| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haitao Long, Guanglong Zhang, Yue Zhou, Liqing Qin, Danxue Zhu, Jiayi Chen, Bo Liu, Huayuan Tan, Danping Chen, Zhurui Li, Chengpeng Li, Zhenchao Wan. A Novel Tryptanthrin Derivative D6 Induces Apoptosis and DNA Damage in Non-small-cell Lung Cancer Cells Through Regulating the EGFR Pathway. Anti-cancer agents in medicinal chemistry. 2024-07-22. PMID:39034729. |
a novel tryptanthrin derivative d6 induces apoptosis and dna damage in non-small-cell lung cancer cells through regulating the egfr pathway. |
2024-07-22 |
2024-07-24 |
Not clear |
| Ye Ding, Hao Li, Saisai Cao, Yong Y. Effects of catechin on the malignant biological behavior of gastric cancer cells through the PI3K/Akt signaling pathway. Toxicology and applied pharmacology. 2024-07-15. PMID:39009138. |
the proliferation ability, cell cycle, apoptosis and migration of gastric cancer cells were detected, as well as the protein expression levels of pi3k, p-akt, and akt and the mrna expression levels of akt1, vegfa, egfr, hras, and hsp90aa1 in gastric cancer cells. |
2024-07-15 |
2024-07-18 |
Not clear |
| Zhijun Geng, Lugen Zuo, Jing Li, Lixia Yin, Jingjing Yang, Ting Duan, Lian Wang, Xiaofeng Zhang, Xue Song, Yueyue Wang, Jianguo H. Ginkgetin improved experimental colitis by inhibiting intestinal epithelial cell apoptosis through EGFR/PI3K/AKT signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 14. 2024-07-14. PMID:39003633. |
the underlying mechanism of gk's protective effect was explored by bioinformatics, rescue experiments and molecular docking, and it was found that gk might directly target and activate egfr, thereby interfering with pi3k/akt signaling to inhibit apoptosis of intestinal epithelial cells in vivo and in vitro. |
2024-07-14 |
2024-07-16 |
mouse |
| Zhijun Geng, Lugen Zuo, Jing Li, Lixia Yin, Jingjing Yang, Ting Duan, Lian Wang, Xiaofeng Zhang, Xue Song, Yueyue Wang, Jianguo H. Ginkgetin improved experimental colitis by inhibiting intestinal epithelial cell apoptosis through EGFR/PI3K/AKT signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 14. 2024-07-14. PMID:39003633. |
in conclusion, gk inhibited intestinal epithelial apoptosis in mice with experimental colitis, at least in part, by activating egfr and interfering with pi3k/akt activation, explaining the underlying mechanism for ameliorating colitis, which may provide new options for the treatment of ibd. |
2024-07-14 |
2024-07-16 |
mouse |
| Pei Wang, Yelu Zhou, Juan Wang, Yun Zhou, Xiaohui Zhang, Yanxing Liu, Ang Li, Yangsong He, Shuyi Chen, Airong Qian, Xin Wang, Yongzhan Nie, Daiming Fan, Tianyu Cao, Yuanyuan Lu, Xiaodi Zha. miR-107 reverses the multidrug resistance of gastric cancer by targeting the CGA/EGFR/GATA2 positive feedback circuit. The Journal of biological chemistry. 2024-07-03. PMID:38960034. |
hyperactivation of the egfr signaling pathway contributes to mdr by promoting cancer cell proliferation and inhibiting apoptosis. |
2024-07-03 |
2024-07-10 |
Not clear |
| Hiba N Alsaad, Baan M Al-Jasani, Ammar A Razzak Mahmood, Lubna H Tahtamouni, Khaled M Saleh, Mai F AlSakhen, Sana I Kanaan, Salem R Yasi. Novel 1,3,4-oxadiazole derivatives of naproxen targeting EGFR: Synthesis, molecular docking studies, and cytotoxic evaluation. Drug development research. vol 85. issue 5. 2024-07-03. PMID:38956926. |
the antiproliferative effects of the new compounds were evaluated by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2h-tetrazolium bromide assay, cell cycle analysis, apoptosis detection by microscopy, quantitative reverse transcription-polymerase chain reaction, and immunoblotting, and egfr enzyme inhibition assay. |
2024-07-03 |
2024-07-06 |
Not clear |
| Thomas Morgan Li, Victoria Zyulina, Ethan S Seltzer, Marija Dacic, Yurii Chinenov, Andrea R Daamen, Keila R Veiga, Noa Schwartz, David J Oliver, Pamela Cabahug-Zuckerman, Jose Lora, Yong Liu, William D Shipman, William G Ambler, Sarah F Taber, Karen B Onel, Jonathan H Zippin, Mehdi Rashighi, James G Krueger, Niroshana Anandasabapathy, Inez Rogatsky, Ali Jabbari, Carl P Blobel, Peter E Lipsky, Theresa T L. The interferon-rich skin environment regulates Langerhans cell ADAM17 to promote photosensitivity in lupus. eLife. vol 13. 2024-06-11. PMID:38860651. |
