All Relations between apoptosis and egfr

Publication Sentence Publish Date Extraction Date Species
Ahmed A Gaber, Ayman Abo Elmaaty, Marwa Sharaky, Aliaa A Mosa, Abdullah Yahya Abdullah Alzahrani, Saad Shaaban, Wagdy M Eldehna, Ahmed A Al-Karmalaw. Multi-target rational design and synthesis of novel diphenyl-tethered pyrazolopyrimidines targeting EGFR and topoisomerase II with potential DNA intercalation and apoptosis induction. Bioorganic chemistry. vol 145. 2024-02-22. PMID:38387399. multi-target rational design and synthesis of novel diphenyl-tethered pyrazolopyrimidines targeting egfr and topoisomerase ii with potential dna intercalation and apoptosis induction. 2024-02-22 2024-02-25 Not clear
Yang Zhang, Ye Chen, Li-Li Lu, Xiu-Li Xie, Ren Huan, Li-Fang Wu, Li-Na Tan, Tao Xu, Yong Ji. The Role and Therapeutic Potential of Non-coding RNAs in Resistance to EGFR-TKIs targeted therapy for Non-small Cell Lung Cancer. Current medicinal chemistry. 2024-02-20. PMID:38375847. ncrnas are involved in nsclc resistance to egfr-tkis by mediating cellular drug efflux, epithelial-mesenchymal transition, apoptosis, autophagy, and egfr mutation. 2024-02-20 2024-02-22 Not clear
Biao Wang, Junfeng He, Yan Cui, Sijiu Yu, Huizhu Zhang, Pengqiang Wei, Qian Zhan. The HIF-1α/EGF/EGFR Signaling Pathway Facilitates the Proliferation of Yak Alveolar Type II Epithelial Cells in Hypoxic Conditions. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338723. furthermore, activation of egfr expression under normoxic conditions further promoted at2 cell proliferation while simultaneously suppressing apoptosis. 2024-02-10 2024-02-12 Not clear
Fatemeh Keshavarz, Mohsen Soltanshahi, Fatemeh Khosravani, Farzaneh Bakhshiyan, Amir Ghanbari, Sajad Hassanzadeh, Mozhgan Amirpour, Ghasem Ghalamfars. Thymol-loaded liposomes effectively induced apoptosis and decreased EGFR expression in colorectal cancer cells. Naunyn-Schmiedeberg's archives of pharmacology. 2024-01-19. PMID:38240780. thymol-loaded liposomes effectively induced apoptosis and decreased egfr expression in colorectal cancer cells. 2024-01-19 2024-01-21 Not clear
Fatemeh Ardalan Moghadam Al, Mohammad Mahdi Forghanifard, Vajiheh Zarrinpou. PYGO2 increases proliferation and migration capacities through critical signaling pathways in esophageal squamous cell carcinoma. Journal of biochemical and molecular toxicology. vol 38. issue 1. 2024-01-17. PMID:38229324. the development of esophageal squamous cell carcinoma (escc) involves various genetic abnormalities that affect key cell signaling pathways, including wnt, hh, apoptosis, mapk, egfr, akt, notch, and emt. 2024-01-17 2024-01-19 Not clear
Fatemeh Ardalan Moghadam Al, Mohammad Mahdi Forghanifard, Vajiheh Zarrinpou. PYGO2 increases proliferation and migration capacities through critical signaling pathways in esophageal squamous cell carcinoma. Journal of biochemical and molecular toxicology. vol 38. issue 1. 2024-01-17. PMID:38229324. furthermore, pygo2 gene expression induction analysis showed the correlation of several involved genes in wnt, hh, apoptosis, mapk, egfr, akt, and emt pathways with various lncrnas. 2024-01-17 2024-01-19 Not clear
Fatma G Abdulrahman, Hamada S Abulkhair, Hoda S El Saeed, Nehad M El-Dydamony, Ebtehal M Hussein. Design, synthesis, and mechanistic insight of novel imidazolones as potential EGFR inhibitors and apoptosis inducers. Bioorganic chemistry. vol 144. 2024-01-14. PMID:38219482. design, synthesis, and mechanistic insight of novel imidazolones as potential egfr inhibitors and apoptosis inducers. 2024-01-14 2024-01-17 Not clear
Chuanchuan Zhou, Haitao Zeng, Xingxing Xiao, Li Wang, Lei Jia, Yanan Shi, Minfang Zhang, Cong Fang, Yanyan Zeng, Taibao Wu, Jiana Huang, Xiaoyan Lian. Global crotonylome identifies EP300-regulated ANXA2 crotonylation in cumulus cells as a regulator of oocyte maturation. International journal of biological macromolecules. 2024-01-04. PMID:38176486. crotonylation of anxa2 enhanced the anxa2-egfr binding, and then activated the egfr pathway to affect cumulus cell proliferation and apoptosis. 2024-01-04 2024-01-07 mouse
