| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiangpeng Lin, Riken Chen, Huizhao Liao, Yuzhuo Zhang, Zhenzhen Zheng, Cheng Hon. Mechanisms of cordycepin in the treatment of pulmonary arterial hypertension in rats based on metabonomics and transcriptomics. Scientific reports. vol 14. issue 1. 2024-05-30. PMID:38816406. |
evaluations included hematoxylin and eosin staining for pulmonary vascular remodeling, cck-8 assay, edu, and tunel kits for cell viability, proliferation, and apoptosis, respectively, and western blot for protein expression. |
2024-05-30 |
2024-06-02 |
rat |
| Li Chen, Ya-Jun Zhang, Hong-Wen Qin, Wu-Jing Hu, Yan-Jiao Liu, Guo-Sheng Xiao, Hui-Hui DU, Dong-Lin Yan. [Study on mechanism of inhibiting proliferation of head and neck cancer cells by citral, active ingredient of lemon essential oil]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 9. 2024-05-30. PMID:38812137. |
the cell cycle arrest and apoptosis induction of head and neck cancer cells by citral were evaluated by flow cytometry, and western blot was used to detect the effect of citral on the expression levels of cell cycle-and apoptosis-related proteins in head and neck cancer cells. |
2024-05-30 |
2024-06-17 |
Not clear |
| Chang-Long Fu, Yan-Ming Lin, Hai-Shui Tu, Jin-Xia Ye, Yan-Feng Huang, De-Zun Ma, Chun-Song Zhen. [Mechanism of Tougu Xiaotong Capsules in delaying degeneration of osteoarthritis by regulating cholesterol metabolism in chondrocytes through lncRNA MALAT1]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 7. 2024-05-30. PMID:38812190. |
western blot results showed that compared with the model group, protein expressions of abca1, apoa1, lxrβ, chop, and caspase-3 in the tgxtc group were significantly decreased, after lncrna malat1 knockdown, the regulation and apoptosis of abca1, apoa1, lxrβ, chop, and caspase-3 in tg-induced mouse chondrocytes were weakened by tgxtc. |
2024-05-30 |
2024-06-08 |
mouse |
| Jun-Yu He, Jia-Xin Yang, Shi-Ying Qin, Jing-Qi Zheng, Yi-Ran Guo, Tian-Xing M. [Exploration of mechanism of total triterpenoids from fruits of Chaenomeles speciosa against senescent GES-1 cells induced by D-galactose based on Gln/GLS1/α-KG metabolic axis and mitochondrial apoptosis signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 8. 2024-05-30. PMID:38812238. |
the mrna and protein expressions of gls1 and the related genes of the mitochondrial apoptosis signaling pathway were measured by real-time fluorescence quantitative pcr and western blot. |
2024-05-30 |
2024-06-08 |
Not clear |
| Tairan Zhang, Xidong Wan. Modafinil lightens apoptosis and inflammatory response in hepatic ischemia-reperfusion injury through inactivation of TLR9/Myd88/p38 signaling. Drug development research. vol 85. issue 4. 2024-05-30. PMID:38812444. |
terminal-deoxynucleoitidyl transferase-mediated nick end labeling assay and western blot appraised apoptosis. |
2024-05-30 |
2024-06-08 |
mouse |
| Hui Wang, Xiaopei Yan, Li X. [Aloperine suppresses TLR4/NF-κB/NLRP3 signaling to ameliorate cigarette smoke-induced injury to human bronchial epithelial cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 40. issue 5. 2024-05-25. PMID:38790097. |
cell apoptosis was evaluated using the terminal-deoxynucleotidyl transferase-mediated dutp-biotin nick end labeling assay (tunel) and western blot analysis. |
2024-05-25 |
2024-05-27 |
human |
| Tingting Xua. Tripartite Motif-containing Protein 11 Silencing Inhibits Proliferation and Glycolysis and Promotes Apoptosis of Esophageal Squamous Cell Carcinoma Cells by Inactivating Signal Transduction and Activation of Transcription Factor 3/c-Myc Signaling. Journal of physiological investigation. vol 67. issue 1. 2024-05-23. PMID:38780271. |
