| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nadav Shalit, Ran Barzilay, Gal Shoval, Dan Shlosberg, Nofar Mor, Nofar Zweigenhaft, Abraham Weizman, Amir Krivo. Characteristics of Synthetic Cannabinoid and Cannabis Users Admitted to a Psychiatric Hospital: A Comparative Study. The Journal of clinical psychiatry. vol 77. issue 8. 2017-06-30. PMID:27379411. |
psychotic and affective exacerbations associated with synthetic cannabinoid (sc) use are becoming an emerging concern in psychiatric hospitals. |
2017-06-30 |
2023-08-13 |
Not clear |
| Carmen Walter, Bruno G Oertel, Lisa Felden, Christian A Kell, Ulrike Nöth, Johannes Vermehren, Jochen Kaiser, Ralf Deichmann, Jörn Lötsc. Brain Mapping-Based Model of Δ(9)-Tetrahydrocannabinol Effects on Connectivity in the Pain Matrix. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 6. 2017-01-05. PMID:26514581. |
these findings may have consequences for the way thc effects are currently interpreted: as cannabinoids are increasingly considered in pain treatment, present results provide relevant information about how thc interferes with the affective component of pain. |
2017-01-05 |
2023-08-13 |
human |
| Marie Fitzgibbon, David P Finn, Michelle Roch. High Times for Painful Blues: The Endocannabinoid System in Pain-Depression Comorbidity. The international journal of neuropsychopharmacology. vol 19. issue 3. 2016-12-13. PMID:26342110. |
however, the past decade has seen mounting evidence supporting a role for the endogenous cannabinoid (endocannabinoid) system in affective and nociceptive processing, and thus, alterations in this system may play a key role in reciprocal interactions between depression and pain. |
2016-12-13 |
2023-08-13 |
Not clear |
| Kiri L Wills, Linda A Parke. Effect of Pharmacological Modulation of the Endocannabinoid System on Opiate Withdrawal: A Review of the Preclinical Animal Literature. Frontiers in pharmacology. vol 7. 2016-07-22. PMID:27445822. |
additionally, the brain regions mediating somatic and affective opiate withdrawal are elucidated with respect to their modulation by the endocannabinoid system. |
2016-07-22 |
2023-08-13 |
Not clear |
| Kiri L Wills, Linda A Parke. Effect of Pharmacological Modulation of the Endocannabinoid System on Opiate Withdrawal: A Review of the Preclinical Animal Literature. Frontiers in pharmacology. vol 7. 2016-07-22. PMID:27445822. |
the behaviors measured to quantify somatic opiate withdrawal and the paradigms employed to assess affective opiate withdrawal (e.g., conditioned place aversion) in both acutely and chronically dependent animals are discussed in relation to the ability of the endocannabinoid system to modulate these behaviors. |
2016-07-22 |
2023-08-13 |
Not clear |
| Kiri L Wills, Linda A Parke. Effect of Pharmacological Modulation of the Endocannabinoid System on Opiate Withdrawal: A Review of the Preclinical Animal Literature. Frontiers in pharmacology. vol 7. 2016-07-22. PMID:27445822. |
ultimately, a review of these findings reveals dissociations between the brain regions mediating somatic and affective opiate withdrawal, and the ability of cannabinoid type 1 (cb1) receptor agonism/antagonism to interfere with opiate withdrawal within different brain sub regions. |
2016-07-22 |
2023-08-13 |
Not clear |
| Carmen La Porta, S Andreea Bura, Jone Llorente-Onaindia, Antoni Pastor, Francisco Navarrete, María Salud García-Gutiérrez, Rafael De la Torre, Jorge Manzanares, Jordi Monfort, Rafael Maldonad. Role of the endocannabinoid system in the emotional manifestations of osteoarthritis pain. Pain. vol 156. issue 10. 2016-06-27. PMID:26067584. |
patients with knee osteoarthritis and healthy controls were recruited to evaluate pain, affective, and cognitive symptoms, as well as plasma endocannabinoid levels and cannabinoid receptor gene expression in peripheral blood lymphocytes. |
2016-06-27 |
2023-08-13 |
mouse |
| Brian C Shonesy, Rebecca J Bluett, Teniel S Ramikie, Rita Báldi, Daniel J Hermanson, Philip J Kingsley, Lawrence J Marnett, Danny G Winder, Roger J Colbran, Sachin Pate. Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation. Cell reports. vol 9. issue 5. 2015-08-17. PMID:25466252. |
however, the role of the most-abundant endocannabinoid 2-arachidonoylglycerol (2-ag) in the physiological regulation of affective behaviors is not well understood. |
2015-08-17 |
2023-08-13 |
mouse |
| Erik B Oleson, Roger Cachope, Aurelie Fitoussi, Joseph F Chee. Tales from the dark side: do neuromodulators of drug withdrawal require changes in endocannabinoid tone? Progress in neuro-psychopharmacology & biological psychiatry. vol 52. 2014-12-12. PMID:23911441. |
we next describe how the endocannabinoid system modulates phasic dopamine release events and how it might be harnessed to treat negative affective states in addiction. |
2014-12-12 |
2023-08-12 |
Not clear |
| Walter Fratta, Liana Fattor. Molecular mechanisms of cannabinoid addiction. Current opinion in neurobiology. vol 23. issue 4. 2014-02-27. PMID:23490548. |
similarly to other drugs of abuse, repeated exposure to cannabinoids causes brain neuroadaptations that persist long after drug effects, contribute to the negative affective states during withdrawal, and ultimately facilitate relapse. |
