All Relations between apoptosis and akt

Publication Sentence Publish Date Extraction Date Species
Shuai Yan, Lu Chen, Hao Zhuang, Hui Yang, Yinmo Yang, Ning Zhang, Rong Li. HDAC Inhibition Sensitize Hepatocellular Carcinoma to Lenvatinib via Suppressing AKT Activation. International journal of biological sciences. vol 20. issue 8. 2024-06-21. PMID:38904018. furthermore, combinational application of lenvatinib and hdac inhibitor or akt inhibitor synergistically inhibits hcc cell proliferation and induces cell apoptosis. 2024-06-21 2024-06-23 Not clear
Mannan Nouri, Andreas Varkaris, Maya Ridinger, Susan L Dalrymple, Christopher M Dennehy, John T Isaacs, David J Einstein, W Nathaniel Brennen, Steven P Bal. AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer. Molecular cancer therapeutics. 2024-06-19. PMID:38894678. we confirmed in vitro synergy between onv and the akt inhibitor ipatasertib (ipa) and found that the combination increased apoptosis. 2024-06-19 2024-06-21 Not clear
Shaoheng Chen, Jia Han, Huimin Deng, Yuanshan Lu, Zhicheng Wang, Qi Zhang, Rong Xi. Platelet PD-L1 inhibits storage-induced apoptosis by sustaining activation of the AKT signalling pathway. Thrombosis research. vol 240. 2024-06-15. PMID:38878739. platelet pd-l1 inhibits storage-induced apoptosis by sustaining activation of the akt signalling pathway. 2024-06-15 2024-06-18 mouse
Shaoheng Chen, Jia Han, Huimin Deng, Yuanshan Lu, Zhicheng Wang, Qi Zhang, Rong Xi. Platelet PD-L1 inhibits storage-induced apoptosis by sustaining activation of the AKT signalling pathway. Thrombosis research. vol 240. 2024-06-15. PMID:38878739. therefore, platelet pd-l1 inhibits storage-induced apoptosis by sustaining activation of the akt signalling pathway, which is expected to become a target for alleviating platelet storage lesions (psls) under current blood bank conditions. 2024-06-15 2024-06-18 mouse
Warumporn Yingsunthonwattana, Pakkakul Sangsuriya, Premruethai Supungul, Anchalee Tassanakajo. Litopenaeus vannamei heat shock protein 90 (LvHSP90) interacts with white spot syndrome virus protein, WSSV322, to modulate hemocyte apoptosis during viral infection. Fish & shellfish immunology. 2024-06-13. PMID:38871140. moreover, the co-silencing of lvhsp90 and wssv322 triggered apoptosis by the mitochondrial pathway, resulting in the upregulation of pro-apoptotic protein expression (bax) and the downregulation of anti-apoptotic protein expression (bcl, akt). 2024-06-13 2024-06-16 Not clear
Yihong Chen, Chrysostomi Gialeli, Junyan Shen, Pontus Dunér, Björn Walse, Annette Duelli, Rhawnie Caing-Carlsson, Anna M Blom, John R Zibert, Anna Hultgårdh Nilsson, Jan Alenfall, Chun Liang, Jan Nilsso. Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular repair responses and angiogenesis. Pharmacological research. 2024-06-13. PMID:38871237. stimulation of human umbilical vein endothelial cells with fol-026 resulted in phosphorylation of vegfr-2, erk1/2 and akt, increased cell growth and migration, stimulation of endothelial tube formation and inhibition of apoptosis in vitro. 2024-06-13 2024-06-16 human
Mengling Li, Jibran Sualeh Muhammad, Qing-Li Zhao, Shahbaz Ahmad Zakki, Yusuke Hiraku, Hideki Hatta, Xiaopeng Tong, Zheng-Guo Cui, Chengai W. Protective effects of baicalin against phenylarsine oxide-induced cytotoxicity in human skin keratinocytes. Bioorganic chemistry. vol 150. 2024-06-12. PMID:38865859. treatment of pao alone induces the jnk, p38 and caspase-3 activation, which were engaged in the apoptosis induction, while the activity of akt was significantly inhibited, which was engaged in the suppression of apoptosis. 2024-06-12 2024-06-15 human
