| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Q Song, Y Kuang, V M Dixit, C Vincen. Boo, a novel negative regulator of cell death, interacts with Apaf-1. The EMBO journal. vol 18. issue 1. 1999-02-18. PMID:9878060. |
like ced-9, the mammalian homologues boo and bcl-xl interact with the human counterpart of ced-4, apaf-1, and thereby regulate apoptosis. |
1999-02-18 |
2023-08-12 |
human |
| L del Peso, V M González, G Núñe. Caenorhabditis elegans EGL-1 disrupts the interaction of CED-9 with CED-4 and promotes CED-3 activation. The Journal of biological chemistry. vol 273. issue 50. 1999-01-14. PMID:9837929. |
expression of ced-4 and ced-3 resulted in decreased survival and apoptosis of mammalian cells, activities that could be inhibited by ced-9. |
1999-01-14 |
2023-08-12 |
caenorhabditis_elegans |
| M Yasuda, C D'Sa-Eipper, X L Gong, G Chinnadura. Regulation of apoptosis by a Caenorhabditis elegans BNIP3 homolog. Oncogene. vol 17. issue 19. 1998-12-10. PMID:9824163. |
in cells coexpressing ced-9, cebnip3 and ced-3, all three proteins exist as a ternary complex suggesting that ced-9 may suppress cooperative apoptosis induced by ced-3 and cebnip3 by simultaneous complex formation with ced-3 and cebnip3. |
1998-12-10 |
2023-08-12 |
human |
| J Han, H D Wallen, G Nuñez, E Whit. E1B 19,000-molecular-weight protein interacts with and inhibits CED-4-dependent, FLICE-mediated apoptosis. Molecular and cellular biology. vol 18. issue 10. 1998-11-05. PMID:9742122. |
this trimolecular complex of ced-4, ced-3, and ced-9 is functional in that ced-9 inhibits ced-4 from activating ced-3 and thereby inhibits apoptosis in heterologous systems. |
1998-11-05 |
2023-08-12 |
caenorhabditis_elegans |
| S Hisahara, H Kanuka, S Shoji, S Yoshikawa, H Okano, M Miur. Caenorhabditis elegans anti-apoptotic gene ced-9 prevents ced-3-induced cell death in Drosophila cells. Journal of cell science. vol 111 ( Pt 6). 1998-07-01. PMID:9471995. |
furthermore, apoptosis of sl2 cells that was induced by a drosophila cell-death gene, reaper, was shown to be partially prevented by ced-9, bcl-2 and bcl-xl. |
1998-07-01 |
2023-08-12 |
human |
| D Wu, H D Wallen, N Inohara, G Nuñe. Interaction and regulation of the Caenorhabditis elegans death protease CED-3 by CED-4 and CED-9. The Journal of biological chemistry. vol 272. issue 34. 1997-09-15. PMID:9261161. |
expression of wild-type ced-4 promotes the ability of ced-3 to induce apoptosis in mammalian cells, which is inhibited by ced-9. |
1997-09-15 |
2023-08-12 |
caenorhabditis_elegans |
| S Seshagiri, L K Mille. Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced apoptosis. Current biology : CB. vol 7. issue 7. 1997-08-28. PMID:9210374. |
genetic studies in the nematode c. elegans have identified three key genes involved in apoptosis, ced-3, ced-4 and ced-9. |
1997-08-28 |
2023-08-12 |
caenorhabditis_elegans |
| J C Ree. Mechanisms of Bcl-2 family protein function and dysfunction in health and disease. Behring Institute Mitteilungen. issue 97. 1997-03-14. PMID:8950468. |
since the discovery of bcl-2 a decade ago, several other cellular and viral genes encoding homologous proteins have been identified, some of which suppress cell death akin to bcl-2 (bcl-xl, mcl-1, a1/bfl-1, nr13, ced-9, bhrf-1) and others which promote apoptosis (bax, bcl-xs, bak, bik, bad). |
1997-03-14 |
2023-08-12 |
human |
| B W Stewar. Mechanisms of apoptosis: integration of genetic, biochemical, and cellular indicators. Journal of the National Cancer Institute. vol 86. issue 17. 1994-09-19. PMID:8064887. |
expression of the mammalian bcl-2 gene (homologous to ced-9) suppresses apoptosis in many systems. |
1994-09-19 |
2023-08-12 |
human |
| L Fesu. Biochemical events in naturally occurring forms of cell death. FEBS letters. vol 328. issue 1-2. 1993-09-09. PMID:8344412. |
negative regulators of the process (ced-9 gene product in programmed death of cells in caenorhabditis elegans and bcl-2 protein in apoptosis) have been described. |
1993-09-09 |
2023-08-12 |
caenorhabditis_elegans |
| D L Vau. Toward an understanding of the molecular mechanisms of physiological cell death. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 3. 1993-03-05. PMID:8430086. |
in the nematode caenorhabditis elegans programmed cell deaths are mediated by a mechanism controlled by the ced-9 gene; in mammals apoptosis can often be inhibited by expression of the bcl-2 gene. |
1993-03-05 |
2023-08-12 |
human |