| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joseph Ryan Polli, Yanqiong Zhang, Xiaoping Pa. Dispersed crude oil amplifies germ cell apoptosis in Caenorhabditis elegans, followed a CEP-1-dependent pathway. Archives of toxicology. vol 88. issue 3. 2015-05-12. PMID:24496467. |
genes involved in the apoptosis pathway were dysregulated, which include ced-13, ced-3, ced-4, ced-9, cep-1, dpl-1, efl-1, efl-2, egl-1, egl-38, lin-35, pax-2, and sir-2.1. |
2015-05-12 |
2023-08-12 |
human |
| Yun Wang, Shunchang Wang, Xun Luo, Yanan Yang, Fenglei Jian, Xuemin Wang, Lucheng Xi. The roles of DNA damage-dependent signals and MAPK cascades in tributyltin-induced germline apoptosis in Caenorhabditis elegans. Chemosphere. vol 108. 2014-10-22. PMID:24534158. |
tbt-induced apoptosis was blocked in the bcl-2 gain-of-function strain ced-9(n1950), whereas tbt induced a minor increase in the bh3-only protein egl-1 mutated strain egl-1(n1084n3082). |
2014-10-22 |
2023-08-12 |
caenorhabditis_elegans |
| Carlos Giovanni Silva-García, Rosa Estela Navarr. The C. elegans TIA-1/TIAR homolog TIAR-1 is required to induce germ cell apoptosis. Genesis (New York, N.Y. : 2000). vol 51. issue 10. 2014-04-25. PMID:23913578. |
we also show that tiar-1 acts downstream of ced-9 (a bcl2 homolog) to induce apoptosis under stress conditions, and apparently does not seem to regulate ced-4 or ced-3 mrnas accumulation directly. |
2014-04-25 |
2023-08-12 |
caenorhabditis_elegans |
| Daniel P Denning, Victoria Hatch, H Robert Horvit. Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans. PLoS genetics. vol 9. issue 3. 2013-06-13. PMID:23505386. |
unlike ced-3, csp-1 is not regulated by the apaf-1 homolog ced-4 or the bcl-2 homolog ced-9, revealing that csp-1 functions independently of the canonical genetic pathway for apoptosis. |
2013-06-13 |
2023-08-12 |
caenorhabditis_elegans |
| Michael Chiorazzi, Lixin Rui, Yandan Yang, Michele Ceribelli, Nima Tishbi, Carine W Maurer, Stella M Ranuncolo, Hong Zhao, Weihong Xu, Wing-Chung C Chan, Elaine S Jaffe, Randy D Gascoyne, Elias Campo, Andreas Rosenwald, German Ott, Jan Delabie, Lisa M Rimsza, Shai Shaham, Louis M Staud. Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 10. 2013-05-02. PMID:23431138. |
dre-1 functions in parallel to egl-1, requires ced-9 for activity, and binds to ced-9, suggesting that dre-1 promotes apoptosis by inactivating ced-9. |
2013-05-02 |
2023-08-12 |
human |
| Shun-Chang Wang, Zhi-Zhong Geng, Yun Wang, Zhong-Hua Tong, Han-Qing Y. Essential roles of p53 and MAPK cascades in microcystin-LR-induced germline apoptosis in Caenorhabditis elegans. Environmental science & technology. vol 46. issue 6. 2012-09-13. PMID:22353034. |
mc-lr-induced apoptosis was blocked in bcl-2 gain-of-function strain ced-9(n1950), whereas it showed a slight increase in bh3-only protein egl-1 mutated strain. |
2012-09-13 |
2023-08-12 |
caenorhabditis_elegans |
| Qin-Li Ruan, Jing-Juan Ju, Yun-Hui Li, Xiao-Bo Li, Ran Liu, Ge-Yu Liang, Juan Zhang, Yue-Pu Pu, Da-Yong Wang, Li-Hong Yi. Chlorpyrifos exposure reduces reproductive capacity owing to a damaging effect on gametogenesis in the nematode Caenorhabditis elegans. Journal of applied toxicology : JAT. vol 32. issue 7. 2012-08-20. PMID:22180373. |
