| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuting Shao, Yunhui Li, Dayong Wan. Polylactic acid microplastics cause transgenerational reproductive toxicity associated with activation of insulin and hedgehog ligands in C. elegans. The Science of the total environment. 2024-06-08. PMID:38851356. |
meanwhile, transgenerational increase in germline apoptosis was detected after pla-mp exposure at p0-g, which was associated with transgenerational dysregulation in expressions of genes governing apoptosis (ced-3, ced-4, egl-1, and ced-9) and dna damage related genes (cep-1, mrt-2, hus-1, and clk-2). |
2024-06-08 |
2024-06-11 |
caenorhabditis_elegans |
| Yuting Shao, Xin Hua, Yunhui Li, Dayong Wan. Comparison of reproductive toxicity between pristine and aged polylactic acid microplastics in Caenorhabditis elegans. Journal of hazardous materials. vol 466. 2024-01-20. PMID:38244453. |
meanwhile, aged pla-mps caused more severe enhancement in germline apoptosis and alterations in expressions of ced-9, ced-4, ced-3, and egl-1 governing cell apoptosis. |
2024-01-20 |
2024-01-23 |
caenorhabditis_elegans |
| Zhengying Liu, Xin Hua, Yue Zhao, Qian Bian, Dayong Wan. Polyethylene nanoplastics cause reproductive toxicity associated with activation of both estrogenic hormone receptor NHR-14 and DNA damage checkpoints in C. elegans. The Science of the total environment. 2023-10-01. PMID:37778542. |
accompanied with alteration in expressions of genes (egl-1, ced-9, ced-4, and ced-3) governing cell apoptosis, germline apoptosis was enhanced by pe-np. |
2023-10-01 |
2023-10-07 |
caenorhabditis_elegans |
| Yuting Shao, Yuxing Wang, Xin Hua, Yunhui Li, Dayong Wan. Polylactic acid microparticles in the range of μg/L reduce reproductive capacity by affecting the gonad development and the germline apoptosis in Caenorhabditis elegans. Chemosphere. 2023-06-14. PMID:37315859. |
accompanied with the enhancement in germline apoptosis, exposure to 10 and 100 μg/l pla mp decreased expression of ced-9 and increased expressions of ced-3, ced-4, and egl-1. |
2023-06-14 |
2023-08-14 |
caenorhabditis_elegans |
| Yuting Shao, Yuxing Wang, Xin Hua, Yunhui Li, Dayong Wan. Polylactic acid microparticles in the range of μg/L reduce reproductive capacity by affecting the gonad development and the germline apoptosis in Caenorhabditis elegans. Chemosphere. 2023-06-14. PMID:37315859. |
moreover, the induction of germline apoptosis in pla mp exposed nematodes was suppressed by rnai of ced-3, ced-4, and egl-1, and strengthened by rnai of ced-9. |
2023-06-14 |
2023-08-14 |
caenorhabditis_elegans |
| Xin Hua, Xiao Feng, Geyu Liang, Jie Chao, Dayong Wan. Long-term exposure to 6-PPD quinone reduces reproductive capacity by enhancing germline apoptosis associated with activation of both DNA damage and cell corpse engulfment in Caenorhabditis elegans. Journal of hazardous materials. vol 454. 2023-04-29. PMID:37119572. |
meanwhile, exposure to 1 and 10 μg/l 6-ppdq enhanced the germline apoptosis, which was accompanied by upregulation of ced-3, ced-4, and egl-1 expressions and downregulation of ced-9 expression. |
2023-04-29 |
2023-08-14 |
caenorhabditis_elegans |
| Xin Hua, Xiao Feng, Yingshun Hua, Dayong Wan. Paeoniflorin attenuates polystyrene nanoparticle-induced reduction in reproductive capacity and increase in germline apoptosis through suppressing DNA damage checkpoints in Caenorhabditis elegans. The Science of the total environment. 2023-02-12. PMID:36775158. |
in addition, in 100 μg/l ps-np exposed nematodes, treatment with 100 mg/l paeoniflorin modulated the expressions of genes governing germline apoptosis as indicated by the decrease in ced-3, ced-4, an egl-1 expressions and the increase in ced-9 expression. |
