| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rahul V G, Govindaraj Ellur, Amir A Gaber, Prem Kumar Govindappa, John C Elfa. 4-aminopyridine attenuates inflammation and apoptosis and increases angiogenesis to promote skin regeneration following a burn injury in mice. Cell death discovery. vol 10. issue 1. 2024-10-04. PMID:39366954. |
4-ap attenuated apoptosis, with decreases in apoptotic markers bax, caspase-9, and caspase-3 and increases in anti-apoptotic markers bcl2 and bcl-xl. |
2024-10-04 |
2024-10-07 |
mouse |
| Mohammad Yousefi Zardak, Fatemeh Keshavarz, Ali Mahyaei, Morteza Gholami, Fatemeh Sadat Moosavi, Elham Abbasloo, Farzaneh Abdollahi, Maryam Hossein Rezaei, Elham Madadizadeh, Nasrin Soltani, Fatemeh Bejeshk, Niyan Salehi, Fahimeh Rostamabadi, Fatemeh Bagheri, Mahla Jafaraghae, Mahdiyeh Ranjbar Zeydabadi, Meraj Baghgoli, Gholamreza Sepehri, Mohammad Abbas Bejesh. Quercetin as a therapeutic agent activate the Nrf2/Keap1 pathway to alleviate lung ischemia-reperfusion injury. Scientific reports. vol 14. issue 1. 2024-10-04. PMID:39367100. |
furthermore, we examined markers related to inflammation (interleukin-1β and tumor necrosis factor alpha), oxidative stress (malondialdehyde, total oxidant status, superoxide dismutase, glutathione peroxidase, total antioxidant capacity), lung edema (wet/dry lung weight ratio and total protein concentration), apoptosis (bax and bcl2 protein), and histopathological alterations (intra-alveolar edema, alveolar hemorrhage, and neutrophil infiltration). |
2024-10-04 |
2024-10-07 |
rat |
| Peng Sun, Hanqing Huang, Jian-Chao Ma, Binyang Feng, Yiqing Zhang, Genggeng Qin, Weian Zeng, Zhong-Kai Cu. Repurposing propofol for breast cancer therapy through promoting apoptosis and arresting cell cycle. Oncology reports. vol 52. issue 5. 2024-10-04. PMID:39364744. |
propofol promoted apoptosis in 4t1 cells through upregulation of bax and cleaved caspase 3, while downregulating b‑cell lymphoma‑extra large. |
2024-10-04 |
2024-10-07 |
mouse |
| Lian Yi, Yewei Qu, Qi Zhang, Shanshan Shi, Fangqin Li, Changda Qu, Yushi Tang, Shirong Wen, Yujun Pa. Enforced HCELL Expression Enhances Bone Marrow Stromal Cells Homing and Amelioration of Cerebral Ischemia-Reperfusion Injury via induction of PGE2. Stem cells (Dayton, Ohio). 2024-10-04. PMID:39364762. |
furthermore, the transplantation led to a decrease in apoptosis by up-regulating bcl-2 and down-regulating bax, also reduced the mrna levels of inflammatory factors, such as interleukin-1β (il-1β), il-2, il-6 and tumor necrosis factor-alpha (tnf-α) in the ischemic brain tissue. |
2024-10-04 |
2024-10-07 |
Not clear |
| Tineng Yang, Xiaoyang Peng, Xi Huang, Peng Cao, Hualei Che. COL6A1 Inhibits the Malignant Development of Bladder Cancer by Regulating FBN1. Cell biochemistry and biophysics. 2024-10-04. PMID:39365515. |
moreover, the col6a1 overexpression suppressed the viability, migration, and invasion, while promoting apoptosis of blca cell lines, with increased caspase-3, bax, and p53, and decreased bcl-2. |
2024-10-04 |
2024-10-07 |
mouse |
| Juie Nahushkumar Rana, Sohail Mumtaz, Ihn Han, Eun Ha Cho. Harnessing the synergy of nanosecond high-power microwave pulses and cisplatin to increase the induction of apoptosis in cancer cells through the activation of ATR/ATM and intrinsic pathways. Free radical biology & medicine. 2024-10-03. PMID:39362289. |
additionally, upregulation of atr/atm, chk1/chk2, p53, and caspase 3/8, bax, parp, and bcl2 confirms dna damage and mitochondrial dysfunction, leading to apoptosis. |
2024-10-03 |
2024-10-07 |
Not clear |
