| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuting Shao, Yunhui Li, Dayong Wan. Polylactic acid microplastics cause transgenerational reproductive toxicity associated with activation of insulin and hedgehog ligands in C. elegans. The Science of the total environment. 2024-06-08. PMID:38851356. |
meanwhile, transgenerational increase in germline apoptosis was detected after pla-mp exposure at p0-g, which was associated with transgenerational dysregulation in expressions of genes governing apoptosis (ced-3, ced-4, egl-1, and ced-9) and dna damage related genes (cep-1, mrt-2, hus-1, and clk-2). |
2024-06-08 |
2024-06-11 |
caenorhabditis_elegans |
| Yuting Shao, Xin Hua, Yunhui Li, Dayong Wan. Comparison of reproductive toxicity between pristine and aged polylactic acid microplastics in Caenorhabditis elegans. Journal of hazardous materials. vol 466. 2024-01-20. PMID:38244453. |
meanwhile, aged pla-mps caused more severe enhancement in germline apoptosis and alterations in expressions of ced-9, ced-4, ced-3, and egl-1 governing cell apoptosis. |
2024-01-20 |
2024-01-23 |
caenorhabditis_elegans |
| Zhengying Liu, Xin Hua, Yue Zhao, Qian Bian, Dayong Wan. Polyethylene nanoplastics cause reproductive toxicity associated with activation of both estrogenic hormone receptor NHR-14 and DNA damage checkpoints in C. elegans. The Science of the total environment. 2023-10-01. PMID:37778542. |
accompanied with alteration in expressions of genes (egl-1, ced-9, ced-4, and ced-3) governing cell apoptosis, germline apoptosis was enhanced by pe-np. |
2023-10-01 |
2023-10-07 |
caenorhabditis_elegans |
| Yuting Shao, Yuxing Wang, Xin Hua, Yunhui Li, Dayong Wan. Polylactic acid microparticles in the range of μg/L reduce reproductive capacity by affecting the gonad development and the germline apoptosis in Caenorhabditis elegans. Chemosphere. 2023-06-14. PMID:37315859. |
accompanied with the enhancement in germline apoptosis, exposure to 10 and 100 μg/l pla mp decreased expression of ced-9 and increased expressions of ced-3, ced-4, and egl-1. |
2023-06-14 |
2023-08-14 |
caenorhabditis_elegans |
| Yuting Shao, Yuxing Wang, Xin Hua, Yunhui Li, Dayong Wan. Polylactic acid microparticles in the range of μg/L reduce reproductive capacity by affecting the gonad development and the germline apoptosis in Caenorhabditis elegans. Chemosphere. 2023-06-14. PMID:37315859. |
moreover, the induction of germline apoptosis in pla mp exposed nematodes was suppressed by rnai of ced-3, ced-4, and egl-1, and strengthened by rnai of ced-9. |
2023-06-14 |
2023-08-14 |
caenorhabditis_elegans |
| Xin Hua, Xiao Feng, Geyu Liang, Jie Chao, Dayong Wan. Long-term exposure to 6-PPD quinone reduces reproductive capacity by enhancing germline apoptosis associated with activation of both DNA damage and cell corpse engulfment in Caenorhabditis elegans. Journal of hazardous materials. vol 454. 2023-04-29. PMID:37119572. |
meanwhile, exposure to 1 and 10 μg/l 6-ppdq enhanced the germline apoptosis, which was accompanied by upregulation of ced-3, ced-4, and egl-1 expressions and downregulation of ced-9 expression. |
2023-04-29 |
2023-08-14 |
caenorhabditis_elegans |
| Xin Hua, Xiao Feng, Yingshun Hua, Dayong Wan. Paeoniflorin attenuates polystyrene nanoparticle-induced reduction in reproductive capacity and increase in germline apoptosis through suppressing DNA damage checkpoints in Caenorhabditis elegans. The Science of the total environment. 2023-02-12. PMID:36775158. |