in addition, western blot was employed to detect the expression of proteins related to apoptosis, glycolysis, and stat3/c-myc signaling. |
2024-05-23 |
2024-05-27 |
human |
| Zhongbiao Wu, Zhongyan Zhu, Liyuan F. Integrating GEO, network pharmacology, and in vitro assays to explore the pharmacological mechanism of Bruceae Fructus against laryngeal cancer. Naunyn-Schmiedeberg's archives of pharmacology. vol 397. issue 6. 2024-05-22. PMID:38032489. |
flow cytometry was utilized to detect apoptosis to examine the influence of beta-sitosterol on laryngeal cancer cell apoptosis, and then detected mrna and protein expression levels of 10 key genes by rt-qpcr and western blot assay. |
2024-05-22 |
2024-05-27 |
Not clear |
| Yuqun Hong, Xiahenazi Abudukeremu, Feifei She, Yanling Che. SOAT1 in gallbladder cancer: Clinicopathological significance and avasimibe therapeutics. Journal of biochemical and molecular toxicology. vol 38. issue 6. 2024-05-21. PMID:38770938. |
furthermore, the effects of avastin on the proliferation, migration, and invasion capabilities of these gallbladder cancer cell lines were studied, and its ability to induce cell apoptosis was evaluated using flow cytometry, western blot, and immunohistochemical methods. |
2024-05-21 |
2024-05-27 |
Not clear |
| Xin Zeng, Fei Luo, Ya-Hong Cheng, Jiefang Gao, Hong Din. α-linolenic acid ameliorates pentylenetetrazol-induced neuron apoptosis and neurological impairment in mice with seizures via down-regulating JAK2/STAT3 pathway. The British journal of nutrition. 2024-05-21. PMID:38772904. |
finally, through molecular docking and western blot studies, we revealed the potential mechanism of ala ameliorates pentylenetetrazol-induced neuron apoptosis and neurological impairment in mice with seizures by downregulating the jak2/stat3 pathway. |
2024-05-21 |
2024-05-27 |
mouse |
| Zhang Jin-Yi, He Yu-Mo, Zhou Jing-Yu, Weng Shu-Feng, Ma Hui-Xia, Lin Tai-Yue, Xu Yin. Hsa_circ_0007460 affects the survival of intracellular Mycobacterium tuberculosis by regulating autophagy and apoptosis of macrophages. Yi chuan = Hereditas. vol 45. issue 11. 2024-05-20. PMID:38764269. |
furthermore, western blot (wb), cell counting kit-8 (cck-8), plate counting, and immunofluorescence experiments revealed that hsa_circ_0007460 could regulate apoptosis and autophagy of macrophages. |
2024-05-20 |
2024-05-27 |
human |
| Karla Melo, Carolina Ramos Dos Santos, Edna Cristina Santos Franco, Arnaldo Jorge Martins Filho, Samir Mansour Moraes Casseb, Pedro Fernando da Costa Vasconcelo. Exploring the interplay between miRNAs, apoptosis and viral load, in Dengue virus infection. Virology. vol 596. 2024-05-18. PMID:38761641. |
methodologically, the study employs quantitative pcr for viral load and mirna expression analysis, and western blot for apoptosis and bcl2 detection, with a statistical framework that includes anova and correlation analysis to discern significant differences and relationships. |
2024-05-18 |
2024-05-27 |
Not clear |
| Shuang Gao, Na Li, Zhongjing Lin, Yisheng Zhong, Yanuo Wang, Xi She. Inhibition of NLRP3 inflammasome by MCC950 under hypoxia alleviates photoreceptor apoptosis via inducing autophagy in Müller glia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 10. 2024-05-16. PMID:38752538. |
retinal autophagy, apoptosis, and related pathways were evaluated by western blot, immunofluorescent labeling, transmission electron microscopy, and tunel assay. |
2024-05-16 |
2024-05-27 |
mouse |
| Shuang Gao, Na Li, Zhongjing Lin, Yisheng Zhong, Yanuo Wang, Xi She. Inhibition of NLRP3 inflammasome by MCC950 under hypoxia alleviates photoreceptor apoptosis via inducing autophagy in Müller glia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 10. 2024-05-16. PMID:38752538. |
