| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ye Ding, Hao Li, Saisai Cao, Yong Y. Effects of catechin on the malignant biological behavior of gastric cancer cells through the PI3K/Akt signaling pathway. Toxicology and applied pharmacology. 2024-07-15. PMID:39009138. |
the proliferation ability, cell cycle, apoptosis and migration of gastric cancer cells were detected, as well as the protein expression levels of pi3k, p-akt, and akt and the mrna expression levels of akt1, vegfa, egfr, hras, and hsp90aa1 in gastric cancer cells. |
2024-07-15 |
2024-07-18 |
Not clear |
| Nianping Zhang, Peng Guo, Yan Zhao, Xiao Qiu, Shuai Shao, Zhenzhong Liu, Zong Ga. Pharmacological mechanisms of puerarin in the treatment of Parkinson's disease: An overview. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-07-13. PMID:39002442. |
puerarin inhibits cell apoptosis through the phosphatidylinositol-4,5-bisphosphate 3-kinase (pi3k)/protein kinase b (akt) and c-jun n-terminal kinase (jnk) signaling pathways. |
2024-07-13 |
2024-07-16 |
Not clear |
| Liu-Dan Liang, Hui-Xin Peng, Mei-Jin Huang, Li-Ye Su, Jia-Wei Huang, Jian-le Lao, Zhao-He Huang, Yan Li. HGF ameliorates cardiomyocyte apoptosis and inflammatory response in septic patients via the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway. Gene. 2024-07-13. PMID:39002784. |
hgf ameliorates cardiomyocyte apoptosis and inflammatory response in septic patients via the phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt) pathway. |
2024-07-13 |
2024-07-16 |
Not clear |
| Shuangmei Tong, Jian Wu, Yun Song, Wenhuan Fu, Yifan Yuan, Pin Zhong, Yinlong Liu, Bin Wan. IDH1-mutant metabolite D-2-hydroxyglutarate inhibits proliferation and sensitizes glioma to temozolomide via down-regulating ITGB4/PI3K/AKT. Cell death discovery. vol 10. issue 1. 2024-07-09. PMID:38982076. |
in subsequent cellular experiments, we found that the idh1-mutant metabolite d-2hg suppresses integrin subunit beta 4 (itgb4) expression, and down-regulate the phosphorylation levels of pi3k and akt, ultimately inhibiting cell proliferation while promoting apoptosis, thereby improving glioma prognosis. |
2024-07-09 |
2024-07-12 |
Not clear |
| Maryam Moosavi, Roksana Soukhaklari, Saeid Bagheri-Mohammadi, Bita Firouzan, Pegah Javadpour, Rasoul Ghasem. Nanocurcumin prevents memory impairment, hippocampal apoptosis, Akt and CaMKII-α signaling disruption in the central STZ model of Alzheimer's disease in rat. Behavioural brain research. 2024-06-28. PMID:38942084. |
nanocurcumin prevents memory impairment, hippocampal apoptosis, akt and camkii-α signaling disruption in the central stz model of alzheimer's disease in rat. |
2024-06-28 |
2024-07-01 |
rat |
| Maryam Moosavi, Roksana Soukhaklari, Saeid Bagheri-Mohammadi, Bita Firouzan, Pegah Javadpour, Rasoul Ghasem. Nanocurcumin prevents memory impairment, hippocampal apoptosis, Akt and CaMKII-α signaling disruption in the central STZ model of Alzheimer's disease in rat. Behavioural brain research. 2024-06-28. PMID:38942084. |
these findings might suggest that nanocurcumin can restore memory deficit, hippocampal apoptosis as well as akt and camkii-α signaling disruption associated with brain insulin resistance. |
2024-06-28 |
2024-07-01 |
rat |
| Yusuff Olayiwola, Lauren S Gollaho. Chlorogenic Acid and Cinnamaldehyde in Combination Inhibit Metastatic Traits and Induce Apoptosis via Akt Downregulation in Breast Cancer Cells. International journal of molecular sciences. vol 25. issue 12. 2024-06-27. PMID:38928123. |
