest that arsenite-induced apoptosis occurs independently of p53/ cep-1 and the dna damage response (ddr) genes hus-1, clk-2, and egl-1 and that the c. elegans caspase gene ced-3, apaf-1 homologue ced-4, and the mapk signaling pathways are essential for germline apoptosis. |
2008-10-09 |
2023-08-12 |
caenorhabditis_elegans |
| Anton Gartner, Peter R Boag, T Keith Blackwel. Germline survival and apoptosis. WormBook : the online review of C. elegans biology. 2008-09-22. PMID:18781708. |
one category of germline apoptosis, dubbed "physiological" germline apoptosis, reduces the number of cells that complete oogenesis, and is independent of the bh3-only apoptosis effecter egl-1. |
2008-09-22 |
2023-08-12 |
caenorhabditis_elegans |
| E S Blum, M Driscoll, S Shaha. Noncanonical cell death programs in the nematode Caenorhabditis elegans. Cell death and differentiation. vol 15. issue 7. 2008-08-28. PMID:18437162. |
genetic studies of the nematode caenorhabditis elegans have uncovered four genes, egl-1 (bh3 only), ced-9 (bcl-2 related), ced-4 (apoptosis protease activating factor-1), and ced-3 (caspase), which function in a linear pathway to promote developmental cell death in this organism. |
2008-08-28 |
2023-08-12 |
caenorhabditis_elegans |
| Sebastian Greiss, Björn Schumacher, Kaj Grandien, Jonathan Rothblatt, Anton Gartne. Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family. BMC genomics. vol 9. 2008-08-20. PMID:18627611. |
cep-1 acts as a transcription activator in a primordial p53 pathway that involves cep-1 activation and the cep-1 dependent transcriptional induction of the worm bh3 only domain encoding genes egl-1 and ced-13 to induce germ cell apoptosis. |
2008-08-20 |
2023-08-12 |
caenorhabditis_elegans |
| Sebastian Greiss, Björn Schumacher, Kaj Grandien, Jonathan Rothblatt, Anton Gartne. Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family. BMC genomics. vol 9. 2008-08-20. PMID:18627611. |
egl-1 and ced-13 proteins inactivate bcl-2 like ced-9 to trigger ced-4 and ced-3 caspase dependent germ cell apoptosis. |
2008-08-20 |
2023-08-12 |
caenorhabditis_elegans |
| Claus Schertel, Barbara Conrad. C. elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions. Development (Cambridge, England). vol 134. issue 20. 2008-02-15. PMID:17881492. |
finally, we demonstrate that lin-35, dpl-1 and efl-2, but not efl-1, function either downstream of or in parallel to cep-1 p53 (also known as tp53) and egl-1 bh3-only to cause dna damage-induced germ cell apoptosis. |
2008-02-15 |
2023-08-12 |
human |