| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Noda, S Yoshimura, M Sawada, T Naganawa, T Iwama, S Nakashima, N Saka. Role of ceramide during cisplatin-induced apoptosis in C6 glioma cells. Journal of neuro-oncology. vol 52. issue 1. 2001-12-05. PMID:11451199. |
role of ceramide during cisplatin-induced apoptosis in c6 glioma cells. |
2001-12-05 |
2023-08-12 |
rat |
| S Noda, S Yoshimura, M Sawada, T Naganawa, T Iwama, S Nakashima, N Saka. Role of ceramide during cisplatin-induced apoptosis in C6 glioma cells. Journal of neuro-oncology. vol 52. issue 1. 2001-12-05. PMID:11451199. |
pretreatment of c6 cells with glutathione or n-acetyl-cysteine, which are known to block the activation of neutral magnesium-dependent sphingomyelinase, inhibited ceramide formation, leading to suppression of both activation of caspase-3(-like) proteases and apoptosis by cisplatin. |
2001-12-05 |
2023-08-12 |
rat |
| M A Bae, J E Pie, B J Son. Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinase-related cell death pathway. Molecular pharmacology. vol 60. issue 4. 2001-10-04. PMID:11562448. |
acetaminophen induces apoptosis of c6 glioma cells by activating the c-jun nh(2)-terminal protein kinase-related cell death pathway. |
2001-10-04 |
2023-08-12 |
Not clear |
| M A Bae, J E Pie, B J Son. Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinase-related cell death pathway. Molecular pharmacology. vol 60. issue 4. 2001-10-04. PMID:11562448. |
aap caused time- and concentration-dependent apoptosis and dna fragmentation of c6 glioma cells used as a model. |
2001-10-04 |
2023-08-12 |
Not clear |
| H Kim, Y S Kim, S Y Kim, K Su. The plant flavonoid wogonin suppresses death of activated C6 rat glial cells by inhibiting nitric oxide production. Neuroscience letters. vol 309. issue 1. 2001-09-27. PMID:11489548. |
because glial cells have been previously shown to undergo no-dependent apoptosis upon inflammatory activation and this auto-regulatory process may be negatively affected by exogenous factors possessing anti-inflammatory activities, we examined the effects of wogonin on no production and activation-induced cell death of c6 rat glial cells. |
2001-09-27 |
2023-08-12 |
rat |
| P Cuevas, F Carceller, D Diaz, D Reimers, M Fernández, R M Lozano, R González-Corrochano, G Giménez-Galleg. Abolished angiogenicity and tumorigenicity of rat glioma by 1-naphthalenemonosulfonate. Neuroscience letters. vol 308. issue 3. 2001-09-20. PMID:11479019. |
it has been shown that naphthalenesulfonates, with a common chemical function to the family of suramins and suradistas, mimic their inhibitory activity, abolishing fgf-induced angiogenesis in vivo, and inducing apoptosis of c6 glioma cells in culture. |
2001-09-20 |
2023-08-12 |
rat |
| C Sánchez, M L de Ceballos, T Gomez del Pulgar, D Rueda, C Corbacho, G Velasco, I Galve-Roperh, J W Huffman, S Ramón y Cajal, M Guzmá. Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor. Cancer research. vol 61. issue 15. 2001-08-16. PMID:11479216. |
experiments carried out with c6 glioma cells in culture evidenced the internalization of the cb(2) but not the cb(1) receptor upon jwh-133 challenge and showed that selective activation of the cb(2) receptor signaled apoptosis via enhanced ceramide synthesis de novo. |
2001-08-16 |
2023-08-12 |
mouse |
| Q W Yan, X G Zhen, T X Wang, K Y Xu, M Dong, Y C D. Indirect neurotrophic effect of neuropeptide ZNC(C)PR on PC12 cells via peptide-stimulation of C6 cells. Acta pharmacologica Sinica. vol 21. issue 5. 2001-07-12. PMID:11324437. |
to understand the mechanism of neurotrophic action of neuropeptide znc(c)pr and its effect on which could affect both growth and apoptosis of c6 cells. |
2001-07-12 |
2023-08-12 |
Not clear |
| S Yokoyama, H Hirano, N Wakimaru, K P Sarker, J Kurats. Inhibitory effect of epigallocatechin-gallate on brain tumor cell lines in vitro. Neuro-oncology. vol 3. issue 1. 2001-05-31. PMID:11305413. |
quantitative study by flow cytometry demonstrated that lower doses of egcg (12.5, 25, 50 microg/ml) induced apoptosis in u-373 mg, u-87 mg, and c6 cells; however, only the highest dose (100 microg/ml) induced apoptosis in mtt/e cells. |
2001-05-31 |
2023-08-12 |
human |
| M S Kim, Y P Cheong, H S So, K M Lee, T Y Kim, J Oh, Y T Chung, Y Son, B R Kim, R Par. Protective effects of morphine in peroxynitrite-induced apoptosis of primary rat neonatal astrocytes: potential involvement of G protein and phosphatidylinositol 3-kinase (PI3 kinase). Biochemical pharmacology. vol 61. issue 7. 2001-04-19. PMID:11274962. |
morphine significantly protected primary rat astrocytes from apoptosis mediated by sodium nitroprusside, an no donor, and sin-1 in a dose-dependent manner, whereas it did not in other types of cells including c6 glioma, raw 264.7, and hl-60 cells. |