Mengling Li, Jibran Sualeh Muhammad, Qing-Li Zhao, Shahbaz Ahmad Zakki, Yusuke Hiraku, Hideki Hatta, Xiaopeng Tong, Zheng-Guo Cui, Chengai W. Protective effects of baicalin against phenylarsine oxide-induced cytotoxicity in human skin keratinocytes. Bioorganic chemistry. vol 150. 2024-06-12. PMID:38865859. however, bcn treatment restored the pao-induced suppression of sirt3 and akt expression, reduced intracellular ros generation, and markedly suppressed both caspase-3 activation and apoptosis induction. 2024-06-12 2024-06-15 human
Xiangyu Chen, Binghua Sun, Shuai L. Downregulation of HIGD1B induces mitochondria-mediated apoptosis in gastric cancer cells by inactivating Akt and ERK pathways. Drug development research. vol 85. issue 4. 2024-06-12. PMID:38863387. downregulation of higd1b induces mitochondria-mediated apoptosis in gastric cancer cells by inactivating akt and erk pathways. 2024-06-12 2024-06-14 Not clear
Xiangyu Chen, Binghua Sun, Shuai L. Downregulation of HIGD1B induces mitochondria-mediated apoptosis in gastric cancer cells by inactivating Akt and ERK pathways. Drug development research. vol 85. issue 4. 2024-06-12. PMID:38863387. moreover, higd1b deficiency significantly induced mitochondria-mediated apoptosis in gc cells by inactivating akt and erk pathways. 2024-06-12 2024-06-14 Not clear
Jesús Herrera-Bravo, Lisandra Herrera Belén, María Elena Reyes, Victor Silva, Soledad Fuentealba, Cristian Paz, Pía Loren, Luis A Salazar, Javad Sharifi-Rad, Daniela Calin. Thymol as adjuvant in oncology: molecular mechanisms, therapeutic potentials, and prospects for integration in cancer management. Naunyn-Schmiedeberg's archives of pharmacology. 2024-06-07. PMID:38847831. thymol has been shown to induce programmed cell death (apoptosis), halt the cell division cycle (cell cycle arrest), and inhibit cancer spread (metastasis) through modulation of critical signaling pathways, including phosphoinositide 3-kinase (pi3k), protein kinase b (akt), extracellular signal-regulated kinase (erk), mechanistic target of rapamycin (mtor), and wnt/β-catenin. 2024-06-07 2024-06-10 Not clear
Yajun Zhu, Xiaoguo Li, Xingwei Lei, Liuyang Tang, Daochen Wen, Bo Zeng, Xiaofeng Zhang, Zichao Huang, Zongduo Gu. The potential mechanism and clinical application value of remote ischemic conditioning in stroke. Neural regeneration research. 2024-06-07. PMID:38845225. mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the notch1/phosphatidylinositol 3-kinase/ akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. 2024-06-07 2024-06-10 Not clear
Peng Sun, Kang Huo, Fude Liu, Yawen Cheng, Chen Chen, Jianfeng Han, Jia Y. Regulation and molecular mechanism of adiponectin on the proliferation, apoptosis, autophagy, and chemosensitivity of LN18 Glioma cell line. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 6. 2024-06-05. PMID:38836664. this study aimed to explore the regulatory effects and associated mechanisms of adiponectin on apoptosis and proliferation in the ln18 glioma cell line through the ampk and akt signaling pathways. 2024-06-05 2024-06-07 Not clear
Jiali Chen, Qinghe Zeng, Xu Wang, Rui Xu, Weidong Wang, Yuliang Huang, Qi Sun, Wenhua Yuan, Pinger Wang, Di Chen, Peijian Tong, Hongting Ji. Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling. eLife. vol 13. 2024-05-31. PMID:38819423. aberrant methylation and expression of tnxb promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via akt signaling. 2024-05-31 2024-06-02 mouse