2023-02-12 |
2023-08-14 |
caenorhabditis_elegans |
| Chi-Wei Huang, Pei-Ling Yen, Yu-Hsuan Kuo, Chun-Han Chang, Vivian Hsiu-Chuan Lia. Nanoplastic exposure in soil compromises the energy budget of the soil nematode C. elegans and decreases reproductive fitness. Environmental pollution (Barking, Essex : 1987). 2022-09-02. PMID:36055456. |
we also find that the number of germ cell corpses (31%-55% increase) and the mrna levels of germline apoptosis marker gene ced-3 (14%-31% increase) were significantly higher with greater np soil exposure (10, 100, and 1000 mg/kg), while intracellular atp levels were significantly reduced. |
2022-09-02 |
2023-08-14 |
caenorhabditis_elegans |
| Yunjiang Yu, Xin Hua, Haibo Chen, Yue Yang, Yao Dang, Mingdeng Xian. Tetrachlorobisphenol A mediates reproductive toxicity in Caenorhabditis elegans via DNA damage-induced apoptosis. Chemosphere. 2022-04-15. PMID:35427672. |
apoptosis was nearly abolished in ced-4 and ced-3 mutants and blocked in hus-1, egl-1, cep-1, and ced-9 mutants. |
2022-04-15 |
2023-08-13 |
caenorhabditis_elegans |
| Chi-Wei Huang, Zhi-Ying Kung, Chia-Cheng We. UV-filter octyl methoxycinnamate causes reproductive toxicity associated with germline apoptosis and vitellogenin decrease in Caenorhabditis elegans. Aquatic toxicology (Amsterdam, Netherlands). vol 247. 2022-04-09. PMID:35397382. |
decreased mrna levels of vitellogenin-related genes (vit-2 and vit-6) and increased mrna levels of apoptosis-related genes (egl-1 and ced-3) were observed in 10 μm omc-treated c. elegans (experimental concentrations = 0, 10 μm), suggesting that reproductive toxicity was associated with decreased vitellogenin levels and germline apoptosis. |
2022-04-09 |
2023-08-13 |
caenorhabditis_elegans |
| Haibo Chen, Yue Yang, Chen Wang, Xin Hua, Hui Li, Dongli Xie, Mingdeng Xiang, Yunjiang Y. Reproductive toxicity of UV-photodegraded polystyrene microplastics induced by DNA damage-dependent cell apoptosis in Caenorhabditis elegans. The Science of the total environment. 2021-12-17. PMID:34919931. |
additionally, the number of cell corpses and apoptosis-related gene expression (e.g., ced-3, ced-4, and ced-9) were significantly altered, indicating induction of apoptosis. |
2021-12-17 |
2023-08-13 |
caenorhabditis_elegans |
| Haibo Chen, Yue Yang, Chen Wang, Xin Hua, Hui Li, Dongli Xie, Mingdeng Xiang, Yunjiang Y. Reproductive toxicity of UV-photodegraded polystyrene microplastics induced by DNA damage-dependent cell apoptosis in Caenorhabditis elegans. The Science of the total environment. 2021-12-17. PMID:34919931. |
germline apoptosis induced by aged ps-mps was altered in egl-1, hus-1, cep-1, ced-3, ced-4, and ced-9 mutants. |
2021-12-17 |
2023-08-13 |
caenorhabditis_elegans |
| Ling Jin, Ting-Ting Dou, Jing-Ya Chen, Ming-Xiu Duan, Quan Zhen, Hua-Zhang Wu, Yun-Li Zha. Sublethal toxicity of graphene oxide in Caenorhabditis elegans under multi-generational exposure. Ecotoxicology and environmental safety. vol 229. 2021-12-11. PMID:34890989. |
simultaneously, the fertility function of the nematode was impaired under consecutive exposure as reduced brood sizes and oocytes numbers, increased apoptosis of germline, and aberrant expression of reproductive related genes ced-3, ced-4, ced-9, egl-1 and ced-13 were detected in exposed worms. |
2021-12-11 |
2023-08-13 |
human |
| Yu Liu, Weiping Zhang, Ying Wang, Huimin Liu, Shouan Zhang, Xiaoxue Ji, Kang Qia. Oxidative stress, intestinal damage, and cell apoptosis: Toxicity induced by fluopyram in Caenorhabditis elegans. Chemosphere. vol 286. issue Pt 3. 2021-11-17. PMID:34388432. |
