| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoyu Yu, Hanbing Gao, Jie Zhang, Qiaojun Fang, Wenjie Kang, Haiqiong Shang, Xiangyu Lou, Ming Gua. ARC protects cochlear hair cells from neomycin-induced ototoxicity via the Ras/JNK signaling pathway. Toxicology letters. vol 403. 2024-12-15. PMID:39667535. |
the present study was designed to investigate the role and mechanism of the apoptosis repressor with caspase recruitment domain (arc) in protecting the neomycin-induced hair cell damage. |
2024-12-15 |
2024-12-21 |
Not clear |
| Xiaoyu Yu, Hanbing Gao, Jie Zhang, Qiaojun Fang, Wenjie Kang, Haiqiong Shang, Xiangyu Lou, Ming Gua. ARC protects cochlear hair cells from neomycin-induced ototoxicity via the Ras/JNK signaling pathway. Toxicology letters. vol 403. 2024-12-15. PMID:39667535. |
we have found the arc overexpression in hei-oc1 cells can increase the cell viability and decrease cell apoptosis after neomycin injury. |
2024-12-15 |
2024-12-21 |
Not clear |
| Xiaoyu Yu, Hanbing Gao, Jie Zhang, Qiaojun Fang, Wenjie Kang, Haiqiong Shang, Xiangyu Lou, Ming Gua. ARC protects cochlear hair cells from neomycin-induced ototoxicity via the Ras/JNK signaling pathway. Toxicology letters. vol 403. 2024-12-15. PMID:39667535. |
this study indicates that arc can protect the hair cells from neomycin-induced apoptosis through ras/jnk signaling pathway. |
2024-12-15 |
2024-12-21 |
Not clear |
| Xiang Ao, Guoqiang Ji, Bingqiang Zhang, Wei Ding, Jianxun Wang, Ying Liu, Junqiang Xu. Role of apoptosis repressor with caspase recruitment domain in human health and chronic diseases. Annals of medicine. vol 56. issue 1. 2024-10-01. PMID:39351758. |
apoptosis repressor with caspase recruitment domain (arc) is a highly potent and multifunctional suppressor of various types of programmed cell death (pcd) (e.g. |
2024-10-01 |
2024-10-03 |
human |
| Peimin Lin, Jie Xu, Fan Yang, Dan Li, Rong Zhang, Yongxiang Jiang, Tianyu Zhen. Elevated concentrations of amyloid-β oligomers and their proapoptotic effects on age-related cataract. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 17. 2024-09-09. PMID:39247969. |
here, we demonstrated that the accumulation of aβos in the lens epithelium of age-related cataract (arc) patients increased during arc progression and that this alteration was consistent with the changes in mitochondrial function, oxidative stress, and cellular apoptosis. |
2024-09-09 |
2024-09-11 |
human |
| Guang-Nan Jin, Yu Wang, Yi-Ming Liu, Yu-Nan Lu, Jing-Mei Lu, Jing-He Wang, Jing-Wen Ma, Yan-Zhu Quan, Hong-Yan Gao, Yue-Xian Cui, Xiang Xu, Lian-Xun Pia. Arctiin Mitigates Neuronal Injury by Modulating the P2X7R/NLPR3 Inflammasome Signaling Pathway. Inflammation. 2024-08-17. PMID:39154088. |
arc attenuated neuroinflammatory responses and neuronal apoptosis by inhibiting the overactivation of the p2x7 receptor (p2x7r)/nod-like receptor family pyrin domain-containing 3 (nlrp3) inflammasome signaling pathway, similar to the effect of a438079 (p2x7r antagonist). |
2024-08-17 |
2024-08-20 |
mouse |
| Xi Zou, Jun Zhang, Yong Wang, Dong Zhou, Guohua Deng, Zhinan Li. PeerJ. vol 12. 2024-04-15. PMID:38618568. |
apoptosis of lens epithelial cells (lecs) is closely related to arc formation. |
2024-04-15 |
2024-04-17 |
human |
