| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F J Tan, A Z Fire, R B Hil. Regulation of apoptosis by C. elegans CED-9 in the absence of the C-terminal transmembrane domain. Cell death and differentiation. vol 14. issue 11. 2008-01-22. PMID:17703231. |
taken together, these data are consistent with a multimodal character of ced-9 action, with an ability to regulate apoptosis through interactions in the cytosol coexisting with additional evolutionarily conserved role(s) at the membrane. |
2008-01-22 |
2023-08-12 |
caenorhabditis_elegans |
| Hillel T Schwartz, H Robert Horvit. The C. elegans protein CEH-30 protects male-specific neurons from apoptosis independently of the Bcl-2 homolog CED-9. Genes & development. vol 21. issue 23. 2008-01-04. PMID:18056428. |
the c. elegans protein ceh-30 protects male-specific neurons from apoptosis independently of the bcl-2 homolog ced-9. |
2008-01-04 |
2023-08-12 |
mouse |
| Hillel T Schwartz, H Robert Horvit. The C. elegans protein CEH-30 protects male-specific neurons from apoptosis independently of the Bcl-2 homolog CED-9. Genes & development. vol 21. issue 23. 2008-01-04. PMID:18056428. |
the established mechanism for the regulation of specific programmed cell deaths in c. elegans is the transcriptional control of the bh3-only gene egl-1, which inhibits the bcl-2 homolog ced-9; similarly, most regulation of vertebrate apoptosis involves the bcl-2 superfamily. |
2008-01-04 |
2023-08-12 |
mouse |
| Yonatan B Tzur, Ayelet Margalit, Naomi Melamed-Book, Yosef Gruenbau. Matefin/SUN-1 is a nuclear envelope receptor for CED-4 during Caenorhabditis elegans apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 36. 2006-10-19. PMID:16938876. |
induction of apoptosis begins when the proapoptotic protein egl-1 is expressed and binds ced-9. |
2006-10-19 |
2023-08-12 |
caenorhabditis_elegans |
| Petrina Delivani, Colin Adrain, Rebecca C Taylor, Patrick J Duriez, Seamus J Marti. Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics. Molecular cell. vol 21. issue 6. 2006-04-26. PMID:16543146. |
however, ced-9 failed to inhibit mitochondrial cytochrome c release or apoptosis induced by diverse triggers in mammalian cells. |
2006-04-26 |
2023-08-12 |
Not clear |
| W D Fairlie, M A Perugini, M Kvansakul, L Chen, D C S Huang, P M Colma. CED-4 forms a 2 : 2 heterotetrameric complex with CED-9 until specifically displaced by EGL-1 or CED-13. Cell death and differentiation. vol 13. issue 3. 2006-04-20. PMID:16167070. |
in cells undergoing apoptosis, the bcl-2 homology domain 3 (bh3)-only protein egl-1 binds to ced-9 at the mitochondrial membrane to cause the release of ced-4, which oligomerises and facilitates the activation of the caspase ced-3. |
2006-04-20 |
2023-08-12 |
caenorhabditis_elegans |
| G V Putcha, E M Johnso. Men are but worms: neuronal cell death in C elegans and vertebrates. Cell death and differentiation. vol 11. issue 1. 2004-08-25. PMID:14647239. |
their studies of lineage determination in worms established the 'central dogma' of apoptosis: the bh3-only protein egl-1 is induced in cells destined to die, interacts with the bcl-2-like inhibitor ced-9, displacing the adaptor ced-4, which then promotes activation of the caspase ced-3. |
2004-08-25 |
2023-08-12 |
human |
| S Ottilie, Y Wang, S Banks, J Chang, N J Vigna, S Weeks, R C Armstrong, L C Fritz, T Oltersdor. Mutational analysis of the interacting cell death regulators CED-9 and CED-4. Cell death and differentiation. vol 4. issue 7. 2003-10-23. PMID:14555965. |
it has recently been demonstrated that ced-4, an inducer of apoptosis for which no mammalian equivalent has been reported, can interact with ced-9 and bcl-x(l). |
2003-10-23 |
2023-08-12 |
caenorhabditis_elegans |
| M Shibata, S Kanamori, Y Ohsawa, T Watanabe, Y Yayoi, M Miura, E Kominami, Y Uchiyam. Prevention of apoptosis of mammalian cells by the CED-3-cleaved form of CED-9. Archives of histology and cytology. vol 64. issue 1. 2001-08-23. PMID:11310501. |
prevention of apoptosis of mammalian cells by the ced-3-cleaved form of ced-9. |
2001-08-23 |
2023-08-12 |
caenorhabditis_elegans |
| M Shibata, S Kanamori, Y Ohsawa, T Watanabe, Y Yayoi, M Miura, E Kominami, Y Uchiyam. Prevention of apoptosis of mammalian cells by the CED-3-cleaved form of CED-9. Archives of histology and cytology. vol 64. issue 1. 2001-08-23. PMID:11310501. |
ced-9 prevents apoptosis in embryonic cells of caenorhabditis elegans but not in mammalian cells. |
2001-08-23 |
2023-08-12 |
caenorhabditis_elegans |