chlorogenic acid and cinnamaldehyde in combination inhibit metastatic traits and induce apoptosis via akt downregulation in breast cancer cells. |
2024-06-27 |
2024-06-29 |
Not clear |
| Yusuff Olayiwola, Lauren S Gollaho. Chlorogenic Acid and Cinnamaldehyde in Combination Inhibit Metastatic Traits and Induce Apoptosis via Akt Downregulation in Breast Cancer Cells. International journal of molecular sciences. vol 25. issue 12. 2024-06-27. PMID:38928123. |
the hypothesis was that cga and ca in combination decrease the metastatic potential of breast cancer cells by inhibiting their invasive and migratory abilities as well as the induction of apoptosis via the downregulation of the akt, disrupting its signal transduction pathway. |
2024-06-27 |
2024-06-29 |
Not clear |
| Yusuff Olayiwola, Lauren S Gollaho. Chlorogenic Acid and Cinnamaldehyde in Combination Inhibit Metastatic Traits and Induce Apoptosis via Akt Downregulation in Breast Cancer Cells. International journal of molecular sciences. vol 25. issue 12. 2024-06-27. PMID:38928123. |
in summary, the present study demonstrated that cga and ca in combination downregulated akt activation, inhibited the metastatic potential, and induced apoptosis in different breast cancer cell lines. |
2024-06-27 |
2024-06-29 |
Not clear |
| Shuai He, Yuxiang Chen, Hui Wang, Shupei Li, Yu Wei, Hui Zhang, Qian Gao, Fengsong Wang, Ruijie Zhan. Neuroprotective Effects of Chlorogenic Acid: Modulation of Akt/Erk1/2 Signaling to Prevent Neuronal Apoptosis in Parkinson's Disease. Free radical biology & medicine. 2024-06-26. PMID:38925315. |
our recent investigations revealed that reactive oxygen species (ros) and pd-toxins like 6-hydroxydopamine (6-ohda) can induce neuronal apoptosis through over-activation of akt signaling. |
2024-06-26 |
2024-06-29 |
mouse |
| Shuai He, Yuxiang Chen, Hui Wang, Shupei Li, Yu Wei, Hui Zhang, Qian Gao, Fengsong Wang, Ruijie Zhan. Neuroprotective Effects of Chlorogenic Acid: Modulation of Akt/Erk1/2 Signaling to Prevent Neuronal Apoptosis in Parkinson's Disease. Free radical biology & medicine. 2024-06-26. PMID:38925315. |
combining the erk1/2 inhibitor u0126 with cga could reverse 6-ohda-induced akt inhibition, ros, and apoptosis in the cells. |
2024-06-26 |
2024-06-29 |
mouse |
| Qian Jiang, Yayun Chen, Siping Zheng, Lina Sui, Dalang Yu, Furong Qing, Wenji He, Qiuxiang Xiao, Tianfu Guo, Li Xu, Zhichun Liu, Zhiping Li. AIM2 enhances Candida albicans infection through promoting macrophage apoptosis via AKT signaling. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-06-25. PMID:38918243. |
aim2 enhances candida albicans infection through promoting macrophage apoptosis via akt signaling. |
2024-06-25 |
2024-06-29 |
mouse |
| Shuai Yan, Lu Chen, Hao Zhuang, Hui Yang, Yinmo Yang, Ning Zhang, Rong Li. HDAC Inhibition Sensitize Hepatocellular Carcinoma to Lenvatinib via Suppressing AKT Activation. International journal of biological sciences. vol 20. issue 8. 2024-06-21. PMID:38904018. |
furthermore, combinational application of lenvatinib and hdac inhibitor or akt inhibitor synergistically inhibits hcc cell proliferation and induces cell apoptosis. |
2024-06-21 |
2024-06-23 |
Not clear |
| Mannan Nouri, Andreas Varkaris, Maya Ridinger, Susan L Dalrymple, Christopher M Dennehy, John T Isaacs, David J Einstein, W Nathaniel Brennen, Steven P Bal. AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer. Molecular cancer therapeutics. 2024-06-19. PMID:38894678. |