we have previously shown that langerhans cells (lcs) limit keratinocyte apoptosis and photosensitivity via a disintegrin and metalloprotease 17 (adam17)-mediated release of epidermal growth factor receptor (egfr) ligands and that lc adam17 sheddase activity is reduced in lupus. |
2024-06-11 |
2024-06-14 |
mouse |
| Harika Atmaca, Suleyman Ilhan, Çisil Çamli Pulat, Buse Aysen Dundar, Metin Zor. Evaluation of Novel Spiro-pyrrolopyridazine Derivatives as Anticancer Compounds: In Vitro Selective Cytotoxicity, Induction of Apoptosis, EGFR Inhibitory Activity, and Molecular Docking Analysis. ACS omega. vol 9. issue 22. 2024-06-10. PMID:38854531. |
evaluation of novel spiro-pyrrolopyridazine derivatives as anticancer compounds: in vitro selective cytotoxicity, induction of apoptosis, egfr inhibitory activity, and molecular docking analysis. |
2024-06-10 |
2024-06-14 |
Not clear |
| Anjana Sajeev, Bethsebie Sailo, Jyothsna Unnikrishnan, Ayesha Talukdar, Mohammed S Alqahtani, Mohamed Abbas, Athba Alqahtani, Gautam Sethi, Ajaikumar B Kunnumakar. Unlocking the Potential of Berberine: Advancing Cancer Therapy through Chemosensitization and Combination Treatments. Cancer letters. 2024-06-07. PMID:38849013. |
bbr's ability to modulate chemoresistance is attributed to its diverse mechanisms of action, including inducing dna breaks, inhibition of drug efflux pumps, modulation of apoptosis and necroptosis, downregulating multidrug resistance genes, enhancing immune response, suppressing angiogenesis and targeting multiple pathways within cancer cells, including protein kinase b/mammalian target of rapamycin (akt/mtor), epidermal growth factor receptor (egfr), mitogen-activated protein kinase (mapk), nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb), poly(adp-ribose) polymerase (parp1), janus kinase/signal transducers and activators of transcription (jak-stat), wnt/β-catenin etc. |
2024-06-07 |
2024-06-10 |
Not clear |
| Yanan Wang, Yongfeng Lao, Rongxin Li, Chengyu You, Liangliang Qing, Xi Xiao, Shuai Liu, Wenyun Wang, Yu Zhao, Zhilong Don. Network pharmacological analysis and experimental study of melatonin in chronic prostatitis/chronic pelvic pain syndrome. Naunyn-Schmiedeberg's archives of pharmacology. 2024-05-31. PMID:38822120. |
enrichment analysis indicates that mt affects cp/cpps through various biological processes, and pathway analysis emphasizes the significance of pi3k-akt, mapk, ras, foxo, hif-1, egfr, and apoptosis pathways. |
2024-05-31 |
2024-06-02 |
Not clear |
| Jing Sun, Wen-Juan Xu, Lin-Ying Zhong, Jian-Bo Chen, Ling Don. [UPLC-QE-Orbitrap-MS combined with network pharmacology to explore differential components and mechanisms of raw and scorched rhubarb for treatment of ulcerative colitis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 7. 2024-05-30. PMID:38812196. |
network pharmacology and molecular docking suggested that free anthraquinones, gallic acid, and 5-hmf may act on core targets such as b-cell lymphoma-2(bcl2), epidermal growth factor receptor(egfr), tumor necrosis factor(tnf), and caspase-3(casp3) and influence the signaling pathways such as phosphoinositide-3-kinase/protein kinase b(pi3k/akt), hypoxia inducible factor-1(hif-1), tnf, and mitogen-activated protein kinase(mapk), so as to regulate the inflammation response, oxidative stress, and cell apoptosis to relieve uc symptoms. |
2024-05-30 |
2024-06-17 |
mouse |
| Qinyao Wei, Juan Li, Xinyan Li, Jialin Xiang, Yao Zhang, Huadong Yin, Can Cu. CircRAB11A act as miR-24-5p sponge promotes proliferation and resists apoptosis of chicken granulosa cell via EGFR/ERK1/2 and RAB11A/ PI3K/AKT pathways. Poultry science. vol 103. issue 7. 2024-05-28. PMID:38806000. |
rab11a or egfr promoted proliferation and suppressed apoptosis in gcs through the phosphatidylinositol-kinase (pi3k)/akt or extracellular signal-regulated kinase (erk)1/2 pathway. |
2024-05-28 |
2024-06-03 |
chicken |
| Jingyu Mao, Qin Lu, Fei Gao, Hao Liu, Jinchuan Ta. Antagonistic Effect of Jiawei Shengjiang San on a Rat Model of Diabetic Nephropathy: Related to EGFR/MAPK3/1 Signaling Pathway. Journal of visualized experiments : JoVE. issue 207. 2024-05-27. PMID:38801274. |
