| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xin Zhang, Wen Ma, Huanyi Liu, Yuanchu Liu, Yaling Zhang, Sitong He, Xiaoli Ding, Baolin Li, Yaping Ya. Daphnetin protects neurons in an Alzheimer disease mouse model and normal rat neurons by inhibiting BACE1 activity and activating the Nrf2/HO-1 pathway. Journal of neuropathology and experimental neurology. vol 83. issue 8. 2024-07-19. PMID:38819094. |
furthermore, in vitro experiments utilizing isolated rat neurons assessing rna expression profiling, immunofluorescence, tunel assay, and western-blot analysis, suggested the potential of daph for regulating bdnf and gm-csf expression and mitigating aβ1-42-induced cortical injury, synaptic loss, and apoptosis. |
2024-07-19 |
2024-07-21 |
mouse |
| Ayman Alzu'bi, Ejlal Abu-El-Rub, Fatimah Almahasneh, Lena Tahat, Rabaa Y Athamneh, Ramada Khasawneh, Hiba Alzoubi, Doaa S Ghorab, Rawan Almazari, Mazhar Salim Al Zoubi, Raed M Al-Zoub. Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice. Neurotoxicology. vol 103. 2024-06-08. PMID:38823587. |
these findings were found to be correlated with increased level of oxidative stress, neuroinflammation, and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (bdnf), which plays an essential role in modulating synaptic plasticity integral for promoting learning and memory in the hippocampus. |
2024-06-08 |
2024-06-11 |
mouse |
| Amira A El-Gazar, Soad Z El-Emam, Shorouk M El-Sayyad, Shereen S El-Mancy, Sahar M Fayez, Nermin M Sheta, Asmaa K Al-Mokaddem, Ghada M Raga. Pegylated polymeric micelles of boswellic acid-selenium mitigates repetitive mild traumatic brain injury: Regulation of miR-155 and miR-146a/BDNF/ Klotho/Foxo3a cue. International immunopharmacology. vol 134. 2024-05-05. PMID:38705029. |
besides, connexin43 (cx43) expression as well as klotho and brain-derived neurotrophic factor (bdnf) were upregulated with diminished neuronal cell death and apoptosis because of reduced forkhead box class o3a(foxo3a) expression in the pmbs-treated group. |
2024-05-05 |
2024-05-08 |
rat |
| Mehran Cheriki, Masoumeh Habibian, Seyyed Jafar Moosav. Curcumin attenuates brain aging by reducing apoptosis and oxidative stress. Metabolic brain disease. 2024-04-30. PMID:38687459. |
therefore, we investigated the protective effects of curcumin on brain apoptosis and oxidative stress, brain-derived neurotrophic factor (bdnf), and vascular endothelial growth factor (vegf) in aged rats. |
2024-04-30 |
2024-05-03 |
rat |
| Mehran Cheriki, Masoumeh Habibian, Seyyed Jafar Moosav. Curcumin attenuates brain aging by reducing apoptosis and oxidative stress. Metabolic brain disease. 2024-04-30. PMID:38687459. |
the study indicates that curcumin could alleviate brain aging which may be due to attenuating oxidative stress, inhibiting apoptosis, and up-regulating sod activity, which in turn enhances vegf and bdnf. |
2024-04-30 |
2024-05-03 |
rat |
| Yuhai Xu, Xin Xin, Tianzhu Ta. Decoding the Neurotoxic Effects of Propofol: Insights into the RARα-Snhg1-Bdnf Regulatory Cascade. American journal of physiology. Cell physiology. 2024-04-15. PMID:38618701. |
the findings draw a clear link between propofol-induced neurotoxicity and the amplification of rar signaling pathways, impacting hippocampal development and apoptosis and leading to increased rarα and snhg1 and decreased bdnf. |
2024-04-15 |
2024-04-17 |
Not clear |
| Mina Makvand, Seyed Davood Mirtorabi, Arezoo Campbell, Alireza Zali, Ghasem Ahangar. Exploring neuroadaptive cellular pathways in chronic morphine exposure: An in-vitro analysis of cabergoline and Mdivi-1 co-treatment effects on the autophagy-apoptosis axis. Journal of cellular biochemistry. 2024-04-05. PMID:38577900. |
this combination therapy normalized autophagy and reduced oxidative stress by enhancing total-antioxidant capacity, mitigating apoptosis, restoring bdnf expression, and balancing apoptotic elements. |