Yichao Liao, Feng Wei, Zhelin He, Jingxue He, Yanlin Ai, Cui Guo, Li Zhou, Dan Luo, Chengen Li, Yueqiang Wen, Jinhao Zeng, Xiao M. Animal-derived natural products for hepatocellular carcinoma therapy: current evidence and future perspectives. Frontiers in pharmacology. vol 15. 2024-05-29. PMID:38803433. the mechanism of action involving apoptosis induction, autophagy induction, anti-proliferation, anti-migration, and anti-drug resistance via phosphoinositide 3-kinase (pi3k)/protein kinase b (akt)/mammalian target of rapamycin (mtor), ras/extracellular signal regulated kinases (erk)/mitogen-activated protein kinase (mapk), wnt/β-catenin, and janus kinase (jak)/signal transducer and activator of transcription (stat) pathways. 2024-05-29 2024-06-03 human
Zhansheng Zhu, Shanwen Liang, Yu Hong, Yangzhi Qi, Qian Sun, Xinyi Zhu, Yuxin Wei, Yang Xu, Qianxue Che. Bufotalin enhances apoptosis and TMZ chemosensitivity of glioblastoma cells by promoting mitochondrial dysfunction via AKT signaling pathway. Aging. vol 16. 2024-05-29. PMID:38809514. bufotalin enhances apoptosis and tmz chemosensitivity of glioblastoma cells by promoting mitochondrial dysfunction via akt signaling pathway. 2024-05-29 2024-06-03 Not clear
Chi Teng Vong, Dechao Tan, Fengyun Liao, Zhejie Chen, Zhangmei Chen, Hisa Hui Ling Tseng, Wai San Cheang, Shengpeng Wang, Yitao Wan. Ginsenoside Rk1 Ameliorates ER Stress-Induced Apoptosis through Directly Activating IGF-1R in Mouse Pancreatic [Formula: see text]-Cells and Diabetic Pancreas. The American journal of Chinese medicine. 2024-05-27. PMID:38798150. we demonstrated that ginsenoside rk1 alleviated er stress-induced apoptosis in min6 cells, which was accomplished by directly targeting and activating insulin-like growth factor 1 receptor (igf-1r), thus activating the phosphoinositide 3-kinase (pi3k)/protein kinase b (akt)/bcl-2-associated agonist of cell death (bad)-b-cell lymphoma-2 (bcl-2) pathway. 2024-05-27 2024-05-31 mouse
Janice M Santiago-O'Farrill, Alicia Blessing Bollu, Hailing Yang, Vivian Orellana, Marc Pina, Xudong Zhang, Jinsong Liu, Robert C Bast, Zhen L. Crizotinib enhances PARP inhibitor efficacy in ovarian cancer cells and xenograft models by inducing autophagy. Molecular cancer research : MCR. 2024-05-23. PMID:38780897. mechanistically, the combination resulted in increased levels of reactive oxygen species (ros), induced dna damage, and decreased the phosphorylation of akt, mtor, and ulk-1, contributing to increased olaparib-induced autophagy and apoptosis. 2024-05-23 2024-05-27 human
Jiani Wang, Xiang Wu, Jincai Fang, Qian L. Intervention of exogenous VEGF protect brain microvascular endothelial cells from hypoxia-induced injury by regulating PLCγ/RAS/ERK and PI3K/AKT pathways. Experimental gerontology. vol 192. 2024-05-22. PMID:38718888. interference from exogenous vegf-e activated plcγ1/erk-1/2 and akt pathways, promoting cell proliferation and inhibiting apoptosis of hypoxic brain microvascular endothelial cells. 2024-05-22 2024-05-27 Not clear
Ju-Bin Kang, Phil-Ok Ko. Retinoic acid alleviates the reduction of Akt and Bad phosphorylation and regulates Bcl-2 family protein interactions in animal models of ischemic stroke. PloS one. vol 19. issue 5. 2024-05-16. PMID:38753710. phosphorylated akt is important in regulating survival and apoptosis. 2024-05-16 2024-05-27 Not clear