| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenming Xue, Jiaxin Wang, Yao Hou, Di Wu, Hongwei Wang, Qiyue Jia, Qiyue Jiang, Yan Wang, Chenzhao Song, Yifei Wang, Zhonghui Zhu, Lin Tia. Lung decellularized matrix-derived 3D spheroids: Exploring silicosis through the impact of the Nrf2/Bax pathway on myofibroblast dynamics. Heliyon. vol 10. issue 13. 2024-07-23. PMID:39040273. |
in the nrf2 knockout spheroids, bax is also significantly downregulated; after intervention with bax inhibitors, a significant downregulation of bax-induced apoptosis was also detected in the nrf2-overexpressed spheroids. |
2024-07-23 |
2024-07-25 |
mouse |
| Wenming Xue, Jiaxin Wang, Yao Hou, Di Wu, Hongwei Wang, Qiyue Jia, Qiyue Jiang, Yan Wang, Chenzhao Song, Yifei Wang, Zhonghui Zhu, Lin Tia. Lung decellularized matrix-derived 3D spheroids: Exploring silicosis through the impact of the Nrf2/Bax pathway on myofibroblast dynamics. Heliyon. vol 10. issue 13. 2024-07-23. PMID:39040273. |
in contrast, bax-induced apoptosis showed a significant upregulation trend in nrf2-overexpressed spheroids after intervention with bax agonists. |
2024-07-23 |
2024-07-25 |
mouse |
| Lu Wang, Ran Luo, Yin-Xu Zhao, Yu Zou, Ming Bu, Yu Li. [Ergosterol peroxide inducing apoptosis of human hepatocellular carcinoma by regulating mitochondrial apoptosis pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 12. 2024-07-23. PMID:39041100. |
the effects of different concentrations of ep on the protein expression of mitochondrial apoptosis pathway-related proteins b cell lymphoma 2(bcl-2), cytochrome c(cyt-c), bcl-2-related x protein(bax), caspase-3, cleaved caspase-3, caspase-9, and cleaved caspase-9 were examined by using western blot. |
2024-07-23 |
2024-07-25 |
human |
| Jia-Ping Zhang, Ting Zhang, Hui Wu, Da-Qiang Wu, Jing Shao, Ting-Ting Liu, Tian-Ming Wang, Chang-Zhong Wan. [Mechanism of protective effect of n-butanol extract of Pulsatilla Decoction on vaginal epithelial cells under Candida albicans stimulation through EGFR/MAPK pathway based on transcriptomics]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 11. 2024-07-23. PMID:39041162. |
in addition, bepd downregulated the pro-apoptotic protein bax expression and up-regulated the anti-apoptotic protein bcl-2 expression, leading to a reduction in c. glabrata-induced cell apoptosis. |
2024-07-23 |
2024-07-25 |
mouse |
| Zahra Nazeri, Vahid Zarezade, Mostafa Jamalan, Maryam Cheraghzadeh, Shirin Azizidoost, Alireza Kheirolla. Carbon nanotubes induce cytotoxicity and apoptosis through increasing protein levels of Bax and ROS in mouse skin fibroblasts. Research in pharmaceutical sciences. vol 19. issue 2. 2024-07-22. PMID:39035585. |
carbon nanotubes induce cytotoxicity and apoptosis through increasing protein levels of bax and ros in mouse skin fibroblasts. |
2024-07-22 |
2024-07-24 |
mouse |
| Mahdieh Ahmadi Kamalabadi, Hamid Ostadebrahimi, Fereshteh Koosha, Asieh Fatemidokht, Iman Menbari Oskuie, Fatemeh Amin, Amin Shiralizadeh Dezful. Gd-GQDs as nanotheranostic platform for the treatment of HPV-positive oropharyngeal cancer. Medical oncology (Northwood, London, England). vol 41. issue 8. 2024-07-22. PMID:39037549. |
in contrast, the combination group exhibited a significant increase in bax protein expression, suggesting that cells could undergo apoptosis independent of the p53 pathway. |
2024-07-22 |
2024-07-24 |
Not clear |
| Lu Jiang, Shaonan Yang, Ling Deng, Jingjing Luo, Xiaoling Zhang, Sha Chen, Zhi Don. ARL13B promotes cell cycle through the sonic hedgehog signaling pathway to alleviate nerve damage during cerebral ischemia/reperfusion in rats. Biochemical pharmacology. 2024-07-22. PMID:39038552. |
furthermore, arl13b significantly increased the expression of shh pathway-related proteins and the anti-apoptotic protein bcl-2, while decreased the expression of pro-apoptotic protein bax, thus reducing apoptosis. |
