| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuting Shao, Yunhui Li, Dayong Wan. Polylactic acid microplastics cause transgenerational reproductive toxicity associated with activation of insulin and hedgehog ligands in C. elegans. The Science of the total environment. 2024-06-08. PMID:38851356. |
meanwhile, transgenerational increase in germline apoptosis was detected after pla-mp exposure at p0-g, which was associated with transgenerational dysregulation in expressions of genes governing apoptosis (ced-3, ced-4, egl-1, and ced-9) and dna damage related genes (cep-1, mrt-2, hus-1, and clk-2). |
2024-06-08 |
2024-06-11 |
caenorhabditis_elegans |
| Yuting Shao, Xin Hua, Yunhui Li, Dayong Wan. Comparison of reproductive toxicity between pristine and aged polylactic acid microplastics in Caenorhabditis elegans. Journal of hazardous materials. vol 466. 2024-01-20. PMID:38244453. |
meanwhile, aged pla-mps caused more severe enhancement in germline apoptosis and alterations in expressions of ced-9, ced-4, ced-3, and egl-1 governing cell apoptosis. |
2024-01-20 |
2024-01-23 |
caenorhabditis_elegans |
| Zhengying Liu, Xin Hua, Yue Zhao, Qian Bian, Dayong Wan. Polyethylene nanoplastics cause reproductive toxicity associated with activation of both estrogenic hormone receptor NHR-14 and DNA damage checkpoints in C. elegans. The Science of the total environment. 2023-10-01. PMID:37778542. |
accompanied with alteration in expressions of genes (egl-1, ced-9, ced-4, and ced-3) governing cell apoptosis, germline apoptosis was enhanced by pe-np. |
2023-10-01 |
2023-10-07 |
caenorhabditis_elegans |
| Yuting Shao, Yuxing Wang, Xin Hua, Yunhui Li, Dayong Wan. Polylactic acid microparticles in the range of μg/L reduce reproductive capacity by affecting the gonad development and the germline apoptosis in Caenorhabditis elegans. Chemosphere. 2023-06-14. PMID:37315859. |
accompanied with the enhancement in germline apoptosis, exposure to 10 and 100 μg/l pla mp decreased expression of ced-9 and increased expressions of ced-3, ced-4, and egl-1. |
2023-06-14 |
2023-08-14 |
caenorhabditis_elegans |
| Yuting Shao, Yuxing Wang, Xin Hua, Yunhui Li, Dayong Wan. Polylactic acid microparticles in the range of μg/L reduce reproductive capacity by affecting the gonad development and the germline apoptosis in Caenorhabditis elegans. Chemosphere. 2023-06-14. PMID:37315859. |
moreover, the induction of germline apoptosis in pla mp exposed nematodes was suppressed by rnai of ced-3, ced-4, and egl-1, and strengthened by rnai of ced-9. |
2023-06-14 |
2023-08-14 |
caenorhabditis_elegans |
| Xin Hua, Xiao Feng, Geyu Liang, Jie Chao, Dayong Wan. Long-term exposure to 6-PPD quinone reduces reproductive capacity by enhancing germline apoptosis associated with activation of both DNA damage and cell corpse engulfment in Caenorhabditis elegans. Journal of hazardous materials. vol 454. 2023-04-29. PMID:37119572. |
meanwhile, exposure to 1 and 10 μg/l 6-ppdq enhanced the germline apoptosis, which was accompanied by upregulation of ced-3, ced-4, and egl-1 expressions and downregulation of ced-9 expression. |
2023-04-29 |
2023-08-14 |
caenorhabditis_elegans |
| Xin Hua, Xiao Feng, Yingshun Hua, Dayong Wan. Paeoniflorin attenuates polystyrene nanoparticle-induced reduction in reproductive capacity and increase in germline apoptosis through suppressing DNA damage checkpoints in Caenorhabditis elegans. The Science of the total environment. 2023-02-12. PMID:36775158. |
in addition, in 100 μg/l ps-np exposed nematodes, treatment with 100 mg/l paeoniflorin modulated the expressions of genes governing germline apoptosis as indicated by the decrease in ced-3, ced-4, an egl-1 expressions and the increase in ced-9 expression. |