moreover, the expression of genes associated with oxidative stress (e.g., gst-4, sod-3, fat-7, mev-1 and daf-16), intestinal damage (e.g., mtm-6, nhx-2, opt-2, pkc-3, par-6, act-5 and egl-8), and cell apoptosis (e.g., ced-13, ced-3, egl-38, efl-2, cep-1 and lgg-1) was significantly influenced after exposure to fluopyram. |
2021-11-17 |
2023-08-13 |
cat |
| Hongdan Zhang, Tongtong Liu, Xuelong Song, Qinyu Zhou, Jielin Tang, Qianyu Sun, Yuepu Pu, Lihong Yin, Juan Zhan. Study on the reproductive toxicity and mechanism of tri-n-butyl phosphate (TnBP) in Caenorhabditis elegans. Ecotoxicology and environmental safety. vol 227. 2021-11-10. PMID:34673412. |
furthermore, tnbp exposure caused abnormal gene expressions of cell apoptosis (ced-9, ced-4 and ced-3), dna damage (hus-1, clk-2, cep-1 and egl-1) and oxidative stress (mev-1 and gas-1). |
2021-11-10 |
2023-08-13 |
caenorhabditis_elegans |
| Kan Fu, Jianchun Zhang, Lanying Wang, Xu Zhao, Yanping Lu. Xanthotoxin induced photoactivated toxicity, oxidative stress and cellular apoptosis in Caenorhabditis elegans under ultraviolet A. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 251. 2021-11-05. PMID:34673249. |
ros accumulation in the bodies further caused the contents of mda, protein carbonyl and lipofuscin to increase significantly, the mitochondrial membrane potential to be severely damaged, apoptosis to occur, and the apoptosis genes ced-3 and ced-4 to be significantly upregulated. |
2021-11-05 |
2023-08-13 |
cat |
| Joseph Ryan Polli, Mary Farwell, Xiaoping Pa. Detection of Caenorhabditis elegans Germ Cell Apoptosis Following Exposure to Environmental Contaminant Mixtures: A Crude Oil-Dispersant Mixture Example. Methods in molecular biology (Clifton, N.J.). vol 2326. 2021-08-13. PMID:34097257. |
in addition, qrt-pcr was utilized to demonstrate the aberrant expression of apoptosis (ced-13, ced-3, ced-4, ced-9, cep-1, dpl-1, efl-1, efl-2, egl-1, egl-38, lin-35, pax-2, and sir-2.1) and cytochrome p450 (cyp14a3, cyp35a1, cyp35a2, cyp35a5, and cyp35c1) protein-coding genes following exposure to dispersed crude oil. |
2021-08-13 |
2023-08-13 |
caenorhabditis_elegans |
| Yoon Lim, Loretta Dorstyn, Sharad Kuma. The p53-caspase-2 axis in the cell cycle and DNA damage response. Experimental & molecular medicine. vol 53. issue 4. 2021-05-25. PMID:33854186. |
despite high similarity with ced-3 and its fly and mammalian counterparts (dronc and caspase-9, respectively), the function of caspase-2 in apoptosis has remained enigmatic. |
2021-05-25 |
2023-08-13 |
Not clear |
| Yunjiang Yu, Haibo Chen, Xin Hua, Zhengdong Wang, Liangzhong Li, Zongrui Li, Mingdeng Xiang, Ping Din. Long-term toxicity of lindane through oxidative stress and cell apoptosis in Caenorhabditis elegans. Environmental pollution (Barking, Essex : 1987). vol 272. 2021-02-10. PMID:33218777. |
moreover, chronic exposure to 100 ng/l lindane significantly influenced the expression of genes related to oxidative stress and cell apoptosis (e.g., isp-1, sod-3, ced-3, and cep-1 genes). |
2021-02-10 |
2023-08-13 |
human |
| Pan Young Jeong, Ashish Kumar, Pradeep M Joshi, Joel H Rothma. Intertwined Functions of Separase and Caspase in Cell Division and Programmed Cell Death. Scientific reports. vol 10. issue 1. 2020-11-30. PMID:32273538. |
loss of sep-1 results in extra surviving cells in a weak ced-3(-) mutant, and suppresses the embryonic lethality of a mutant defective for the apoptotic suppressor ced-9/bcl-2 implicating sep-1 in execution of apoptosis. |
2020-11-30 |
2023-08-13 |
caenorhabditis_elegans |