we confirmed in vitro synergy between onv and the akt inhibitor ipatasertib (ipa) and found that the combination increased apoptosis. |
2024-06-19 |
2024-06-21 |
Not clear |
| Shaoheng Chen, Jia Han, Huimin Deng, Yuanshan Lu, Zhicheng Wang, Qi Zhang, Rong Xi. Platelet PD-L1 inhibits storage-induced apoptosis by sustaining activation of the AKT signalling pathway. Thrombosis research. vol 240. 2024-06-15. PMID:38878739. |
platelet pd-l1 inhibits storage-induced apoptosis by sustaining activation of the akt signalling pathway. |
2024-06-15 |
2024-06-18 |
mouse |
| Shaoheng Chen, Jia Han, Huimin Deng, Yuanshan Lu, Zhicheng Wang, Qi Zhang, Rong Xi. Platelet PD-L1 inhibits storage-induced apoptosis by sustaining activation of the AKT signalling pathway. Thrombosis research. vol 240. 2024-06-15. PMID:38878739. |
therefore, platelet pd-l1 inhibits storage-induced apoptosis by sustaining activation of the akt signalling pathway, which is expected to become a target for alleviating platelet storage lesions (psls) under current blood bank conditions. |
2024-06-15 |
2024-06-18 |
mouse |
| Warumporn Yingsunthonwattana, Pakkakul Sangsuriya, Premruethai Supungul, Anchalee Tassanakajo. Litopenaeus vannamei heat shock protein 90 (LvHSP90) interacts with white spot syndrome virus protein, WSSV322, to modulate hemocyte apoptosis during viral infection. Fish & shellfish immunology. 2024-06-13. PMID:38871140. |
moreover, the co-silencing of lvhsp90 and wssv322 triggered apoptosis by the mitochondrial pathway, resulting in the upregulation of pro-apoptotic protein expression (bax) and the downregulation of anti-apoptotic protein expression (bcl, akt). |
2024-06-13 |
2024-06-16 |
Not clear |
| Yihong Chen, Chrysostomi Gialeli, Junyan Shen, Pontus Dunér, Björn Walse, Annette Duelli, Rhawnie Caing-Carlsson, Anna M Blom, John R Zibert, Anna Hultgårdh Nilsson, Jan Alenfall, Chun Liang, Jan Nilsso. Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular repair responses and angiogenesis. Pharmacological research. 2024-06-13. PMID:38871237. |
stimulation of human umbilical vein endothelial cells with fol-026 resulted in phosphorylation of vegfr-2, erk1/2 and akt, increased cell growth and migration, stimulation of endothelial tube formation and inhibition of apoptosis in vitro. |
2024-06-13 |
2024-06-16 |
human |
| Mengling Li, Jibran Sualeh Muhammad, Qing-Li Zhao, Shahbaz Ahmad Zakki, Yusuke Hiraku, Hideki Hatta, Xiaopeng Tong, Zheng-Guo Cui, Chengai W. Protective effects of baicalin against phenylarsine oxide-induced cytotoxicity in human skin keratinocytes. Bioorganic chemistry. vol 150. 2024-06-12. PMID:38865859. |
treatment of pao alone induces the jnk, p38 and caspase-3 activation, which were engaged in the apoptosis induction, while the activity of akt was significantly inhibited, which was engaged in the suppression of apoptosis. |
2024-06-12 |
2024-06-15 |
human |
| Mengling Li, Jibran Sualeh Muhammad, Qing-Li Zhao, Shahbaz Ahmad Zakki, Yusuke Hiraku, Hideki Hatta, Xiaopeng Tong, Zheng-Guo Cui, Chengai W. Protective effects of baicalin against phenylarsine oxide-induced cytotoxicity in human skin keratinocytes. Bioorganic chemistry. vol 150. 2024-06-12. PMID:38865859. |
however, bcn treatment restored the pao-induced suppression of sirt3 and akt expression, reduced intracellular ros generation, and markedly suppressed both caspase-3 activation and apoptosis induction. |
2024-06-12 |
2024-06-15 |
human |