Ting Yang, Sijuan Tian, Juan Zhao, Meili Pei, Minyi Zhao, Xiaofeng Yan. LncRNA ABHD11-AS1 activates EGFR signaling to promote cervical cancer progression by preventing FUS-mediated degradation of ABHD11 mRNA. Cell cycle (Georgetown, Tex.). 2023-12-26. PMID:38146687. knockdown of abhd11-as1 and egfr significantly inhibited the proliferation, migration, and invasion and promoted apoptosis of siha and hela cells by up-regulating p21 and bax and down-regulating cyclin d1, bcl2, mmp9, and vimentin. 2023-12-26 2023-12-28 Not clear
Xuxiu Lu, Rilei Yu, Zhen Li, Mengke Yang, Jiajia Dai, Ming Li. JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers. Cancer letters. 2023-12-15. PMID:38101609. importantly, jc-010a abolished acquired resistance induced by targeted therapies: in kras-mutant cancers, jc-010a abrogated selumetinib-induced adaptive resistance mediated by rtk/shp2; in bcr-abl-driven leukemia cells, we demonstrated jc-010a inhibited bcr-abl t315i mutation-mediated imatinib resistance and proposed a novel mechanism of jc-010a involving the disrupted co-interaction of shp2, bcr-abl, and hsp90; in non-small cell lung cancer (nsclc) cells, jc-010a inhibited both egfr t790m/c797s mutation and alternate rtk-driven resistance to gefitinib or osimertinib; importantly, we first proposed a novel potential therapeutic strategy for ret-rearranged cancer, we confirmed that jc-010a monotherapy inhibited cell resistance to blu-667, and jc-010a/blu-667 combination prolonged anticancer response both in vivo and in vitro cancer models by inhibiting the alternate met activation-induced ras/mapk reactivation, thereby promoting cancer cell apoptosis. 2023-12-15 2023-12-18 Not clear
Momoko Gyoten, Yi Luo, Rina Fujiwara-Tani, Shiori Mori, Ruiko Ogata, Shingo Kishi, Hiroki Kuniyas. Lovastatin Treatment Inducing Apoptosis in Human Pancreatic Cancer Cells by Inhibiting Cholesterol Rafts in Plasma Membrane and Mitochondria. International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38069135. in the three gem-resistant cell lines derived from mia and panc1, the lipid rafts in the cell membrane and the mitochondria were increased to activate egfr and akt and to increase bcl2-bax binding, which suppressed apoptosis. 2023-12-09 2023-12-17 human
Syam Mohan, Mohammed Ageeli Hakami, Hamad Ghaleb Dailah, Asaad Khalid, Asim Najmi, Khalid Zoghebi, Maryam A Halaw. The emerging role of noncoding RNAs in the EGFR signaling pathway in lung cancer. Pathology, research and practice. vol 253. 2023-12-09. PMID:38070221. micrornas, as versatile post-transcriptional regulators, have been shown to target various components of the egfr pathway, influencing cancer cell proliferation, migration, and apoptosis. 2023-12-09 2023-12-17 Not clear
Ibrahim H Eissa, Reda G Yousef, Eslam B Elkaeed, Aisha A Alsfouk, Dalal Z Husein, Ibrahim M Ibrahim, Hesham A El-Mahdy, Hazem Elkady, Ahmed M Metwal. Computer-Assisted Drug Discovery of a Novel Theobromine Derivative as an EGFR Protein-Targeted Apoptosis Inducer. Evolutionary bioinformatics online. vol 19. 2023-12-04. PMID:38046652. computer-assisted drug discovery of a novel theobromine derivative as an egfr protein-targeted apoptosis inducer. 2023-12-04 2023-12-10 Not clear
Ibrahim H Eissa, Reda G Yousef, Eslam B Elkaeed, Aisha A Alsfouk, Dalal Z Husein, Ibrahim M Ibrahim, Hesham A El-Mahdy, Hazem Elkady, Ahmed M Metwal. Computer-Assisted Drug Discovery of a Novel Theobromine Derivative as an EGFR Protein-Targeted Apoptosis Inducer. Evolutionary bioinformatics online. vol 19. 2023-12-04. PMID:38046652. the overexpression of the epidermal growth factor receptor (egfr) marks it as a pivotal target in cancer treatment, with the aim of reducing its proliferation and inducing apoptosis. 2023-12-04 2023-12-10 Not clear