moreover, expression patterns of the genes spe-10, spe-15, fer-1, prg-1, glp-1, mlh-1, cyb-3, ced-3, ced-4 and ced-9 (which are associated with spermatid size, spermatid activation and morphology, oocyte morphology, oocyte function, and apoptosis) were altered after chlorpyrifos exposure. |
2012-08-20 |
2023-08-12 |
caenorhabditis_elegans |
| Chia-Hui Lee, Huang-Meng Chen, Li-Ke Yeh, Meng-Yen Hong, Guewha Steven Huan. Dosage-dependent induction of behavioral decline in Caenorhabditis elegans by long-term treatment of static magnetic fields. Journal of radiation research. vol 53. issue 1. 2012-06-22. PMID:22302042. |
mutations in genes involved in major apoptotic pathways, that is, ced-3, ced-4, and ced-9, abolished this smf-induced behavioral decline; this is consistent with the hypothesis that the apoptosis pathways are involved in the smf-induced mobility decline. |
2012-06-22 |
2023-08-12 |
caenorhabditis_elegans |
| E Pourkarimi, S Greiss, A Gartne. Evidence that CED-9/Bcl2 and CED-4/Apaf-1 localization is not consistent with the current model for C. elegans apoptosis induction. Cell death and differentiation. vol 19. issue 3. 2012-06-08. PMID:21886181. |
in c. elegans, the bh3-only domain protein egl-1, the apaf-1 homolog ced-4 and the ced-3 caspase are required for apoptosis induction, whereas the bcl-2 homolog ced-9 prevents apoptosis. |
2012-06-08 |
2023-08-12 |
caenorhabditis_elegans |
| Jean-Yves Paul, Douglas K Becker, Martin B Dickman, Robert M Harding, Harjeet K Khanna, James L Dal. Apoptosis-related genes confer resistance to Fusarium wilt in transgenic 'Lady Finger' bananas. Plant biotechnology journal. vol 9. issue 9. 2012-02-27. PMID:21819535. |
embryogenic cell suspensions of the banana cultivar, 'lady finger', were stably transformed with animal genes that negatively regulate apoptosis, namely bcl-xl, ced-9 and bcl-2 3' utr, and independently transformed plant lines were regenerated for testing. |
2012-02-27 |
2023-08-12 |
Not clear |
| A J Ross, M Li, B Yu, M X Gao, W B Derr. The EEL-1 ubiquitin ligase promotes DNA damage-induced germ cell apoptosis in C. elegans. Cell death and differentiation. vol 18. issue 7. 2011-09-30. PMID:21233842. |
furthermore, eel-1 acts in parallel to the p53-like gene cep-1 and intersects the core apoptosis pathway upstream of the bcl-2/mcl-1 orthologue ced-9. |
2011-09-30 |
2023-08-12 |
human |
| Matija Dreze, Benoit Charloteaux, Stuart Milstein, Pierre-Olivier Vidalain, Muhammed A Yildirim, Quan Zhong, Nenad Svrzikapa, Viviana Romero, Géraldine Laloux, Robert Brasseur, Jean Vandenhaute, Mike Boxem, Michael E Cusick, David E Hill, Marc Vida. 'Edgetic' perturbation of a C. elegans BCL2 ortholog. Nature methods. vol 6. issue 11. 2009-12-03. PMID:19855391. |
using ced-9 edgetic alleles, we uncovered a new potential functional link between apoptosis and a centrosomal protein. |
2009-12-03 |
2023-08-12 |
caenorhabditis_elegans |
| David G Breckenridge, Byung-Ho Kang, Ding Xu. Bcl-2 proteins EGL-1 and CED-9 do not regulate mitochondrial fission or fusion in Caenorhabditis elegans. Current biology : CB. vol 19. issue 9. 2009-08-11. PMID:19327994. |
to better understand the potential roles of bcl-2 family proteins in regulating mitochondrial dynamics, we carried out a detailed analysis of mitochondria in animals that either lose or have increased activity of egl-1 and ced-9, two bcl-2 family genes that induce and inhibit apoptosis in c. elegans, respectively. |
2009-08-11 |