| Shanhe Liu, Dongmei Su, Zhaoyi Sun, Tianhua Piao, Sijia Li, Lina Guan, Yanjiang Fu, Gaobo Zhang, Tingsong Cui, Wenna Zhu, Xu Ma, Shanshan H. Epigallocatechin gallate delays age-related cataract development via the RASSF2/AKT pathway. European journal of pharmacology. 2023-11-18. PMID:37979829. |
age-related cataract (arc) is a common eye disease, the main cause of which is oxidative stress-mediated apoptosis of lens epithelial cells (lecs). |
2023-11-18 |
2023-11-20 |
mouse |
| Miao Li, Zhaofeng Pan, Qi He, Jiacong Xiao, Baihao Chen, Fanchen Wang, Pan Kang, Haoran Luo, Jianliang Li, Jiaxu Zeng, Shaocong Li, Junzheng Yang, Haibin Wang, Chi Zho. Arctiin attenuates iron overload‑induced osteoporosis by regulating the PI3K/Akt pathway. International journal of molecular medicine. vol 52. issue 5. 2023-10-06. PMID:37800616. |
notably, arc treatment reversed the decreased viability and increased apoptosis in mc3t3‑e1 cells originally induced by ferric ammonium citrate, whilst promoting the formation of mineralized bone nodules in mc3t3‑e1 cells. |
2023-10-06 |
2023-10-07 |
mouse |
| Miaomiao Sun, Ke Li, Xiao Li, Huajun Wang, Li Li, Guangying Zhen. lncRNA TUG1 regulates Smac/DIABLO expression by competitively inhibiting miR-29b and modulates the apoptosis of lens epithelial cells in age-related cataracts. Chinese medical journal. 2023-05-15. PMID:37185343. |
this study aimed to explore the mechanism by which lncrna tug1 mediates lens epithelial cell apoptosis in age-related cataracts (arc) by regulating the micrornas (mir-29b)/second mitochondria-derived activator of caspases axis, and to identify more non-surgical strategies for cataract treatment. |
2023-05-15 |
2023-08-14 |
Not clear |
| Xu Pei, Mi Tian, Yao Wang, Yuewen Xin, Junliang Jiang, Yunyun Wang, Ye Gon. Advances in the knowledge on the role of apoptosis repressor with caspase recruitment domain in hemorrhagic stroke. Journal of intensive medicine. vol 3. issue 2. 2023-05-15. PMID:37188117. |
the apoptosis repressor with caspase recruitment domain (arc) plays a critical role in extrinsic apoptosis initiation |
2023-05-15 |
2023-08-14 |
Not clear |
| Wenyi Zhang, Anran Wu, Guowei Zhang, Xuemeng Ding, Lihua Kang, Tianqiu Zhou, Min Ji, Huaijin Gua. Ubiquitination of Ku70 by Parkin promotes apoptosis of lens epithelial cells. The FEBS journal. 2023-03-31. PMID:37000041. |
oxidative damage-triggered apoptosis in lens epithelial cells (lecs) is considered as a main risk factor in the pathogenesis of age-related cataract (arc). |
2023-03-31 |
2023-08-14 |
mouse |
| Rui Li, Haohao Zhu, Qian Li, Jiancen Tang, Yiping Jin, Hongping Cu. METTL3-mediated m6A modification of has_circ_0007905 promotes age-related cataract progression through miR-6749-3p/EIF4EBP1. PeerJ. vol 11. 2023-03-13. PMID:36908822. |
loss-of-function assays and rescue assays were used to explore the effect and mechanism of circrna on arc cell proliferation and apoptosis. |
2023-03-13 |
2023-08-14 |
Not clear |
| Anran Wu, Wenyi Zhang, Guowei Zhang, Xuemeng Ding, Lihua Kang, Tianqiu Zhou, Min Ji, Huaijin Gua. Age-related cataract: GSTP1 ubiquitination and degradation by Parkin inhibits its anti-apoptosis in lens epithelial cells. Biochimica et biophysica acta. Molecular cell research. 2023-03-05. PMID:36871745. |
oxidative stress-induced apoptosis of lens epithelial cells (lecs) contributes to the pathogenesis of age-related cataract (arc). |