autophagic activity in müller glia after nlrp3 inflammasome inhibition, together with its influence on photoreceptor death, was studied using western blot, immunofluorescence staining, mrfp-gfp-lc3 adenovirus transfection, cell viability, proliferation, and apoptosis assays. |
2024-05-16 |
2024-05-27 |
mouse |
| Mitesh Joshi, Purvi Bhat. Ameliorated in vitro anti-cancer efficacy of methotrexate loaded zinc oxide nanoparticles in breast cancer cell lines MCF-7 & MDA-MB-231 and its acute toxicity study. Nanotechnology. 2024-05-15. PMID:38746972. |
in vitro assays, including cell cycle analysis, apoptosis assay, and western blot analysis to study the protein expression were performed. |
2024-05-15 |
2024-05-27 |
Not clear |
| Xiaofan Yang, Yuling Ni. CTRP 9 mitigates the apoptosis and unfolded protein response of OGD/R-induced retinal ganglion cells by regulating the AMPK pathway. Polish journal of pathology : official journal of the Polish Society of Pathologists. vol 75. issue 1. 2024-05-14. PMID:38741428. |
flow cytometry, enzyme-linked immunosorbent assay and western blot assay were performed to assess cell apoptosis. |
2024-05-14 |
2024-05-27 |
Not clear |
| Nathalie Wilke, Corazon Frias, Albrecht Berkessel, Aram Proko. (2,6-Dimethylphenyl)arsonic Acid Induces Apoptosis through the Mitochondrial Pathway, Downregulates XIAP, and Overcomes Multidrug Resistance to Cytostatic Drugs in Leukemia and Lymphoma Cells In Vitro. International journal of molecular sciences. vol 25. issue 9. 2024-05-11. PMID:38731935. |
mechanistic investigations of as2-mediated apoptosis involving fadd (fas-associated death domain)-deficient or smac (second mitochondria-derived activator of caspases)/diablo (direct iap binding protein with low pi)-overexpressing cell lines, western blot analysis of caspase-9 cleavage, and measurements of mitochondrial membrane integrity identified the mitochondrial apoptosis pathway as the main mode of action. |
2024-05-11 |
2024-05-27 |
Not clear |
| Ran Lee, Won-Young Lee, Hyun-Jung Par. Anticancer Effects of Mitoquinone via Cell Cycle Arrest and Apoptosis in Canine Mammary Gland Tumor Cells. International journal of molecular sciences. vol 25. issue 9. 2024-05-11. PMID:38732133. |
these findings were supported using western blot analysis, demonstrating elevated levels of cleaved caspase-3, a hallmark of apoptosis, and decreased expression of cyclin-dependent kinase (cdk) 2 and cyclin d4, pivotal regulators of the cell cycle. |
2024-05-11 |
2024-05-27 |
human |
| Shujiang Zhuo, Sufei Song, Chaoyi Wang, Zhe Wang, Ming Zhang, Daobin Lin, Kaili Che. Inflammatory corpuscle AIM2 facilitates macrophage foam cell formation by inhibiting cholesterol efflux protein ABCA1. Scientific reports. vol 14. issue 1. 2024-05-11. PMID:38734775. |
the intracellular cholesterol efflux rate was detected by scintillation counting; high-performance liquid chromatography (hplc) was used to detect intracellular cholesterol levels; apoptosis levels were detected by tunel kit; levels of inflammatory markers (il-1β, il-18, ros, and gsh) were detected by elisa kits; and levels of aim2 and abca1 proteins were detected by western blot. |
2024-05-11 |
2024-05-27 |
Not clear |
| Fang Bian, Fan-Hong Niu, Ping-Yuan Qu, Fang Gong, Jian-Zhou Ya. Glycyrrhizic acid inhibits DNA damage repair and enhances cisplatin-induced apoptosis of melanoma cells. Chemical biology & drug design. vol 103. issue 5. 2024-05-10. PMID:38725079. |
after that, cell counting kit-8 (cck-8) was employed for testing the cell viability, flow cytometry for the apoptosis, comet assay for the dna damage of cells, and western blot for the cleaved-caspase3, caspase3, bcl-2, and γh2ax protein expression levels. |
2024-05-10 |
2024-05-27 |
human |