2023-08-12 |
caenorhabditis_elegans |
| Qinfang Shen, Fengsong Qin, Zhiyang Gao, Jie Cui, Hui Xiao, Zhiheng Xu, Chonglin Yan. Adenine nucleotide translocator cooperates with core cell death machinery to promote apoptosis in Caenorhabditis elegans. Molecular and cellular biology. vol 29. issue 14. 2009-07-13. PMID:19414600. |
in cells destined to die, egl-1 binds to ced-9 and results in the release of ced-4 from the mitochondrion-tethered ced-9-ced-4 complex to the perinucleus, which facilitates processing of the ced-3 caspase to cause apoptosis. |
2009-07-13 |
2023-08-12 |
caenorhabditis_elegans |
| Shunchang Wang, Lijun Wu, Yun Wang, Xun Luo, Yun L. Copper-induced germline apoptosis in Caenorhabditis elegans: the independent roles of DNA damage response signaling and the dependent roles of MAPK cascades. Chemico-biological interactions. vol 180. issue 2. 2009-06-26. PMID:19497412. |
the knockout of checkpoint genes hus-1, clk-2, the bcl-2 homolog ced-9, and the bh3-only domain egl-1 did not prevent cells of the germline from copper-induced apoptosis. |
2009-06-26 |
2023-08-12 |
caenorhabditis_elegans |
| E S Blum, M Driscoll, S Shaha. Noncanonical cell death programs in the nematode Caenorhabditis elegans. Cell death and differentiation. vol 15. issue 7. 2008-08-28. PMID:18437162. |
genetic studies of the nematode caenorhabditis elegans have uncovered four genes, egl-1 (bh3 only), ced-9 (bcl-2 related), ced-4 (apoptosis protease activating factor-1), and ced-3 (caspase), which function in a linear pathway to promote developmental cell death in this organism. |
2008-08-28 |
2023-08-12 |
caenorhabditis_elegans |
| Sebastian Greiss, Björn Schumacher, Kaj Grandien, Jonathan Rothblatt, Anton Gartne. Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family. BMC genomics. vol 9. 2008-08-20. PMID:18627611. |
egl-1 and ced-13 proteins inactivate bcl-2 like ced-9 to trigger ced-4 and ced-3 caspase dependent germ cell apoptosis. |
2008-08-20 |
2023-08-12 |
caenorhabditis_elegans |
| Claus Schertel, Barbara Conrad. C. elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions. Development (Cambridge, England). vol 134. issue 20. 2008-02-15. PMID:17881492. |
we present evidence that lin-35 promotes germ cell apoptosis by repressing the expression of ced-9, an anti-apoptotic c. elegans gene that is orthologous to the human proto-oncogene bcl2. |
2008-02-15 |
2023-08-12 |
human |
| F J Tan, A Z Fire, R B Hil. Regulation of apoptosis by C. elegans CED-9 in the absence of the C-terminal transmembrane domain. Cell death and differentiation. vol 14. issue 11. 2008-01-22. PMID:17703231. |
regulation of apoptosis by c. elegans ced-9 in the absence of the c-terminal transmembrane domain. |
2008-01-22 |
2023-08-12 |
caenorhabditis_elegans |
| F J Tan, A Z Fire, R B Hil. Regulation of apoptosis by C. elegans CED-9 in the absence of the C-terminal transmembrane domain. Cell death and differentiation. vol 14. issue 11. 2008-01-22. PMID:17703231. |
both of these apoptotic activities were retained in a construct where ced-9 lacking the transmembrane domain was targeted to the cytosolic surface of the endoplasmic reticulum and derived organelles, suggesting that in wild-type animals, accumulation at mitochondria is not essential for ced-9 to either inhibit or promote apoptosis in c. elegans. |
2008-01-22 |
2023-08-12 |
caenorhabditis_elegans |