2023-02-12 |
2023-08-14 |
caenorhabditis_elegans |
| C Narendra Reddy, Ramasubbu Sankararamakrishna. Molecular dynamics studies of CED-4/CED-9/EGL-1 ternary complex reveal CED-4 release mechanism in the linear apoptotic pathway of Caenorhabditis elegans. Proteins. 2022-12-21. PMID:36541866. |
the caenorhabditis elegans proteins ced-9, ced-4 and egl-1 involved in apoptosis are respectively homologous to anti-apoptotic bcl-2 proteins, apaf-1 and the "bh3-only" pro-apototic proteins in mammals. |
2022-12-21 |
2023-08-14 |
caenorhabditis_elegans |
| Shenyao Ni, Huijun Zhang, Lingyan Sun, Yanan Zhao, Chengcheng Pei, Yaguang Nie, Xiaodong Liu, Lijun Wu, An X. Transgenerational reproductive toxicity of 2,4,6-trinitrotoluene (TNT) and its metabolite 4-ADNT in Caenorhabditis elegans. Environmental toxicology and pharmacology. 2022-04-18. PMID:35436606. |
the apoptotic effects of tnt were blocked in mutants of cep-1 (w40), egl-1 (n487), and hus-1 (op241), indicating conserved genotoxic response genes was involved in mediating tnt-induced germ cell apoptosis. |
2022-04-18 |
2023-08-13 |
caenorhabditis_elegans |
| Yunjiang Yu, Xin Hua, Haibo Chen, Yue Yang, Yao Dang, Mingdeng Xian. Tetrachlorobisphenol A mediates reproductive toxicity in Caenorhabditis elegans via DNA damage-induced apoptosis. Chemosphere. 2022-04-15. PMID:35427672. |
apoptosis was nearly abolished in ced-4 and ced-3 mutants and blocked in hus-1, egl-1, cep-1, and ced-9 mutants. |
2022-04-15 |
2023-08-13 |
caenorhabditis_elegans |
| Chi-Wei Huang, Zhi-Ying Kung, Chia-Cheng We. UV-filter octyl methoxycinnamate causes reproductive toxicity associated with germline apoptosis and vitellogenin decrease in Caenorhabditis elegans. Aquatic toxicology (Amsterdam, Netherlands). vol 247. 2022-04-09. PMID:35397382. |
decreased mrna levels of vitellogenin-related genes (vit-2 and vit-6) and increased mrna levels of apoptosis-related genes (egl-1 and ced-3) were observed in 10 μm omc-treated c. elegans (experimental concentrations = 0, 10 μm), suggesting that reproductive toxicity was associated with decreased vitellogenin levels and germline apoptosis. |
2022-04-09 |
2023-08-13 |
caenorhabditis_elegans |
| Haibo Chen, Yue Yang, Chen Wang, Xin Hua, Hui Li, Dongli Xie, Mingdeng Xiang, Yunjiang Y. Reproductive toxicity of UV-photodegraded polystyrene microplastics induced by DNA damage-dependent cell apoptosis in Caenorhabditis elegans. The Science of the total environment. 2021-12-17. PMID:34919931. |
germline apoptosis induced by aged ps-mps was altered in egl-1, hus-1, cep-1, ced-3, ced-4, and ced-9 mutants. |
2021-12-17 |
2023-08-13 |
caenorhabditis_elegans |
| Sarah Fausett, Nausicaa Poullet, Clotilde Gimond, Anne Vielle, Michele Bellone, Christian Braendl. Germ cell apoptosis is critical to maintain Caenorhabditis elegans offspring viability in stressful environments. PloS one. vol 16. issue 12. 2021-12-12. PMID:34879088. |
in contrast, mutations in ced-9 and egl-1 that primarily block apoptosis in the soma but not in the germline, did not exhibit such reduced embryonic survival under environmental stress. |
2021-12-12 |
2023-08-13 |
caenorhabditis_elegans |
| Ling Jin, Ting-Ting Dou, Jing-Ya Chen, Ming-Xiu Duan, Quan Zhen, Hua-Zhang Wu, Yun-Li Zha. Sublethal toxicity of graphene oxide in Caenorhabditis elegans under multi-generational exposure. Ecotoxicology and environmental safety. vol 229. 2021-12-11. PMID:34890989. |
simultaneously, the fertility function of the nematode was impaired under consecutive exposure as reduced brood sizes and oocytes numbers, increased apoptosis of germline, and aberrant expression of reproductive related genes ced-3, ced-4, ced-9, egl-1 and ced-13 were detected in exposed worms. |