| M Shibata, S Kanamori, Y Ohsawa, T Watanabe, Y Yayoi, M Miura, E Kominami, Y Uchiyam. Prevention of apoptosis of mammalian cells by the CED-3-cleaved form of CED-9. Archives of histology and cytology. vol 64. issue 1. 2001-08-23. PMID:11310501. |
we show here that the prevention of apoptosis in mammalian cells requires a ced-3-cleaved form (68-280) of ced-9 which is localized in the inner mitochondrial membrane. |
2001-08-23 |
2023-08-12 |
caenorhabditis_elegans |
| M Shibata, S Kanamori, Y Ohsawa, T Watanabe, Y Yayoi, M Miura, E Kominami, Y Uchiyam. Prevention of apoptosis of mammalian cells by the CED-3-cleaved form of CED-9. Archives of histology and cytology. vol 64. issue 1. 2001-08-23. PMID:11310501. |
these results suggest that the ced-3-cleaved form of ced-9 prevents apoptosis in mammalian cells by localizing to the inner mitochondrial membrane. |
2001-08-23 |
2023-08-12 |
caenorhabditis_elegans |
| S Conus, T Rossé, C Borne. Failure of Bcl-2 family members to interact with Apaf-1 in normal and apoptotic cells. Cell death and differentiation. vol 7. issue 10. 2001-05-24. PMID:11279541. |
ced-9 blocks programmed cell death (apoptosis) in the nematode c. elegans by binding to and neutralizing ced-4, an essential activator of the aspartate-directed cysteine protease (caspase) ced-3. |
2001-05-24 |
2023-08-12 |
caenorhabditis_elegans |
| S Conus, T Rossé, C Borne. Failure of Bcl-2 family members to interact with Apaf-1 in normal and apoptotic cells. Cell death and differentiation. vol 7. issue 10. 2001-05-24. PMID:11279541. |
in mammals, the ced-9 homologs bcl-2 and bcl-xl also block apoptosis by interfering with the activation of ced-3-like caspases. |
2001-05-24 |
2023-08-12 |
caenorhabditis_elegans |
| S Gaumer, I Guénal, S Brun, L Théodore, B Mignott. Bcl-2 and Bax mammalian regulators of apoptosis are functional in Drosophila. Cell death and differentiation. vol 7. issue 9. 2000-11-14. PMID:11042675. |
studies of apoptosis in c. elegans have allowed the identification of three genes, ced-3, ced-4 and ced-9. |
2000-11-14 |
2023-08-12 |
caenorhabditis_elegans |
| S Gaumer, I Guénal, S Brun, L Théodore, B Mignott. Bcl-2 and Bax mammalian regulators of apoptosis are functional in Drosophila. Cell death and differentiation. vol 7. issue 9. 2000-11-14. PMID:11042675. |
ced-9 belongs to the bcl-2 family which includes negative (bcl-2) and positive (bax) regulators of apoptosis. |
2000-11-14 |
2023-08-12 |
caenorhabditis_elegans |
| L del Peso, V M Gonzalez, N Inohara, R E Ellis, G Núñe. Disruption of the CED-9.CED-4 complex by EGL-1 is a critical step for programmed cell death in Caenorhabditis elegans. The Journal of biological chemistry. vol 275. issue 35. 2000-10-03. PMID:10846174. |
finally, the ability of egl-1 to promote apoptosis is impaired by the replacement of wild-type ced-9 with ced-9g169e, and this effect is correlated with the inability of egl-1 to induce the displacement of ced-4 from the ced-9.ced-4 complex. |
2000-10-03 |
2023-08-12 |
caenorhabditis_elegans |
| M R Aliso. Identifying and quantifying apoptosis: a growth industry in the face of death. The Journal of pathology. vol 188. issue 2. 2000-02-29. PMID:10398152. |
apoptosis remains one of the hottest topics in cell biology, and great strides are being made in unravelling the complex interplay between the various regulatory molecules, particularly between the mammalian homologues of the nematode caenorhabditis elegans death regulatory proteins ced-3, ced-4 and ced-9. |
2000-02-29 |
2023-08-12 |
caenorhabditis_elegans |
| K Urase, T Momoi, E Fujita, K Isahara, Y Uchiyama, A Tokunaga, K Nakayama, N Motoyam. Bcl-xL is a negative regulator of caspase-3 activation in immature neurons during development. Brain research. Developmental brain research. vol 116. issue 1. 1999-10-07. PMID:10446348. |
caspases and bcl-xl, the mammalian homologues of the caenorhabditis elegans (c. elegans) ced-3 and ced-9 genes, respectively, regulate apoptosis of various cells. |
1999-10-07 |
2023-08-12 |
mouse |
| R Robles, X J Tao, A M Trbovich, D V Maravel, R Nahum, G I Perez, K I Tilly, J L Till. Localization, regulation and possible consequences of apoptotic protease-activating factor-1 (Apaf-1) expression in granulosa cells of the mouse ovary. Endocrinology. vol 140. issue 6. 1999-06-03. PMID:10342853. |
these data, combined with previous observations regarding the role of homologs of the two other c. elegans cell death regulatory genes, ced-9 (bcl-2 family members) and ced-3 (caspases), in atresia fully support the hypothesis that granulosa cell apoptosis is precisely coordinated by all three major arms of a cell death program conserved through evolution. |
1999-06-03 |
2023-08-12 |
mouse |