2014-02-27 |
2023-08-12 |
Not clear |
| Michael C Lee, Markus Ploner, Katja Wiech, Ulrike Bingel, Vishvarani Wanigasekera, Jonathan Brooks, David K Menon, Irene Trace. Amygdala activity contributes to the dissociative effect of cannabis on pain perception. Pain. vol 154. issue 1. 2013-06-18. PMID:23273106. |
nonetheless, the frontal-limbic distribution of cannabinoid receptors in the brain suggests that cannabis may target preferentially the affective qualities of pain. |
2013-06-18 |
2023-08-12 |
human |
| Antonia Serrano, Patricia Rivera, Francisco J Pavon, Juan Decara, Juan Suárez, Fernando Rodriguez de Fonseca, Loren H Parson. Differential effects of single versus repeated alcohol withdrawal on the expression of endocannabinoid system-related genes in the rat amygdala. Alcoholism, clinical and experimental research. vol 36. issue 6. 2012-10-18. PMID:22141465. |
endogenous cannabinoids such as anandamide and 2-arachidonoylglycerol (2-ag) exert important regulatory influences on neuronal signaling, participate in short- and long-term forms of neuroplasticity, and modulate stress responses and affective behavior in part through the modulation of neurotransmission in the amygdala. |
2012-10-18 |
2023-08-12 |
rat |
| Antonia Serrano, Patricia Rivera, Francisco J Pavon, Juan Decara, Juan Suárez, Fernando Rodriguez de Fonseca, Loren H Parson. Differential effects of single versus repeated alcohol withdrawal on the expression of endocannabinoid system-related genes in the rat amygdala. Alcoholism, clinical and experimental research. vol 36. issue 6. 2012-10-18. PMID:22141465. |
alcohol consumption alters brain endocannabinoid levels, and alcohol dependence is associated with dysregulated amygdalar function, stress responsivity, and affective control. |
2012-10-18 |
2023-08-12 |
rat |
| Christine A Rabinak, Chandra Sekhar Sripada, Mike Angstadt, Harriet de Wit, K Luan Pha. Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affect. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 6. 2012-09-20. PMID:22160489. |
cannabinoids affect positive and negative affective experience and emotional perception, possibly by modulating limbic brain reactivity. |
2012-09-20 |
2023-08-12 |
Not clear |
| R J McLaughlin, G Gobb. Cannabinoids and emotionality: a neuroanatomical perspective. Neuroscience. vol 204. 2012-07-23. PMID:21827834. |
given the crucial role of this corticolimbic network in regulating emotional behavior, it is palpable that alterations in endocannabinoid signaling within any of these structures could have profound implications for the pathophysiological development of affective illnesses. |
2012-07-23 |
2023-08-12 |
Not clear |
| Antonia Serrano, Loren H Parson. Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors. Pharmacology & therapeutics. vol 132. issue 3. 2012-03-01. PMID:21798285. |
in this review we discuss the effects of drug intake on brain endocannabinoid signaling, evidence implicating the endocannabinoid system in the motivation for drug consumption, and drug-induced alterations in endocannabinoid function that may contribute to various aspects of addiction including dysregulated synaptic plasticity, increased stress responsivity, negative affective states, drug craving and relapse to drug taking. |
2012-03-01 |
2023-08-12 |
Not clear |
| Maria Mavrikaki, Eirini Markaki, George G Nomikos, George Panagi. Chronic WIN55,212-2 elicits sustained and conditioned increases in intracranial self-stimulation thresholds in the rat. Behavioural brain research. vol 209. issue 1. 2010-05-25. PMID:20097234. |
the present data demonstrate cannabinoid-predictive stimuli that may gain affective salience and play an important role in maintaining cannabinoid administration. |
2010-05-25 |
2023-08-12 |
rat |
| Staci A Gruber, Jadwiga Rogowska, Deborah A Yurgelun-Tod. Altered affective response in marijuana smokers: an FMRI study. Drug and alcohol dependence. vol 105. issue 1-2. 2009-11-30. PMID:19656642. |
endogenous cannabinoids regulate a variety of emotional responses, including anxiety, mood control, and aggression; nevertheless, little is known about smokers' responses to affective stimuli. |
2009-11-30 |
2023-08-12 |
human |
| Jamie Horder, Philip J Cowen, Martina Di Simplicio, Michael Browning, Catherine J Harme. Acute administration of the cannabinoid CB1 antagonist rimonabant impairs positive affective memory in healthy volunteers. Psychopharmacology. vol 205. issue 1. 2009-09-02. PMID:19337726. |
acute administration of the cannabinoid cb1 antagonist rimonabant impairs positive affective memory in healthy volunteers. |
2009-09-02 |
2023-08-12 |
human |
| Michaela Kress, R Kune. Mode of action of cannabinoids on nociceptive nerve endings. Experimental brain research. vol 196. issue 1. 2009-08-20. PMID:19306092. |
for clinical exploitation of the analgesic properties of cannabinoids, a major challenge is to devise strategies that reduce or abolish their adverse effects on cognitive, affective and motor functions without attenuating their analgesic effects. |
2009-08-20 |
2023-08-12 |
Not clear |