2021-12-11 |
2023-08-13 |
human |
| Hongdan Zhang, Tongtong Liu, Xuelong Song, Qinyu Zhou, Jielin Tang, Qianyu Sun, Yuepu Pu, Lihong Yin, Juan Zhan. Study on the reproductive toxicity and mechanism of tri-n-butyl phosphate (TnBP) in Caenorhabditis elegans. Ecotoxicology and environmental safety. vol 227. 2021-11-10. PMID:34673412. |
furthermore, tnbp exposure caused abnormal gene expressions of cell apoptosis (ced-9, ced-4 and ced-3), dna damage (hus-1, clk-2, cep-1 and egl-1) and oxidative stress (mev-1 and gas-1). |
2021-11-10 |
2023-08-13 |
caenorhabditis_elegans |
| Joseph Ryan Polli, Mary Farwell, Xiaoping Pa. Detection of Caenorhabditis elegans Germ Cell Apoptosis Following Exposure to Environmental Contaminant Mixtures: A Crude Oil-Dispersant Mixture Example. Methods in molecular biology (Clifton, N.J.). vol 2326. 2021-08-13. PMID:34097257. |
in addition, qrt-pcr was utilized to demonstrate the aberrant expression of apoptosis (ced-13, ced-3, ced-4, ced-9, cep-1, dpl-1, efl-1, efl-2, egl-1, egl-38, lin-35, pax-2, and sir-2.1) and cytochrome p450 (cyp14a3, cyp35a1, cyp35a2, cyp35a5, and cyp35c1) protein-coding genes following exposure to dispersed crude oil. |
2021-08-13 |
2023-08-13 |
caenorhabditis_elegans |
| Anh T Tran, Eric M Chapman, Mathieu N Flamand, Bin Yu, Samuel J Krempel, Thomas F Duchaine, Matthew Eroglu, W Brent Derr. MiR-35 buffers apoptosis thresholds in the C. elegans germline by antagonizing both MAPK and core apoptosis pathways. Cell death and differentiation. vol 26. issue 12. 2020-10-01. PMID:30952991. |
here we show mir-35-42 mirna family play a dual role in antagonizing both ndk-1, a positive regulator of mapk signalling, and the bh3-only pro-apoptotic protein egl-1 to regulate the magnitude of dna damage-induced apoptosis in the c. elegans germline. |
2020-10-01 |
2023-08-13 |
human |
| N Mukherjee, N Joardar, S P Sinha Bab. Antifilarial activity of azadirachtin fuelled through reactive oxygen species induced apoptosis: a thorough molecular study on Setaria cervi. Journal of helminthology. vol 93. issue 5. 2019-08-07. PMID:30032733. |
the downregulation of anti-apoptotic ced-9 and upregulation of proapoptotic egl-1, ced-4 and ced-3 at both the transcription and translation levels confirmed apoptosis execution at the molecular level. |
2019-08-07 |
2023-08-13 |
Not clear |
| Chia-Wen Tsai, Rong-Tzong Tsai, Shih-Ping Liu, Chang-Shi Chen, Min-Chen Tsai, Shao-Hsuan Chien, Huey-Shan Hung, Shinn-Zong Lin, Woei-Cherng Shyu, Ru-Huei F. Neuroprotective Effects of Betulin in Pharmacological and Transgenic Caenorhabditis elegans Models of Parkinson's Disease. Cell transplantation. vol 26. issue 12. 2018-12-11. PMID:29390878. |
moreover, we found that the enhancement of proteasomes activity by promoting rpn1 expression and downregulation of the apoptosis pathway gene, egl-1, may be the molecular mechanism for betulin-mediated protection against pd pathology. |
2018-12-11 |
2023-08-13 |
caenorhabditis_elegans |
| Brittany O'Donnell, Lily Huo, Joseph R Polli, Li Qiu, David N Collier, Baohong Zhang, Xiaoping Pa. From the Cover: ZnO Nanoparticles Enhanced Germ Cell Apoptosis in Caenorhabditis elegans, in Comparison with ZnCl2. Toxicological sciences : an official journal of the Society of Toxicology. vol 156. issue 2. 2018-02-15. PMID:28003440. |
genes involved in the apoptosis pathway (ced-13, ced-3, ced-4, ced-9, cep-1, dpl-1, efl-1, efl-2, egl-1, egl-38, lin-35, pax-2, and sir-2.1) were in general upregulated in response to zno np exposure. |
2018-02-15 |
2023-08-13 |
caenorhabditis_elegans |