2024-04-05 |
2024-04-07 |
human |
| Umit Yilmaz, Kevser Tanbek, Semir Gul, Ahmet Koc, Mehmet Gul, Suleyman Sanda. Intracerebroventricular BDNF infusion may reduce cerebral ischemia/reperfusion injury by promoting autophagy and suppressing apoptosis. Journal of cellular and molecular medicine. vol 28. issue 8. 2024-03-23. PMID:38520223. |
intracerebroventricular bdnf infusion may reduce cerebral ischemia/reperfusion injury by promoting autophagy and suppressing apoptosis. |
2024-03-23 |
2024-03-26 |
rat |
| Chunyan Gong, Xiaona He, Guiliang Li, Dayu Wang, Yonghua Yang, Yanping Shi, Wenbing Su, Yuanxian W. miR-497-5p promoted neuronal injury in ischemic stroke by inhibiting the BDNF/TrkB/PI3K/Akt pathway. General physiology and biophysics. vol 43. issue 2. 2024-03-13. PMID:38477607. |
bdnf inhibited cell apoptosis and oxidative stress injury in pc12 cells. |
2024-03-13 |
2024-03-15 |
Not clear |
| Kening Liu, Xu Zhou, Chunjin Li, Caomeihui Shen, Guitian He, Tong Chen, Maosheng Cao, Xue Chen, Boqi Zhang, Lu Che. YTHDF2 as a Mediator in BDNF-Induced Proliferation of Porcine Follicular Granulosa Cells. International journal of molecular sciences. vol 25. issue 4. 2024-02-24. PMID:38397033. |
in female mammals, the proliferation and apoptosis of granulosa cells (gcs) are critical in determining the fate of follicles and are influenced by various factors, including brain-derived neurotrophic factor (bdnf). |
2024-02-24 |
2024-02-26 |
Not clear |
| Yi-Ju Lee, Chang-Mao Lin, Yun-Ching Chang, Mon-Yuan Yang, Chau-Jong Wang, Li-Sung Hs. Nelumbo nucifera leaves extract ameliorated scopolamine-induced cognition impairment via enhanced adult hippocampus neurogenesis. Environmental toxicology. 2024-02-14. PMID:38351887. |
overall, our results revealed that n. nucifera leaf extracts and q3g promoted adult hippocampus neurogenesis and prevented apoptosis to mitigate scopolamine-induced cognition dysfunction through the regulation of bdnf signaling pathway. |
2024-02-14 |
2024-02-16 |
mouse |
| Micaela Gliozzi, Anna Rita Coppoletta, Antonio Cardamone, Vincenzo Musolino, Cristina Carresi, Saverio Nucera, Stefano Ruga, Federica Scarano, Francesca Bosco, Lorenza Guarnieri, Roberta Macrì, Rocco Mollace, Catherine Belzung, Vincenzo Mollac. The dangerous "West Coast Swing" by hyperglycaemia and chronic stress in the mouse hippocampus: role of kynurenine catabolism. Pharmacological research. 2024-02-01. PMID:38301816. |
we demonstrated that the coexistence of hyperglycaemia and chronic stress worsened hippocampal damage through alternative mechanisms, such as glut-4 and bdnf down-expression, denoting mitochondrial dysfunction and apoptosis on one hand and evoking the compromission of neurogenesis on the other. |
2024-02-01 |
2024-02-04 |
mouse |
| Xinyi Bi, Shulan Liu, Degao Liu, Changzhong L. Elucidating the role of Brain-Derived Neurotrophic Factor (BDNF) and its receptor Tyrosine Receptor Kinase B (TrkB) in the development and symptoms of endometriosis. The International journal of neuroscience. 2024-01-30. PMID:38287513. |
in order to gain a deeper understanding of the pathogenesis related to ems, this article reviews the roles of bdnf and trkb in ems, particularly in terms of aberrant apoptosis and autophagy, cell invasion, proliferation, angiogenesis, oxidative stress, and inflammatory reactions, as well as their relationship with the symptoms associated with ems. |
2024-01-30 |
2024-02-01 |
Not clear |
| Amira A Goma, Alyaa R Salama, Hossam G Tohamy, Rashed R Rashed, Mustafa Shukry, Sara E El-Kaza. Examining the Influence of Zinc Oxide Nanoparticles and Bulk Zinc Oxide on Rat Brain Functions: a Comprehensive Neurobehavioral, Antioxidant, Gene Expression, and Histopathological Investigation. Biological trace element research. 2024-01-08. PMID:38190061. |