2023-03-05 |
2023-08-14 |
Not clear |
| Kun Liu, Dongfeng Lan, Chunyang Li, Songpo Liu, Xiaofang Dai, Tao Song, Xianyao Wang, Qinghong Kong, Zhixu He, Jun Tan, Jidong Zhan. A double-edged sword: role of apoptosis repressor with caspase recruitment domain (ARC) in tumorigenesis and ischaemia/reperfusion (I/R) injury. Apoptosis : an international journal on programmed cell death. 2023-01-18. PMID:36652128. |
a double-edged sword: role of apoptosis repressor with caspase recruitment domain (arc) in tumorigenesis and ischaemia/reperfusion (i/r) injury. |
2023-01-18 |
2023-08-14 |
Not clear |
| Kun Liu, Dongfeng Lan, Chunyang Li, Songpo Liu, Xiaofang Dai, Tao Song, Xianyao Wang, Qinghong Kong, Zhixu He, Jun Tan, Jidong Zhan. A double-edged sword: role of apoptosis repressor with caspase recruitment domain (ARC) in tumorigenesis and ischaemia/reperfusion (I/R) injury. Apoptosis : an international journal on programmed cell death. 2023-01-18. PMID:36652128. |
apoptosis repressor with caspase recruitment domain (arc) acts as a potent and multifunctional inhibitor of apoptosis, which is mainly expressed in postmitotic cells, including cardiomyocytes. |
2023-01-18 |
2023-08-14 |
Not clear |
| Kun Liu, Dongfeng Lan, Chunyang Li, Songpo Liu, Xiaofang Dai, Tao Song, Xianyao Wang, Qinghong Kong, Zhixu He, Jun Tan, Jidong Zhan. A double-edged sword: role of apoptosis repressor with caspase recruitment domain (ARC) in tumorigenesis and ischaemia/reperfusion (I/R) injury. Apoptosis : an international journal on programmed cell death. 2023-01-18. PMID:36652128. |
due to the powerful inhibition of apoptosis, arc is mainly reported to act as a cardioprotective factor during ischaemia‒reperfusion (i/r) injury, preventing cardiomyocytes from being devastated by various catastrophes, including oxidative stress, calcium overload, and mitochondrial dysfunction in the circulatory system. |
2023-01-18 |
2023-08-14 |
Not clear |
| Shanhe Liu, Dongmei Su, Zhaoyi Sun, Lina Guan, Zhongying Wang, Gaobo Zhang, Guiqian Zheng, Tingsong Cui, Xu Ma, Shanshan H. High MST2 expression regulates lens epithelial cell apoptosis in age-related cataracts through YAP1 targeting GLUT1. Archives of biochemistry and biophysics. 2022-04-22. PMID:35452623. |
this study investigated the relevance of mst2/yap1/glut1 in arc development in vivo and in vitro, and explored the role and possible mechanisms of this pathway in oxidative damage-mediated apoptosis of lens epithelial cells (lecs). |
2022-04-22 |
2023-08-13 |
mouse |
| Rui Chen, Min Yan. Melatonin Inhibits OGD/R-Induced H9c2 Cardiomyocyte Pyroptosis via Regulation of MT2/miR-155/FOXO3a/ARC Axis. International heart journal. vol 63. issue 2. 2022-03-31. PMID:35354753. |
melatonin treatment also led to an increased level of apoptosis repressor with caspase recruitment domain (arc), which was inhibited by foxo3a sirna. |
2022-03-31 |
2023-08-13 |
Not clear |
| Refaat A Ei. Acylated ghrelin protection inhibits apoptosis in the remote myocardium post-myocardial infarction by inhibiting calcineurin and activating ARC. Archives of physiology and biochemistry. 2021-12-29. PMID:34965150. |
acylated ghrelin protection inhibits apoptosis in the remote myocardium post-myocardial infarction by inhibiting calcineurin and activating arc. |
2021-12-29 |
2023-08-13 |
rat |