| Arif Ul Hasan, Satoshi Serada, Sachiko Sato, Mami Obara, Sho Hirata, Yukako Nagase, Yukiko Kondo, Eiichi Tair. KDM4B Histone Demethylase Inhibition Attenuates Tumorigenicity of Malignant Melanoma Cells by Overriding the p53-Mediated Tumor Suppressor Pathway. Journal of cellular biochemistry. 2024-10-03. PMID:39358852. |
interestingly, despite the reduction of p53, these interventions augmented apoptosis and senescence-induced cell death by activating pathways downstream of p53, as evidenced by reduced levels of pro-survival bcl-2 and bcl-xl proteins and increased production of pro-apoptotic cleaved caspase-3, caspase-7, bax, and the senescence inducer cdkn1a. |
2024-10-03 |
2024-10-05 |
mouse |
| He-Ping Xu, Feng Zhan, Hong Wang, Jie Lin, Huan Ni. Down-regulation of RTEL1 Improves M1/M2 Macrophage Polarization by Promoting SFRP2 in Fibroblasts-derived Exosomes to Alleviate COPD. Cell biochemistry and biophysics. vol 82. issue 3. 2024-10-01. PMID:38805113. |
through in vitro experiments, knockdown of rtel1 inhibited macrophage proliferation, inflammation (mmp9, il-1β and tnf-α), and promoted apoptosis (bax, cleaved-caspase3, bcl-2) in cs extract-induced lung fibroblasts. |
2024-10-01 |
2024-10-03 |
mouse |
| Congjian He, Jiahui Zhou, Xixi Wu, Yujin Zhou, Siya Wang, Bo Liu, Ting Luo, Ying Chen, Jia Yuan, Di Wang, Chen Zhang, Jinfeng Sh. Hyaluronic acid-zein shell-core biopolymer nanoparticles enhance hepatocellular carcinoma therapy of celastrol via CD44-mediated cellular uptake. International journal of biological macromolecules. 2024-10-01. PMID:39353524. |
further studies revealed that cel/zein@ha nps induced apoptosis in hepatocellular carcinoma cells by modulating bax and bcl-2 expression, while also inhibiting tumor angiogenesis by decreasing cd31 and vegf levels. |
2024-10-01 |
2024-10-05 |
mouse |
| Weihua Chen, Xin Liu, Ziping Zhang, Yadong Yua. Sinomenine Hydrochloride Regulates the Apoptosis of Endothelial Cells through PPAR-γ to Alleviate PAH. International heart journal. vol 65. issue 5. 2024-09-29. PMID:39343596. |
it reversed the expression of bcl2 and bax and prevented the apoptosis of endothelial cells. |
2024-09-29 |
2024-10-02 |
rat |
| Alireza Habibi, Aynaz Davari, Khosro Isazade. A novel LL-37@NH2@Fe3O4 inhibits the proliferation of the leukemia K562 cells: in-vitro study. Scientific reports. vol 14. issue 1. 2024-09-28. PMID:39333586. |
further analysis revealed that apoptosis occurred through increased expression of tp53 and bax genes compared to the bcl-2 gene. |
2024-09-28 |
2024-10-01 |
Not clear |
| Ting Zou, Jun-Yan Liu, Zhao-Qian Liu, Di Xiao, Juan Che. The Role of ADCY1 in Regulating the Sensitivity of Platinum-Based Chemotherapy in NSCLC. Pharmaceuticals (Basel, Switzerland). vol 17. issue 9. 2024-09-28. PMID:39338283. |
it may control cell apoptosis by regulating the classical apoptosis biomarkers bax and bcl2. |
2024-09-28 |
2024-10-01 |
Not clear |
| Esther García-Díez, María Elvira López-Oliva, Jara Pérez-Jiménez, María Ángeles Martín, Sonia Ramo. Cocoa and Carob Supplementation, Alone or in Combination with Metformin, Protects against Hepatorenal Injury in Zucker Diabetic Fatty Rats. Nutrients. vol 16. issue 18. 2024-09-28. PMID:39339687. |
the combination of cc and metformin boosted several benefits as certain parameters related to morphological and structural alterations, apoptosis, oxidative stress, glucose homeostasis, and insulin resistance, were improved in comparison to animals receiving the cc-supplemented diet or metformin alone; these include the following: apoptotic index, bax, hepatic insulin receptor or glutathione content, among others. |