znonp-5 upregulated the expression of brain-derived neurotrophic factor (bdnf) mrna, while bzno-5 showed increased bdnf mrna expression and decreased expression of genes related to apoptosis and inflammation. |
2024-01-08 |
2024-01-10 |
rat |
| Ruyu Wang, Yiwei Chen, Zhiying Wang, Baorui Cao, Jinxin Du, Tingting Deng, Meina Yang, Jinxiang Ha. Antidepressant effect of licorice total flavonoids and liquiritin: A review. Heliyon. vol 9. issue 11. 2023-12-11. PMID:38074876. |
studies have shown that lf and liquiritin can exert their antidepressant effects by improving depressive behavior, regulating endocrine and hypothalamic-pituitary-adrenal (hpa) axis function, affecting the brain-derived neurotrophic factor (bdnf)/tyrosine kinase b (trkb) signaling pathway, enhancing synaptic plasticity, increasing monoamine neurotransmitter levels, protecting nerve cells, reducing inflammation, preventing apoptosis, reducing oxidation and other ways. |
2023-12-11 |
2023-12-17 |
Not clear |
| Dibyakanti Mishra, Priyam Narain, Upma Dave, James Gome. Role of ALS-associated OPTN-K489E mutation in neuronal cell-death regulation. Molecular and cellular neurosciences. 2023-11-02. PMID:37918554. |
our results show that optn-k489e mutation changes the relative gene expressions of mirna-9, rest, corest and bdnf, and causes apoptosis. |
2023-11-02 |
2023-11-08 |
Not clear |
| Jingwen Shi, Yue Qi, Yuanchen Sun, Ying Huan. KLK4 promotes proliferation, migration, invasion, and pro-angiogenesis of endometrial stromal cells via regulation of regulation of BDNF production in endometriosis. The American journal of pathology. 2023-11-02. PMID:37918799. |
finally, we showed that bdnf as a vital downstream substrate of klk4 maintained the proliferation, metastasis, and pro-angiogenesis abilities and inhibited apoptosis of escs through a rescue study. |
2023-11-02 |
2023-11-08 |
Not clear |
| Abdulhadi Bima, Basmah Eldakhakhny, Aliaa A Alamoudi, Zuhier Awan, Abrar Alnami, Salwa Mohamed Abo-Elkhair, Hussein Sakr, Fatma Mohamed Ghoneim, Ayman Elsamanoud. Molecular Study of the Protective Effect of a Low-Carbohydrate, High-Fat Diet against Brain Insulin Resistance in an Animal Model of Metabolic Syndrome. Brain sciences. vol 13. issue 10. 2023-10-30. PMID:37891752. |
in conclusion, mets is associated with dysregulated cerebral gene expression of bdnf, s100b, and tnf-α and disturbed igf-1 signaling, with increased apoptosis and neuroinflammation. |
2023-10-30 |
2023-11-08 |
rat |
| Ravel Ray, Stuti Goel, Hind Al Khashali, Ban Darweesh, Ben Haddad, Caroline Wozniak, Robert Ranzenberger, Jeneen Khalil, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evan. Regulation of Soluble E-Cadherin Signaling in Non-Small-Cell Lung Cancer Cells by Nicotine, BDNF, and β-Adrenergic Receptor Ligands. Biomedicines. vol 11. issue 9. 2023-09-28. PMID:37760996. |
in investigating the function of se-cad, we found that immunodepletion of se-cad from the media of a549 cells untreated or treated with bdnf, nicotine, or epinephrine reduced activation of egfr and igf-1r, decreased pi3k and erk1/2 activities, increased p53 activation, decreased cell viability, and increased apoptosis, while no effects were found using h1299 cells under all conditions tested. |
2023-09-28 |
2023-10-07 |
Not clear |
| Anton Shkundin, Angelos Halari. Associations of BDNF/BDNF-AS SNPs with Depression, Schizophrenia, and Bipolar Disorder. Journal of personalized medicine. vol 13. issue 9. 2023-09-28. PMID:37763162. |
in contrast, bdnf antisense rna (bdnf-as) is linked to the regulation and control of bdnf, facilitating its suppression and contributing to neurotoxicity, apoptosis, and decreased cell viability. |
2023-09-28 |
2023-10-07 |
Not clear |