Wael A A Fadaly, Taha H Zidan, Nesma M Kahk, Fatma E A Mohamed, Marwa M Abdelhakeem, Rehab G Khalil, Mohamed T M Nem. New pyrazolyl-thiazolidinone/thiazole derivatives as celecoxib/dasatinib analogues with selective COX-2, HER-2 and EGFR inhibitory effects: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis, molecular modelling and ADME studies. Journal of enzyme inhibition and medicinal chemistry. vol 38. issue 1. 2023-11-27. PMID:38010912. new pyrazolyl-thiazolidinone/thiazole derivatives as celecoxib/dasatinib analogues with selective cox-2, her-2 and egfr inhibitory effects: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis, molecular modelling and adme studies. 2023-11-27 2023-11-29 Not clear
Dujuan Li, Lifei Lian, Lei Huang, Marcin Gamdzyk, Yi Huang, Desislava Doycheva, Gaigai Li, Shufeng Yu, Yong Guo, Ruiqing Kang, Hong Tang, Jiping Tang, Lingfei Kong, John H Zhan. Delayed recanalization reduced neuronal apoptosis and neurological deficits by enhancing liver-derived trefoil factor 3-mediated neuroprotection via LINGO2/EGFR/Src signaling pathway after middle cerebral artery occlusion in rats. Experimental neurology. 2023-11-07. PMID:37935323. lingo2 sirna knockdown or egfr inhibitor reversed the effects of delayed recanalization on apoptosis and brain expressions of lingo2, p-egfr, p-src and bcl-2. 2023-11-07 2023-11-20 rat
Seung-On Lee, Mee-Hyun Lee, Ah-Won Kwak, Jin-Young Lee, Goo Yoon, Sang Hoon Joo, Yung Hyun Choi, Jin Woo Park, Jung-Hyun Shi. Licochalcone H Targets EGFR and AKT to Suppress the Growth of Oxaliplatin -Sensitive and -Resistant Colorectal Cancer Cells. Biomolecules & therapeutics. vol 31. issue 6. 2023-10-30. PMID:37899744. taken together lch inhibits the growth of ox-sensitive and ox-resistant crc cells by targeting egfr and akt, and inducing ros generation and er stress-mediated apoptosis. 2023-10-30 2023-11-08 Not clear
Koh Furugaki, Takaaki Fujimura, Hayato Mizuta, Takuya Yoshimoto, Takashi Asakawa, Yasushi Yoshimura, Shigeki Yoshiur. FGFR blockade inhibits targeted therapy-tolerant persister in basal FGFR1- and FGF2-high cancers with driver oncogenes. NPJ precision oncology. vol 7. issue 1. 2023-10-25. PMID:37880373. the combination of fgfr and targeted tkis enhanced cell growth inhibition and apoptosis induction in basal fgfr1- and fgf2-high protein expressing cells with alk-rearranged and epidermal growth factor receptor (egfr)-mutated nsclc, human epidermal growth factor receptor 2 (her2)-amplified breast cancer, or v-raf murine sarcoma viral oncogene homolog b1 (braf)-mutated melanoma by preventing compensatory extracellular signal-regulated kinase (erk) reactivation. 2023-10-25 2023-11-08 human
Nihan Verimli, S İrem Goralı, Beyza Abisoglu, Cem Levent Altan, Bilgesu Onur Sucu, Ersin Karatas, Ahmet Tulek, Cigdem Bayraktaroglu, Mustafa Caglar Beker, S Sibel Erde. Development of light and pH-dual responsive self-quenching theranostic SPION to make EGFR overexpressing micro tumors glow and destroy. Journal of photochemistry and photobiology. B, Biology. vol 248. 2023-10-20. PMID:37862898. anti-egfr scfv targeted spion caused nearly 2-fold higher cell death via apoptosis in high egfr expressing panc-1 cell line. 2023-10-20 2023-11-08 Not clear
Zhenxing Wang, Lanxin Li, Chunhong Chu, Xiangkai Wei, Qian Liu, Rui Wang, Guoliang Zhang, Guangyao Wu, Ying Wang, Lei An, Xiaodong L. CUDC‑101 is a potential target inhibitor for the EGFR‑overexpression bladder cancer cells. International journal of oncology. vol 63. issue 6. 2023-10-13. PMID:37830158. the molecular mechanism underlying its development is complex, but its carcinogenesis has been proposed to occur with cell proliferation and resistance to apoptosis, driven by the signaling activity of abundant egfr and receptor tyrosine‑protein kinase erbb‑2. 2023-10-13 2023-10-15 Not clear