2024-07-22 |
2024-07-25 |
rat |
| Xiu-Li Zhang, Jia-Peng Li, Mei-Zhu Wu, Jin-Kong Wu, Shu-Yu He, Yao Lu, Qi-Hang Ding, Ying Wen, Lin-Zi Long, Chang-Geng Fu, Ali Farman, A-Ling Shen, Jun Pen. Quercetin protects against hypertensive renal injury by attenuating apoptosis: an integrated approach using network pharmacology and RNA-Seq. Journal of cardiovascular pharmacology. 2024-07-19. PMID:39027976. |
network pharmacology analysis identified multiple potential candidate targets (including tp53, bcl-2 and bax) and enriched signaling pathways (including apoptosis and p53 signaling pathway). |
2024-07-19 |
2024-07-21 |
mouse |
| Yaya Song, Chunlin Long, Weizhe Chen, Hao Li, Haofeng Zhao, Liya Li. Cratoxylum formosum ssp. pruniflorum induces gastric cancer cell apoptosis and pyroptosis through the elevation of ROS and cell cycle arrest. Cell biochemistry and biophysics. 2024-07-19. PMID:39028496. |
in vitro experiments demonstrated that cf significantly inhibited the proliferation and migration of gc cells, increased intracellular reactive oxygen species (ros), malondialdehyde (mda) and lactate dehydrogenase (ldh) levels, arrested the cell cycle at the s-phase, induced apoptosis and pyroptosis, and upregulated expression of apoptosis proteins (bax, bax/bcl-2, cleaved-caspase-3/caspase-3), and pyroptosis proteins (gsdmd-n/gsdmd and gsdme-n/gsdme), while downregulating expression of cell cycle proteins (cdk2 and cyclin a1) as well as necroptosis proteins (rip1 and mlkl). |
2024-07-19 |
2024-07-21 |
Not clear |
| Wei-Chen Yeh, Yun-Chieh Tu, Pei-Ling Hsu, Chu-Wan Lee, Hsin-Hsien Yu, Bor-Chyuan S. Combination of Vismodegib and Paclitaxel Enhances Cytotoxicity via Bak-mediated Mitochondrial Damage in EGFR-Mutant Non-Small Cell Lung Cancer Cells. Cell biochemistry and biophysics. 2024-07-19. PMID:39030332. |
we previously demonstrated that the hedgehog inhibitor vismodegib (vis) potentiates paclitaxel (ptx)-induced cytotoxicity via suppression of bax phosphorylation, which promotes accumulation of mitochondrial damage and apoptosis in egfr-wt nsclc cells. |
2024-07-19 |
2024-07-22 |
Not clear |
| Hossein Rezaei, Alireza Iranbakhsh, Abbas Akhavan Sepahi, Amir Mirzaie, Kambiz Larijan. Formulation, preparation of niosome loaded zinc oxide nanoparticles and biological activities. Scientific reports. vol 14. issue 1. 2024-07-19. PMID:39030347. |
in addition, the impact of niosomes on the expression of genes involved in the apoptosis (bcl2, casp3, casp9, bax) at the mrna level was measured. |
2024-07-19 |
2024-07-22 |
Not clear |
| Wei Zhou, Huizhong Li, Jinxiu Song, Feng Suo, Maosheng Gu, Suhua Q. Healthy Plasma Exosomes Exert Potential Neuroprotective Effects against Methylmalonic Acid-Induced Hippocampal Neuron Injury. ACS chemical neuroscience. 2024-07-18. PMID:39026168. |
mma promoted cell apoptosis, disrupted the metabolic balance, and altered the expression of b-cell lymphoma-2 (bcl-2), bcl2-associated x (bax), and synaptophysin-1 (syp-1), and these changes may be involved in mma-induced neuronal apoptosis. |
2024-07-18 |
2024-07-21 |
mouse |
| Yao Ma, Manjie Bao, Yanping Peng, Jieqing Gao, Jinrong Ba. Eco-friendly Nanoparticles Synthesized from Salvia sclarea Ethanol Extract Protect against STZ-induced Diabetic Nephropathy in Rats via Antioxidant, Anti-inflammatory, and Apoptosis Mechanisms. Journal of oleo science. 2024-07-17. PMID:39019617. |
the treatment procedure spanned for a period of 12 weeks in diabetic rats and were evaluated for inflammatory markers (tumor necrosis factor-α, antioxidant markers (superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx) and glutathione (gsh) and apoptosis markers (bcl-2, bax, cleaved-caspase-3). |
2024-07-17 |
2024-07-20 |
rat |