kegg enrichment analysis denoted that jwsjs mitigates diabetic nephropathy by modulating lipids and atherosclerosis, the pi3k-akt signaling pathway, apoptosis, and the hif-1 signaling pathway, with mitogen-activated protein kinase 1 (mapk1), mapk3, epidermal growth factor receptor (egfr), and serine/threonine-protein kinase 1 (akt1) identified as collective targets of multiple pathways. |
2024-05-27 |
2024-05-31 |
rat |
| Łukasz Biegała, Damian Kołat, Arkadiusz Gajek, Elżbieta Płuciennik, Agnieszka Marczak, Agnieszka Śliwińska, Michał Mikula, Aneta Rogalsk. Uncovering miRNA-mRNA Regulatory Networks Related to Olaparib Resistance and Resensitization of Cells. vol 13. issue 10. 2024-05-24. PMID:38786089. |
resensitized peo1-or cells were enriched in growth factor signaling via pdgf, egfr, fgfr1, vegfr2, and tgfβr, regulation of the cell cycle via the g2/m checkpoint, and caspase-mediated apoptosis. |
2024-05-24 |
2024-05-27 |
Not clear |
| Qi Li, Bo Li, Qian Wang, Chengen Wang, Miao Yu, Tianfu X. Marine-derived EGFR inhibitors: novel compounds targeting breast cancer growth and drug resistance. Frontiers in pharmacology. vol 15. 2024-05-17. PMID:38751788. |
these compounds not only induced early apoptosis through caspase-3 activation but also showed significant inhibitory effects on egfr mutations associated with drug resistance (t790m, l858r, and l858r/t790m), demonstrating high egfr kinase selectivity. |
2024-05-17 |
2024-05-27 |
Not clear |
| Qi Li, Bo Li, Qian Wang, Chengen Wang, Miao Yu, Tianfu X. Marine-derived EGFR inhibitors: novel compounds targeting breast cancer growth and drug resistance. Frontiers in pharmacology. vol 15. 2024-05-17. PMID:38751788. |
furthermore, binding competition assays using surface plasmon resonance technology revealed that tandyukisin and trichoharzin bound to distinct sites on egfr and that their combined use enhanced apoptosis in bc cells. |
2024-05-17 |
2024-05-27 |
Not clear |
| Rui Wang, Wenrui Cui, Lanxin Li, Xiangkai Wei, Chunhong Chu, Guoliang Zhang, Chenxue Liu, Huixia Xu, Chenyang Liu, Ke Wang, Yanming Li, Lei A. BDTX-189, a novel tyrosine kinase inhibitor, inhibits cell activity via ERK and AKT pathways in the EGFR C797S triple mutant cells. Chemico-biological interactions. vol 395. 2024-05-09. PMID:38710274. |
meanwhile, bdtx-189 reduces the protein phosphorylation levels of egfr, erk, and akt, promoting apoptosis. |
2024-05-09 |
2024-05-27 |
Not clear |
| Tomohito Doke, Shizheng Huang, Chengxiang Qiu, Xin Sheng, Matthew Seasock, Hongbo Liu, Ziyuan Ma, Matthew Palmer, Katalin Suszta. Genome-wide association studies identify the role of caspase-9 in kidney disease. Science advances. vol 7. issue 45. 2024-04-15. PMID:34739325. |
in summary, here, we prioritized casp9 as an egfr gwas target gene and demonstrated the causal role of casp9 in kidney disease development via improving mitophagy and lowering inflammation and apoptosis. |
2024-04-15 |
2024-04-17 |
mouse |
| Olusola Olalekan Elekofehinti, Ifeoluwa Rachael Adetoyi, Hannah Oluwaseun Popoola, Folasade Oluwatobiloba Ayodeji, Foluso Adeola Taiwo, Moses Orimoloye Akinjiyan, Omowunmi Funmilayo Koledoye, Opeyemi Iwaloye, Abayomi Emmanuel Adegboyeg. Discovery of potential epidermal growth factor receptor inhibitors from black pepper for the treatment of lung cancer: an In silico pharmacology. vol 12. issue 1. 2024-04-11. PMID:38601803. |
discovery of potential epidermal growth factor receptor inhibitors from black pepper for the treatment of lung cancer: an a tyrosine kinase receptor known as epidermal growth factor receptor (egfr) is one of the main tumour markers in many cancer types and also plays a crucial role in cell proliferation, differentiation, angiogenesis, and apoptosis, which is a result of the auto-phosphorylations (kinase activity enhancement) that trigger signals involved in different cellular processes. |
2024-04-11 |
2024-04-13 |
Not clear |
| Sha Lv, Qianrong Pan, Weijing Lu, Weisong Zhang, Naike Wang, Lijuan Huang, Lianjing Li, Jieyao Liu, Jiamei Ma, Zhan Li, Yong Huang, Qiudi Deng, Xueping Le. Tenovin 3 induces apoptosis and ferroptosis in EGFR 19del non small cell lung cancer cells. Scientific reports. vol 14. issue 1. 2024-04-01. PMID:38561419. |
tenovin 3 induces apoptosis and ferroptosis in egfr 19del non small cell lung cancer cells. |
2024-04-01 |
2024-04-04 |
Not clear |