in addition, in 100 μg/l ps-np exposed nematodes, treatment with 100 mg/l paeoniflorin modulated the expressions of genes governing germline apoptosis as indicated by the decrease in ced-3, ced-4, an egl-1 expressions and the increase in ced-9 expression. |
2023-02-12 |
2023-08-14 |
caenorhabditis_elegans |
| C Narendra Reddy, Ramasubbu Sankararamakrishna. Molecular dynamics studies of CED-4/CED-9/EGL-1 ternary complex reveal CED-4 release mechanism in the linear apoptotic pathway of Caenorhabditis elegans. Proteins. 2022-12-21. PMID:36541866. |
the caenorhabditis elegans proteins ced-9, ced-4 and egl-1 involved in apoptosis are respectively homologous to anti-apoptotic bcl-2 proteins, apaf-1 and the "bh3-only" pro-apototic proteins in mammals. |
2022-12-21 |
2023-08-14 |
caenorhabditis_elegans |
| Yunjiang Yu, Xin Hua, Haibo Chen, Yue Yang, Yao Dang, Mingdeng Xian. Tetrachlorobisphenol A mediates reproductive toxicity in Caenorhabditis elegans via DNA damage-induced apoptosis. Chemosphere. 2022-04-15. PMID:35427672. |
apoptosis was nearly abolished in ced-4 and ced-3 mutants and blocked in hus-1, egl-1, cep-1, and ced-9 mutants. |
2022-04-15 |
2023-08-13 |
caenorhabditis_elegans |
| Haibo Chen, Yue Yang, Chen Wang, Xin Hua, Hui Li, Dongli Xie, Mingdeng Xiang, Yunjiang Y. Reproductive toxicity of UV-photodegraded polystyrene microplastics induced by DNA damage-dependent cell apoptosis in Caenorhabditis elegans. The Science of the total environment. 2021-12-17. PMID:34919931. |
additionally, the number of cell corpses and apoptosis-related gene expression (e.g., ced-3, ced-4, and ced-9) were significantly altered, indicating induction of apoptosis. |
2021-12-17 |
2023-08-13 |
caenorhabditis_elegans |
| Haibo Chen, Yue Yang, Chen Wang, Xin Hua, Hui Li, Dongli Xie, Mingdeng Xiang, Yunjiang Y. Reproductive toxicity of UV-photodegraded polystyrene microplastics induced by DNA damage-dependent cell apoptosis in Caenorhabditis elegans. The Science of the total environment. 2021-12-17. PMID:34919931. |
germline apoptosis induced by aged ps-mps was altered in egl-1, hus-1, cep-1, ced-3, ced-4, and ced-9 mutants. |
2021-12-17 |
2023-08-13 |
caenorhabditis_elegans |
| Sarah Fausett, Nausicaa Poullet, Clotilde Gimond, Anne Vielle, Michele Bellone, Christian Braendl. Germ cell apoptosis is critical to maintain Caenorhabditis elegans offspring viability in stressful environments. PloS one. vol 16. issue 12. 2021-12-12. PMID:34879088. |
in contrast, mutations in ced-9 and egl-1 that primarily block apoptosis in the soma but not in the germline, did not exhibit such reduced embryonic survival under environmental stress. |
2021-12-12 |
2023-08-13 |
caenorhabditis_elegans |
| Ling Jin, Ting-Ting Dou, Jing-Ya Chen, Ming-Xiu Duan, Quan Zhen, Hua-Zhang Wu, Yun-Li Zha. Sublethal toxicity of graphene oxide in Caenorhabditis elegans under multi-generational exposure. Ecotoxicology and environmental safety. vol 229. 2021-12-11. PMID:34890989. |
simultaneously, the fertility function of the nematode was impaired under consecutive exposure as reduced brood sizes and oocytes numbers, increased apoptosis of germline, and aberrant expression of reproductive related genes ced-3, ced-4, ced-9, egl-1 and ced-13 were detected in exposed worms. |
2021-12-11 |
2023-08-13 |
human |
| Hang Hu, Xinshan Zhao, Yalei Cui, Shengkang Li, Yi Gon. SpTIA-1 suppresses WSSV infection by promoting apoptosis in mud crab (Scylla paramamosain). Molecular immunology. vol 140. 2021-12-07. PMID:34715578. |
tia-1 (t cell restricted intracellular antigen-1) is a kind of rna-binding protein which serves as the downstream of ced-9 (a bcl2 homolog) and induces apoptosis under stress conditions. |
2021-12-07 |