2024-09-28 |
2024-10-01 |
rat |
| Lisanne Brueck, Sascha Roocke, Veronika Matschke, Annette Richter-Unruh, Katrin Marcus-Alic, Carsten Theiss, Sarah Stahlk. FGF23 and Cell Stress in SaOS-2 Cells-A Model Reflecting X-Linked Hypophosphatemia Dynamics. Cells. vol 13. issue 18. 2024-09-27. PMID:39329699. |
additionally, we observed higher apoptosis rates of the cells after 24-72 h in vitro and upregulated proteins associated with er stress and apoptosis, such as chop, xbp1 (spliced and unspliced), grp94, eif2α, and bax. |
2024-09-27 |
2024-09-29 |
Not clear |
| Masoud Karimi-Googheri, Zahra Madjd, Jafar Kiani, Ziba Shabani, Mohammad Kazemi Arababadi, Mazaher Gholipourmalekabad. The Effects of Severe Symptoms of SARS-CoV-2 Infections on the Anti/Proapoptotic Molecules: A 6-Month Cohort Study. Viral immunology. 2024-09-25. PMID:39321348. |
this cohort study examined the expression of p53, bcl-2, bid, bak, and bax molecules, the genes associated with induction or inhibition of apoptosis, in the sars-cov-2-infected patients with severe and mild symptoms in an iranian population. |
2024-09-25 |
2024-09-28 |
Not clear |
| Eman I Hassanen, Hayam A Mansour, Marwa Y Issa, Marwa A Ibrahim, Wafaa A Mohamed, Mahmoud A Mahmou. Epigallocatechin gallate-rich fraction alleviates histamine-induced neurotoxicity in rats via inactivating caspase-3/JNK signaling pathways. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-09-25. PMID:39322001. |
moreover, his promoted apoptosis, which is indicated by increasing jnk, and bax and decreasing bcl-2 gene expressions. |
2024-09-25 |
2024-09-28 |
rat |
| Fatemeh Rahmati-Dehkordi, Hadi Khanifar, Alireza Zare-Hoseinabadi, Ehsan Dadgostar, Hamed Jafarpour, Michael Aschner, Hamed Mirzaei, Omid Reza Tamtaji, Fatemeh Nabavizade. Potential of Edaravone Dexborneol in the treatment of cerebral ischemia: focus on cell death-related signaling pathways. Molecular biology reports. vol 51. issue 1. 2024-09-23. PMID:39312062. |
for example, it inhibits apoptosis by increasing bcl2, and reducing bax and caspase-3 expression. |
2024-09-23 |
2024-09-26 |
Not clear |
| Nader Sheibani, Yanzhi Sang, Shoujian Wang, Christine M Sorenso. Bax expression impacts postnatal retinal vascular development and hyperoxia sensitivity. Experimental eye research. vol 248. 2024-09-23. PMID:39307450. |
bim, a bh3 only protein bcl-2 family member, binds and activates bax and/or bak to facilitate apoptosis. |
2024-09-23 |
2024-09-26 |
mouse |
| Dan-Ni Zhong, Yun-Ping Pan, Heng Fan, Jie-Li L. Protective Effect of Salidroside on Acute Kidney Injury in Sepsis by Inhibiting Oxidative Stress, Mitochondrial Damage, and Cell Apoptosis. Biological & pharmaceutical bulletin. vol 47. issue 9. 2024-09-23. PMID:39313391. |
moreover, slds stabilized mitochondrial damage induced by clp, inhibited tecs apoptosis, increased bcl-2 mrna level, and decreased bax and caspase-3 mrna levels. |
2024-09-23 |
2024-09-26 |
mouse |
| Ming Bu, Wen-Kang Ren, Lu Wang, Chun-Xue Sun, Ran Luo, Xiao-Shan Guo, Yu Lin, Peng-Ling Ge, Ji-Cheng Li. [Anti-breast cancer effect of a mitochondrion-targeted derivative of ergosterol peroxide in vitro and in vivo]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 15. 2024-09-22. PMID:39307746. |
however, mito-ep increased the apoptosis rate, elevated the ros level, decreased mitochondrial membrane potential, up-regulated the protein levels of bax, cyt c, cleaved caspase-7, and cleaved caspase-9, and down-regulated the protein level of bcl-2(all p<0.05). |
2024-09-22 |
2024-09-26 |
mouse |