2001-04-19 |
2023-08-12 |
rat |
| M Sawada, S Nakashima, Y Banno, H Yamakawa, K Hayashi, K Takenaka, Y Nishimura, N Sakai, Y Nozaw. Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells. Cell death and differentiation. vol 7. issue 9. 2000-11-14. PMID:11042671. |
ordering of ceramide formation, caspase activation, and bax/bcl-2 expression during etoposide-induced apoptosis in c6 glioma cells. |
2000-11-14 |
2023-08-12 |
Not clear |
| M Sawada, S Nakashima, Y Banno, H Yamakawa, K Hayashi, K Takenaka, Y Nishimura, N Sakai, Y Nozaw. Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells. Cell death and differentiation. vol 7. issue 9. 2000-11-14. PMID:11042671. |
the present study was designed to elucidate the mechanisms of etoposide-induced apoptosis in c6 glioma cells. |
2000-11-14 |
2023-08-12 |
Not clear |
| M Sawada, S Nakashima, Y Banno, H Yamakawa, K Hayashi, K Takenaka, Y Nishimura, N Sakai, Y Nozaw. Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells. Cell death and differentiation. vol 7. issue 9. 2000-11-14. PMID:11042671. |
reduced glutathione or n-acetylcysteine, which could reduce ceramide formation by inhibiting sphingomyelinase activity, prevented c6 cells from etoposide-induced apoptosis through blockage of caspase-3 activation and change of the bax/bcl-2 ratio. |
2000-11-14 |
2023-08-12 |
Not clear |
| M Sawada, S Nakashima, Y Banno, H Yamakawa, K Hayashi, K Takenaka, Y Nishimura, N Sakai, Y Nozaw. Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells. Cell death and differentiation. vol 7. issue 9. 2000-11-14. PMID:11042671. |
taken together, these results suggest that ceramide may function as a mediator of etoposide-induced apoptosis of c6 glioma cells, which induces increase in the bax/bcl-2 ratio followed by release of cytochrome c leading to caspases-9 and -3 activation. |
2000-11-14 |
2023-08-12 |
Not clear |
| D Krajcí, V Mares, V Lisá, A Spanová, J Vorlíce. Ultrastructure of nuclei of cisplatin-treated C6 glioma cells undergoing apoptosis. European journal of cell biology. vol 79. issue 5. 2000-11-08. PMID:10887968. |
ultrastructure of nuclei of cisplatin-treated c6 glioma cells undergoing apoptosis. |
2000-11-08 |
2023-08-12 |
Not clear |
| D Krajcí, V Mares, V Lisá, A Spanová, J Vorlíce. Ultrastructure of nuclei of cisplatin-treated C6 glioma cells undergoing apoptosis. European journal of cell biology. vol 79. issue 5. 2000-11-08. PMID:10887968. |
c6 glioma cells, treated with a cytostatic dose of cisplatin (1.66 x 10(-5) m) ceased dividing by 24 h and, most of them had undergone apoptosis by 72-96 h. the reactive cells were classified into 5 types (t-i to v), according to the ultrastructure of nuclei. |
2000-11-08 |
2023-08-12 |
Not clear |
| M Sawada, S Nakashima, Y Banno, H Yamakawa, K Takenaka, J Shinoda, Y Nishimura, N Sakai, Y Nozaw. Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells. Oncogene. vol 19. issue 31. 2000-08-24. PMID:10918609. |
etoposide, cisplatin and tumor necrosis factor-alpha induced apoptosis of c6 rat glioma cells which was associated with ceramide formation due to activation of neutral sphingomyelinase, followed by release of mitochondrial cytochrome c into the cytosol and activation of caspases-9 and -3. |
2000-08-24 |
2023-08-12 |
human |
| T A Mobio, I Baudrimont, A Sanni, T W Shier, D Saboureau, S D Dano, Y Ueno, P S Steyn, E E Crepp. Prevention by vitamin E of DNA fragmentation and apoptosis induced by fumonisin B1 in C6 glioma cells. Archives of toxicology. vol 74. issue 2. 2000-08-17. PMID:10839479. |
prevention by vitamin e of dna fragmentation and apoptosis induced by fumonisin b1 in c6 glioma cells. |
2000-08-17 |
2023-08-12 |
human |
| T A Mobio, I Baudrimont, A Sanni, T W Shier, D Saboureau, S D Dano, Y Ueno, P S Steyn, E E Crepp. Prevention by vitamin E of DNA fragmentation and apoptosis induced by fumonisin B1 in C6 glioma cells. Archives of toxicology. vol 74. issue 2. 2000-08-17. PMID:10839479. |
evidence for induction of apoptosis by fb1 was first obtained when c6 glioma cells were incubated with fumonisin b1 (3-27 microm) causing dna fragmentation profiles showing dna laddering in gel electrophoresis and apoptotic bodies revealed by chromatin staining with acridine orange and ethidium bromide. |
2000-08-17 |
2023-08-12 |
human |
| L Buzańska, B Zabłocka, A Dybel, K Domańska-Janik, J Albrech. Delayed induction of apoptosis by ammonia in C6 glioma cells. Neurochemistry international. vol 37. issue 2-3. 2000-08-14. PMID:10812214. |
delayed induction of apoptosis by ammonia in c6 glioma cells. |
2000-08-14 |
2023-08-12 |
Not clear |