2023-08-13 |
Not clear |
| Hongdan Zhang, Tongtong Liu, Xuelong Song, Qinyu Zhou, Jielin Tang, Qianyu Sun, Yuepu Pu, Lihong Yin, Juan Zhan. Study on the reproductive toxicity and mechanism of tri-n-butyl phosphate (TnBP) in Caenorhabditis elegans. Ecotoxicology and environmental safety. vol 227. 2021-11-10. PMID:34673412. |
furthermore, tnbp exposure caused abnormal gene expressions of cell apoptosis (ced-9, ced-4 and ced-3), dna damage (hus-1, clk-2, cep-1 and egl-1) and oxidative stress (mev-1 and gas-1). |
2021-11-10 |
2023-08-13 |
caenorhabditis_elegans |
| Joseph Ryan Polli, Mary Farwell, Xiaoping Pa. Detection of Caenorhabditis elegans Germ Cell Apoptosis Following Exposure to Environmental Contaminant Mixtures: A Crude Oil-Dispersant Mixture Example. Methods in molecular biology (Clifton, N.J.). vol 2326. 2021-08-13. PMID:34097257. |
in addition, qrt-pcr was utilized to demonstrate the aberrant expression of apoptosis (ced-13, ced-3, ced-4, ced-9, cep-1, dpl-1, efl-1, efl-2, egl-1, egl-38, lin-35, pax-2, and sir-2.1) and cytochrome p450 (cyp14a3, cyp35a1, cyp35a2, cyp35a5, and cyp35c1) protein-coding genes following exposure to dispersed crude oil. |
2021-08-13 |
2023-08-13 |
caenorhabditis_elegans |
| N Mukherjee, N Joardar, S P Sinha Bab. Antifilarial activity of azadirachtin fuelled through reactive oxygen species induced apoptosis: a thorough molecular study on Setaria cervi. Journal of helminthology. vol 93. issue 5. 2019-08-07. PMID:30032733. |
the downregulation of anti-apoptotic ced-9 and upregulation of proapoptotic egl-1, ced-4 and ced-3 at both the transcription and translation levels confirmed apoptosis execution at the molecular level. |
2019-08-07 |
2023-08-13 |
Not clear |
| Brittany O'Donnell, Lily Huo, Joseph R Polli, Li Qiu, David N Collier, Baohong Zhang, Xiaoping Pa. From the Cover: ZnO Nanoparticles Enhanced Germ Cell Apoptosis in Caenorhabditis elegans, in Comparison with ZnCl2. Toxicological sciences : an official journal of the Society of Toxicology. vol 156. issue 2. 2018-02-15. PMID:28003440. |
genes involved in the apoptosis pathway (ced-13, ced-3, ced-4, ced-9, cep-1, dpl-1, efl-1, efl-2, egl-1, egl-38, lin-35, pax-2, and sir-2.1) were in general upregulated in response to zno np exposure. |
2018-02-15 |
2023-08-13 |
caenorhabditis_elegans |
| Maria Doligalska, Kinga Jóźwicka, Katarzyna Donskow-Łysoniewska, Małgorzata Kalinowsk. The antiparasitic activity of avenacosides against intestinal nematodes. Veterinary parasitology. vol 241. 2017-12-29. PMID:28579031. |
in the surviving l3 larvae exposed to avenacosides, the expression of ced-9, a protein of the apoptosis pathway, was identified by western blotting. |
2017-12-29 |
2023-08-13 |
mouse |
| Niladri Mukherjee, Pravat Kumar Parida, Abhishek Santra, Tamashree Ghosh, Ananya Dutta, Kuladip Jana, Anup Kumar Misra, Santi P Sinha Bab. Oxidative stress plays major role in mediating apoptosis in filarial nematode Setaria cervi in the presence of trans-stilbene derivatives. Free radical biology & medicine. vol 93. 2016-12-13. PMID:26849945. |
along with the ros generation and oxidative stress, the decreased expression of anti-apoptotic ced-9 gene and increased expression of nematode specific pro-apoptotic genes, egl-1, ced-4 and ced-3 at the level of transcription and translation level; the up-regulation of caspase-3 activity and involvement of caspase-8,9,3, cytochrome-c and parp were also observed and which denotes the probable existence of both extrinsic and intrinsic pathways apoptosis in parasitic nematodes. |
2016-12-13 |
2023-08-13 |
Not clear |