| Lulu Yang, Bo Meng, Xiaoyun Gong, You Jiang, Xuping Shentu, Zhichao Xu. Investigation of the synergistic effect mechanism underlying sequential use of palbociclib and cisplatin through integral proteomic and glycoproteomic analysis. Anti-cancer drugs. 2024-07-16. PMID:39011652. |
as a result, the sequential use of two drugs induced a higher expression level of apoptosis proteins bax and bak. |
2024-07-16 |
2024-07-18 |
Not clear |
| Sheyda Jodeiry Zaer, Mahmoudreza Aghamaali, Souzan Najafi, Seyed Samad Hosseini, Mohammad Amini, Mohammad Amin Doustvandi, Nazila Mozammel, Behzad Baradaran, Amir Ali Mokhtarzade. MicroRNA-143 overexpression enhances the chemosensitivity of A172 glioblastoma cells to carmustine. Naunyn-Schmiedeberg's archives of pharmacology. 2024-07-15. PMID:39007927. |
the obtained results evidenced that mir-143 transfection could promote the sensitivity of a172 cells to carmustine and enhance carmustine-induced apoptosis via modulating the expression levels of caspase-3, caspase-9, bax, and bcl-2. |
2024-07-15 |
2024-07-18 |
human |
| Zhijun Geng, Lugen Zuo, Jing Li, Lixia Yin, Jingjing Yang, Ting Duan, Lian Wang, Xiaofeng Zhang, Xue Song, Yueyue Wang, Jianguo H. Ginkgetin improved experimental colitis by inhibiting intestinal epithelial cell apoptosis through EGFR/PI3K/AKT signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 14. 2024-07-14. PMID:39003633. |
in addition, in dss mice and tnf-α-induced colonic organoids, gk protected the intestinal barrier and inhibited intestinal epithelial cell apoptosis, by improving permeability and inhibiting the number of apoptotic cells and the expression of key apoptotic regulators (cleaved caspase 3, bax and bcl-2). |
2024-07-14 |
2024-07-16 |
mouse |
| Fu-Hong Liu, Xing-Cheng Lin, Yu-Wei Liu, Tian-Tian Zhang, Yang-Bo Zhang, Zhuo-Long Xie, Yuan Zhan, Ping H. Harmine inhibits the proliferation and migration and promotes the apoptosis of colon cancer cells via inhibition of the FAK/AKT and ERK Journal of Asian natural products research. 2024-07-13. PMID:39001813. |
additionally, harmine-induced apoptosis in colon cancer cells by regulating the expression of bcl-2 and bax. |
2024-07-13 |
2024-07-16 |
Not clear |
| Ping Li, Zhengang Li, Qixiu Sun, Wei Zhang, Xine Huang, Mohan Si, Xinjun Du, Shuo Wan. Protective effect and mechanism of Lycium ruthenicum Murray anthocyanins against retinal damage induced by blue light exposure. Journal of food science. 2024-07-12. PMID:38992868. |
furthermore, lra could ameliorate oxidative stress-induced apoptosis by upregulating bcl-2 and downregulating bax and caspase-3 protein expression. |
2024-07-12 |
2024-07-14 |
Not clear |
| Qian Zhang, Xiuzhi Fei, Yue Li, Hengwei Zhang, Lu Chen, Jianping Ruan, Ning Don. Epigallocatechin-3-gallate Attenuates Fluoride Induced Apoptosis Via PI3K/FoxO1 Pathway in Ameloblast-like Cells. Toxicon : official journal of the International Society on Toxinology. 2024-07-12. PMID:38996976. |
we observed that naf triggered apoptotic alterations in cell morphology, excessive naf arrested cell cycle at the g1, and induced apoptosis by up-regulating bax and down-regulating bcl-2. |
2024-07-12 |
2024-07-15 |
Not clear |
| Fei Zhao, Dan-Yang Chen, Bo Jing, Yu Jiang, Lan-Yue Liu, Hui Son. Effect of Flammulina velutipes polysaccharide on mitochondrial apoptosis in lung adenocarcinoma A549 cells. Scientific reports. vol 14. issue 1. 2024-07-12. PMID:38997305. |
the results of flow cytometry experiments and mitochondrial membrane potential, rt-qpcr, and western blot showed that fvp-s1 and fvp-c were able to decrease the mitochondrial membrane potential, increase the expression level of apoptotic proteins casepase-3 and casepase-9 proteins, and at the same time, increase the ratio of bax and bcl-2, which promoted apoptosis of tumor cells. |
2024-07-12 |
2024-07-15 |
Not clear |